Maternal Systemic Lupus Erythematosus and Neonatal Outcomes: A Tertiary Single Center Hospital Experience in Turkey.

IF 0.7 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2025-07-01 Epub Date: 2025-05-30 DOI:10.1080/15513815.2025.2507276

Gizem Kavram, Beril Yaşa, Elmas Zeynep İnce, Elif Kirit, Meltem Bor, Leyla Bilgin, Mustafa Törehan Aslan, Emine Asuman Çoban

{"title":"Maternal Systemic Lupus Erythematosus and Neonatal Outcomes: A Tertiary Single Center Hospital Experience in Turkey.","authors":"Gizem Kavram, Beril Yaşa, Elmas Zeynep İnce, Elif Kirit, Meltem Bor, Leyla Bilgin, Mustafa Törehan Aslan, Emine Asuman Çoban","doi":"10.1080/15513815.2025.2507276","DOIUrl":null,"url":null,"abstract":"Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects women of childbearing age. SLE is associated with many maternal and neonatal morbidities. The aim of this study was to evaluate the neonatal outcomes of infants born to mothers with SLE.Methods: This retrospective cohort study included data on 57 Turkish mother-infant pairs over a 10-year period. Demographic data of the newborns and the presence of neonatal morbidities such as cardiovascular, hematological involvement, and congenital anomalies were the primary outcomes of the study.Results: The median maternal age and gestational age at delivery were 30 (22-43) years and 37.6 (24.1-40.9) weeks, respectively. Thirteen (22.8%) of the mothers were primigravid and 59.6% (n = 34) of the deliveries were by cesarean section. Anti-Ro, anti-La, and anti-dsDNA autoantibodies were present in 38.6% (n = 22) of the mothers. Only one woman developed pre-eclampsia. Nine (15.8%) of the newborns were preterm, 8 (14%) were intrauterine growth restricted. The mean birth weight of the infants was 2846 (675-4240) grams. Three infants (5.2%) required resuscitation in the delivery room. One infant (1.8%) developed a complete atrioventricular block and 1 (1.8%) had esophageal atresia. None of the infants developed the typical rash of neonatal lupus.Conclusions: SLE is an important systemic disease that can complicate pregnancy and neonatal outcomes. Optimal multidisciplinary antenatal care of the mother is essential to improve maternal and fetal outcomes.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"322-332"},"PeriodicalIF":0.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fetal and Pediatric Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/15513815.2025.2507276","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/30 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PATHOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects women of childbearing age. SLE is associated with many maternal and neonatal morbidities. The aim of this study was to evaluate the neonatal outcomes of infants born to mothers with SLE.

Methods: This retrospective cohort study included data on 57 Turkish mother-infant pairs over a 10-year period. Demographic data of the newborns and the presence of neonatal morbidities such as cardiovascular, hematological involvement, and congenital anomalies were the primary outcomes of the study.

Results: The median maternal age and gestational age at delivery were 30 (22-43) years and 37.6 (24.1-40.9) weeks, respectively. Thirteen (22.8%) of the mothers were primigravid and 59.6% (n = 34) of the deliveries were by cesarean section. Anti-Ro, anti-La, and anti-dsDNA autoantibodies were present in 38.6% (n = 22) of the mothers. Only one woman developed pre-eclampsia. Nine (15.8%) of the newborns were preterm, 8 (14%) were intrauterine growth restricted. The mean birth weight of the infants was 2846 (675-4240) grams. Three infants (5.2%) required resuscitation in the delivery room. One infant (1.8%) developed a complete atrioventricular block and 1 (1.8%) had esophageal atresia. None of the infants developed the typical rash of neonatal lupus.

Conclusions: SLE is an important systemic disease that can complicate pregnancy and neonatal outcomes. Optimal multidisciplinary antenatal care of the mother is essential to improve maternal and fetal outcomes.

查看原文本刊更多论文

母体系统性红斑狼疮和新生儿结局：土耳其三级单中心医院经验。

系统性红斑狼疮（SLE）是一种主要影响育龄妇女的自身免疫性疾病。SLE与许多孕产妇和新生儿疾病有关。本研究的目的是评估SLE母亲所生婴儿的新生儿结局。方法：这项回顾性队列研究包括了57对土耳其母婴在10年期间的数据。新生儿的人口统计数据和新生儿发病率（如心血管、血液系统受累和先天性异常）的存在是研究的主要结果。结果：产妇年龄中位数为30（22-43）岁，分娩时胎龄中位数为37.6（24.1-40.9）周。13例（22.8%）产妇为初产妇，59.6% （n = 34）产妇为剖宫产。38.6% （n = 22）的母亲存在抗ro、抗la和抗dsdna自身抗体。只有一名女性出现了先兆子痫。早产9例（15.8%），宫内生长受限8例（14%）。婴儿的平均出生体重为2846（675-4240）克。3名婴儿（5.2%）需要在产房进行复苏。1名婴儿（1.8%）发生完全性房室传导阻滞，1名（1.8%）发生食管闭锁。没有一个婴儿出现典型的新生儿狼疮皮疹。结论：SLE是一种重要的全身性疾病，可使妊娠和新生儿结局复杂化。母亲的最佳多学科产前保健是必不可少的，以改善产妇和胎儿的结局。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.