{"title":"Midline Hand Drift as a Possible Sign of Neurologic Disorder.","authors":"Theresa Anne Koch-Tran, Glen R Finney","doi":"10.1097/WNN.0000000000000405","DOIUrl":"10.1097/WNN.0000000000000405","url":null,"abstract":"<p><p>Movement and maintenance of posture involve many interacting factors that rely on a broad neural network. These factors include proprioception, body schema, and peripersonal and extrapersonal space, all of which may be affected in individuals with neurocognitive disorders. Frontal release signs are a common clinical finding in such individuals, resulting from the disruption of the related neural networks. In this case series, we discuss the potential clinical relevance of midline hand drift (MHD). MHD is a rarely documented physical exam finding in which one or both hands move toward the midline when the individual is seated upright with their eyes open, arms outstretched, and palms facing upwards. Upon examination, 24 individuals with a chief complaint of worsening memory were found to have MHD. All 24 individuals with MHD had at least mild cognitive impairment, and 22 were also diagnosed with a neurodegenerative disorder. The most common diagnoses among these individuals were Parkinson disease dementia, Lewy body dementia, and vascular dementia. Nine of the 24 patients demonstrated no frontal release signs upon examination. MHD may be a useful clinical finding that aids in the diagnosis of an underlying neurocognitive disorder. Assessing for MHD may be most beneficial for individuals who are in the earlier stages of neurocognitive decline. They may show mild impairment on the Mini-Mental State Examination or the Montreal Cognitive Assessment, but no other characteristic findings (eg, frontal release signs).</p>","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"38 3","pages":"120-133"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Matter of Mind: A Neurologist's View of Brain-Behavior Relationships.","authors":"Howard S Kirshner","doi":"10.1097/WNN.0000000000000398","DOIUrl":"https://doi.org/10.1097/WNN.0000000000000398","url":null,"abstract":"","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"38 3","pages":"150-151"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Rabbi, a Priest, and an Agnostic Walk into a Bar….","authors":"Lealani Mae Y Acosta","doi":"10.1097/WNN.0000000000000394","DOIUrl":"10.1097/WNN.0000000000000394","url":null,"abstract":"","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"136-137"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ken Heilman: A Life Well Lived.","authors":"Glen R Finney","doi":"10.1097/WNN.0000000000000406","DOIUrl":"https://doi.org/10.1097/WNN.0000000000000406","url":null,"abstract":"","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"38 3","pages":"75-77"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recognizing the Contributions of Dr. Kenneth M. Heilman.","authors":"Johanna Veader","doi":"10.1097/WNN.0000000000000401","DOIUrl":"https://doi.org/10.1097/WNN.0000000000000401","url":null,"abstract":"","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"38 3","pages":"78"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Case Reports and Case Studies: An Endangered Species.","authors":"Kenneth M Heilman","doi":"10.1097/WNN.0000000000000403","DOIUrl":"https://doi.org/10.1097/WNN.0000000000000403","url":null,"abstract":"","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"38 3","pages":"117-119"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stories About Ken.","authors":"Lorie Gage Richards","doi":"10.1097/WNN.0000000000000397","DOIUrl":"https://doi.org/10.1097/WNN.0000000000000397","url":null,"abstract":"","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"38 3","pages":"135"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Power of Prions: The Strange and Essential Proteins That Can Cause Alzheimer's, Parkinson's, and Other Diseases.","authors":"Howard S Kirshner","doi":"10.1097/WNN.0000000000000388","DOIUrl":"10.1097/WNN.0000000000000388","url":null,"abstract":"","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"73-74"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Validating the Telephone Montreal Cognitive Assessment Scale-Hindi as a Remote Screening Tool for Mild Cognitive Impairment.","authors":"Rubina Mulchandani, Udita Grover, Shomik Ray, Sheetal Gandotra, Rajinder K Dhamija, Tanica Lyngdoh","doi":"10.1097/WNN.0000000000000389","DOIUrl":"10.1097/WNN.0000000000000389","url":null,"abstract":"<p><strong>Background: </strong>Mild cognitive impairment (MCI) is a neurocognitive disorder that adversely affects cognitive function and is often a precursor to dementia. Early diagnosis of MCI can guide timely treatment and delay dementia onset. The Montreal Cognitive Assessment (MoCA) is an effective screening tool for MCI. Remotely administered versions of the MoCA have gained popularity during the recent pandemic.</p><p><strong>Objective: </strong>This study aimed to validate a new Hindi version of the Telephone MoCA (T-MoCA) in older adult outpatients at a tertiary hospital in Delhi, India.</p><p><strong>Methods: </strong>We developed and validated a Hindi version of the T-MoCA (T-MoCA-Hindi) using the previously validated MoCA-Hindi as the gold standard. We administered both instruments to older adult patients with a 2-week gap between sessions. To assess the reliability of the new T-MoCA-Hindi, we used the Bland-Altman plot and Cronbach alpha. We used a receiver operating characteristic curve to estimate accuracy.</p><p><strong>Results: </strong>A total of 243 individuals enrolled in this study. The T-MoCA-Hindi and the MoCA-Hindi showed a high level of agreement. A Cronbach alpha of 0.84 indicated good internal consistency. The area under the curve in the receiver operating characteristic analysis was 93.5%, indicating excellent accuracy and validity and demonstrating high sensitivity and specificity at an optimal cut-off score of 18/19 points.</p><p><strong>Conclusion: </strong>These findings show that the T-MoCA-Hindi is a valid tool for remote identification of MCI in India. The use of remote versions of diagnostic tools can be leveraged to conduct research when in-person approaches may not be feasible.</p>","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"35-42"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary Tauopathy With Logopenic/Semantic Mixed Progressive Aphasia and Frontotemporal Dementia-like Behavior.","authors":"Akihiro Takasaki, Yoshiyuki Nishio, Yuto Satake, Matasaburo Kobayashi, Mariko Sakai, Kohji Mori, Kazunari Ishii, Manabu Ikeda","doi":"10.1097/WNN.0000000000000391","DOIUrl":"10.1097/WNN.0000000000000391","url":null,"abstract":"<p><p>Here we present the cases of two individuals with language and behavioral symptoms indicative of the early clinical manifestations of both Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD). Phonological language symptoms similar to those evident in logopenic variant primary progressive aphasia suggested AD pathology, while semantic impairment and behavioral changes (ie, abnormal eating behavior and disinhibition) suggested a diagnosis of FTLD. Multimodal neuroimaging studies revealed underlying neuropathology indicative of primary tauopathy with presumable 3/4-repeat isoform, devoid of amyloid deposition. We suggest that these cases may represent a previously unrecognized syndrome associated with non-Alzheimer primary tauopathy.</p>","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"60-65"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}