原发性进行性失语症的研究进展:综述。

IF 1.3 4区 医学 Q4 BEHAVIORAL SCIENCES
Andrew Kertesz, Elizabeth Finger, David G Munoz
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引用次数: 0

摘要

我们对原发性进行性失语症(PPA)的定义、分类和流行病学进行了综述;对 PPA 临床综合征的分类进行了更新;对 PPA 的神经解剖学、病理学和遗传学的最新进展以及生物标志物和治疗方法的研究进行了综述。此外,还回顾了对神经变性中的语言组织和疾病传播概念做出贡献的 PPA 研究。此外,还讨论了异质性与临床表型的关系及其与生物学、病理学和遗传学进展的关系等问题,以及 PPA 与其他疾病(如额颞叶痴呆症、皮质基底变性、进行性核上性麻痹、皮克病和肌萎缩侧索硬化症)的关系。本文提出了支持将这些疾病视为一个实体而非多个实体的论点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Progress in Primary Progressive Aphasia: A Review.

We present a review of the definition, classification, and epidemiology of primary progressive aphasia (PPA); an update of the taxonomy of the clinical syndrome of PPA; and recent advances in the neuroanatomy, pathology, and genetics of PPA, as well as the search for biomarkers and treatment. PPA studies that have contributed to concepts of language organization and disease propagation in neurodegeneration are also reviewed. In addition, the issues of heterogeneity versus the relationships of the clinical phenotypes and their relationship to biological, pathological, and genetic advances are discussed, as is PPA's relationship to other conditions such as frontotemporal dementia, corticobasal degeneration, progressive supranuclear palsy, Pick disease, and amyotrophic lateral sclerosis. Arguments are presented in favor of considering these conditions as one entity versus many.

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来源期刊
CiteScore
2.40
自引率
7.10%
发文量
68
审稿时长
>12 weeks
期刊介绍: Cognitive and Behavioral Neurology (CBN) is a forum for advances in the neurologic understanding and possible treatment of human disorders that affect thinking, learning, memory, communication, and behavior. As an incubator for innovations in these fields, CBN helps transform theory into practice. The journal serves clinical research, patient care, education, and professional advancement. The journal welcomes contributions from neurology, cognitive neuroscience, neuropsychology, neuropsychiatry, and other relevant fields. The editors particularly encourage review articles (including reviews of clinical practice), experimental and observational case reports, instructional articles for interested students and professionals in other fields, and innovative articles that do not fit neatly into any category. Also welcome are therapeutic trials and other experimental and observational studies, brief reports, first-person accounts of neurologic experiences, position papers, hypotheses, opinion papers, commentaries, historical perspectives, and book reviews.
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