Fetal and Pediatric Pathology最新文献

Evolving Concepts in Etiology of Biliary Atresia: Insights and Perspectives from India.

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-04-03 DOI: 10.1080/15513815.2025.2477704

Anil Kumar Ram, Akshit Vats, Alka Bhatia, Yashwant Kumar

引用次数: 0

Hirschsprung Disease with Prenatal Signs: Case Report and Review of the Literature.

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-03-20 DOI: 10.1080/15513815.2025.2476459

C Marchetto, G Bracalente, P Midrio

引用次数: 0

The Great Mimicker: Langerhans Cell Histiocytosis Mimicking Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy.

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-03-20 DOI: 10.1080/15513815.2025.2476463

Tanvi Jha, Prajwala Gupta, Varun Garg, Vivek Dewan

引用次数: 0

Testicular Torsion in a 14-Year-Old with Sertoli Cell Granular Cell Change and Sertoli Nodules.

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-03-01 Epub Date: 2025-01-29 DOI: 10.1080/15513815.2025.2458665

Randall Craver

引用次数: 0

Efficacy of Frozen Section Technique as a Rapid Diagnostic Tool in the Diagnosis of Funisitis in Premature Deliveries.

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI: 10.1080/15513815.2025.2457617

P Sivathangam, D Srinivasamurthy, Vani Krishnamurthy

{"title":"Efficacy of Frozen Section Technique as a Rapid Diagnostic Tool in the Diagnosis of Funisitis in Premature Deliveries.","authors":"P Sivathangam, D Srinivasamurthy, Vani Krishnamurthy","doi":"10.1080/15513815.2025.2457617","DOIUrl":"10.1080/15513815.2025.2457617","url":null,"abstract":"Introduction: Presence of leucocytic infiltration in perivascular area or in Wharton jelly indicates funisitis. While conventional histopathological examination is the gold standard, its time delay hampers timely intervention. The frozen section technique offers a rapid alternative, enabling clinicians to promptly manage preterm early onset sepsis.Methods: This is a prospective study of 18 months. 125 preterms analyzed. Frozen sections and conventional sections of umbilical cord prepared and examined for inflammation by two researchers. Diagnostic accuracy of frozen sections versus conventional sections evaluated for sensitivity and specificity in detecting funisitis.Results: The frozen section of the umbilical cord was 85.5% sensitive and 86.7% specific in diagnosing funisitis. The inter-rater agreement for diagnosing funisitis was 72.2%. Funisitis on frozen section was 82.2% sensitive and 26.3% specific in diagnosing neonatal sepsis.Conclusion: Frozen section examination of umbilical cord has good diagnostic ability in detecting funisitis. The inter-rater agreement is substantial.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"106-113"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two GNPTAB Variations Caused Mucolipidosis II Alpha/Beta in a Chinese Family.

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-03-01 Epub Date: 2025-02-16 DOI: 10.1080/15513815.2025.2466057

Jingxin Yang, Chao Liu, Qian Geng, Liyuan Chen, Lei Zhang, Weiqing Wu

引用次数: 0

Multinucleated Giants: Unveiling Pediatric Renal Epithelioid PEComa.

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-03-01 Epub Date: 2025-02-21 DOI: 10.1080/15513815.2025.2458677

Aileen Azari-Yam, Mohammad Vasei, Moeinadin Safavi

引用次数: 0

Early- and Late-Onset Intrahepatic Cholestasis of Pregnancy: A Comparison of Maternal and Neonatal Outcomes.

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-03-01 Epub Date: 2025-02-11 DOI: 10.1080/15513815.2025.2463983

Meryem Hocaoglu, Ozgul Bulut, Irem Unal, Gokcem Inanc Karaman, Dilan Unsal Kaya, Abdulkadir Turgut

{"title":"Early- and Late-Onset Intrahepatic Cholestasis of Pregnancy: A Comparison of Maternal and Neonatal Outcomes.","authors":"Meryem Hocaoglu, Ozgul Bulut, Irem Unal, Gokcem Inanc Karaman, Dilan Unsal Kaya, Abdulkadir Turgut","doi":"10.1080/15513815.2025.2463983","DOIUrl":"10.1080/15513815.2025.2463983","url":null,"abstract":"Introduction: We investigated the maternal and neonatal outcomes of early- and late-onset intrahepatic cholestasis of pregnancy (ICP).Methods: A total of 198 pregnant women were recruited into this retrospective cohort study. Women with ICP (n = 84) were classified into two groups: (1) Early-onset ICP (n = 36): pregnancy duration at diagnosis <34 weeks; (2) Late-onset ICP (n = 48): pregnancy duration at diagnosis ≥34 weeks. Maternal and neonatal outcomes were compared among the three groups.Results: The assisted reproductive technology (ART) pregnancy rate and serum bile acid (SBA) levels were significantly higher in the early-onset ICP group with adverse perinatal outcome (APO) than those without. Notably, the birth weight was significantly lower among neonates in the early-onset group of ICP than among neonates in the late-onset ICP and control groups (p < 0.001). Birth weight (OR = 0.998, 95% CI: 0.997-0.999, p = 0.041)was associated with early-onset ICP, according to the multivariate analysis. Receiver-operating characteristic (ROC) analysis revealed that a cutoff value of 36.8 weeks for gestational age at diagnosis and 9.6 mmol/L for SBA can distinguish between ICP patients with APO and those without.Discussion: Early-onset ICP is associated with low birth weight. ART pregnancies and women with higher SBA concentrations needed to be closely monitor for possible adverse perinatal outcomes in early-onset ICP.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"114-130"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pseudomonal Vasculopathy of the Central Nervous System in a 2-Year-Old Female With an IRAK4-Related Immunodeficiency.

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-03-01 Epub Date: 2025-01-23 DOI: 10.1080/15513815.2025.2449948

Kayla Hoerschgen, Morgan Stottlemyre, Celeste Brancato, Louis P Dehner

{"title":"Pseudomonal Vasculopathy of the Central Nervous System in a 2-Year-Old Female With an IRAK4-Related Immunodeficiency.","authors":"Kayla Hoerschgen, Morgan Stottlemyre, Celeste Brancato, Louis P Dehner","doi":"10.1080/15513815.2025.2449948","DOIUrl":"10.1080/15513815.2025.2449948","url":null,"abstract":"Background: Pseudomonas aeruginosa (PA), a gram-negative bacillus, has varied clinical manifestations with septicemia as the most lethal. PA infection is usually regarded as opportunistic and often nosocomial. Case Presentation: We present a case of a \"healthy\" pediatric patient presenting with upper respiratory symptoms who rapidly deteriorated. Blood cultures grew Pseudomonas aeruginosa shortly after death. The postmortem examination revealed Pseudomonal vasculopathy of the central nervous system and genetic testing detected an autosomal recessive pathogenic variant in IRAK-4. Discussion: Community-acquired Pseudomonal sepsis in previously healthy children is rare. Studies have found that up to 20% of children presenting with sepsis have an underlying immune defect. Deficiency of IRAK-4 predisposes patients to recurrent, life-threatening, microbial infections, notably Streptococcus pneumoniae, Staphylococcus aureus, and PA. Conclusion: A primary immunodeficiency should be suspected in a \"healthy\" child presenting with sepsis by an unexpected bacterium as the clinical consequences may be severe and the findings may have reproductive implications for the parents.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"131-137"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Yolk Sac Tumor of the Liver: An Important Differential for Liver Mass with Elevated Serum Alpha-Fetoprotein in the Pediatric Population. 肝卵黄囊肿瘤：小儿肝脏肿块与血清甲胎蛋白升高的重要鉴别依据

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-03-01 Epub Date: 2025-02-05 DOI: 10.1080/15513815.2025.2457616

Mai He, Kayla Hoerschgen, Amy E Armstrong, Lili Zhang, Patrick Dillon, Frances White, Louis P Dehner

{"title":"Yolk Sac Tumor of the Liver: An Important Differential for Liver Mass with Elevated Serum Alpha-Fetoprotein in the Pediatric Population.","authors":"Mai He, Kayla Hoerschgen, Amy E Armstrong, Lili Zhang, Patrick Dillon, Frances White, Louis P Dehner","doi":"10.1080/15513815.2025.2457616","DOIUrl":"10.1080/15513815.2025.2457616","url":null,"abstract":"Introduction: Yolk sac tumor (YST) is a malignant germ cell tumor with 10-15% arising in extragonadal sites. Methods: A search through our institution's database from January 01, 1990, to December 31, 2020, for \"yolk sac tumor\" or \"endodermal sinus tumor\" and \"liver\". Results: Our search yielded three cases. A 20-month-old girl with a liver mass and serum alpha-fetoprotein (AFP) level of 46558.0 ng/mL. The neoplasm was papillary with Schiller-Duval bodies. A 2-year-old boy with hepatic masses and adrenal mass with a serum AFP of 106,604.5 ng/mL. Numerous Schiller-Duval bodies were present. A 7-month-old girl with a liver mass, lung nodules, and retroperitoneal masses. Serum AFP was in the 800s ng/mL. Hepatoid and microcystic YST were mixed with hepatoblastoma (HBL). All three cases were positive for CAM5.2, SALL4, Glypican-3, beta-catenin, and AFP. Conclusion: Hepatic yolk sac tumor should be considered in the differential of a liver mass in pediatric patients with elevated AFP.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"98-105"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0