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Annual Review of Biomedical Engineering最新文献

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Integrating Upper-Limb Prostheses with the Human Body: Technology Advances, Readiness, and Roles in Human–Prosthesis Interaction 上肢假肢与人体的结合：技术进步、准备情况以及在人与假肢互动中的作用
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2024-04-10 DOI: 10.1146/annurev-bioeng-110222-095816
He (Helen) Huang, Levi J. Hargrove, Max Ortiz-Catalan, Jonathon W. Sensinger
{"title":"Integrating Upper-Limb Prostheses with the Human Body: Technology Advances, Readiness, and Roles in Human–Prosthesis Interaction","authors":"He (Helen) Huang, Levi J. Hargrove, Max Ortiz-Catalan, Jonathon W. Sensinger","doi":"10.1146/annurev-bioeng-110222-095816","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-110222-095816","url":null,"abstract":"Significant advances in bionic prosthetics have occurred in the past two decades. The field's rapid expansion has yielded many exciting technologies that can enhance the physical, functional, and cognitive integration of a prosthetic limb with a human. We review advances in the engineering of prosthetic devices and their interfaces with the human nervous system, as well as various surgical techniques for altering human neuromusculoskeletal systems for seamless human–prosthesis integration. We discuss significant advancements in research and clinical translation, focusing on upper limb prosthetics since they heavily rely on user intent for daily operation, although many discussed technologies have been extended to lower limb prostheses as well. In addition, our review emphasizes the roles of advanced prosthetics technologies in complex interactions with humans and the technology readiness levels (TRLs) of individual research advances. Finally, we discuss current gaps and controversies in the field and point out future research directions, guided by TRLs.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"32 1","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasmonic-Driven Regulation of Biomolecular Activity In Situ 等离子体驱动的生物分子活性原位调控
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2024-04-10 DOI: 10.1146/annurev-bioeng-110222-105043
Chen Xie, Tingting Zhang, Zhenpeng Qin
{"title":"Plasmonic-Driven Regulation of Biomolecular Activity In Situ","authors":"Chen Xie, Tingting Zhang, Zhenpeng Qin","doi":"10.1146/annurev-bioeng-110222-105043","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-110222-105043","url":null,"abstract":"Selective and remote manipulation of activity for biomolecules, including protein, DNA, and lipids, is crucial to elucidate the molecular function and to develop biomedical applications. While advances in tool development, such as optogenetics, have significantly impacted these directions, the requirement for genetic modification significantly limits their therapeutic applications. Plasmonic nanoparticle heating has brought new opportunities to the field, as hot nanoparticles are unique point heat sources at the nanoscale. In this review, we summarize fundamental engineering problems such as plasmonic heating and the resulting biomolecular responses. We highlight the biological responses and applications of manipulating biomolecules and provide perspectives for future directions in the field.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"38 1","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive Models for Health Deterioration: Understanding Disease Pathways for Personalized Medicine. 健康恶化的预测模型:了解个性化医疗的疾病途径。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-02-28 DOI: 10.1146/annurev-bioeng-110220-030247
Bjoern M Eskofier, Jochen Klucken
{"title":"Predictive Models for Health Deterioration: Understanding Disease Pathways for Personalized Medicine.","authors":"Bjoern M Eskofier, Jochen Klucken","doi":"10.1146/annurev-bioeng-110220-030247","DOIUrl":"10.1146/annurev-bioeng-110220-030247","url":null,"abstract":"<p><p>Artificial intelligence (AI) and machine learning (ML) methods are currently widely employed in medicine and healthcare. A PubMed search returns more than 100,000 articles on these topics published between 2018 and 2022 alone. Notwithstanding several recent reviews in various subfields of AI and ML in medicine, we have yet to see a comprehensive review around the methods' use in longitudinal analysis and prediction of an individual patient's health status within a personalized disease pathway. This review seeks to fill that gap. After an overview of the AI and ML methods employed in this field and of specific medical applications of models of this type, the review discusses the strengths and limitations of current studies and looks ahead to future strands of research in this field. We aim to enable interested readers to gain a detailed impression of the research currently available and accordingly plan future work around predictive models for deterioration in health status.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"131-156"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9595664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epitranscriptional Regulation: From the Perspectives of Cardiovascular Bioengineering. 表转录调控:从心血管生物工程的角度。
IF 12.8 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-03-08 DOI: 10.1146/annurev-bioeng-081922-021233
Zhen Bouman Chen, Ming He, Julie Yi-Shuan Li, John Y-J Shyy, Shu Chien
{"title":"Epitranscriptional Regulation: From the Perspectives of Cardiovascular Bioengineering.","authors":"Zhen Bouman Chen, Ming He, Julie Yi-Shuan Li, John Y-J Shyy, Shu Chien","doi":"10.1146/annurev-bioeng-081922-021233","DOIUrl":"10.1146/annurev-bioeng-081922-021233","url":null,"abstract":"<p><p>The central dogma of gene expression involves DNA transcription to RNA and RNA translation into protein. As key intermediaries and modifiers, RNAs undergo various forms of modifications such as methylation, pseudouridylation, deamination, and hydroxylation. These modifications, termed epitranscriptional regulations, lead to functional changes in RNAs. Recent studies have demonstrated crucial roles for RNA modifications in gene translation, DNA damage response, and cell fate regulation. Epitranscriptional modifications play an essential role in development, mechanosensing, atherogenesis, and regeneration in the cardiovascular (CV) system, and their elucidation is critically important to understanding the molecular mechanisms underlying CV physiology and pathophysiology. This review aims at providing biomedical engineers with an overview of the epitranscriptome landscape, related key concepts, recent findings in epitranscriptional regulations, and tools for epitranscriptome analysis. The potential applications of this important field in biomedical engineering research are discussed.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"157-184"},"PeriodicalIF":12.8,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9959757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current Trends in Anti-Aging Strategies. 抗衰老策略的当前趋势。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 DOI: 10.1146/annurev-bioeng-120122-123054
Robert S Rosen, Martin L Yarmush
{"title":"Current Trends in Anti-Aging Strategies.","authors":"Robert S Rosen, Martin L Yarmush","doi":"10.1146/annurev-bioeng-120122-123054","DOIUrl":"10.1146/annurev-bioeng-120122-123054","url":null,"abstract":"<p><p>The process of aging manifests from a highly interconnected network of biological cascades resulting in the degradation and breakdown of every living organism over time. This natural development increases risk for numerous diseases and can be debilitating. Academic and industrial investigators have long sought to impede, or potentially reverse, aging in the hopes of alleviating clinical burden, restoring functionality, and promoting longevity. Despite widespread investigation, identifying impactful therapeutics has been hindered by narrow experimental validation and the lack of rigorous study design. In this review, we explore the current understanding of the biological mechanisms of aging and how this understanding both informs and limits interpreting data from experimental models based on these mechanisms. We also discuss select therapeutic strategies that have yielded promising data in these model systems with potential clinical translation. Lastly, we propose a unifying approach needed to rigorously vet current and future therapeutics and guide evaluation toward efficacious therapies.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"363-385"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9606163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Emerging Penetrating Neural Electrodes: In Pursuit of Large Scale and Longevity. 新兴穿透式神经电极:追求大规模和长寿。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 DOI: 10.1146/annurev-bioeng-090622-050507
Lan Luan, Rongkang Yin, Hanlin Zhu, Chong Xie
{"title":"Emerging Penetrating Neural Electrodes: In Pursuit of Large Scale and Longevity.","authors":"Lan Luan, Rongkang Yin, Hanlin Zhu, Chong Xie","doi":"10.1146/annurev-bioeng-090622-050507","DOIUrl":"10.1146/annurev-bioeng-090622-050507","url":null,"abstract":"<p><p>Penetrating neural electrodes provide a powerful approach to decipher brain circuitry by allowing for time-resolved electrical detections of individual action potentials. This unique capability has contributed tremendously to basic and translational neuroscience, enabling both fundamental understandings of brain functions and applications of human prosthetic devices that restore crucial sensations and movements. However, conventional approaches are limited by the scarce number of available sensing channels and compromised efficacy over long-term implantations. Recording longevity and scalability have become the most sought-after improvements in emerging technologies. In this review, we discuss the technological advances in the past 5-10 years that have enabled larger-scale, more detailed, and longer-lasting recordings of neural circuits at work than ever before. We present snapshots of the latest advances in penetration electrode technology, showcase their applications in animal models and humans, and outline the underlying design principles and considerations to fuel future technological development.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"185-205"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11078330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9606165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineered Compounds to Control Ice Nucleation and Recrystallization. 控制冰核和再结晶的工程化合物。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-04-27 DOI: 10.1146/annurev-bioeng-082222-015243
Nishaka William, Sophia Mangan, Rob N Ben, Jason P Acker
{"title":"Engineered Compounds to Control Ice Nucleation and Recrystallization.","authors":"Nishaka William, Sophia Mangan, Rob N Ben, Jason P Acker","doi":"10.1146/annurev-bioeng-082222-015243","DOIUrl":"10.1146/annurev-bioeng-082222-015243","url":null,"abstract":"<p><p>One of the greatest concerns in the subzero storage of cells, tissues, and organs is the ability to control the nucleation or recrystallization of ice. In nature, evidence of these processes, which aid in sustaining internal temperatures below the physiologic freezing point for extended periods of time, is apparent in freeze-avoidant and freeze-tolerant organisms. After decades of studying these proteins, we now have easily accessible compounds and materials capable of recapitulating the mechanisms seen in nature for biopreser-vation applications. The output from this burgeoning area of research can interact synergistically with other novel developments in the field of cryobiology, making it an opportune time for a review on this topic.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"333-362"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9606309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Noninvasive Monitoring to Detect Dehydration: Are We There Yet? 无创监测脱水:我们做到了吗?
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-02-28 DOI: 10.1146/annurev-bioeng-062117-121028
Martha Gray, Judith S Birkenfeld, Ian Butterworth
{"title":"Noninvasive Monitoring to Detect Dehydration: Are We There Yet?","authors":"Martha Gray, Judith S Birkenfeld, Ian Butterworth","doi":"10.1146/annurev-bioeng-062117-121028","DOIUrl":"10.1146/annurev-bioeng-062117-121028","url":null,"abstract":"<p><p>The need for hydration monitoring is significant, especially for the very young and elderly populations who are more vulnerable to becoming dehydrated and suffering from the effects that dehydration brings. This need has been among the drivers of considerable effort in the academic and commercial sectors to provide a means for monitoring hydration status, with a special interest in doing so outside the hospital or clinical setting. This review of emerging technologies provides an overview of many technology approaches that, on a theoretical basis, have sensitivity to water and are feasible as a routine measurement. We review the evidence of technical validation and of their use in humans. Finally, we highlight the essential need for these technologies to be rigorously evaluated for their diagnostic potential, as a necessary step to meet the need for hydration monitoring outside of the clinical environment.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"23-49"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9595669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analytical Techniques for Single-Cell Biochemical Assays of Lipids. 脂质单细胞生化分析技术。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-04-17 DOI: 10.1146/annurev-bioeng-110220-034007
Ming Yao, Manibarathi Vaithiyanathan, Nancy L Allbritton
{"title":"Analytical Techniques for Single-Cell Biochemical Assays of Lipids.","authors":"Ming Yao, Manibarathi Vaithiyanathan, Nancy L Allbritton","doi":"10.1146/annurev-bioeng-110220-034007","DOIUrl":"10.1146/annurev-bioeng-110220-034007","url":null,"abstract":"<p><p>Lipids are essential cellular components forming membranes, serving as energy reserves, and acting as chemical messengers. Dysfunction in lipid metabolism and signaling is associated with a wide range of diseases including cancer and autoimmunity. Heterogeneity in cell behavior including lipid signaling is increasingly recognized as a driver of disease and drug resistance. This diversity in cellular responses as well as the roles of lipids in health and disease drive the need to quantify lipids within single cells. Single-cell lipid assays are challenging due to the small size of cells (∼1 pL) and the large numbers of lipid species present at concentrations spanning orders of magnitude. A growing number of methodologies enable assay of large numbers of lipid analytes, perform high-resolution spatial measurements, or permit highly sensitive lipid assays in single cells. Covered in this review are mass spectrometry, Raman imaging, and fluorescence-based assays including microscopy and microseparations.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"281-309"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11032153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9597217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering Therapeutics to Detoxify Hemoglobin, Heme, and Iron. 解毒血红蛋白、血红素和铁的工程疗法。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 DOI: 10.1146/annurev-bioeng-081622-031203
Ivan S Pires, François Berthiaume, Andre F Palmer
{"title":"Engineering Therapeutics to Detoxify Hemoglobin, Heme, and Iron.","authors":"Ivan S Pires, François Berthiaume, Andre F Palmer","doi":"10.1146/annurev-bioeng-081622-031203","DOIUrl":"10.1146/annurev-bioeng-081622-031203","url":null,"abstract":"<p><p>Hemolysis (i.e., red blood cell lysis) can increase circulatory levels of cell-free hemoglobin (Hb) and its degradation by-products, namely heme (h) and iron (Fe). Under homeostasis, minor increases in these three hemolytic by-products (Hb/h/Fe) are rapidly scavenged and cleared by natural plasma proteins. Under certain pathophysiological conditions, scavenging systems become overwhelmed, leading to the accumulation of Hb/h/Fe in the circulation. Unfortunately, these species cause various side effects such as vasoconstriction, hypertension, and oxidative organ damage. Therefore, various therapeutics strategies are in development, ranging from supplementation with depleted plasma scavenger proteins to engineered biomimetic protein constructs capable of scavenging multiple hemolytic species. In this review, we briefly describe hemolysis and the characteristics of the major plasma-derived protein scavengers of Hb/h/Fe. Finally, we present novel engineering approaches designed to address the toxicity of these hemolytic by-products.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"1-21"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9606164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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