Fetal and Pediatric Pathology最新文献_第2页

Clinical Diagnostic Value of miR-193a-5p in Neonatal Acute Respiratory Distress Syndrome and Analysis of Its Effect on Human Lung Epithelial Cells.

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-03-01 Epub Date: 2025-01-23 DOI: 10.1080/15513815.2024.2447579

Chuanrui Zhu, Lun Zhang, Hongfen Ma, Cuicui Zhang, Fang Cheng, Hong An, Wenxiang Zhu

{"title":"Clinical Diagnostic Value of miR-193a-5p in Neonatal Acute Respiratory Distress Syndrome and Analysis of Its Effect on Human Lung Epithelial Cells.","authors":"Chuanrui Zhu, Lun Zhang, Hongfen Ma, Cuicui Zhang, Fang Cheng, Hong An, Wenxiang Zhu","doi":"10.1080/15513815.2024.2447579","DOIUrl":"10.1080/15513815.2024.2447579","url":null,"abstract":"Aim: To explore the clinical value of miR-193a-5p in neonatal acute respiratory distress syndrome (ARDS) and its role in ARDS cell model in vitro. Methods: RT-qPCR was utilized to detect miR-193a-5p level. Correlation analysis was implemented to assess the correlation between miR-193a-5p and clinical indicators (IL-6, IL-1β, TNF-α, LUS). Human lung epithelial cells induced by LPS were used to construct ARDS cell model. The effects of miR-193a-5p on cell viability, apoptosis and inflammation were evaluated by CCK-8, flow cytometry and ELISA. The target gene of miR-193a-5p was predicted and verified by StarBaseV2.0 and luciferase reporter gene, respectively. Results: MiR-193a-5p level in the ARDS group was down-regulated. MiR-193a-5p levels were negatively correlated with clinical indicators. In vitro studies revealed that up-regulation of miR-193a-5p significantly improved LPS-induced apoptosis, inflammation and viability inhibition. Conclusion: The expression of miR-193a-5p was decreased in neonatal ARDS, it is negatively correlated with the pro-inflammatory factors levels.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"85-97"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological Features of Diffuse Hemispheric Glioma, H3G34-Mutant.

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-03-01 Epub Date: 2025-02-28 DOI: 10.1080/15513815.2025.2460560

Juan Cao, Yongxian Chen, Guocheng Yang, Xiaoxiao He, Hailun Chen, Zaoling Luo, Jingting Liao, Zhihui Huang, Weiguo Cao

{"title":"Clinicopathological Features of Diffuse Hemispheric Glioma, H3G34-Mutant.","authors":"Juan Cao, Yongxian Chen, Guocheng Yang, Xiaoxiao He, Hailun Chen, Zaoling Luo, Jingting Liao, Zhihui Huang, Weiguo Cao","doi":"10.1080/15513815.2025.2460560","DOIUrl":"10.1080/15513815.2025.2460560","url":null,"abstract":"Objective: To investigate the clinical manifestations, radiographic features, and pathological characteristics of three cases of diffuse hemispheric gliomas, H3G34-mutant (H3G34 DHG).Methods: This study used a single-center retrospective cohort approach to analyze 45 pediatric-type diffuse high-grade glioma cases.Results: Histologically, case 1 and case 2 had glioblastoma structures, and case 3 had primitive neuroectodermal tumor (PNET) morphology with ganglion cell differentiation. Immunohistochemical staining revealed diffuse expression of H3G34R and P53, but no expression of Olig2, ATRX, IDH1/2 and BRAF V600E in tumor cells in all three cases.Conclusions: H3 G34 DHG occurs more significantly in younger patients, and nearly all lesions are located in the cerebral hemisphere. MRI showed mass effects, edema and mild enhancement. The histological type showed glioblastoma structure and PNET morphology. Immunohistochemistry showed that the expression of H3G34R was more significant in PNET morphology.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"148-156"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic Eosinophilic Infiltrates of Infants of Diabetic Mothers Revisited. 糖尿病母亲对婴儿胰腺嗜酸性粒细胞浸润的再观察。

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-03-01 Epub Date: 2024-12-11 DOI: 10.1080/15513815.2024.2440798

Randall Craver

引用次数: 0

The Impact of the "Newborn Gang" Scandal on Türkiye's Neonatal Healthcare Community.

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-02-28 DOI: 10.1080/15513815.2025.2469584

Didem Yüksel

引用次数: 0

Opening of the Mitochondrial Permeability Transition Pore Mediated Myocardial Damage After Perinatal Asphyxia in Neonatal Rats.

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-02-24 DOI: 10.1080/15513815.2025.2466804

Zhixin Chen, Jianqin Chen, Yongheng Chen, Xiaoyi Fang

{"title":"Opening of the Mitochondrial Permeability Transition Pore Mediated Myocardial Damage After Perinatal Asphyxia in Neonatal Rats.","authors":"Zhixin Chen, Jianqin Chen, Yongheng Chen, Xiaoyi Fang","doi":"10.1080/15513815.2025.2466804","DOIUrl":"https://doi.org/10.1080/15513815.2025.2466804","url":null,"abstract":"Objectives: This study investigated the mechanisms underlying myocardial damage after perinatal hypoxia.Methods: An intrauterine hypoxia-ischemia model (I/U HI) and a hypoxia/reoxygenation (H/R) model were established. Myocardial damage, mitochondrial function, and mitochondria permeability transition pore (MPTP) opening were determined. The results, presented as means ± SD, were analyzed using SPSS.Results: Intrauterine hypoxia induced cardiac damage, mitochondrial dysfunction, and MPTP opening in neonatal rats. H/R led to apoptosis and MPTP opening. cTnI and apoptosis-inducing factor (AIF) levels were positively correlated with the degree of MPTP opening. The larger degree of MPTP opening combined with the significant increases in the Ca2+, ROS, and decreases in mitochondrial membrane potential and ATP levels. The larger degree of MPTP opening combined with the stronger release of cytochrome c and AIF.Conclusions: Increased MPTP opening may play a crucial role in perinatal asphyxia-induced myocardial damage in neonatal rats.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"1-19"},"PeriodicalIF":0.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Archival Stewards.

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-02-20 DOI: 10.1080/15513815.2025.2466803

Randall Craver

引用次数: 0

A Case Report of 10q24.32 Microduplication Associated with Split Hand/Foot Malformation (SHFM) in Prenatal Diagnosis. 10q24.32微重复与手足裂形畸形（SHFM）产前诊断1例

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1080/15513815.2024.2440465

Marco Fabiani, Katia Margiotti, Francesco Libotte, Maria Luce Genovesi, Antonella Cima, Alvaro Mesoraca, Claudio Giorlandino

引用次数: 0

Association Between Placental Pathology and Early-Onset Fetal Growth Restriction: A Systematic Review. 胎盘病理与早发性胎儿生长受限之间的关系：一项系统综述。

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1080/15513815.2024.2437642

Beatriz Pinheiro, Inês Sarmento-Gonçalves, Carla Ramalho

引用次数: 0

A Rare Case of Meckel-Gruber Syndrome with Congenital Intestinal Atresia and Abdominal Pseudocyst Clinic. 一例罕见的梅克尔-格鲁伯综合征伴先天性肠闭锁和腹部假囊肿病例。

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-01-01 Epub Date: 2024-10-16 DOI: 10.1080/15513815.2024.2414178

Sevgi Ulusoy Tangul, Gizem Gencan

{"title":"A Rare Case of Meckel-Gruber Syndrome with Congenital Intestinal Atresia and Abdominal Pseudocyst Clinic.","authors":"Sevgi Ulusoy Tangul, Gizem Gencan","doi":"10.1080/15513815.2024.2414178","DOIUrl":"10.1080/15513815.2024.2414178","url":null,"abstract":"Background: Meckel-Gruber syndrome (MGS) is a rare disease with a fatal, autosomal recessive inheritance pattern. This article mentions the neonatal MGS case followed by intestinal atresia and meconium pseudocyst clinic. Case presentation: Bile-containing-fluid was aspirated from the fetus, which was found to have polyhydramnios, gastric dilatation, lung hypoplasia, and cystic formation with a diameter of 68*62mm in the abdomen at 32 weeks of gestation in the intrauterine period. The cyst recurred after 2 weeks. We operated the patient with the preliminary diagnosis of meconium pseudocyst due to intrauterine perforation. The general condition was moderate in the postoperative period, and intermittent bilious vomiting continued. We performed an ileostomy on the patient due to his inability to tolerate oral intake, lack of passage, and abdominal distension. In addition, as a result of liver biopsy, cholestasis, cholestatic changes, bile-duct loss, and ductular reaction were detected. According to the current clinical findings and genetic analysis results, the patient was diagnosed with MGS. Conclusion: Autosomal recessive, fatal diseases such as MGS are pathologies with a high probability of recurrence with each pregnancy. Therefore, awareness needs to be increased to prevent these diseases.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"63-68"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Fetal Reduction Necessary in Triplet Pregnancy? Single Tertiary Center Experience. 三胞胎妊娠有必要减少胎儿数量吗？单一三级中心体验。

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2025-01-01 Epub Date: 2024-12-03 DOI: 10.1080/15513815.2024.2434050

Sukran Dogru, Huriye Ezveci, Fikriye Karanfil Yaman, Fatih Akkus, Pelin Bahceci, Ali Acar

{"title":"Is Fetal Reduction Necessary in Triplet Pregnancy? Single Tertiary Center Experience.","authors":"Sukran Dogru, Huriye Ezveci, Fikriye Karanfil Yaman, Fatih Akkus, Pelin Bahceci, Ali Acar","doi":"10.1080/15513815.2024.2434050","DOIUrl":"10.1080/15513815.2024.2434050","url":null,"abstract":"Objective: This study aims to evaluate the perinatal outcomes of triplet pregnancies reduced from triplets to twins with fetal reduction (FR), followed expectantly without FR, and reduced to triplets from higher-order multiple pregnancies (HOMP) with FR.Materials and methods: Multifetal pregnancies followed at the university hospital in the last 8 years were evaluated retrospectively. The study group was composed of three groups. The first group was those who started as trichorionic-triamniotic (TCTA) triplets and were followed by triplets. The second group consisted of HOMPs reduced to TCTA triplets with FR. The third group consisted of pregnant women who started as TCTA triplets and were reduced to dichorionic-diamniotic (DCDA) twins with FR.Results: A total of 69 multifetal pregnancies were included in the study. No statistical difference was observed between miscarriage rates in all groups (p = 0.190). Birth rates below 32 weeks were similar between groups (p = 0.158). The birth rates below 34 weeks were statistically significantly lower in the group in which DCDA was reduced by TCTA compared to the other two groups (p = 0.001). The first and second fetus weights in the group reduced to DCDA twins from TCTA were higher than the group followed expectantly, they were similar to the triplets reduced from HOMP. Stillbirth rates were similar in all groups (p = 0.057).Conclusion: In TCTA pregnancies, when the priority is three live-born babies, expectant management seems to be a reasonable choice, considering the low rate of miscarriage and high rate of survivor neonates in this group.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"14-24"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0