实验室中的认知个体内变异性与艾滋病毒感染老年人日常生活中更大的执行功能障碍有关。

IF 1.3 4区医学 Q4 BEHAVIORAL SCIENCES

Cognitive and Behavioral Neurology Pub Date : 2024-03-01 DOI:10.1097/WNN.0000000000000358

Natalie C Ridgely, Steven Paul Woods, Troy A Webber, Andrea I Mustafa, Darrian Evans

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引用次数: 0

摘要

背景：执行功能障碍在HIV感染者中很常见，它会对健康行为和生活质量产生不利影响。个体内变异性（IIV）是衡量认知测试中个体内变异的指标，在PWH中更高，被认为反映了认知功能障碍。目的：评估实验室中的认知IIV是否与老年PWH自我报告的日常生活中的执行功能障碍有关。方法：参与者包括71名年龄≥50岁的PWH，他们完成了Cogstate电池组的6个子测验和额叶系统行为量表（FrSBe；自报版）的2个子测验。认知IIV是根据Cogstate计算的，作为根据年龄调整的标准T评分得出的变异系数。结果：Cogstate测量的认知IIV与当前执行功能障碍的FrSBe评分有显著、积极、中等程度的相关性，但与去抑制无关。结论：Cogstate测量的实验室中较高的认知IIV可能与老年PWH在日常生活中执行功能障碍的HIV相关症状的表达有关。

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Cognitive Intra-individual Variability in the Laboratory Is Associated With Greater Executive Dysfunction in the Daily Lives of Older Adults With HIV.

Background: Executive dysfunction, which is common among persons with HIV (PWH), can have an adverse impact on health behaviors and quality of life. Intra-individual variability (IIV) is a measure of within-person variability across cognitive tests that is higher in PWH and is thought to reflect cognitive dyscontrol.

Objective: To assess whether cognitive IIV in the laboratory is associated with self-reported executive dysfunction in daily life among older PWH.

Method: Participants included 71 PWH aged ≥50 years who completed six subtests from the Cogstate battery and two subscales from the Frontal Systems Behavior Scale (FrSBe; self-report version). Cognitive IIV was calculated from the Cogstate as the coefficient of variation derived from age-adjusted normative T scores.

Results: Cognitive IIV as measured by the Cogstate showed a significant, positive, medium-sized association with current FrSBe ratings of executive dysfunction but not disinhibition.

Conclusion: Higher cognitive IIV in the laboratory as measured by the Cogstate may be related to the expression of HIV-associated symptoms of executive dysfunction in daily life for older PWH.

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来源期刊

Cognitive and Behavioral Neurology 医学-行为科学

CiteScore

2.40

自引率

7.10%

发文量

审稿时长

>12 weeks

期刊介绍： Cognitive and Behavioral Neurology (CBN) is a forum for advances in the neurologic understanding and possible treatment of human disorders that affect thinking, learning, memory, communication, and behavior. As an incubator for innovations in these fields, CBN helps transform theory into practice. The journal serves clinical research, patient care, education, and professional advancement. The journal welcomes contributions from neurology, cognitive neuroscience, neuropsychology, neuropsychiatry, and other relevant fields. The editors particularly encourage review articles (including reviews of clinical practice), experimental and observational case reports, instructional articles for interested students and professionals in other fields, and innovative articles that do not fit neatly into any category. Also welcome are therapeutic trials and other experimental and observational studies, brief reports, first-person accounts of neurologic experiences, position papers, hypotheses, opinion papers, commentaries, historical perspectives, and book reviews.