Leyla Sero, Duygu Tuncel, Mehmet Nur Talay, Mehmet Salih Karaca, Ozlem Gul, Nilufer Okur
{"title":"新生儿缺氧缺血性脑病心功能的评价。","authors":"Leyla Sero, Duygu Tuncel, Mehmet Nur Talay, Mehmet Salih Karaca, Ozlem Gul, Nilufer Okur","doi":"10.1080/15513815.2025.2490029","DOIUrl":null,"url":null,"abstract":"<p><p><b>Introduction:</b> The aim of our study was to evaluate the role of cardiac markers in determining prognosis in newborns with Perinatal Asphyxia (PA). <b>Method:</b> Patients with a pH <7-7.15 base deficit -12> mmol/L were defined as PA. NT-proBNP, cardiac Troponin I (cTnI), creatine kinase MB levels were analyzed. Patients with excitus during follow-up were compared with patients with pathological MRI findings and cardiac markers. <b>Results:</b> A total of 115 infants with perinatal asphyxia were included in the study.cTnI levels was median 0.63 (min 0.1-max 4.2) ng/ml significantly higher in patients who died (<i>p</i> = .006). The predictive power of cTnI was evaluated and the threshold value of cTnI for predicting mortality was determined as 0.428 ng/ml with 87.5% sensitivity and 87.2% specificity. <b>Conclusion:</b> We found that cTnI level analyzed in the first hours of life in newborn infants with PA has value in predicting both mortality and cranial affections.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"206-214"},"PeriodicalIF":0.7000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of Cardiac Functions in Neonates with Hypoxic Ischemic Encephalopathy.\",\"authors\":\"Leyla Sero, Duygu Tuncel, Mehmet Nur Talay, Mehmet Salih Karaca, Ozlem Gul, Nilufer Okur\",\"doi\":\"10.1080/15513815.2025.2490029\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Introduction:</b> The aim of our study was to evaluate the role of cardiac markers in determining prognosis in newborns with Perinatal Asphyxia (PA). <b>Method:</b> Patients with a pH <7-7.15 base deficit -12> mmol/L were defined as PA. NT-proBNP, cardiac Troponin I (cTnI), creatine kinase MB levels were analyzed. Patients with excitus during follow-up were compared with patients with pathological MRI findings and cardiac markers. <b>Results:</b> A total of 115 infants with perinatal asphyxia were included in the study.cTnI levels was median 0.63 (min 0.1-max 4.2) ng/ml significantly higher in patients who died (<i>p</i> = .006). The predictive power of cTnI was evaluated and the threshold value of cTnI for predicting mortality was determined as 0.428 ng/ml with 87.5% sensitivity and 87.2% specificity. <b>Conclusion:</b> We found that cTnI level analyzed in the first hours of life in newborn infants with PA has value in predicting both mortality and cranial affections.</p>\",\"PeriodicalId\":50452,\"journal\":{\"name\":\"Fetal and Pediatric Pathology\",\"volume\":\" \",\"pages\":\"206-214\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fetal and Pediatric Pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/15513815.2025.2490029\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/21 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fetal and Pediatric Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/15513815.2025.2490029","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/21 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PATHOLOGY","Score":null,"Total":0}
Evaluation of Cardiac Functions in Neonates with Hypoxic Ischemic Encephalopathy.
Introduction: The aim of our study was to evaluate the role of cardiac markers in determining prognosis in newborns with Perinatal Asphyxia (PA). Method: Patients with a pH <7-7.15 base deficit -12> mmol/L were defined as PA. NT-proBNP, cardiac Troponin I (cTnI), creatine kinase MB levels were analyzed. Patients with excitus during follow-up were compared with patients with pathological MRI findings and cardiac markers. Results: A total of 115 infants with perinatal asphyxia were included in the study.cTnI levels was median 0.63 (min 0.1-max 4.2) ng/ml significantly higher in patients who died (p = .006). The predictive power of cTnI was evaluated and the threshold value of cTnI for predicting mortality was determined as 0.428 ng/ml with 87.5% sensitivity and 87.2% specificity. Conclusion: We found that cTnI level analyzed in the first hours of life in newborn infants with PA has value in predicting both mortality and cranial affections.
期刊介绍：
Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports.
The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.
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