Unifocal Type-3 Mixed Histiocytosis in a 10-Years Old Child.

IF 0.7 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2024-01-01 Epub Date: 2023-08-22 DOI:10.1080/15513815.2023.2245489

Arturo Bonometti

引用次数: 0

Abstract

Background: Histiocytoses patients present with highly heterogeneous clinical and histopathological pictures requiring multidisciplinary management. Mixed histiocytosis is a recently described group of syndromes defined by the histological overlap of Langerhans cell histiocytosis and other histiocytic proliferations that include three clinically and prognostically different conditions (i.e., Type-1-3 mixed histiocytosis).

Case report: We describe a 10 year-old boy with unifocal (type-3) mixed histiocytosis - Langerhans cell histiocytosis combined with a lesion with features intermediate between Rosai-Dorfman disease and reticulohistiocytosis. Sixty months after excision, the child is disease free.

Discussion: Cutaneous type-3 mixed histiocytosis (Langerhans cell histiocytosis with Rosai-Dorfman disease/reticulohistiocytosis) may occur in older childhood, be unifocal, and be cured by surgical excision.

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一名 10 岁儿童的单灶 3 型混合组织细胞增生症

背景：组织细胞增生症患者的临床和组织病理学表现高度异质性，需要多学科治疗。混合型组织细胞增生症是最近描述的一组综合征，其定义是朗格汉斯细胞组织细胞增生症和其他组织细胞增生症的组织学重叠，包括三种临床和预后不同的病症（即 1-3 型混合型组织细胞增生症）：我们描述了一名患有单灶（3 型）混合组织细胞增生症--朗格汉斯细胞组织细胞增生症的 10 岁男孩，他的病变特征介于罗赛-多夫曼病和网状组织细胞增生症之间。切除术后 60 个月，患儿未再发病：讨论：皮肤3型混合组织细胞增生症（朗格汉斯细胞组织细胞增生症合并罗赛-多夫曼病/网状组织细胞增生症）可能发生在年龄较大的儿童期，为单灶，手术切除后即可治愈。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.