Cognitive and Behavioral Neurology最新文献_第4页

Poststroke Executive Function in Relation to White Matter Damage on Clinically Acquired CT Brain Imaging. 脑卒中后执行功能与临床CT脑成像白质损伤的关系。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2024-03-01 DOI: 10.1097/WNN.0000000000000355

Georgina Hobden, Margaret Jane Moore, Grant Mair, Sarah T Pendlebury, Nele Demeyere

{"title":"Poststroke Executive Function in Relation to White Matter Damage on Clinically Acquired CT Brain Imaging.","authors":"Georgina Hobden, Margaret Jane Moore, Grant Mair, Sarah T Pendlebury, Nele Demeyere","doi":"10.1097/WNN.0000000000000355","DOIUrl":"10.1097/WNN.0000000000000355","url":null,"abstract":"Background: Executive function (EF) impairments are prevalent post stroke and are associated with white matter (WM) damage on MRI. However, less is known about the relationship between poststroke EF and WM damage on CT imaging.Objective: To investigate the relationship between poststroke EF and WM damage associated with stroke lesions and WM hypointensities (WMHs) on clinically acquired CT imaging.Method: This study analyzed data from the Oxford Cognitive Screening Program, which recruited individuals aged ≥18 years with a confirmed stroke from an acute stroke unit. The individuals completed a follow-up assessment 6 months post stroke. We included individuals with a CT scan showing a visible stroke who completed follow-up EF assessment using the Oxford Cognitive Screen-Plus rule-finding task. We manually delineated stroke lesions and quantified then dichotomized WM damage caused by the stroke using the HCP-842 atlas. We visually rated then dichotomized WMHs using the Age-Related White Matter Changes Scale.Results: Among 87 stroke survivors (M age = 73.60 ± 11.75; 41 female; 61 ischemic stroke), multivariable linear regression showed that stroke damage to the medial lemniscus ( B = -8.86, P < 0.001) and the presence of WMHs ( B = -5.42, P = 0.005) were associated with poorer EF 6 months post stroke after adjusting for covariates including age and education.Conclusion: Poorer EF was associated with WM damage caused by stroke lesions and WMHs on CT. These results confirm the importance of WM integrity for EF post stroke and demonstrate the prognostic utility of CT-derived imaging markers for poststroke cognitive outcomes.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"23-31"},"PeriodicalIF":1.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41156247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barriers to Alzheimer Disease Clinical Trial Participation in a Minority Population. 少数群体参与阿尔茨海默病临床试验的障碍。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2024-03-01 DOI: 10.1097/WNN.0000000000000359

Anson Y Lee, Julia R Jahansooz, Darrell Guittu, Rexton Suzuki, Lauren Pak, Kyle M Ishikawa, Connor Goo, John J Chen, Enrique Carrazana, Jason Viereck, Kore K Liow

{"title":"Barriers to Alzheimer Disease Clinical Trial Participation in a Minority Population.","authors":"Anson Y Lee, Julia R Jahansooz, Darrell Guittu, Rexton Suzuki, Lauren Pak, Kyle M Ishikawa, Connor Goo, John J Chen, Enrique Carrazana, Jason Viereck, Kore K Liow","doi":"10.1097/WNN.0000000000000359","DOIUrl":"10.1097/WNN.0000000000000359","url":null,"abstract":"Background: Alzheimer disease (AD), the most common neurodegenerative disorder in the United States, disproportionately burdens minority populations.Objective: To explore barriers to AD clinical trial participation by Asian and Native Hawaiian patients diagnosed with AD or mild cognitive impairment.Method: We surveyed 187 patients with a Mini-Mental State Examination score ≥14 between January 2022 and June 2022. The score cutoff for clinical trial eligibility was set by the institution. Individuals also completed a 15-question telephone survey that assessed demographics, barriers to clinical trial participation, and clinical trial improvement methods.Results: Forty-nine patients responded, with a response rate of 26%. Asian and Native Hawaiian patients were less likely than White patients to participate in AD trials. The main barrier to participation was a lack of information about AD trials. Providing additional information regarding AD trials to patients and family members were listed as the top two reasons patients would consider participating in a clinical trial.Conclusion: Insufficient information about AD clinical trials is the primary barrier to participation among Asian and Native Hawaiian patients, followed by difficulty coordinating transportation and, in the case of Asians, the time required for clinical trials. Increased outreach, education, and assistance with logistics in these populations should be pursued to improve rates of participation in clinical trials.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"40-47"},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive Intra-individual Variability in the Laboratory Is Associated With Greater Executive Dysfunction in the Daily Lives of Older Adults With HIV. 实验室中的认知个体内变异性与艾滋病毒感染老年人日常生活中更大的执行功能障碍有关。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2024-03-01 DOI: 10.1097/WNN.0000000000000358

Natalie C Ridgely, Steven Paul Woods, Troy A Webber, Andrea I Mustafa, Darrian Evans

{"title":"Cognitive Intra-individual Variability in the Laboratory Is Associated With Greater Executive Dysfunction in the Daily Lives of Older Adults With HIV.","authors":"Natalie C Ridgely, Steven Paul Woods, Troy A Webber, Andrea I Mustafa, Darrian Evans","doi":"10.1097/WNN.0000000000000358","DOIUrl":"10.1097/WNN.0000000000000358","url":null,"abstract":"Background: Executive dysfunction, which is common among persons with HIV (PWH), can have an adverse impact on health behaviors and quality of life. Intra-individual variability (IIV) is a measure of within-person variability across cognitive tests that is higher in PWH and is thought to reflect cognitive dyscontrol.Objective: To assess whether cognitive IIV in the laboratory is associated with self-reported executive dysfunction in daily life among older PWH.Method: Participants included 71 PWH aged ≥50 years who completed six subtests from the Cogstate battery and two subscales from the Frontal Systems Behavior Scale (FrSBe; self-report version). Cognitive IIV was calculated from the Cogstate as the coefficient of variation derived from age-adjusted normative T scores.Results: Cognitive IIV as measured by the Cogstate showed a significant, positive, medium-sized association with current FrSBe ratings of executive dysfunction but not disinhibition.Conclusion: Higher cognitive IIV in the laboratory as measured by the Cogstate may be related to the expression of HIV-associated symptoms of executive dysfunction in daily life for older PWH.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"32-39"},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49693571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive and Behavioral Neurology thanks these reviewers for their invaluable service during 2023. 认知与行为神经学》感谢这些审稿人在 2023 年期间提供的宝贵服务。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2024-03-01 DOI: 10.1097/WNN.0000000000000366

引用次数: 0

Anatomical Organization of the Amygdala: A Brief Visual Review 杏仁核的解剖组织：视觉简评

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2023-12-11 DOI: 10.1097/wnn.0000000000000364

Amauri Dalla Corte, Giulia Pinzetta, Andressa Goldman Ruwel, Taylor Felipe Alves Maia, Theonas Leal, Leonardo Almeida Frizon, Gustavo Rassier Isolan

引用次数: 0

New Frontier: The First Year of an Adult Neurodevelopmental Disabilities Clinic 新领域：成人神经发育障碍诊所的第一年

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2023-12-11 DOI: 10.1097/wnn.0000000000000362

Jessica S. Sanders, Moriah Mabry, Sharon Scarbro, Christopher M. Filley

{"title":"New Frontier: The First Year of an Adult Neurodevelopmental Disabilities Clinic","authors":"Jessica S. Sanders, Moriah Mabry, Sharon Scarbro, Christopher M. Filley","doi":"10.1097/wnn.0000000000000362","DOIUrl":"https://doi.org/10.1097/wnn.0000000000000362","url":null,"abstract":"\u0000 \u0000 As patients with neurodevelopmental disorders (NDDs) transition from pediatric to adult health care systems, they often have difficulty finding physicians to address their NDD-related needs. In response to this care gap, we established a new consultation clinic within a behavioral neurology clinic in an adult neurology department to address the neurodevelopmental concerns of these adult patients.\u0000 \u0000 \u0000 \u0000 To characterize the population of adult patients with NDDs seen in the adult NDD clinic in its first year.\u0000 \u0000 \u0000 \u0000 Data were obtained by a retrospective chart review of all patients with NDDs seen in the adult NDD clinic from September 2020 through December 2021.\u0000 \u0000 \u0000 \u0000 Of the 86 patients who were seen in the adult NDD clinic, the average age was 34 years (SD = 15, range = 18–74 years). Developmental diagnoses included intellectual disability (63%), autism spectrum disorder (47%), Down syndrome (15%), cerebral palsy (9%), and other genetic disorders (26%). Comorbidities addressed included behavioral concerns (34%), anxiety (29%), seizure disorders (22%), and depression (15%). Behavioral and/or mental health concerns prompted 65% of the initial clinic visits. The most common recommendation made was to begin or increase exercise (59%), followed by facilitating connection to community, social, and employment resources.\u0000 \u0000 \u0000 \u0000 Adults with NDDs have diagnoses, comorbidities, and concerns that are similar to, but also distinct from, those addressed in other adult neurology clinics. This study addresses the need for, and feasibility of, caring for the diverse population of adults with NDDs in an adult neurology setting.\u0000","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"10 12","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138584462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caring for Patients With Functional Neurological Disorder—A New Paradigm 护理功能性神经紊乱患者--新范例

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2023-12-11 DOI: 10.1097/wnn.0000000000000361

M. Lopez, Kristen Mordecai, Anna E. Blanken, W. LaFrance

引用次数: 0

Predictive Ability of Frontal Assessment Battery for Cognitive Improvement After Shunt Surgery in Individuals With Idiopathic Normal Pressure Hydrocephalus. 额叶评估电池对特发性常压脑积水患者分流术后认知改善的预测能力。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2023-12-01 DOI: 10.1097/WNN.0000000000000350

Yuki Asahara, Machiko Suda, Shusaku Omoto, Kazushige Kobayashi, Masamichi Atsuchi, Hiroyasu Nagashima, Masahiko Suzuki

{"title":"Predictive Ability of Frontal Assessment Battery for Cognitive Improvement After Shunt Surgery in Individuals With Idiopathic Normal Pressure Hydrocephalus.","authors":"Yuki Asahara, Machiko Suda, Shusaku Omoto, Kazushige Kobayashi, Masamichi Atsuchi, Hiroyasu Nagashima, Masahiko Suzuki","doi":"10.1097/WNN.0000000000000350","DOIUrl":"10.1097/WNN.0000000000000350","url":null,"abstract":"Background: The predictive ability of the Frontal Assessment Battery (FAB) for postoperative cognitive improvement in idiopathic normal pressure hydrocephalus (iNPH) is unstudied.Objective: To compare the predictive ability of the FAB and the Mini-Mental State Examination (MMSE) for postoperative cognitive improvement in individuals with iNPH after shunt surgery.Method: We retrospectively reviewed the medical records of individuals with iNPH who had shunt surgery between January 2016 and October 2018. Individuals had completed the tap test and clinical evaluations (FAB, MMSE, Timed Up and Go [TUG]) both before and 24-48 hours after CSF tapping and after surgery. We excluded individuals without complete clinical evaluations and those with shunt surgery performed >6 months after CSF tapping. Factors associated with postoperative FAB and MMSE improvement as per the 2011 iNPH guidelines were extracted using univariate and multivariate logistic regression analyses. Independent variables were baseline FAB and MMSE scores, FAB and MMSE score changes and TUG amelioration rate after CSF tapping, Evans index, age, and days from CSF tapping to surgery and from surgery to postoperative assessment.Results: The mean number of days from CSF tapping to surgery and from surgery to postoperative assessment were 77.5 (SD = 36.0) and 42.0 (SD = 14.5), respectively. Logistic regression analyses showed significant associations in the univariate analyses of postoperative FAB improvement with baseline FAB scores ( P = 0.043) and with FAB score changes after CSF tapping ( P = 0.047).Conclusion: The FAB may help predict postoperative cognitive improvement after shunt surgery better than the MMSE.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"228-236"},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9920823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can the Ability to Recognize Facial Emotions in Individuals With Neurodegenerative Disease be Improved? A Systematic Review and Meta-analysis. 神经退行性疾病患者识别面部情绪的能力可以提高吗?系统回顾和荟萃分析。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2023-12-01 DOI: 10.1097/WNN.0000000000000348

Naz Mirzai, Kévin Polet, Adeline Morisot, Solange Hesse, Alain Pesce, Sandrine Louchart de la Chapelle, Galina Iakimova

{"title":"Can the Ability to Recognize Facial Emotions in Individuals With Neurodegenerative Disease be Improved? A Systematic Review and Meta-analysis.","authors":"Naz Mirzai, Kévin Polet, Adeline Morisot, Solange Hesse, Alain Pesce, Sandrine Louchart de la Chapelle, Galina Iakimova","doi":"10.1097/WNN.0000000000000348","DOIUrl":"10.1097/WNN.0000000000000348","url":null,"abstract":"Background: Facial emotion recognition (FER) is commonly impaired in individuals with neurodegenerative disease (NDD). This impairment has been linked to an increase in behavioral disorders and caregiver burden.Objective: To identify interventions targeting the improvement of FER ability in individuals with NDD and investigate the magnitude of the efficacy of the interventions. We also wanted to explore the duration of the effects of the intervention and their possible impacts on behavioral and psychological symptoms of dementia and caregiver burden.Method: We included 15 studies with 604 individuals who had been diagnosed with NDD. The identified interventions were categorized into three types of approach (cognitive, neurostimulation, and pharmacological) as well as a combined approach (neurostimulation with pharmacological).Results: The three types of approaches pooled together had a significant large effect size for FER ability improvement (standard mean difference: 1.21, 95% CI = 0.11, 2.31, z = 2.15, P = 0.03). The improvement lasted post intervention, in tandem with a decrease in behavioral disorders and caregiver burden.Conclusion: A combination of different approaches for FER ability improvement may be beneficial for individuals with NDD and their caregivers.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"202-218"},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9761689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a Speech-based Composite Score for Remotely Quantifying Language Changes in Frontotemporal Dementia. 开发一种基于语音的复合评分，用于远程量化额颞叶痴呆患者的语言变化。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2023-12-01 DOI: 10.1097/WNN.0000000000000356

Jessica Robin, Mengdan Xu, Liam D Kaufman, William Simpson, Stella McCaughey, Nadine Tatton, Charles Wolfus, Michael Ward

{"title":"Development of a Speech-based Composite Score for Remotely Quantifying Language Changes in Frontotemporal Dementia.","authors":"Jessica Robin, Mengdan Xu, Liam D Kaufman, William Simpson, Stella McCaughey, Nadine Tatton, Charles Wolfus, Michael Ward","doi":"10.1097/WNN.0000000000000356","DOIUrl":"10.1097/WNN.0000000000000356","url":null,"abstract":"Background: Changes to speech and language are common symptoms across different subtypes of frontotemporal dementia (FTD). These changes affect the ability to communicate, impacting everyday functions. Accurately assessing these changes may help clinicians to track disease progression and detect response to treatment.Objective: To determine which aspects of speech show significant change over time and to develop a novel composite score for tracking speech and language decline in individuals with FTD.Method: We recruited individuals with FTD to complete remote digital speech assessments based on a picture description task. Speech samples were analyzed to derive acoustic and linguistic measures of speech and language, which were tested for longitudinal change over the course of the study and were used to compute a novel composite score.Results: Thirty-six (16 F, 20 M; M age = 61.3 years) individuals were enrolled in the study, with 27 completing a follow-up assessment 12 months later. We identified eight variables reflecting different aspects of language that showed longitudinal decline in the FTD clinical syndrome subtypes and developed a novel composite score based on these variables. The resulting composite score demonstrated a significant effect of change over time, high test-retest reliability, and a correlation with standard scores on various other speech tasks.Conclusion: Remote digital speech assessments have the potential to characterize speech and language abilities in individuals with FTD, reducing the burden of clinical assessments while providing a novel measure of speech and language abilities that is sensitive to disease and relevant to everyday function.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"237-248"},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0