Cognitive and Behavioral Neurology最新文献_第2页

Barriers to the use of Methylphenidate in Pediatric Neuro-oncology Services. 儿童神经肿瘤服务中使用哌甲酯的障碍。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2024-06-01 DOI: 10.1097/WNN.0000000000000357

Alexander J Hagan, Simon Bailey, Sarah J Verity

{"title":"Barriers to the use of Methylphenidate in Pediatric Neuro-oncology Services.","authors":"Alexander J Hagan, Simon Bailey, Sarah J Verity","doi":"10.1097/WNN.0000000000000357","DOIUrl":"10.1097/WNN.0000000000000357","url":null,"abstract":"Background: Survivors of childhood CNS tumors are at a significant risk of chronic and multifaceted neurocognitive late effects. Recent findings indicate the potential utility of methylphenidate in addressing neurocognitive and academic plateauing and improving quality-of-life outcomes in this clinical population. However, the prescription of methylphenidate in neuro-oncology services remains inconsistent.Objective: To explore the neurocognitive assessment and rehabilitative interventions (including the use of methylphenidate) offered to survivors of childhood CNS tumors within mainland UK.Method: We used a semi-structured questionnaire to gather qualitative data from clinical psychologists and neuropsychologists within National Health Service pediatric neuro-oncology principal treatment centers (PTCs) during May 2018. Thematic analytical methods were used to explore themes within the collected data.Results: Eleven (58%) of the 19 PTCs returned the completed questionnaire. Respondents reported inadequate resource of psychology in many pediatric neuro-oncology PTCs, which limited the provision of methylphenidate to a restricted proportion of the patient group (i.e., those with the most profound neurocognitive difficulties). Respondents reported an interest in exploring the utility of methylphenidate in their patient group yet described a lack of appropriate evidence of its efficacy. In addition, respondents highlighted the need for the provision of accessible research summaries and treatment protocols addressing the use of methylphenidate.Conclusion: We anticipate that national collaboration between clinicians and researchers working in the cancer survivorship field will support the advancement of interventions such as methylphenidate for the growing clinical population of survivors of childhood CNS tumors.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41172289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consciousness: How Our Brains Turn Matter Into Meaning. 意识：我们的大脑如何将物质转化为意义。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2024-06-01 DOI: 10.1097/WNN.0000000000000367

Howard S Kirshner

引用次数: 0

The Covenant of Water. 《水的盟约》。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2024-03-01 DOI: 10.1097/WNN.0000000000000360

Howard S Kirshner

引用次数: 0

Progress in Primary Progressive Aphasia: A Review. 原发性进行性失语症的研究进展：综述。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2024-03-01 DOI: 10.1097/WNN.0000000000000365

Andrew Kertesz, Elizabeth Finger, David G Munoz

引用次数: 0

Poststroke Executive Function in Relation to White Matter Damage on Clinically Acquired CT Brain Imaging. 脑卒中后执行功能与临床CT脑成像白质损伤的关系。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2024-03-01 DOI: 10.1097/WNN.0000000000000355

Georgina Hobden, Margaret Jane Moore, Grant Mair, Sarah T Pendlebury, Nele Demeyere

{"title":"Poststroke Executive Function in Relation to White Matter Damage on Clinically Acquired CT Brain Imaging.","authors":"Georgina Hobden, Margaret Jane Moore, Grant Mair, Sarah T Pendlebury, Nele Demeyere","doi":"10.1097/WNN.0000000000000355","DOIUrl":"10.1097/WNN.0000000000000355","url":null,"abstract":"Background: Executive function (EF) impairments are prevalent post stroke and are associated with white matter (WM) damage on MRI. However, less is known about the relationship between poststroke EF and WM damage on CT imaging.Objective: To investigate the relationship between poststroke EF and WM damage associated with stroke lesions and WM hypointensities (WMHs) on clinically acquired CT imaging.Method: This study analyzed data from the Oxford Cognitive Screening Program, which recruited individuals aged ≥18 years with a confirmed stroke from an acute stroke unit. The individuals completed a follow-up assessment 6 months post stroke. We included individuals with a CT scan showing a visible stroke who completed follow-up EF assessment using the Oxford Cognitive Screen-Plus rule-finding task. We manually delineated stroke lesions and quantified then dichotomized WM damage caused by the stroke using the HCP-842 atlas. We visually rated then dichotomized WMHs using the Age-Related White Matter Changes Scale.Results: Among 87 stroke survivors (M age = 73.60 ± 11.75; 41 female; 61 ischemic stroke), multivariable linear regression showed that stroke damage to the medial lemniscus ( B = -8.86, P < 0.001) and the presence of WMHs ( B = -5.42, P = 0.005) were associated with poorer EF 6 months post stroke after adjusting for covariates including age and education.Conclusion: Poorer EF was associated with WM damage caused by stroke lesions and WMHs on CT. These results confirm the importance of WM integrity for EF post stroke and demonstrate the prognostic utility of CT-derived imaging markers for poststroke cognitive outcomes.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41156247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barriers to Alzheimer Disease Clinical Trial Participation in a Minority Population. 少数群体参与阿尔茨海默病临床试验的障碍。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2024-03-01 DOI: 10.1097/WNN.0000000000000359

Anson Y Lee, Julia R Jahansooz, Darrell Guittu, Rexton Suzuki, Lauren Pak, Kyle M Ishikawa, Connor Goo, John J Chen, Enrique Carrazana, Jason Viereck, Kore K Liow

{"title":"Barriers to Alzheimer Disease Clinical Trial Participation in a Minority Population.","authors":"Anson Y Lee, Julia R Jahansooz, Darrell Guittu, Rexton Suzuki, Lauren Pak, Kyle M Ishikawa, Connor Goo, John J Chen, Enrique Carrazana, Jason Viereck, Kore K Liow","doi":"10.1097/WNN.0000000000000359","DOIUrl":"10.1097/WNN.0000000000000359","url":null,"abstract":"Background: Alzheimer disease (AD), the most common neurodegenerative disorder in the United States, disproportionately burdens minority populations.Objective: To explore barriers to AD clinical trial participation by Asian and Native Hawaiian patients diagnosed with AD or mild cognitive impairment.Method: We surveyed 187 patients with a Mini-Mental State Examination score ≥14 between January 2022 and June 2022. The score cutoff for clinical trial eligibility was set by the institution. Individuals also completed a 15-question telephone survey that assessed demographics, barriers to clinical trial participation, and clinical trial improvement methods.Results: Forty-nine patients responded, with a response rate of 26%. Asian and Native Hawaiian patients were less likely than White patients to participate in AD trials. The main barrier to participation was a lack of information about AD trials. Providing additional information regarding AD trials to patients and family members were listed as the top two reasons patients would consider participating in a clinical trial.Conclusion: Insufficient information about AD clinical trials is the primary barrier to participation among Asian and Native Hawaiian patients, followed by difficulty coordinating transportation and, in the case of Asians, the time required for clinical trials. Increased outreach, education, and assistance with logistics in these populations should be pursued to improve rates of participation in clinical trials.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive and Behavioral Neurology thanks these reviewers for their invaluable service during 2023. 认知与行为神经学》感谢这些审稿人在 2023 年期间提供的宝贵服务。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2024-03-01 DOI: 10.1097/WNN.0000000000000366

引用次数: 0

Cognitive Intra-individual Variability in the Laboratory Is Associated With Greater Executive Dysfunction in the Daily Lives of Older Adults With HIV. 实验室中的认知个体内变异性与艾滋病毒感染老年人日常生活中更大的执行功能障碍有关。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2024-03-01 DOI: 10.1097/WNN.0000000000000358

Natalie C Ridgely, Steven Paul Woods, Troy A Webber, Andrea I Mustafa, Darrian Evans

{"title":"Cognitive Intra-individual Variability in the Laboratory Is Associated With Greater Executive Dysfunction in the Daily Lives of Older Adults With HIV.","authors":"Natalie C Ridgely, Steven Paul Woods, Troy A Webber, Andrea I Mustafa, Darrian Evans","doi":"10.1097/WNN.0000000000000358","DOIUrl":"10.1097/WNN.0000000000000358","url":null,"abstract":"Background: Executive dysfunction, which is common among persons with HIV (PWH), can have an adverse impact on health behaviors and quality of life. Intra-individual variability (IIV) is a measure of within-person variability across cognitive tests that is higher in PWH and is thought to reflect cognitive dyscontrol.Objective: To assess whether cognitive IIV in the laboratory is associated with self-reported executive dysfunction in daily life among older PWH.Method: Participants included 71 PWH aged ≥50 years who completed six subtests from the Cogstate battery and two subscales from the Frontal Systems Behavior Scale (FrSBe; self-report version). Cognitive IIV was calculated from the Cogstate as the coefficient of variation derived from age-adjusted normative T scores.Results: Cognitive IIV as measured by the Cogstate showed a significant, positive, medium-sized association with current FrSBe ratings of executive dysfunction but not disinhibition.Conclusion: Higher cognitive IIV in the laboratory as measured by the Cogstate may be related to the expression of HIV-associated symptoms of executive dysfunction in daily life for older PWH.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49693571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomical Organization of the Amygdala: A Brief Visual Review 杏仁核的解剖组织：视觉简评

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2023-12-11 DOI: 10.1097/wnn.0000000000000364

Amauri Dalla Corte, Giulia Pinzetta, Andressa Goldman Ruwel, Taylor Felipe Alves Maia, Theonas Leal, Leonardo Almeida Frizon, Gustavo Rassier Isolan

引用次数: 0

New Frontier: The First Year of an Adult Neurodevelopmental Disabilities Clinic 新领域：成人神经发育障碍诊所的第一年

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2023-12-11 DOI: 10.1097/wnn.0000000000000362

Jessica S. Sanders, Moriah Mabry, Sharon Scarbro, Christopher M. Filley

{"title":"New Frontier: The First Year of an Adult Neurodevelopmental Disabilities Clinic","authors":"Jessica S. Sanders, Moriah Mabry, Sharon Scarbro, Christopher M. Filley","doi":"10.1097/wnn.0000000000000362","DOIUrl":"https://doi.org/10.1097/wnn.0000000000000362","url":null,"abstract":"\u0000 \u0000 As patients with neurodevelopmental disorders (NDDs) transition from pediatric to adult health care systems, they often have difficulty finding physicians to address their NDD-related needs. In response to this care gap, we established a new consultation clinic within a behavioral neurology clinic in an adult neurology department to address the neurodevelopmental concerns of these adult patients.\u0000 \u0000 \u0000 \u0000 To characterize the population of adult patients with NDDs seen in the adult NDD clinic in its first year.\u0000 \u0000 \u0000 \u0000 Data were obtained by a retrospective chart review of all patients with NDDs seen in the adult NDD clinic from September 2020 through December 2021.\u0000 \u0000 \u0000 \u0000 Of the 86 patients who were seen in the adult NDD clinic, the average age was 34 years (SD = 15, range = 18–74 years). Developmental diagnoses included intellectual disability (63%), autism spectrum disorder (47%), Down syndrome (15%), cerebral palsy (9%), and other genetic disorders (26%). Comorbidities addressed included behavioral concerns (34%), anxiety (29%), seizure disorders (22%), and depression (15%). Behavioral and/or mental health concerns prompted 65% of the initial clinic visits. The most common recommendation made was to begin or increase exercise (59%), followed by facilitating connection to community, social, and employment resources.\u0000 \u0000 \u0000 \u0000 Adults with NDDs have diagnoses, comorbidities, and concerns that are similar to, but also distinct from, those addressed in other adult neurology clinics. This study addresses the need for, and feasibility of, caring for the diverse population of adults with NDDs in an adult neurology setting.\u0000","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138584462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0