Cognitive and Behavioral Neurology最新文献

Validating the Telephone Montreal Cognitive Assessment Scale-Hindi as a Remote Screening Tool for Mild Cognitive Impairment. 验证电话蒙特利尔认知评估量表-印度语作为轻度认知障碍远程筛查工具的有效性。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-03-25 DOI: 10.1097/WNN.0000000000000389

Rubina Mulchandani, Udita Grover, Shomik Ray, Sheetal Gandotra, Rajinder K Dhamija, Tanica Lyngdoh

{"title":"Validating the Telephone Montreal Cognitive Assessment Scale-Hindi as a Remote Screening Tool for Mild Cognitive Impairment.","authors":"Rubina Mulchandani, Udita Grover, Shomik Ray, Sheetal Gandotra, Rajinder K Dhamija, Tanica Lyngdoh","doi":"10.1097/WNN.0000000000000389","DOIUrl":"https://doi.org/10.1097/WNN.0000000000000389","url":null,"abstract":"Background: Mild cognitive impairment (MCI) is a neurocognitive disorder that adversely affects cognitive function and is often a precursor to dementia. Early diagnosis of MCI can guide timely treatment and delay dementia onset. The Montreal Cognitive Assessment (MoCA) is an effective screening tool for MCI. Remotely administered versions of the MoCA have gained popularity during the recent pandemic.Objective: This study aimed to validate a new Hindi version of the Telephone MoCA (T-MoCA) in older adult outpatients at a tertiary hospital in Delhi, India.Methods: We developed and validated a Hindi version of the T-MoCA (T-MoCA-Hindi) using the previously validated MoCA-Hindi as the gold standard. We administered both instruments to older adult patients with a 2-week gap between sessions. To assess the reliability of the new T-MoCA-Hindi, we used the Bland-Altman plot and Cronbach alpha. We used a receiver operating characteristic curve to estimate accuracy.Results: A total of 243 individuals enrolled in this study. The T-MoCA-Hindi and the MoCA-Hindi showed a high level of agreement. A Cronbach alpha of 0.84 indicated good internal consistency. The area under the curve in the receiver operating characteristic analysis was 93.5%, indicating excellent accuracy and validity and demonstrating high sensitivity and specificity at an optimal cut-off score of 18/19 points.Conclusion: These findings show that the T-MoCA-Hindi is a valid tool for remote identification of MCI in India. The use of remote versions of diagnostic tools can be leveraged to conduct research when in-person approaches may not be feasible.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Power of Prions: The Strange and Essential Proteins That Can Cause Alzheimer's, Parkinson's, and Other Diseases.

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-03-12 DOI: 10.1097/WNN.0000000000000388

Howard S Kirshner

引用次数: 0

Voluntary Swallowing Initiation Difficulty After Dorsomedial Prefrontal Cortex Damage: A Case Report. 后内侧前额叶皮层损伤后自主吞咽启动困难1例报告。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-03-01 DOI: 10.1097/WNN.0000000000000383

Nanae Motojima, Michitaka Funayama, Asuka Nakajima, Tomoyuki Nakamura, Mikoto Baba, Shusuke Kobayashi

引用次数: 0

Late-onset CSF1R-related Disorder: A Case Report. 迟发性csf1r相关疾病1例报告

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-03-01 DOI: 10.1097/WNN.0000000000000385

Lixue Chen, Haoyou Xu, Zhifu Lu

{"title":"Late-onset CSF1R-related Disorder: A Case Report.","authors":"Lixue Chen, Haoyou Xu, Zhifu Lu","doi":"10.1097/WNN.0000000000000385","DOIUrl":"10.1097/WNN.0000000000000385","url":null,"abstract":"CSF1R-related disorder, a catastrophic neurodegenerative disease, arises from genetic mutations in the colony-stimulating CSF1R. Initial misdiagnosis is common, as demonstrated by this case involving a 52-year-old female who presented with symptoms of limb numbness and weakness. Differential diagnosis first indicated Parkinsonism, lacunar infarction, and cervical spondylosis. Subsequently, however, this patient's clinical presentation evolved to include bradykinesia, cognitive decline, and a spectrum of neurological manifestations. A Pan-V2 assay revealed a heterozygous mutation in the CSF1R gene. Craniocerebral MRI showed cerebral infarctions, lacunar infarctions, and leukoaraiosis. Despite symptomatic treatments, our patient's clinical status continued to decline until her family chose to discontinue further medical interventions. This case underscores the diagnostic complexities of early detection of CSF1R-related disorders. It emphasizes the importance of including leukodystrophy in such differential diagnoses and the need for prompt genetic screening in patients who present with progressive leukoencephalopathy, especially when cerebrospinal fluid analysis is unremarkable.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"16-20"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How We Age: The Science of Longevity. 我们是如何变老的：长寿的科学。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-03-01 DOI: 10.1097/WNN.0000000000000384

Howard S Kirshner

引用次数: 0

The Turkish Version of the Revised Nottingham Sensory Assessment: Validity and Reliability in Chronic Stroke Survivors. Turkish版本修订诺丁汉感官评估：效度和信度在慢性中风幸存者。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-03-01 DOI: 10.1097/WNN.0000000000000382

Nurten Bilgin, Gokcen Akyurek

{"title":"The Turkish Version of the Revised Nottingham Sensory Assessment: Validity and Reliability in Chronic Stroke Survivors.","authors":"Nurten Bilgin, Gokcen Akyurek","doi":"10.1097/WNN.0000000000000382","DOIUrl":"10.1097/WNN.0000000000000382","url":null,"abstract":"Background: Evaluation of sensory functions in chronic stroke survivors is essential to plan and implement effective treatment and rehabilitation.Objective: To investigate the validity and reliability of the Turkish version of the Revised Nottingham Sensory Assessment (rNSA-T) in chronic stroke survivors.Methods: We applied the World Health Organization's translation protocols to develop the rNAS-T. We then tested its validity and reliability in 85 chronic stroke survivors using criterion validity and consistency for demographic variables, as well as test-retest and inter-rater reliability analyses.Results: The criterion validity of the rNSA-T was supported by significant correlation between participants' scores on the rNSA-T, the Katz Index of Independence in Activities of Daily Living (Katz-AD) ( r = 0.430-0.674, P < 0.05), and the Rivermead Motor Assessment (RMA) ( r = 0.528-0.773, P < 0.05). rNSA-T results remained consistent across variables of sex and side affected by stroke ( P > 0.05). The test-retest reliability of the rNSA-T was excellent in all subdimensions (ICC = 0.865-1.000), as was the inter-rater reliability (κ = 0.875-1.000).Conclusion: The rNSA-T is a valid and reliable tool for evaluation of sensory functions in chronic stroke survivors.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postencephalitic Proper- and Common-name Anomia, Alexia With Agraphia, and Mild Semantic Deficit due to Left Anterior Temporal Lobe Lesion. 左前颞叶病变引起的脑后性名称异常、失读症伴失写症和轻度语义缺陷。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-03-01 DOI: 10.1097/WNN.0000000000000386

Yasuhisa Sakurai, Yuko Ishizaka

{"title":"Postencephalitic Proper- and Common-name Anomia, Alexia With Agraphia, and Mild Semantic Deficit due to Left Anterior Temporal Lobe Lesion.","authors":"Yasuhisa Sakurai, Yuko Ishizaka","doi":"10.1097/WNN.0000000000000386","DOIUrl":"10.1097/WNN.0000000000000386","url":null,"abstract":"Here we report the case of an individual who developed proper- and common-name anomia with no category specificity, alexia with agraphia for kanji (Japanese morphograms), and mild verbal and semantic memory impairment after unilateral herpes simplex encephalitis. Although their common-name anomia, alexia with agraphia, and semantic memory impairment resolved within 2 years, this individual continued to experience proper-name anomia and verbal memory impairment. Encephalitic damage was limited to the left anterior temporal lobe (ATL), amygdala, hippocampus, and parahippocampal gyrus, sparing the mid-fusiform and posterior inferior temporal gyri. Although ATL lesions are not typically associated with semantic memory impairment, we suggest that damage to the left ATL can result in both proper- and common-name anomia, as was evident in the current case. In these cases, proper-name anomia may be more severe and persistent than common-name anomia, which may be mild and significantly improved within several years. In cases of semantic memory deficits, persistent common-name anomia, and severe alexia with agraphia, there is typically more extensive involvement of the temporal lobe than seen in the current case, including the mid-fusiform and posterior inferior temporal gyri.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"21-32"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Lexical-semantic Impairment on Spoken Verb Production in Individuals With Mild Cognitive Impairment. 词汇语义障碍对轻度认知障碍患者口语动词生成的影响。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2024-12-01 DOI: 10.1097/WNN.0000000000000378

Joël Macoir, Robert Laforce, Carol Hudon

{"title":"The Impact of Lexical-semantic Impairment on Spoken Verb Production in Individuals With Mild Cognitive Impairment.","authors":"Joël Macoir, Robert Laforce, Carol Hudon","doi":"10.1097/WNN.0000000000000378","DOIUrl":"10.1097/WNN.0000000000000378","url":null,"abstract":"Background: Although episodic memory is the primary concern in individuals with mild cognitive impairment (MCI), other cognitive functions may also be affected, including language. Language impairment in individuals with MCI has been attributed primarily to the breakdown of semantic representations, difficulties in accessing semantic information, and the weakening of executive functions. However, in most prior studies of word processing in individuals with MCI, researchers have used measures focused on noun production.Objective: To investigate how verb production tasks might aid in detecting cognitive impairment in individuals with MCI.Methods: We compared the performance of 45 individuals with MCI and 45 healthy controls on action naming and action fluency tasks.Results: In the action naming task, the performance of participants with MCI was significantly impaired compared to healthy controls in terms of total score, the number of semantic errors produced, and the use of generic terms. In the action fluency task, participants with MCI produced significantly fewer verbs, fewer clusters, and fewer switches than healthy controls.Conclusion: The results of our study emphasize the utility of verb production tasks in the identification of cognitive impairment in individuals with MCI and provide evidence of the importance of including action naming and action fluency tasks in the assessment of individuals with MCI.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"183-193"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychotropic Polypharmacy Leading to Reversible Dementia: A Case Report. 精神药物多药合用导致可逆性痴呆：病例报告。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2024-12-01 DOI: 10.1097/WNN.0000000000000380

Durjoy Lahiri, Bruna Seixas-Lima, Carlos Roncero, Kathryn Stokes, Swayang Sudha Panda, Howard Chertkow

{"title":"Psychotropic Polypharmacy Leading to Reversible Dementia: A Case Report.","authors":"Durjoy Lahiri, Bruna Seixas-Lima, Carlos Roncero, Kathryn Stokes, Swayang Sudha Panda, Howard Chertkow","doi":"10.1097/WNN.0000000000000380","DOIUrl":"10.1097/WNN.0000000000000380","url":null,"abstract":"Psychotropic polypharmacy presents a diagnostic challenge that may be further complicated by inadequate medication history and underappreciation of the cognitive effects of such polypharmacy. Here we present the case of a 57-year-old man who presented to our memory clinic with progressive cognitive decline and a prior neuropsychological evaluation supporting the diagnosis of a neurodegenerative disorder. He was taking multiple psychotropic medications at the time, but the exact dosages were unclear due to a lack of collateral history. He was also taking prescribed opioids and a combination of buprenorphine and naloxone for pain relief, again with unclear dosages at the time of presentation. Brain imaging and cerebrospinal spinal fluid biomarker testing were negative for Alzheimer pathophysiologic processes. Months later, the patient was taken to the emergency room after an overdose caused by overuse of opioid medications. Once he was taken off all psychoactive medications, the patient's cognitive impairment completely reversed, and he became independent in activities of daily living. Psychotropic polypharmacy can have a myriad of cognitive manifestations which need to be better recognized by clinicians. Deprescription of such medications should be attempted whenever clinically appropriate.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"220-225"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Diagnostic Challenges of Late-onset Neuropsychiatric Symptoms and Early-onset Dementia: A Clinical and Neuropathological Case Study. 迟发性神经精神症状和早发性痴呆的诊断挑战：临床和神经病理病例研究。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2024-12-01 DOI: 10.1097/WNN.0000000000000379

Miguel Restrepo-Martinez, Ramiro Ruiz-Garcia, Jacob Houpt, Lee Cyn Ang, Sumit Chaudhari, Elizabeth Finger

{"title":"The Diagnostic Challenges of Late-onset Neuropsychiatric Symptoms and Early-onset Dementia: A Clinical and Neuropathological Case Study.","authors":"Miguel Restrepo-Martinez, Ramiro Ruiz-Garcia, Jacob Houpt, Lee Cyn Ang, Sumit Chaudhari, Elizabeth Finger","doi":"10.1097/WNN.0000000000000379","DOIUrl":"10.1097/WNN.0000000000000379","url":null,"abstract":"The emergence of new-onset neuropsychiatric symptoms in middle age presents a diagnostic challenge, particularly when differentiating between a primary psychiatric disorder and an early neurodegenerative disease. The discrepancy between bedside clinical diagnosis and subsequent neuropathological findings in such cases further highlights the difficulty of accurately predicting pathology, especially when there are no evident focal lesions or changes in brain volume. Here we present the case of a 59-year-old woman with inconclusive neuroimaging who exhibited pronounced neuropsychiatric and behavioral symptoms initially suggestive of a mood disorder, then of behavioral variant frontotemporal dementia. However, upon autopsy, we identified coexisting Lewy body disease pathology and tau-related changes, including argyrophilic grain disease and primary age-related tauopathy. This case illustrates the challenges encountered when diagnosing late-onset neuropsychiatric symptoms, emphasizes the link between such symptoms and early-onset dementia and argyrophilic grain disease, and contributes to our understanding of the impact of mixed neuropathology in this population. Accurate diagnosis is essential for the development of molecular-specific therapies and, as well as for accurate prognosis and enrollment in clinical trials.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"37 4","pages":"226-236"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0