Annual Review of Biomedical Engineering最新文献_第6页

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-04-17 DOI: 10.1146/annurev-bioeng-111022-121637

Lee E Fisher, Scott F Lempka

引用次数: 0

Recent Advancements in Electroporation Technologies: From Bench to Clinic. 电穿孔技术的最新进展:从实验室到临床。

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-02-28 DOI: 10.1146/annurev-bioeng-110220-023800

Sabrina N Campelo, Po-Hsun Huang, Cullen R Buie, Rafael V Davalos

引用次数: 0

Nanotechnologies for Physiology-Informed Drug Delivery to the Lymphatic System. 向淋巴系统输送生理学知情药物的纳米技术。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-03-31 DOI: 10.1146/annurev-bioeng-092222-034906

Katharina Maisel, Claire A McClain, Amanda Bogseth, Susan N Thomas

引用次数: 0

Bioelectronic Sensor Nodes for Internet of Bodies 身体互联网的生物电子传感器节点

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2022-12-21 DOI: 10.48550/arXiv.2212.11370

Baibhab Chatterjee, P. Mohseni, Shreyas Sen

{"title":"Bioelectronic Sensor Nodes for Internet of Bodies","authors":"Baibhab Chatterjee, P. Mohseni, Shreyas Sen","doi":"10.48550/arXiv.2212.11370","DOIUrl":"https://doi.org/10.48550/arXiv.2212.11370","url":null,"abstract":"Energy-efficient sensing with Physically-secure communication for bio-sensors on, around and within the Human Body is a major area of research today for development of low-cost healthcare, enabling continuous monitoring and/or secure, perpetual operation. These devices, when used as a network of nodes form the Internet of Bodies (IoB), which poses certain challenges including stringent resource constraints (power/area/computation/memory), simultaneous sensing and communication, and security vulnerabilities as evidenced by the DHS and FDA advisories. One other major challenge is to find an efficient on-body energy harvesting method to support the sensing, communication, and security sub-modules. Due to the limitations in the harvested amount of energy, we require reduction of energy consumed per unit information, making the use of in-sensor analytics/processing imperative. In this paper, we review the challenges and opportunities in low-power sensing, processing and communication, with possible powering modalities for future bio-sensor nodes. Specifically, we analyze, compare and contrast (a) different sensing mechanisms such as voltage/current domain vs time-domain, (b) low-power, secure communication modalities including wireless techniques and human-body communication, and (c) different powering techniques for both wearable devices and implants.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"abs/2212.11370 1","pages":""},"PeriodicalIF":9.7,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70569775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomaterials for Hemostasis. 止血用生物材料。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2022-06-06 DOI: 10.1146/annurev-bioeng-012521-101942

Aryssa Simpson, Anita Shukla, Ashley C Brown

引用次数: 13

Improving Antibody Therapeutics by Manipulating the Fc Domain: Immunological and Structural Considerations. 通过控制Fc结构域改善抗体治疗:免疫学和结构考虑。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2022-06-06 DOI: 10.1146/annurev-bioeng-082721-024500

George Delidakis, Jin Eyun Kim, Katia George, George Georgiou

{"title":"Improving Antibody Therapeutics by Manipulating the Fc Domain: Immunological and Structural Considerations.","authors":"George Delidakis, Jin Eyun Kim, Katia George, George Georgiou","doi":"10.1146/annurev-bioeng-082721-024500","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-082721-024500","url":null,"abstract":"Interactions between the crystallizable fragment (Fc) domain of antibodies and a plethora of cellular Fc receptors (FcRs) or soluble proteins form a critical link between humoral and innate immunity. In particular, the immunoglobulin G Fc domain is critical for the clearance of target cells by processes that include (a) cytotoxicity, phagocytosis, or complement lysis; (b) modulation of inflammation; (c) antigen presentation; (d) antibody-mediated receptor clustering; and (e) cytokine release. More than 30 Fc-engineered antibodies aimed primarily at tailoring these effects for optimal therapeutic outcomes are in clinical evaluation or have already been approved. Nonetheless, our understanding of how FcR engagement impacts various immune cell phenotypes is still largely incomplete. Recent insights into FcR biology coupled with advances in Fc:FcR structural analysis, Fc engineering, and mouse models that recapitulate human biology are helping to fill in existing knowledge gaps. These advances will provide a blueprint on how to fine-tune the Fc domain to achieve optimal therapeutic efficacy.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"24 ","pages":"249-274"},"PeriodicalIF":9.7,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648538/pdf/nihms-1844455.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9180285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Technologies to Assess Drug Response and Heterogeneity in Patient-Derived Cancer Organoids. 评估患者生成的癌症器官组织中的药物反应和异质性的技术。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2022-06-06 Epub Date: 2022-03-08 DOI: 10.1146/annurev-bioeng-110220-123503

Melissa C Skala, Dustin A Deming, Jeremy D Kratz

{"title":"Technologies to Assess Drug Response and Heterogeneity in Patient-Derived Cancer Organoids.","authors":"Melissa C Skala, Dustin A Deming, Jeremy D Kratz","doi":"10.1146/annurev-bioeng-110220-123503","DOIUrl":"10.1146/annurev-bioeng-110220-123503","url":null,"abstract":"Patient-derived cancer organoids (PDCOs) are organotypic 3D cultures grown from patient tumor samples. PDCOs provide an exciting opportunity to study drug response and heterogeneity within and between patients. This research can guide new drug development and inform clinical treatment planning. We review technologies to assess PDCO drug response and heterogeneity, discuss best practices for clinically relevant drug screens, and assert the importance of quantifying single-cell and organoid heterogeneity to characterize response. Autofluorescence imaging of PDCO growth and metabolic activity is highlighted as a compelling method to monitor single-cell and single-organoid response robustly and reproducibly. We also speculate on the future of PDCOs in clinical practice and drug discovery.Future development will require standardization of assessment methods for both morphology and function in PDCOs, increased throughput for new drug development, prospective validation with patient outcomes, and robust classification algorithms.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"24 ","pages":"157-177"},"PeriodicalIF":9.7,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177801/pdf/nihms-1802445.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10053517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of Tumor Invasion by the Physical Microenvironment: Lessons from Breast and Brain Cancer. 物理微环境对肿瘤侵袭的调控:来自乳腺癌和脑癌的经验教训。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2022-06-06 DOI: 10.1146/annurev-bioeng-110220-115419

Garrett F Beeghly, Kwasi Y Amofa, Claudia Fischbach, Sanjay Kumar

{"title":"Regulation of Tumor Invasion by the Physical Microenvironment: Lessons from Breast and Brain Cancer.","authors":"Garrett F Beeghly, Kwasi Y Amofa, Claudia Fischbach, Sanjay Kumar","doi":"10.1146/annurev-bioeng-110220-115419","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-110220-115419","url":null,"abstract":"The success of anticancer therapies is often limited by heterogeneity within and between tumors. While much attention has been devoted to understanding the intrinsic molecular diversity of tumor cells, the surrounding tissue microenvironment is also highly complex and coevolves with tumor cells to drive clinical outcomes. Here, we propose that diverse types of solid tumors share common physical motifs that change in time and space, serving as universal regulators of malignancy. We use breast cancer and glioblastoma as instructive examples and highlight how invasion in both diseases is driven by the appropriation of structural guidance cues, contact-dependent heterotypic interactions with stromal cells, and elevated interstitial fluid pressure and flow. We discuss how engineering strategies show increasing value for measuring and modeling these physical propertiesfor mechanistic studies. Moreover, engineered systems offer great promise for developing and testing novel therapies that improve patient prognosis by normalizing the physical tumor microenvironment.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"24 ","pages":"29-59"},"PeriodicalIF":9.7,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177572/pdf/nihms-1781704.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9583783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Cell Trafficking at the Intersection of the Tumor-Immune Compartments. 肿瘤-免疫区室交叉处的细胞运输。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2022-06-06 DOI: 10.1146/annurev-bioeng-110320-110749

Wenxuan Du, Praful Nair, Adrian Johnston, Pei-Hsun Wu, Denis Wirtz

{"title":"Cell Trafficking at the Intersection of the Tumor-Immune Compartments.","authors":"Wenxuan Du, Praful Nair, Adrian Johnston, Pei-Hsun Wu, Denis Wirtz","doi":"10.1146/annurev-bioeng-110320-110749","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-110320-110749","url":null,"abstract":"Migration is an essential cellular process that regulates human organ development and homeostasis as well as disease initiation and progression. In cancer, immune and tumor cell migration is strongly associated with immune cell infiltration, immune escape, and tumor cell metastasis, which ultimately account for more than 90% of cancer deaths. The biophysics and molecular regulation of the migration of cancer and immune cells have been extensively studied separately. However, accumulating evidence indicates that, in the tumor microenvironment, the motilities of immune and cancer cells are highly interdependent via secreted factors such as cytokines and chemokines. Tumor and immune cells constantly express these soluble factors, which produce a tightly intertwined regulatory network for these cells' respective migration. A mechanistic understanding of the reciprocal regulation of soluble factor-mediated cell migration can provide critical information for the development of new biomarkers of tumor progression and of tumor response to immuno-oncological treatments. We review the biophysical andbiomolecular basis for the migration of immune and tumor cells and their associated reciprocal regulatory network. We also describe ongoing attempts to translate this knowledge into the clinic.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"24 ","pages":"275-305"},"PeriodicalIF":9.7,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10476598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function. 直接心脏压迫装置增强心脏生物力学和功能。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2022-04-08 DOI: 10.1146/annurev-bioeng-110220-025309

J. Bonnemain, P. D. del Nido, E. Roche

引用次数: 4