Cognitive and Behavioral Neurology最新文献_第2页

Recognizing the Contributions of Dr. Kenneth M. Heilman. 表彰肯尼斯·m·海尔曼博士的贡献。

IF 1.7 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-09-01 DOI: 10.1097/WNN.0000000000000401

Johanna Veader

引用次数: 0

Case Reports and Case Studies: An Endangered Species. 案例报告和案例研究：一种濒危物种。

IF 1.7 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-09-01 DOI: 10.1097/WNN.0000000000000403

Kenneth M Heilman

引用次数: 0

Stories About Ken. 关于肯的故事。

IF 1.7 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-09-01 DOI: 10.1097/WNN.0000000000000397

Lorie Gage Richards

引用次数: 0

The Power of Prions: The Strange and Essential Proteins That Can Cause Alzheimer's, Parkinson's, and Other Diseases. 朊病毒的力量：能导致阿尔茨海默氏症、帕金森症和其他疾病的奇怪而必需的蛋白质。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-06-01 DOI: 10.1097/WNN.0000000000000388

Howard S Kirshner

引用次数: 0

Validating the Telephone Montreal Cognitive Assessment Scale-Hindi as a Remote Screening Tool for Mild Cognitive Impairment. 验证电话蒙特利尔认知评估量表-印度语作为轻度认知障碍远程筛查工具的有效性。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-06-01 DOI: 10.1097/WNN.0000000000000389

Rubina Mulchandani, Udita Grover, Shomik Ray, Sheetal Gandotra, Rajinder K Dhamija, Tanica Lyngdoh

{"title":"Validating the Telephone Montreal Cognitive Assessment Scale-Hindi as a Remote Screening Tool for Mild Cognitive Impairment.","authors":"Rubina Mulchandani, Udita Grover, Shomik Ray, Sheetal Gandotra, Rajinder K Dhamija, Tanica Lyngdoh","doi":"10.1097/WNN.0000000000000389","DOIUrl":"10.1097/WNN.0000000000000389","url":null,"abstract":"Background: Mild cognitive impairment (MCI) is a neurocognitive disorder that adversely affects cognitive function and is often a precursor to dementia. Early diagnosis of MCI can guide timely treatment and delay dementia onset. The Montreal Cognitive Assessment (MoCA) is an effective screening tool for MCI. Remotely administered versions of the MoCA have gained popularity during the recent pandemic.Objective: This study aimed to validate a new Hindi version of the Telephone MoCA (T-MoCA) in older adult outpatients at a tertiary hospital in Delhi, India.Methods: We developed and validated a Hindi version of the T-MoCA (T-MoCA-Hindi) using the previously validated MoCA-Hindi as the gold standard. We administered both instruments to older adult patients with a 2-week gap between sessions. To assess the reliability of the new T-MoCA-Hindi, we used the Bland-Altman plot and Cronbach alpha. We used a receiver operating characteristic curve to estimate accuracy.Results: A total of 243 individuals enrolled in this study. The T-MoCA-Hindi and the MoCA-Hindi showed a high level of agreement. A Cronbach alpha of 0.84 indicated good internal consistency. The area under the curve in the receiver operating characteristic analysis was 93.5%, indicating excellent accuracy and validity and demonstrating high sensitivity and specificity at an optimal cut-off score of 18/19 points.Conclusion: These findings show that the T-MoCA-Hindi is a valid tool for remote identification of MCI in India. The use of remote versions of diagnostic tools can be leveraged to conduct research when in-person approaches may not be feasible.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"35-42"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Tauopathy With Logopenic/Semantic Mixed Progressive Aphasia and Frontotemporal Dementia-like Behavior. 原发性脑损伤伴语意缺失/语义混合进行性失语和额颞叶痴呆样行为。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-06-01 DOI: 10.1097/WNN.0000000000000391

Akihiro Takasaki, Yoshiyuki Nishio, Yuto Satake, Matasaburo Kobayashi, Mariko Sakai, Kohji Mori, Kazunari Ishii, Manabu Ikeda

引用次数: 0

The Clinical Value of NeuroQuant Hippocampal Volumes and Hippocampal Occupancy Scores in an Academic Medical Center Memory Clinic. 某学术医学中心记忆诊所海马体积和海马占用评分的临床价值。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-06-01 DOI: 10.1097/WNN.0000000000000390

Jeff Schaffert, William Goette, Trung Nguyen, Alka Khera, Robert Ruchinskas

{"title":"The Clinical Value of NeuroQuant Hippocampal Volumes and Hippocampal Occupancy Scores in an Academic Medical Center Memory Clinic.","authors":"Jeff Schaffert, William Goette, Trung Nguyen, Alka Khera, Robert Ruchinskas","doi":"10.1097/WNN.0000000000000390","DOIUrl":"10.1097/WNN.0000000000000390","url":null,"abstract":"Background: NeuroQuant volumetric data proposes to assist clinical diagnoses of mild cognitive impairment (MCI) and Alzheimer disease (AD) through normative hippocampal volume measurements (HVs) and hippocampal occupancy scores (HOCs). We investigated the diagnostic utility of NeuroQuant HVs and HOCs within an academic memory disorders clinic.Methods: Participants ( n = 181) underwent neurologic examination, MRI with NeuroQuant, and neuropsychological assessment. Clinical diagnoses included subjective cognitive concerns ( n = 39), non-amnestic MCI ( n = 33), amnestic MCI ( n = 74), AD ( n = 35). Objective memory impairment ( n = 125) was determined using actuarial criteria (≥2 memory measures ≤1.5 SD below the mean) for each participant. Differences in HVs and HOCs were assessed using ANOVA and χ 2 , while Pearson correlations examined their relationship with the California Verbal Learning Test-2nd Edition (CVLT-II). Receiver operator characteristic curves were used to calculate sensitivity, specificity, predictive values, Youden's Index, and predictive summary index scores.Results: Participants with amnestic MCI, AD, and objective memory impairment had lower HVs and HOCs and a higher frequency of hippocampal atrophy (≤5th percentile) than participants with subjective cognitive concerns, non-amnestic MCI, and no objective memory impairment ( P' s <0.05). However, the sensitivity (0.31-0.77) and specificity (0.68-0.91) of HVs and HOCs were variable for determining objective memory impairment, and correlations with the CVLT-II were modest ( r = 0.20-0.44).Discussion: NeuroQuant HVs and HOCs were lower in participants with amnestic MCI, AD, and memory impairment, but had poor sensitivity and specificity to predict memory impairment, and only a modest association with measurable memory impairment. These measures should be used cautiously as supporting diagnostic tools.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"43-49"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limited Impact of Object Attributes on Event-related Potentials During an Implicit Word Reading Task. 隐式词阅读任务中客体属性对事件相关电位的有限影响。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-06-01 DOI: 10.1097/WNN.0000000000000393

Tobias A Wagner-Altendorf, Marcus Heldmann, Thomas F Münte

{"title":"Limited Impact of Object Attributes on Event-related Potentials During an Implicit Word Reading Task.","authors":"Tobias A Wagner-Altendorf, Marcus Heldmann, Thomas F Münte","doi":"10.1097/WNN.0000000000000393","DOIUrl":"10.1097/WNN.0000000000000393","url":null,"abstract":"Background: Previous research in cognitive science has focused on the encoding and activation of sensory-based object knowledge in the brain during language comprehension, including aspects such as appearance, movement, and taste.Objective: To investigate how different object-related attributes affect event-related potentials (ERPs), specifically the N400 component, during word processing in an implicit task setting.Method: We embedded a set of 420 critical nouns within a list of 2,745 total words and asked 240 participants to read each one, but to respond only to words denoting colors. We categorized each noun by attributes such as familiarity, smell, pain, taste, sound, graspability, and motion. We focused primarily on changes in the N400 component, indicative of semantic processing, across nouns with different attributes.Results: The least familiar stimuli elicited the strongest N400 response, indicating significant ERP variability across familiarity levels with more positive amplitudes for highly familiar stimuli. Among the attributes examined, only the attribute of smell demonstrated a notable, though isolated, increase in N400 amplitude. Other attributes, including pain, taste, sound, graspability, and visual motion showed no significant differences in N400 responses, suggesting a minimal influence on semantic processing in this context.Conclusion: These results suggest that the specific sensory attributes of objects have limited influence on the N400 component of ERPs in implicit reading tasks, highlighting the complexity of semantic networks in cognitive processing. The subtlety of ERP modulations driven by object-related attributes points to the need for further exploration into how these attributes interact within semantic networks during cognitive tasks.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"50-59"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Inflicted Head Injury in Behavioral Variant Frontotemporal Dementia with Compulsive Behaviors: A Case Report. 行为变异性额颞叶痴呆伴强迫行为的自残脑损伤1例报告。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-06-01 DOI: 10.1097/WNN.0000000000000392

Yanghong Yang, David Matuskey, Christopher F A Benjamin, Arman Fesharaki-Zadeh

{"title":"Self-Inflicted Head Injury in Behavioral Variant Frontotemporal Dementia with Compulsive Behaviors: A Case Report.","authors":"Yanghong Yang, David Matuskey, Christopher F A Benjamin, Arman Fesharaki-Zadeh","doi":"10.1097/WNN.0000000000000392","DOIUrl":"10.1097/WNN.0000000000000392","url":null,"abstract":"Here we present the case of a 56-year-old right-handed White male who developed osteomyelitis and empyema after repetitive compulsive excoriation rituals. His recent history included profound personality changes, apathy, loss of empathy, limited insight, behavioral agitation, and episodic memory loss. In addition to these progressive behavioral deficits, he had significant difficulties with executive functioning, leading to the loss of his job and inability to independently perform instrumental activities of daily living. Brain MRI showed asymmetric enlargement of the right lateral ventricle and mild asymmetric parenchymal volume loss in the right hippocampus. 18 F-FDG PET imaging revealed severe hypometabolism in the right hemisphere. Based on this individual's clinical presentation, reported history, and neuroimaging findings, we concluded that his condition was most consistent with a diagnosis of behavioral variant frontotemporal dementia (bvFTD), rather than another psychiatric diagnosis. This case illustrates the importance of differentiating between bvFTD and other psychiatric disorders, as well as the need for further studies to improve clinicians' ability to do so at earlier stages.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"66-72"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How We Age: The Science of Longevity. 我们是如何变老的：长寿的科学。

IF 1.3 4区医学

Cognitive and Behavioral Neurology Pub Date : 2025-03-01 DOI: 10.1097/WNN.0000000000000384

Howard S Kirshner

引用次数: 0