Kaouther Nasri, Nadia Ben Jamaa, Soumeya Siala Gaigi
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Neural Tube Defects in Tunisia: Epidemiological, Biochemical and Genetic Factors.
Introduction: This study resumed epidemiological, biochemical and genetic factors associated with the occurrence of neural tube defects in Tunisia. Material and methods: This work builds on our previously published investigations, utilizing data retrospectively collected during (1991-2011), and prospectively collected between January 1, 2012, and December 30, 2013. Results: Our studies have demontrated that plasma folate, vitamin B12 and vitamin D concentrations were significantly lower in cases compared with controls. Homocysteine concentrations were significantly higher in cases compared with controls. Cases had higher concentrations of heptadecanoic acid, linolelaidic acid and arachidonic acid/(eicosapentaenoic acid + docosahexaenoic acid) ratio than controls. Nervonic acid, arachidonic acid, adrenic acid, Eicosapentaenoic Acid, Docosahexaenoic Acid, and omega 3 polyunsatured fatty acids concentrations were significantly lower in cases. Conclusion: Such research would contribute to a better understanding of the biochemical and genetic variances in mothers, highlighting the suitable status of vitamins, homocysteine, lipid profile, and genotype.
期刊介绍：
Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports.
The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.
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