Cognitive and Behavioral Neurology最新文献

Limited Impact of Object Attributes on Event-related Potentials During an Implicit Word Reading Task. 隐式词阅读任务中客体属性对事件相关电位的有限影响。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-05-07 DOI: 10.1097/WNN.0000000000000393

Tobias A Wagner-Altendorf, Marcus Heldmann, Thomas F Münte

{"title":"Limited Impact of Object Attributes on Event-related Potentials During an Implicit Word Reading Task.","authors":"Tobias A Wagner-Altendorf, Marcus Heldmann, Thomas F Münte","doi":"10.1097/WNN.0000000000000393","DOIUrl":"https://doi.org/10.1097/WNN.0000000000000393","url":null,"abstract":"Background: Previous research in cognitive science has focused on the encoding and activation of sensory-based object knowledge in the brain during language comprehension, including aspects such as appearance, movement, and taste.Objective: To investigate how different object-related attributes affect event-related potentials (ERPs), specifically the N400 component, during word processing in an implicit task setting.Method: We embedded a set of 420 critical nouns within a list of 2,745 total words and asked 240 participants to read each one, but to respond only to words denoting colors. We categorized each noun by attributes such as familiarity, smell, pain, taste, sound, graspability, and motion. We focused primarily on changes in the N400 component, indicative of semantic processing, across nouns with different attributes.Results: The least familiar stimuli elicited the strongest N400 response, indicating significant ERP variability across familiarity levels with more positive amplitudes for highly familiar stimuli. Among the attributes examined, only the attribute of smell demonstrated a notable, though isolated, increase in N400 amplitude. Other attributes, including pain, taste, sound, graspability, and visual motion showed no significant differences in N400 responses, suggesting a minimal influence on semantic processing in this context.Conclusion: These results suggest that the specific sensory attributes of objects have limited influence on the N400 component of ERPs in implicit reading tasks, highlighting the complexity of semantic networks in cognitive processing. The subtlety of ERP modulations driven by object-related attributes points to the need for further exploration into how these attributes interact within semantic networks during cognitive tasks.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Clinical Value of NeuroQuant Hippocampal Volumes and Hippocampal Occupancy Scores in an Academic Medical Center Memory Clinic. 某学术医学中心记忆诊所海马体积和海马占用评分的临床价值。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-05-01 DOI: 10.1097/WNN.0000000000000390

Jeff Schaffert, William Goette, Trung Nguyen, Alka Khera, Robert Ruchinskas

{"title":"The Clinical Value of NeuroQuant Hippocampal Volumes and Hippocampal Occupancy Scores in an Academic Medical Center Memory Clinic.","authors":"Jeff Schaffert, William Goette, Trung Nguyen, Alka Khera, Robert Ruchinskas","doi":"10.1097/WNN.0000000000000390","DOIUrl":"https://doi.org/10.1097/WNN.0000000000000390","url":null,"abstract":"Background: NeuroQuant volumetric data proposes to assist clinical diagnoses of mild cognitive impairment (MCI) and Alzheimer disease (AD) through normative hippocampal volume measurements (HVs) and hippocampal occupancy scores (HOCs). We investigated the diagnostic utility of NeuroQuant HVs and HOCs within an academic memory disorders clinic.Methods: Participants (n = 181) underwent neurologic examination, MRI with NeuroQuant, and neuropsychological assessment. Clinical diagnoses included subjective cognitive concerns (n = 39), non-amnestic MCI (n = 33), amnestic MCI (n = 74), AD (n = 35). Objective memory impairment (n = 125) was determined using actuarial criteria (≥2 memory measures ≤1.5 SD below the mean) for each participant. Differences in HVs and HOCs were assessed using ANOVA and χ2, while Pearson correlations examined their relationship with the California Verbal Learning Test-2nd Edition (CVLT-II). Receiver operator characteristic curves were used to calculate sensitivity, specificity, predictive values, Youden's Index, and predictive summary index scores.Results: Participants with amnestic MCI, AD, and objective memory impairment had lower HVs and HOCs and a higher frequency of hippocampal atrophy (≤5th percentile) than participants with subjective cognitive concerns, non-amnestic MCI, and no objective memory impairment (P's <0.05). However, the sensitivity (0.31-0.77) and specificity (0.68-0.91) of HVs and HOCs were variable for determining objective memory impairment, and correlations with the CVLT-II were modest (r = 0.20-0.44).Discussion: NeuroQuant HVs and HOCs were lower in participants with amnestic MCI, AD, and memory impairment, but had poor sensitivity and specificity to predict memory impairment, and only a modest association with measurable memory impairment. These measures should be used cautiously as supporting diagnostic tools.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Inflicted Head Injury in Behavioral Variant Frontotemporal Dementia with Compulsive Behaviors: A Case Report. 行为变异性额颞叶痴呆伴强迫行为的自残脑损伤1例报告。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-04-29 DOI: 10.1097/WNN.0000000000000392

Yanghong Yang, David Matuskey, Christopher F A Benjamin, Arman Fesharaki-Zadeh

{"title":"Self-Inflicted Head Injury in Behavioral Variant Frontotemporal Dementia with Compulsive Behaviors: A Case Report.","authors":"Yanghong Yang, David Matuskey, Christopher F A Benjamin, Arman Fesharaki-Zadeh","doi":"10.1097/WNN.0000000000000392","DOIUrl":"https://doi.org/10.1097/WNN.0000000000000392","url":null,"abstract":"Here we present the case of a 56-year-old right-handed White male who developed osteomyelitis and empyema after repetitive compulsive excoriation rituals. His recent history included profound personality changes, apathy, loss of empathy, limited insight, behavioral agitation, and episodic memory loss. In addition to these progressive behavioral deficits, he had significant difficulties with executive functioning, leading to the loss of his job and inability to independently perform instrumental activities of daily living. Brain MRI showed asymmetric enlargement of the right lateral ventricle and mild asymmetric parenchymal volume loss in the right hippocampus. 18F-FDG PET imaging revealed severe hypometabolism in the right hemisphere. Based on this individual's clinical presentation, reported history, and neuroimaging findings, we concluded that his condition was most consistent with a diagnosis of behavioral variant frontotemporal dementia (bvFTD), rather than another psychiatric diagnosis. This case illustrates the importance of differentiating between bvFTD and other psychiatric disorders, as well as the need for further studies to improve clinicians' ability to do so at earlier stages.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Tauopathy With Logopenic/Semantic Mixed Progressive Aphasia and Frontotemporal Dementia-like Behavior. 原发性脑损伤伴语意缺失/语义混合进行性失语和额颞叶痴呆样行为。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-04-18 DOI: 10.1097/WNN.0000000000000391

Akihiro Takasaki, Yoshiyuki Nishio, Yuto Satake, Matasaburo Kobayashi, Mariko Sakai, Kohji Mori, Kazunari Ishii, Manabu Ikeda

引用次数: 0

Validating the Telephone Montreal Cognitive Assessment Scale-Hindi as a Remote Screening Tool for Mild Cognitive Impairment. 验证电话蒙特利尔认知评估量表-印度语作为轻度认知障碍远程筛查工具的有效性。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-03-25 DOI: 10.1097/WNN.0000000000000389

Rubina Mulchandani, Udita Grover, Shomik Ray, Sheetal Gandotra, Rajinder K Dhamija, Tanica Lyngdoh

{"title":"Validating the Telephone Montreal Cognitive Assessment Scale-Hindi as a Remote Screening Tool for Mild Cognitive Impairment.","authors":"Rubina Mulchandani, Udita Grover, Shomik Ray, Sheetal Gandotra, Rajinder K Dhamija, Tanica Lyngdoh","doi":"10.1097/WNN.0000000000000389","DOIUrl":"https://doi.org/10.1097/WNN.0000000000000389","url":null,"abstract":"Background: Mild cognitive impairment (MCI) is a neurocognitive disorder that adversely affects cognitive function and is often a precursor to dementia. Early diagnosis of MCI can guide timely treatment and delay dementia onset. The Montreal Cognitive Assessment (MoCA) is an effective screening tool for MCI. Remotely administered versions of the MoCA have gained popularity during the recent pandemic.Objective: This study aimed to validate a new Hindi version of the Telephone MoCA (T-MoCA) in older adult outpatients at a tertiary hospital in Delhi, India.Methods: We developed and validated a Hindi version of the T-MoCA (T-MoCA-Hindi) using the previously validated MoCA-Hindi as the gold standard. We administered both instruments to older adult patients with a 2-week gap between sessions. To assess the reliability of the new T-MoCA-Hindi, we used the Bland-Altman plot and Cronbach alpha. We used a receiver operating characteristic curve to estimate accuracy.Results: A total of 243 individuals enrolled in this study. The T-MoCA-Hindi and the MoCA-Hindi showed a high level of agreement. A Cronbach alpha of 0.84 indicated good internal consistency. The area under the curve in the receiver operating characteristic analysis was 93.5%, indicating excellent accuracy and validity and demonstrating high sensitivity and specificity at an optimal cut-off score of 18/19 points.Conclusion: These findings show that the T-MoCA-Hindi is a valid tool for remote identification of MCI in India. The use of remote versions of diagnostic tools can be leveraged to conduct research when in-person approaches may not be feasible.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Power of Prions: The Strange and Essential Proteins That Can Cause Alzheimer's, Parkinson's, and Other Diseases. 朊病毒的力量：能导致阿尔茨海默氏症、帕金森症和其他疾病的奇怪而必需的蛋白质。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-03-12 DOI: 10.1097/WNN.0000000000000388

Howard S Kirshner

引用次数: 0

How We Age: The Science of Longevity. 我们是如何变老的：长寿的科学。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-03-01 DOI: 10.1097/WNN.0000000000000384

Howard S Kirshner

引用次数: 0

Voluntary Swallowing Initiation Difficulty After Dorsomedial Prefrontal Cortex Damage: A Case Report. 后内侧前额叶皮层损伤后自主吞咽启动困难1例报告。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-03-01 DOI: 10.1097/WNN.0000000000000383

Nanae Motojima, Michitaka Funayama, Asuka Nakajima, Tomoyuki Nakamura, Mikoto Baba, Shusuke Kobayashi

引用次数: 0

Late-onset CSF1R-related Disorder: A Case Report. 迟发性csf1r相关疾病1例报告

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-03-01 DOI: 10.1097/WNN.0000000000000385

Lixue Chen, Haoyou Xu, Zhifu Lu

{"title":"Late-onset CSF1R-related Disorder: A Case Report.","authors":"Lixue Chen, Haoyou Xu, Zhifu Lu","doi":"10.1097/WNN.0000000000000385","DOIUrl":"10.1097/WNN.0000000000000385","url":null,"abstract":"CSF1R-related disorder, a catastrophic neurodegenerative disease, arises from genetic mutations in the colony-stimulating CSF1R. Initial misdiagnosis is common, as demonstrated by this case involving a 52-year-old female who presented with symptoms of limb numbness and weakness. Differential diagnosis first indicated Parkinsonism, lacunar infarction, and cervical spondylosis. Subsequently, however, this patient's clinical presentation evolved to include bradykinesia, cognitive decline, and a spectrum of neurological manifestations. A Pan-V2 assay revealed a heterozygous mutation in the CSF1R gene. Craniocerebral MRI showed cerebral infarctions, lacunar infarctions, and leukoaraiosis. Despite symptomatic treatments, our patient's clinical status continued to decline until her family chose to discontinue further medical interventions. This case underscores the diagnostic complexities of early detection of CSF1R-related disorders. It emphasizes the importance of including leukodystrophy in such differential diagnoses and the need for prompt genetic screening in patients who present with progressive leukoencephalopathy, especially when cerebrospinal fluid analysis is unremarkable.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"16-20"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Turkish Version of the Revised Nottingham Sensory Assessment: Validity and Reliability in Chronic Stroke Survivors. Turkish版本修订诺丁汉感官评估：效度和信度在慢性中风幸存者。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-03-01 DOI: 10.1097/WNN.0000000000000382

Nurten Bilgin, Gokcen Akyurek

{"title":"The Turkish Version of the Revised Nottingham Sensory Assessment: Validity and Reliability in Chronic Stroke Survivors.","authors":"Nurten Bilgin, Gokcen Akyurek","doi":"10.1097/WNN.0000000000000382","DOIUrl":"10.1097/WNN.0000000000000382","url":null,"abstract":"Background: Evaluation of sensory functions in chronic stroke survivors is essential to plan and implement effective treatment and rehabilitation.Objective: To investigate the validity and reliability of the Turkish version of the Revised Nottingham Sensory Assessment (rNSA-T) in chronic stroke survivors.Methods: We applied the World Health Organization's translation protocols to develop the rNAS-T. We then tested its validity and reliability in 85 chronic stroke survivors using criterion validity and consistency for demographic variables, as well as test-retest and inter-rater reliability analyses.Results: The criterion validity of the rNSA-T was supported by significant correlation between participants' scores on the rNSA-T, the Katz Index of Independence in Activities of Daily Living (Katz-AD) ( r = 0.430-0.674, P < 0.05), and the Rivermead Motor Assessment (RMA) ( r = 0.528-0.773, P < 0.05). rNSA-T results remained consistent across variables of sex and side affected by stroke ( P > 0.05). The test-retest reliability of the rNSA-T was excellent in all subdimensions (ICC = 0.865-1.000), as was the inter-rater reliability (κ = 0.875-1.000).Conclusion: The rNSA-T is a valid and reliable tool for evaluation of sensory functions in chronic stroke survivors.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0