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Annual Review of Biomedical Engineering最新文献

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Engineered Compounds to Control Ice Nucleation and Recrystallization. 控制冰核和再结晶的工程化合物。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-04-27 DOI: 10.1146/annurev-bioeng-082222-015243
Nishaka William, Sophia Mangan, Rob N Ben, Jason P Acker
{"title":"Engineered Compounds to Control Ice Nucleation and Recrystallization.","authors":"Nishaka William, Sophia Mangan, Rob N Ben, Jason P Acker","doi":"10.1146/annurev-bioeng-082222-015243","DOIUrl":"10.1146/annurev-bioeng-082222-015243","url":null,"abstract":"<p><p>One of the greatest concerns in the subzero storage of cells, tissues, and organs is the ability to control the nucleation or recrystallization of ice. In nature, evidence of these processes, which aid in sustaining internal temperatures below the physiologic freezing point for extended periods of time, is apparent in freeze-avoidant and freeze-tolerant organisms. After decades of studying these proteins, we now have easily accessible compounds and materials capable of recapitulating the mechanisms seen in nature for biopreser-vation applications. The output from this burgeoning area of research can interact synergistically with other novel developments in the field of cryobiology, making it an opportune time for a review on this topic.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"333-362"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9606309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Noninvasive Monitoring to Detect Dehydration: Are We There Yet? 无创监测脱水:我们做到了吗?
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-02-28 DOI: 10.1146/annurev-bioeng-062117-121028
Martha Gray, Judith S Birkenfeld, Ian Butterworth
{"title":"Noninvasive Monitoring to Detect Dehydration: Are We There Yet?","authors":"Martha Gray, Judith S Birkenfeld, Ian Butterworth","doi":"10.1146/annurev-bioeng-062117-121028","DOIUrl":"10.1146/annurev-bioeng-062117-121028","url":null,"abstract":"<p><p>The need for hydration monitoring is significant, especially for the very young and elderly populations who are more vulnerable to becoming dehydrated and suffering from the effects that dehydration brings. This need has been among the drivers of considerable effort in the academic and commercial sectors to provide a means for monitoring hydration status, with a special interest in doing so outside the hospital or clinical setting. This review of emerging technologies provides an overview of many technology approaches that, on a theoretical basis, have sensitivity to water and are feasible as a routine measurement. We review the evidence of technical validation and of their use in humans. Finally, we highlight the essential need for these technologies to be rigorously evaluated for their diagnostic potential, as a necessary step to meet the need for hydration monitoring outside of the clinical environment.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"23-49"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9595669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analytical Techniques for Single-Cell Biochemical Assays of Lipids. 脂质单细胞生化分析技术。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-04-17 DOI: 10.1146/annurev-bioeng-110220-034007
Ming Yao, Manibarathi Vaithiyanathan, Nancy L Allbritton
{"title":"Analytical Techniques for Single-Cell Biochemical Assays of Lipids.","authors":"Ming Yao, Manibarathi Vaithiyanathan, Nancy L Allbritton","doi":"10.1146/annurev-bioeng-110220-034007","DOIUrl":"10.1146/annurev-bioeng-110220-034007","url":null,"abstract":"<p><p>Lipids are essential cellular components forming membranes, serving as energy reserves, and acting as chemical messengers. Dysfunction in lipid metabolism and signaling is associated with a wide range of diseases including cancer and autoimmunity. Heterogeneity in cell behavior including lipid signaling is increasingly recognized as a driver of disease and drug resistance. This diversity in cellular responses as well as the roles of lipids in health and disease drive the need to quantify lipids within single cells. Single-cell lipid assays are challenging due to the small size of cells (∼1 pL) and the large numbers of lipid species present at concentrations spanning orders of magnitude. A growing number of methodologies enable assay of large numbers of lipid analytes, perform high-resolution spatial measurements, or permit highly sensitive lipid assays in single cells. Covered in this review are mass spectrometry, Raman imaging, and fluorescence-based assays including microscopy and microseparations.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"281-309"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11032153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9597217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering Therapeutics to Detoxify Hemoglobin, Heme, and Iron. 解毒血红蛋白、血红素和铁的工程疗法。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 DOI: 10.1146/annurev-bioeng-081622-031203
Ivan S Pires, François Berthiaume, Andre F Palmer
{"title":"Engineering Therapeutics to Detoxify Hemoglobin, Heme, and Iron.","authors":"Ivan S Pires, François Berthiaume, Andre F Palmer","doi":"10.1146/annurev-bioeng-081622-031203","DOIUrl":"10.1146/annurev-bioeng-081622-031203","url":null,"abstract":"<p><p>Hemolysis (i.e., red blood cell lysis) can increase circulatory levels of cell-free hemoglobin (Hb) and its degradation by-products, namely heme (h) and iron (Fe). Under homeostasis, minor increases in these three hemolytic by-products (Hb/h/Fe) are rapidly scavenged and cleared by natural plasma proteins. Under certain pathophysiological conditions, scavenging systems become overwhelmed, leading to the accumulation of Hb/h/Fe in the circulation. Unfortunately, these species cause various side effects such as vasoconstriction, hypertension, and oxidative organ damage. Therefore, various therapeutics strategies are in development, ranging from supplementation with depleted plasma scavenger proteins to engineered biomimetic protein constructs capable of scavenging multiple hemolytic species. In this review, we briefly describe hemolysis and the characteristics of the major plasma-derived protein scavengers of Hb/h/Fe. Finally, we present novel engineering approaches designed to address the toxicity of these hemolytic by-products.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"1-21"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9606164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photoacoustic Imaging and Characterization of Bone in Medicine: Overview, Applications, and Outlook. 骨在医学中的光声成像与表征:综述、应用与展望。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-03-31 DOI: 10.1146/annurev-bioeng-081622-025405
Eduardo A Gonzalez, Muyinatu A Lediju Bell
{"title":"Photoacoustic Imaging and Characterization of Bone in Medicine: Overview, Applications, and Outlook.","authors":"Eduardo A Gonzalez, Muyinatu A Lediju Bell","doi":"10.1146/annurev-bioeng-081622-025405","DOIUrl":"10.1146/annurev-bioeng-081622-025405","url":null,"abstract":"<p><p>Photoacoustic techniques have shown promise in identifying molecular changes in bone tissue and visualizing tissue microstructure. This capability represents significant advantages over gold standards (i.e., dual-energy X-ray absorptiometry) for bone evaluation without requiring ionizing radiation. Instead, photoacoustic imaging uses light to penetrate through bone, followed by acoustic pressure generation, resulting in highly sensitive optical absorption contrast in deep biological tissues. This review covers multiple bone-related photoacoustic imaging contributions to clinical applications, spanning bone cancer, joint pathologies, spinal disorders, osteoporosis, bone-related surgical guidance, consolidation monitoring, and transsphenoidal and transcranial imaging. We also present a summary of photoacoustic-based techniques for characterizing biomechanical properties of bone, including temperature, guided waves, spectral parameters, and spectroscopy. We conclude with a future outlook based on the current state of technological developments, recent achievements, and possible new directions.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"207-232"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9658608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Bioelectronic Sensor Nodes for the Internet of Bodies. 身体互联网的生物电子传感器节点。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-03-13 DOI: 10.1146/annurev-bioeng-110220-112448
Baibhab Chatterjee, Pedram Mohseni, Shreyas Sen
{"title":"Bioelectronic Sensor Nodes for the Internet of Bodies.","authors":"Baibhab Chatterjee, Pedram Mohseni, Shreyas Sen","doi":"10.1146/annurev-bioeng-110220-112448","DOIUrl":"10.1146/annurev-bioeng-110220-112448","url":null,"abstract":"<p><p>Energy-efficient sensing with physically secure communication for biosensors on, around, and within the human body is a major area of research for the development of low-cost health care devices, enabling continuous monitoring and/or secure perpetual operation. When used as a network of nodes, these devices form the Internet of Bodies, which poses challenges including stringent resource constraints, simultaneous sensing and communication, and security vulnerabilities. Another major challenge is to find an efficient on-body energy-harvesting method to support the sensing, communication, and security submodules. Due to limitations in the amount of energy harvested, we require a reduction in energy consumed per unit information, making the use of in-sensor analytics and processing imperative. In this article, we review the challenges and opportunities of low-power sensing, processing, and communication with possible powering modalities for future biosensor nodes. Specifically, we analyze, compare, and contrast (<i>a</i>) different sensing mechanisms such as voltage/current domain versus time domain, (<i>b</i>) low-power, secure communication modalities including wireless techniques and human body communication, and (<i>c</i>) different powering techniques for wearable devices and implants.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"101-129"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9959756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Label-Free Optical Metabolic Imaging in Cells and Tissues. 细胞和组织中的无标记光学代谢成像。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-04-27 DOI: 10.1146/annurev-bioeng-071516-044730
Irene Georgakoudi, Kyle P Quinn
{"title":"Label-Free Optical Metabolic Imaging in Cells and Tissues.","authors":"Irene Georgakoudi, Kyle P Quinn","doi":"10.1146/annurev-bioeng-071516-044730","DOIUrl":"10.1146/annurev-bioeng-071516-044730","url":null,"abstract":"<p><p>Over the last half century, the autofluorescence of the metabolic cofactors NADH (reduced nicotinamide adenine dinucleotide) and FAD (flavin adenine dinucleotide) has been quantified in a variety of cell types and disease states. With the spread of nonlinear optical microscopy techniques in biomedical research, NADH and FAD imaging has offered an attractive solution to noninvasively monitor cell and tissue status and elucidate dynamic changes in cell or tissue metabolism. Various tools and methods to measure the temporal, spectral, and spatial properties of NADH and FAD autofluorescence have been developed. Specifically, an optical redox ratio of cofactor fluorescence intensities and NADH fluorescence lifetime parameters have been used in numerous applications, but significant work remains to mature this technology for understanding dynamic changes in metabolism. This article describes the current understanding of our optical sensitivity to different metabolic pathways and highlights current challenges in the field. Recent progress in addressing these challenges and acquiring more quantitative information in faster and more metabolically relevant formats is also discussed.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"413-443"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10733979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9606305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Thinking Beyond the Device: An Overview of Human- and Equity-Centered Approaches for Health Technology Design. 超越设备的思考：以人为中心和公平为中心的健康技术设计方法综述。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-04-17 DOI: 10.1146/annurev-bioeng-081922-024834
Natalia M Rodriguez, Grace Burleson, Jacqueline C Linnes, Kathleen H Sienko
{"title":"Thinking Beyond the Device: An Overview of Human- and Equity-Centered Approaches for Health Technology Design.","authors":"Natalia M Rodriguez, Grace Burleson, Jacqueline C Linnes, Kathleen H Sienko","doi":"10.1146/annurev-bioeng-081922-024834","DOIUrl":"10.1146/annurev-bioeng-081922-024834","url":null,"abstract":"<p><p>A shift in the traditional technocentric view of medical device design to a human-centered one is needed to bridge existing translational gaps and improve health equity. To ensure the successful and equitable adoption of health technology innovations, engineers must think beyond the device and the direct end user and must seek a more holistic understanding of broader stakeholder needs and the intended context of use early in a design process. The objectives of this review article are (<i>a</i>) to provide rationale for the need to incorporate meaningful stakeholder analysis and contextual investigation in health technology development and biomedical engineering pedagogy, (<i>b</i>) to review existing frameworks and human- and equity-centered approaches to stakeholder engagement and contextual investigation for improved adoption of innovative technologies, and (<i>c</i>) to present case studyexamples of medical device design that apply these approaches to bridge the gaps between biomedical engineers and the contexts for which they are designing.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"257-280"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10137160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex as a Biological Variable in Tissue Engineering and Regenerative Medicine. 性别在组织工程和再生医学中的生物变量。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-04-27 DOI: 10.1146/annurev-bioeng-092222-030857
Josephine B Allen, Christopher Ludtka, Bryan D James
{"title":"Sex as a Biological Variable in Tissue Engineering and Regenerative Medicine.","authors":"Josephine B Allen, Christopher Ludtka, Bryan D James","doi":"10.1146/annurev-bioeng-092222-030857","DOIUrl":"10.1146/annurev-bioeng-092222-030857","url":null,"abstract":"<p><p>Although sex differences have been noted in cellular function and behavior, therapy efficacy, and disease incidence and outcomes, the adoption of sex as a biological variable in tissue engineering and regenerative medicine remains limited. Furthering the development of personalized, precision medicine requires considering biological sex at the bench and in the clinic. This review provides the basis for considering biological sex when designing tissue-engineered constructs and regenerative therapies by contextualizing sex as a biological variable within the tissue engineering triad of cells, matrices, and signals. To achieve equity in biological sex within medicine requires a cultural shift in science and engineering research, with active engagement by researchers, clinicians, companies, policymakers, and funding agencies.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"311-331"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10118644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural Plasticity in Sensorimotor Brain-Machine Interfaces. 感觉运动脑机接口中的神经可塑性。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-02-28 DOI: 10.1146/annurev-bioeng-110220-110833
Maria C Dadarlat, Ryan A Canfield, Amy L Orsborn
{"title":"Neural Plasticity in Sensorimotor Brain-Machine Interfaces.","authors":"Maria C Dadarlat, Ryan A Canfield, Amy L Orsborn","doi":"10.1146/annurev-bioeng-110220-110833","DOIUrl":"10.1146/annurev-bioeng-110220-110833","url":null,"abstract":"<p><p>Brain-machine interfaces (BMIs) aim to treat sensorimotor neurological disorders by creating artificial motor and/or sensory pathways. Introducing artificial pathways creates new relationships between sensory input and motor output, which the brain must learn to gain dexterous control. This review highlights the role of learning in BMIs to restore movement and sensation, and discusses how BMI design may influence neural plasticity and performance. The close integration of plasticity in sensory and motor function influences the design of both artificial pathways and will be an essential consideration for bidirectional devices that restore both sensory and motor function.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"51-76"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10791144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9595670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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