胎儿NT-proBNP浓度对母体贫血的反应：足月妊娠的研究。

IF 0.6 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2025-07-01 Epub Date: 2025-06-14 DOI:10.1080/15513815.2025.2507254

Kadriye Erdogan, Izzet Ozgurluk, Dilara Kurt, Aslihan Coskun, Zeynep Seyhanli, Ahmet Kurt, Sevinc Cetin, İsmail Burak Gultekin, Busra Korpe

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引用次数: 0

摘要

目的：本研究评估贫血与非贫血足月妊娠脐带血中胎儿n端前b型利钠肽（NT-proBNP）的浓度。材料与方法：本前瞻性病例对照研究将90例孕妇分为两组：45例有母体贫血，45例无母体贫血。分析脐带血NT-proBNP浓度，并收集产妇血红蛋白和铁蛋白水平等数据。结果：贫血组NT-proBNP浓度显著高于对照组（844.42±746.9 pg/mL vs 510.87±378.52 pg/mL, p = 0.01）。贫血组母体铁蛋白水平显著降低（10.02±6.81 vs 37.02±9.79）。结论：贫血妊娠NT-proBNP浓度升高提示胎儿对缺氧的代偿性反应，突出其作为胎儿心血管适应的潜在标志。

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Fetal NT-proBNP Concentrations in Response to Maternal Anemia: A Study of Term Pregnancies.

Objective: This study evaluates fetal N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations in umbilical cord blood from anemic versus non-anemic term pregnancies.

Materials and methods: In this prospective case-control study, 90 pregnant women were divided into two groups: 45 with maternal anemia and 45 without. Umbilical cord blood NT-proBNP concentrations were analyzed, and maternal data including hemoglobin and ferritin levels were collected.

Results: NT-proBNP concentrations were significantly higher in the anemia group (844.42 ± 746.9 pg/mL vs 510.87 ± 378.52 pg/mL, p = 0.01). Maternal ferritin levels were significantly lower in the anemia group (10.02 ± 6.81 vs 37.02 ± 9.79, p < 0.001). A significant inverse relationship was found between hemoglobin and NT-proBNP concentrations (β = -76.27, p < 0.001).

Conclusion: Elevated NT-proBNP concentrations in anemic pregnancies suggest a compensatory fetal response to hypoxia, highlighting its potential as a marker for fetal cardiovascular adaptation.

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.