Cognitive and Behavioral Neurology最新文献_第10页

The Body: A Guide for Occupants. 身体:居住者指南。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2021-12-02 DOI: 10.1097/WNN.0000000000000272

Howard S Kirshner

引用次数: 1

Effects of Cognitive Reserve on Cognition in Individuals With Central Nervous System Disease. 认知储备对中枢神经系统疾病患者认知的影响。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2021-12-02 DOI: 10.1097/WNN.0000000000000282

Varna R Jammula, Heather Leeper, Mark R Gilbert, Diane Cooper, Terri S Armstrong

{"title":"Effects of Cognitive Reserve on Cognition in Individuals With Central Nervous System Disease.","authors":"Varna R Jammula, Heather Leeper, Mark R Gilbert, Diane Cooper, Terri S Armstrong","doi":"10.1097/WNN.0000000000000282","DOIUrl":"10.1097/WNN.0000000000000282","url":null,"abstract":"Cognitive reserve (CR) has been proposed to account for functional outcome differences in brain pathology and its clinical manifestations. The purpose of our paper is to systematically review the effects of CR on cognitive outcomes in individuals with neurodegenerative and structural CNS diseases. We performed a systematic search of PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and PsychInfo using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Seventeen studies met the predetermined inclusion criteria and were selected for review. Education level was the most commonly used measure for CR, and various neuropsychological tests were used to measure cognitive outcomes. Regardless of the CNS disease of the individuals, almost all of the studies reported a positive association between CR and cognitive outcomes when they were evaluated cross-sectionally. However, when evaluated longitudinally, CR had either no effect on, or a negative association with, cognitive outcomes. Based on studies across a broad spectrum of CNS diseases, our findings suggest that CR may serve as a predictor of cognitive outcomes in individuals with CNS diseases. However, studies to date are limited by a lack of imaging analyses and standardized assessment strategies. The ability to use a standardized measure to assess the longitudinal effects of CR may allow for the development of more targeted treatment methods, resulting in improved disease outcomes for individuals.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"34 4","pages":"245-258"},"PeriodicalIF":1.4,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39405585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Cerebellar Ischemia Presenting as Transient Global Amnesia. 小脑缺血表现为短暂性全局性遗忘。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2021-12-02 DOI: 10.1097/WNN.0000000000000287

Jonathan Morena, Hera A Kamdar, Amir Adeli

{"title":"Cerebellar Ischemia Presenting as Transient Global Amnesia.","authors":"Jonathan Morena, Hera A Kamdar, Amir Adeli","doi":"10.1097/WNN.0000000000000287","DOIUrl":"https://doi.org/10.1097/WNN.0000000000000287","url":null,"abstract":"Transient global amnesia (TGA) consists of acute-onset anterograde amnesia and typically resolves within 24 hours. Reported etiologies of TGA include transient ischemia to the hippocampus or thalamus, migraine, venous flow abnormalities, and epilepsy. There are no reports of cerebellar ischemia as an etiology of TGA. A 78-year-old woman with a medical history of diabetes presented to the Ohio State University ER after a period of anterograde amnesia lasting 3 hours. She was alert during the event, but asked the same questions repeatedly. Upon arrival to the ER, she was hypertensive but clinically back to baseline, with no recall of the 3-hour time period. An MRI of her brain revealed an isolated hyperintense signal on diffusion-weighted imaging (DWI) at the junction of the superior cerebellum and vermis, with apparent diffusion coefficient correlation. Vascular imaging of the brain and neck and a routine EEG were unremarkable. We diagnosed her with cerebellar ischemia presenting as TGA. She had no head injury, migraine, or history of epilepsy to suggest alternative etiologies of TGA. An increasing amount of literature has reported that the cerebellum is linked to the limbic system. A case series of SPECT imaging on individuals with TGA revealed transient cerebellar vermis hypoperfusion in addition to hippocampal DWI changes. We present what may be a novel report of isolated cerebellar ischemia presenting as TGA, and we add to the literature for clinicians to consider the possibility that damage to the cerebellum or its circuit to the cerebrum or thalamus can present as TGA.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"34 4","pages":"319-322"},"PeriodicalIF":1.4,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39682745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Dynamic Aphasia as a Variant of Frontotemporal Dementia. 动态失语症是额颞叶痴呆的一种变体。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2021-12-02 DOI: 10.1097/WNN.0000000000000289

Adithya Chandregowda, Heather M Clark, Joseph R Duffy, Mary M Machulda, Val J Lowe, Jennifer L Whitwell, Keith A Josephs

引用次数: 1

Intellectual Curiosity and Action Initiation are Subtypes of Apathy Affected in Huntington Disease Gene Expansion Carriers. 智力好奇心和行动启动是亨廷顿舞蹈症基因扩增携带者中受影响的Apathy的亚型。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2021-12-02 DOI: 10.1097/WNN.0000000000000286

Rebecca K Hendel, Marie N N Hellem, Lena E Hjermind, Jørgen E Nielsen, Asmus Vogel

{"title":"Intellectual Curiosity and Action Initiation are Subtypes of Apathy Affected in Huntington Disease Gene Expansion Carriers.","authors":"Rebecca K Hendel, Marie N N Hellem, Lena E Hjermind, Jørgen E Nielsen, Asmus Vogel","doi":"10.1097/WNN.0000000000000286","DOIUrl":"10.1097/WNN.0000000000000286","url":null,"abstract":"Background: Apathy is a prevalent behavioral syndrome of Huntington disease (HD) that can result in severe loss of function for the individual with HD and substantial caregiver distress. Research-based evidence of apathy is characterized by methodological differences, and there is a deficiency in the evidence concerning the subtypes of apathy.Objective: To characterize apathy in premanifest and motor-manifest HD gene expansion carriers and controls using the Short Problem Behaviors Assessment for Huntington's Disease (PBA-s) and the Lille Apathy Rating Scale (LARS).Method: We included 82 HD gene expansion carriers (premanifest and motor manifest) and 32 controls (Mini-Mental State Examination score ≥24 and Montreal Cognitive Assessment score ≥19) in the study. We quantified apathy using the PBA-s and the LARS and performed correlation analyses between the global LARS score and motor function, cytosine-adenine-guanine repeat length, cytosine-adenine-guanine Age Product score, and neuropsychiatric and cognitive symptoms.Results: The motor-manifest HD gene expansion carriers scored significantly higher than the controls on the global score and the Intellectual Curiosity and Action Initiation subscales of the LARS. Apathy was present in 28% of the HD gene expansion carriers (including 7 premanifest). The apathetic participants had a significantly higher motor score, significantly higher scores on the neuropsychiatric instruments, and significantly lower cognitive scores compared with the controls.Conclusion: Apathy is a frequent syndrome that is found in individuals with HD. Apathy has a specific expression, with symptoms such as reduced initiation, voluntary actions, and interests, that might be related to the underlying neuropathology. Apathy is related to disease progression, neuropsychiatric symptoms, and cognitive impairments.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"34 4","pages":"295-302"},"PeriodicalIF":1.4,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39682743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Impact of Donepezil and Memantine on Behavioral and Psychological Symptoms of Alzheimer Disease: Six-month Open-label Study. 多奈哌齐和美金刚对阿尔茨海默病行为和心理症状的影响：为期六个月的开放标签研究。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2021-12-02 DOI: 10.1097/WNN.0000000000000285

Petra Bago Rožanković, Marjan Rožanković, Jasna Badžak, Maristela Stojić, Ivana Šušak Sporiš

{"title":"Impact of Donepezil and Memantine on Behavioral and Psychological Symptoms of Alzheimer Disease: Six-month Open-label Study.","authors":"Petra Bago Rožanković, Marjan Rožanković, Jasna Badžak, Maristela Stojić, Ivana Šušak Sporiš","doi":"10.1097/WNN.0000000000000285","DOIUrl":"10.1097/WNN.0000000000000285","url":null,"abstract":"Background: Behavioral and psychological symptoms of dementia (BPSD) are common in individuals with Alzheimer disease (AD). Donepezil and memantine are both widely used for the treatment of moderate AD. Objective: To evaluate the effects of donepezil and memantine in relieving BPSD in individuals with moderate AD. Method: We conducted a prospective, randomized, 6-month clinical trial involving 85 individuals with moderate AD divided into two groups: group 1 (n = 42) was treated with donepezil; group 2 (n = 43) was treated with memantine. We used the Neuropsychiatric Inventory (NPI) to assess the prevalence and severity of BPSD at baseline and after 6 months of treatment with donepezil or memantine. Results: The two groups’ baseline characteristics, including age, sex, mean length of education, and disease duration, were comparable, as were their baseline Mini-Mental State Examination scores. The NPI Total score improved from baseline to month 6 in both groups (P < 0.0001). Analyses of the NPI subdomains revealed that both donepezil treatment and memantine treatment produced statistically significant improvement in all of the NPI domains except euphoria and apathy, for which no improvement was observed after memantine treatment. Both treatments were well tolerated, with mostly mild and transient adverse effects. Conclusion: Specific drugs for AD, including donepezil and memantine, may be effective in treating BPSD in individuals with moderate AD, with a favorable safety profile.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"34 4","pages":"288-294"},"PeriodicalIF":1.4,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39682742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Honorific Speech Impairment: A Characteristic Sign of Frontotemporal Dementia. 敬语障碍：额颞叶痴呆的一个特征性体征。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2021-12-02 DOI: 10.1097/WNN.0000000000000284

Weon Kyeong Hong, Ji Hye Yoon, Hyemin Jang, Soo Jin Yoon, So Young Moon, Hee Jin Kim, Duk L Na

{"title":"Honorific Speech Impairment: A Characteristic Sign of Frontotemporal Dementia.","authors":"Weon Kyeong Hong, Ji Hye Yoon, Hyemin Jang, Soo Jin Yoon, So Young Moon, Hee Jin Kim, Duk L Na","doi":"10.1097/WNN.0000000000000284","DOIUrl":"10.1097/WNN.0000000000000284","url":null,"abstract":"Background: Individuals with the behavioral variant of frontotemporal dementia (bvFTD) exhibit various levels of abulia, disinhibition, impaired judgment, and decline in executive function. Empirical evidence has shown that individuals with bvFTD also often exhibit difficulty using honorific speech, which expresses respect to another party or addressee.Objective: To analyze differences in the ability to use honorific speech among individuals with bvFTD, individuals with dementia of the Alzheimer type (AD dementia), and individuals with normal cognition (NC).Method: A total of 53 native Korean speakers (13 bvFTD, 20 AD dementia, and 20 NC) completed an experimental honorific speech task (HST) that involved both expressive and receptive tasks. We analyzed the number of correct responses and error patterns separately for an expressive task and for a receptive task.Results: The bvFTD group had significantly fewer correct responses on the HST compared with the AD dementia and NC groups. The bvFTD group exhibited more misjudgment errors in identifying nonhonorific speech as honorific speech in the expressive task, and significantly longer response times in the receptive task, than the AD dementia and NC groups. Significant associations were identified between HST scores and cortical atrophy in the temporal and frontotemporal lobes.Conclusion: A decline in the ability to use honorific speech may be a diagnosable behavioral and psychiatric symptom for bvFTD in Korean-speaking individuals. This decline in individuals with bvFTD could be attributed to multiple factors, including social manners (politeness) and impaired social language use ability (pragmatics).","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"34 4","pages":"275-287"},"PeriodicalIF":1.4,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39682741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disconnected Motor Intention and Spatial Attention in a Case of Probable Marchiafava-Bignami Disease. 一例疑似马尔基亚法瓦-比格纳米病患者的运动意向与空间注意的脱节。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2021-09-02 DOI: 10.1097/WNN.0000000000000274

Shunsuke Kobayashi, Masaki Hirose, Yukiko Akutsu, Kazumi Hirayama, Yoshinori Ishida, Yoshikazu Ugawa

引用次数: 1

Brain F-18 FDG and F-18 FP-CIT PET/CT Findings of c.856_860delCTCTA Mutation McLeod Syndrome. c.856_860delCTCTA突变McLeod综合征的脑F-18FDG和F-18FP-CIT PET/CT表现。

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2021-09-02 DOI: 10.1097/WNN.0000000000000267

Ho-Sung Ryu, Chae Moon Hong

引用次数: 1

Prevalence of Sleep Disorders and Related Factors in Individuals Undergoing Hemodialysis. 血液透析患者睡眠障碍的患病率及相关因素

IF 1.4 4区医学

Cognitive and Behavioral Neurology Pub Date : 2021-09-02 DOI: 10.1097/WNN.0000000000000278

Seher Kir, İdris Kirhan, Melda Dilek

{"title":"Prevalence of Sleep Disorders and Related Factors in Individuals Undergoing Hemodialysis.","authors":"Seher Kir, İdris Kirhan, Melda Dilek","doi":"10.1097/WNN.0000000000000278","DOIUrl":"https://doi.org/10.1097/WNN.0000000000000278","url":null,"abstract":"Background: The quality of life of individuals undergoing hemodialysis is related to many factors, including sleep disorders.Objective: To determine the prevalence of sleep disorders in individuals undergoing hemodialysis and to assess the effect of clinical and biochemical parameters on their sleep quality.Method: We conducted a cross-sectional descriptive survey in multiple hemodialysis centers. Individuals were interviewed using a questionnaire for obtaining general personal information, the Pittsburgh Sleep Quality Index (PSQI) for assessing sleep quality, and the Epworth Sleepiness Scale (ESS) for assessing excessive daytime sleepiness (EDS).Results: The study included 338 individuals with a median age of 55 years. Poor sleep quality (PSQ) and EDS were present in 41.4% and 6.5% of the individuals, respectively. The individuals' PSQI scores were significantly proportional to their ESS scores. Concerns about the disease and its treatment (60.7%) and poor physical conditions (35.7%) were major reported reasons for PSQ. In a logistic regression analysis, female gender, household income, ESS score, chronic heart failure, and creatinine and parathormone levels were found to be independent predictors of PSQ; household income, PSQ presence, parathormone and potassium levels, and urea reduction ratio were found to be independent predictors of EDS.Conclusion: Sleep disorders are common in individuals undergoing hemodialysis and are related to gender, comorbid diseases, poor economic state, altered biochemical values, dialysis timing, and concerns about the disease and its treatment. Improving these individuals' quality of life through adequate psychological and financial support and early diagnosis of sleep disorders should decrease their mortality and morbidity rates.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"34 3","pages":"161-169"},"PeriodicalIF":1.4,"publicationDate":"2021-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39394194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2