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Fetal and Pediatric Pathology最新文献

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The Effect of the Ganglionic Segment Inflammatory Response to Postoperative Enterocolitis in Hirschsprung Disease. 神经节段炎症反应对赫氏肠病术后小肠结肠炎的影响
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-03-01 Epub Date: 2024-01-25 DOI: 10.1080/15513815.2024.2306280
Yalım Benibol, Ayşe Mine Önenerk Men, Ali Ekber Hakalmaz, Nil Çomunoğlu, Gonca Topuzlu Tekant, Rahşan Özcan
{"title":"The Effect of the Ganglionic Segment Inflammatory Response to Postoperative Enterocolitis in Hirschsprung Disease.","authors":"Yalım Benibol, Ayşe Mine Önenerk Men, Ali Ekber Hakalmaz, Nil Çomunoğlu, Gonca Topuzlu Tekant, Rahşan Özcan","doi":"10.1080/15513815.2024.2306280","DOIUrl":"10.1080/15513815.2024.2306280","url":null,"abstract":"<p><strong>Introduction: </strong>We examined the relationship between proinflammatory cytokines that occur in the inflammatory reaction in the intestine in Hirschsprung disease (HD) and Hirschsprung-associated enterocolitis (HAEC).</p><p><strong>Methods: </strong>Thirty cases (M:27, F:3) operated on due to HD. The cases were divided into three groups: group 1 with pre and post operative EC, group 2 with post-operative, and group 3 with pre-operative EC. The intestinal segments were evaluated by immunohistochemistry for interleukin 1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6).</p><p><strong>Results: </strong>IL-1β staining was significantly higher in the ganglionic zone of groups with enterocolitis compared to the control group (<i>p</i> = 0.012). TNF-α staining in the transitional zone of Group 3 and IL-1β staining in the ganglionic zone of Group 1 was significantly higher than the control group (<i>p</i> = 0.030, <i>p</i> = 0.020).</p><p><strong>Conclusion: </strong>In our study, older age at diagnosis and more than 20% IL-1ß staining in the ganglionic segment were found to be risk factors for HAEC. It is noteworthy that the increase in IL-1ß can be associated with HAEC.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"140-150"},"PeriodicalIF":1.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139546980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression and Clinical Significance of CD30 and CD56 in Lymphoblastic Lymphoma: A Retrospective Analysis on Paraffin-Embedded Tissues by Immunohistochemistry. CD30和CD56在淋巴母细胞淋巴瘤中的表达和临床意义：通过免疫组化对石蜡包埋组织的回顾性分析。
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-03-01 Epub Date: 2024-01-11 DOI: 10.1080/15513815.2023.2301459
Shuqi Li, Shuang Zheng, Xinyi Huang, Wenhui Zhang, Fang Liu, Qinghua Cao
{"title":"Expression and Clinical Significance of CD30 and CD56 in Lymphoblastic Lymphoma: A Retrospective Analysis on Paraffin-Embedded Tissues by Immunohistochemistry.","authors":"Shuqi Li, Shuang Zheng, Xinyi Huang, Wenhui Zhang, Fang Liu, Qinghua Cao","doi":"10.1080/15513815.2023.2301459","DOIUrl":"10.1080/15513815.2023.2301459","url":null,"abstract":"<p><p><b>Background:</b> We evaluated CD30 and CD56 expression in lymphoblastic lymphoma (LBL) and correlated the results with clinicopathological features and prognosis. <b>Methods:</b> Immunohistochemical (IHC) staining was performed on 85 formalin-fixed paraffin-embedded LBL specimens using two CD30 clones and one CD56 antibody clone. <b>Results:</b> Weak and diffuse expression of CD30 was expressed in 4.7% (clone Ber-H2) or 14.1% (clone EPR4102) in LBL, while CD56 was expressed in 24.7%. CD30 and CD56 expression correlated with lactate dehydrogenase levels. CD56-positive expression was closely associated with an unfavorable prognosis. Although CD30 expression exhibited a trend toward poorer overall survival, it did not reach statistical significance. <b>Conclusion:</b> CD56 is a potential negative prognostic marker. These findings suggest that CD30 and CD56 targeted therapies could be potential therapeutic targets for LBL patients.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"111-122"},"PeriodicalIF":1.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differentiation Potential of Hypodifferentiated Subsets of Nephrogenic Rests and Its Relationship to Prognosis in Wilms Tumor 肾原性息肉低分化亚群的分化潜能及其与 Wilms 肿瘤预后的关系
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-01-12 DOI: 10.1080/15513815.2024.2303081
Maolin Liu, Jiandong Lu, Chengjun Yu, Jie Zhao, Ling Wang, Yang Hu, Long Chen, Rong Han, Yan Liu, Miao Sun, Guanghui Wei, Shengde Wu
{"title":"Differentiation Potential of Hypodifferentiated Subsets of Nephrogenic Rests and Its Relationship to Prognosis in Wilms Tumor","authors":"Maolin Liu, Jiandong Lu, Chengjun Yu, Jie Zhao, Ling Wang, Yang Hu, Long Chen, Rong Han, Yan Liu, Miao Sun, Guanghui Wei, Shengde Wu","doi":"10.1080/15513815.2024.2303081","DOIUrl":"https://doi.org/10.1080/15513815.2024.2303081","url":null,"abstract":"Background Wilms tumor (WT) is highly curable, although anaplastic histology or relapse imparts a worse prognosis. Nephrogenic rests (NR) associated with a high risk of developing WT are abnormally...","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":"128 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139464717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter Regarding "Clinicopathological Analysis of Sturge-Weber Syndrome With Focal Cortical Dysplasia FCD IIIc". 关于“Sturge-Weber综合征伴局灶性皮质发育不良FCD IIIc的临床病理分析”的信函。
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-01-01 Epub Date: 2024-01-24 DOI: 10.1080/15513815.2023.2270678
Törehan Özer, Yonca Anik
{"title":"Letter Regarding \"Clinicopathological Analysis of Sturge-Weber Syndrome With Focal Cortical Dysplasia FCD IIIc\".","authors":"Törehan Özer, Yonca Anik","doi":"10.1080/15513815.2023.2270678","DOIUrl":"10.1080/15513815.2023.2270678","url":null,"abstract":"","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"76-78"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49684483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unifocal Type-3 Mixed Histiocytosis in a 10-Years Old Child. 一名 10 岁儿童的单灶 3 型混合组织细胞增生症
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-01-01 Epub Date: 2023-08-22 DOI: 10.1080/15513815.2023.2245489
Arturo Bonometti
{"title":"Unifocal Type-3 Mixed Histiocytosis in a 10-Years Old Child.","authors":"Arturo Bonometti","doi":"10.1080/15513815.2023.2245489","DOIUrl":"10.1080/15513815.2023.2245489","url":null,"abstract":"<p><strong>Background: </strong>Histiocytoses patients present with highly heterogeneous clinical and histopathological pictures requiring multidisciplinary management. Mixed histiocytosis is a recently described group of syndromes defined by the histological overlap of Langerhans cell histiocytosis and other histiocytic proliferations that include three clinically and prognostically different conditions (i.e., Type-1-3 mixed histiocytosis).</p><p><strong>Case report: </strong>We describe a 10 year-old boy with unifocal (type-3) mixed histiocytosis - Langerhans cell histiocytosis combined with a lesion with features intermediate between Rosai-Dorfman disease and reticulohistiocytosis. Sixty months after excision, the child is disease free.</p><p><strong>Discussion: </strong>Cutaneous type-3 mixed histiocytosis (Langerhans cell histiocytosis with Rosai-Dorfman disease/reticulohistiocytosis) may occur in older childhood, be unifocal, and be cured by surgical excision.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"66-70"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10039714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Frontal Phocomelia in a 3-Year-Old Girl. 一名 3 岁女孩的额叶畸形。
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-01-01 Epub Date: 2023-09-16 DOI: 10.1080/15513815.2023.2258417
Martina Vidová Uğurbaş, René Hako, Miloš Kňazovický
{"title":"The Frontal Phocomelia in a 3-Year-Old Girl.","authors":"Martina Vidová Uğurbaş, René Hako, Miloš Kňazovický","doi":"10.1080/15513815.2023.2258417","DOIUrl":"10.1080/15513815.2023.2258417","url":null,"abstract":"<p><p><b>Background:</b> Phocomelia is a congenital limb deformity in which the proximal part of the upper or lower limb does not develop. Occasionally the malformed limb may be located ectopically. <b>Case report:</b> We present a frontal phocomelia in a three-year-old girl with right-hand phocomelia and thoracoschisis. The patient's arm was connected directly from the front of the chest, with a rudimentary thumb and two fingers. The truncated arm was not functional. The acromioclavicular joint was abnormal and ectopic, the limb articulated with the medial side of sternum. The thoracoschisis manifested as eventration of the right liver lobe and right side of chest wall. <b>Conclusion:</b> Ectopic phocomelia can be associated with thoracoschisis, it can be nonfunctional, and can articulate with the sternum.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"71-75"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10269095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methylation Status of IGF-Axis Genes in the Placenta of South Indian Neonates with Appropriate and Small for Gestational Age. 南印度适龄和小胎龄新生儿胎盘中igf轴基因甲基化状态
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-01-01 Epub Date: 2024-01-24 DOI: 10.1080/15513815.2023.2280660
Nithya M N, Krishnappa J, Sheela S R, Venkateswarlu Raavi
{"title":"Methylation Status of IGF-Axis Genes in the Placenta of South Indian Neonates with Appropriate and Small for Gestational Age.","authors":"Nithya M N, Krishnappa J, Sheela S R, Venkateswarlu Raavi","doi":"10.1080/15513815.2023.2280660","DOIUrl":"10.1080/15513815.2023.2280660","url":null,"abstract":"<p><strong>Objective: </strong>Altered methylation patterns of insulin-like growth factor (IGF)-axis genes in small for gestational age (SGA) have been reported in different populations. In the present study, we analyzed the methylation status of IGF-axis genes in the placenta of appropriate for gestational age (AGA) and SGA neonates of South Indian women.</p><p><strong>Methods: </strong>Placental samples were collected from AGA (<i>n</i> = 40) and SAG (<i>n</i> = 40) neonates. The methylation of IGF-axis genes promoter was analyzed using MS-PCR.</p><p><strong>Results: </strong><i>IGF2</i>, <i>H19</i>, <i>IGF1,</i> and <i>IGFR1</i> genes promoter methylation was 2.5, 1.5, 5, and 7.5% lower in SGA compared to AGA, respectively. Co-methylation of IGF-axis genes promoter was 40% and 20% in AGA and SGA, respectively. IGF-axis gene promoter methylation significantly (<i>p</i> < 0.05) influenced the levels of IGFBP3 protein, birth weight, mitotic index, gestational weeks, and <i>IGFR1</i> and <i>IGFR2</i> gene expression.</p><p><strong>Conclusion: </strong>IGF-axis genes methylation was lower in SGA than in AGA, and the methylation significantly influenced the IGF-axis components.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"5-20"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136400120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of a Pediatric Pathologist during and after a Disaster. 儿童病理学家在灾难期间和之后的作用。
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-01-01 Epub Date: 2024-01-24 DOI: 10.1080/15513815.2023.2285578
Randall Craver
{"title":"Role of a Pediatric Pathologist during and after a Disaster.","authors":"Randall Craver","doi":"10.1080/15513815.2023.2285578","DOIUrl":"10.1080/15513815.2023.2285578","url":null,"abstract":"","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"1-4"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138441588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Placenta and Evolving Insights into Pathological Changes of Preeclampsia: A Comprehensive Review of the Last Decade. 人类胎盘与先兆子痫病理变化的演变：近十年的综合回顾。
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-01-01 Epub Date: 2024-01-24 DOI: 10.1080/15513815.2023.2274823
Diana Maria Chiorean, Esra Cobankent Aytekin, Melinda-Ildiko Mitranovici, Sabin Gligore Turdean, Mirpooya Salehi Moharer, Ovidiu Simion Cotoi, Havva Serap Toru
{"title":"Human Placenta and Evolving Insights into Pathological Changes of Preeclampsia: A Comprehensive Review of the Last Decade.","authors":"Diana Maria Chiorean, Esra Cobankent Aytekin, Melinda-Ildiko Mitranovici, Sabin Gligore Turdean, Mirpooya Salehi Moharer, Ovidiu Simion Cotoi, Havva Serap Toru","doi":"10.1080/15513815.2023.2274823","DOIUrl":"10.1080/15513815.2023.2274823","url":null,"abstract":"<p><p>The placenta, the foremost and multifaceted organ in fetal and maternal biology, is pivotal in facilitating optimal intrauterine fetal development. Remarkably, despite its paramount significance, the placenta remains enigmatic, meriting greater comprehension given its central influence on the health trajectories of both the fetus and the mother. Preeclampsia (PE) and intrauterine fetal growth restriction (IUGR), prevailing disorders of pregnancy, stem from compromised placental development. PE, characterized by heightened mortality and morbidity risks, afflicts 5-7% of global pregnancies, its etiology shrouded in ambiguity. Pertinent pathogenic hallmarks of PE encompass inadequate restructuring of uteroplacental spiral arteries, placental ischemia, and elevated levels of vascular endothelial growth factor receptor-1 (VEGFR-1), also recognized as soluble FMS-like tyrosine kinase-1 (sFlt-1). During gestation, the placental derivation of sFlt-1 accentuates its role as an inhibitory receptor binding to VEGF-A and placental growth factor (PlGF), curtailing target cell accessibility. This review expounds upon the placenta's defining cellular component of the trophoblast, elucidates the intricacies of PE pathogenesis, underscores the pivotal contribution of sFlt-1 to maternal pathology and fetal safeguarding, and surveys recent therapeutic strides witnessed in the past decade.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"33-46"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnitude and Determinants of Intestinal Parasites among Children under Five in Ethiopia During 2010-2023: A Systematic Review and Meta-Analysis. 2010-2023年埃塞俄比亚5岁以下儿童肠道寄生虫数量和决定因素:系统回顾和荟萃分析
IF 0.7 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-01-01 Epub Date: 2024-01-24 DOI: 10.1080/15513815.2023.2284920
Abayeneh Girma, Amere Genet
{"title":"Magnitude and Determinants of Intestinal Parasites among Children under Five in Ethiopia During 2010-2023: A Systematic Review and Meta-Analysis.","authors":"Abayeneh Girma, Amere Genet","doi":"10.1080/15513815.2023.2284920","DOIUrl":"10.1080/15513815.2023.2284920","url":null,"abstract":"<p><p><b>Background</b>: Intestinal parasitic infection (IPI) poses a serious public health threat across the globe, particularly in children in low- and middle-income countries like Ethiopia. This study was to provide pooled estimates for the individually available data on IPI and its predictors among children under five in Ethiopia. <b>Methods</b>: Cochrane's <i>Q</i>, <i>I</i><sup>2</sup>, sensitivity analysis, funnel plot, Begg's, and Egger's regression tests were used to check heterogeneity and publication bias. A random-effects model was used to calculate the pooled burden of IPI among children under five. <b>Results</b>: The pooled prevalence of IPI among children under five was 28.27% (95% CI = 20.52-36.03%). Of these, single and mixed infections contribute to 28.02% and 0.25%. Intestinal parasites were significantly associated with eating raw fruits and vegetables [AO = 3.21, 95% CI = 1.11, 5.31]. <b>Conclusion</b>: Under the present scenario, the IPI ranges from 17.78 to 40.05%, and the IPI is higher in community-based studies of children under five.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"47-65"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138441587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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