Umbilical Cord Hypercoiling with Stricture and Intrauterine Fetal Death: Association with Maternal Factors and Implications for Pathogenesis.

IF 0.7 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2025-05-21 DOI:10.1080/15513815.2025.2507250

Aidan Clement, Art Mendoza, Chris Wixom, Peilin Zhang

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引用次数: 0

Abstract

Introduction: Hypercoiling of umbilical cord with stricture (HCS) is one of the most common etiologies of intrauterine fetal death (IUFD). Whether Wharton's Jelly close to fetal abdomen plays roles in pathogenesis is controversial. Methods: Fetal autopsies were reviewed between 2015 and 2022 and HCS with maternal and fetal factors were examined to determine if these factors were relevant to HCS and IUFD. Results: Totally 389 fetal autopsies were reviewed and 75 cases of HCS were identified. HCS was found more frequently in older (maternal age ≥35) multiparous women with longer cords and increased umbilical coiling index (UCI) (both p < 0.01). There was no significant difference in maternal race/ethnicity, BMI, fetal sex, genetics, seasonality, multiple pregnancies or anomalies in HCS. Conclusions: HCS appeared related to maternal characteristics and it occurred more frequently in older multiparous women associated with longer cords. Lack or poorly developed Wharton's jelly close to fetal abdomen plays important role in IUFD.

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脐带过盘伴狭窄和宫内胎儿死亡：与母体因素的关联及其发病机制。

导读：脐带狭窄（HCS）是宫内胎儿死亡（IUFD）最常见的病因之一。胎儿腹部附近的华氏软膏是否在发病机制中起作用尚存争议。方法：回顾2015年至2022年的胎儿尸检，检查HCS与母胎因素，确定这些因素是否与HCS和IUFD相关。结果：共回顾389例胎儿尸检，发现HCS 75例。HCS更常见于年龄较大（母亲年龄≥35岁）、脐带较长且脐带盘绕指数（UCI）增高的多产妇女（均为p）。结论：HCS似乎与产妇特征有关，且在年龄较大、脐带较长的多产妇女中发生的频率更高。靠近胎儿腹部的华顿氏冻缺乏或发育不良在IUFD中起重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.