Congenital Mass Lesions of the Thoracic Cavity- A Fetal Autopsy Study.

IF 0.7 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2025-07-09 DOI:10.1080/15513815.2025.2529888

Umamaheswari Gurusamy, Harini Devi Jeganathan Kaliyaperumal Annadurai, Priyadarshini Kumaraswamy Rajeswaran

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引用次数: 0

Abstract

Objectives: Congenital thoracic mass lesions are generally benign but can cause significant morbidity and mortality due to airway obstruction. This study highlights the role of perinatal autopsy in identifying these lesions and correlates autopsy findings with prenatal imaging.

Materials and methods: A retrospective analysis of fetal autopsies with thoracic mass lesions was conducted over 9 years. A standardized autopsy protocol, including fixation, photography, foetogram, external examination, en-bloc removal, internal examination, and organ block dissection, was followed and compared with prenatal imaging results.

Results: Of 426 fetal autopsies, 20 (4.6%) had thoracic mass lesions. The most common lesion was diaphragmatic hernia (9 cases, 45%), followed by congenital high airway obstruction syndrome (3 cases, 15%). Agreement with prenatal ultrasonography was observed in only 4 cases (20%).

Conclusion: Fetal autopsy is crucial for identifying thoracic mass lesions and determining the cause of death, aiding in genetic counseling and management of future pregnancies.

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先天性胸腔肿块病变-胎儿尸检研究。

目的：先天性胸部肿块病变通常是良性的，但由于气道阻塞可导致显著的发病率和死亡率。这项研究强调了围产期尸检在识别这些病变中的作用，并将尸检结果与产前成像联系起来。材料和方法：回顾性分析了9年来的胸部肿块病变胎儿尸检。采用标准化的尸检方案，包括固定、摄影、影像、外部检查、整体切除、内部检查和器官块剥离，并与产前影像学结果进行比较。结果：426例胎儿尸检中，20例（4.6%）有胸部肿块病变。最常见的病变为膈疝（9例，45%），其次为先天性高气道阻塞综合征（3例，15%）。仅4例（20%）与产前超声检查相符。结论：胎儿尸检对于确定胸部肿块病变和确定死亡原因，帮助遗传咨询和未来妊娠管理至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.