npj Cardiovascular Health最新文献

Persistent and de novo postpartum hypertension: a scoping review of pathophysiology, evaluation, and management. 产后持续和新发高血压：病理生理学、评估和管理的范围综述。

npj Cardiovascular Health Pub Date : 2026-05-04 DOI: 10.1038/s44325-026-00120-x

Mansi Garneni, Alice Huang, Ifeoma Obionu, Zainab Mahmoud

{"title":"Persistent and de novo postpartum hypertension: a scoping review of pathophysiology, evaluation, and management.","authors":"Mansi Garneni, Alice Huang, Ifeoma Obionu, Zainab Mahmoud","doi":"10.1038/s44325-026-00120-x","DOIUrl":"https://doi.org/10.1038/s44325-026-00120-x","url":null,"abstract":"Postpartum hypertension is high blood pressure following delivery that may occur as persistent or de novo postpartum hypertension. This scoping review summarizes current evidence on the epidemiology, risk factors, evaluation, and management of postpartum hypertension and highlights areas for further investigation. Studies on persistent or de novo hypertension in the 12-month postpartum period were eligible for inclusion. Literature searches were performed in MEDLINE, Embase, and Scopus. Of 2132 studies screened, 116 met the inclusion criteria. Postpartum hypertension epidemiologic data are limited, in part due to the absence of a standardized definition. Distinct risk factors for persistent versus de novo disease suggest differing underlying pathophysiologic mechanisms, yet trials of postpartum antihypertensive therapies have not identified a clear first-line agent. While telemedicine interventions have demonstrated improvements in postpartum hypertension outcomes, standardization of diagnostic and treatment thresholds and expanded research into mechanisms and therapeutics for persistent and de novo disease are needed.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulse pressure associates with severity and worse outcomes in patients with stable coronary artery disease. 脉压与稳定型冠状动脉疾病患者的严重程度和较差的预后相关。

npj Cardiovascular Health Pub Date : 2026-05-04 DOI: 10.1038/s44325-026-00118-5

Yan Zhang, Sha Li, Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Rui-Xia Xu, Jie Qian, Ke-Fei Dou, Jian-Jun Li

{"title":"Pulse pressure associates with severity and worse outcomes in patients with stable coronary artery disease.","authors":"Yan Zhang, Sha Li, Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Rui-Xia Xu, Jie Qian, Ke-Fei Dou, Jian-Jun Li","doi":"10.1038/s44325-026-00118-5","DOIUrl":"https://doi.org/10.1038/s44325-026-00118-5","url":null,"abstract":"The association of pulse pressure (PP) with the severity and cardiovascular (CV) outcomes in stable coronary artery disease populations with normal ejection fraction are sparse. We enrolled 7,027 patients and follow-up 36.4 months, a total of 289 events occurred. Both systolic blood pressure (SBP) and PP were significantly increased by Gensini Score quartiles. Meanwhile, the percentage of 3-diseased vessels was increasing by PP quartiles (p < 0.001). On univariate analysis, both PP and SBP were associated with CV death, stroke, and combined outcome (p < 0.05, all). However, after adjusting for potential confounders, PP remains significantly associated with stroke (HR 95%CI 1.019[1.005-1.033]) and combined outcome (HR 95%CI 1.014[1.005-1.023]) while SBP was only associated with stroke (HR 95%CI 1.014[1.003-1.026]). On multivariate analysis, the highest PP quartile consistently associated with stroke and combined outcome (p < 0.05, all). This prospective cohort study suggesting that PP may be a pivotal predictor for CV risk.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Percutaneous Coronary Intervention and vascular access complications: A contemporary review. 经皮冠状动脉介入治疗和血管通路并发症：当代回顾。

npj Cardiovascular Health Pub Date : 2026-04-28 DOI: 10.1038/s44325-026-00125-6

Tanawat Attachaipanich, Muzamil Khawaja, Edwin A Takahashi, Hafeez Ul Hassan Virk, Mahboob Alam, Ian C Gilchrist, Chayakrit Krittanawong

引用次数: 0

Cost-effectiveness of statins, berberine, and combination for primary cardiovascular disease prevention in Scotland. 他汀类药物、小檗碱联合用药在苏格兰预防原发性心血管疾病的成本效益

npj Cardiovascular Health Pub Date : 2026-04-23 DOI: 10.1038/s44325-026-00121-w

Yuanqing Xia, Kathy Leung, Jie V Zhao

{"title":"Cost-effectiveness of statins, berberine, and combination for primary cardiovascular disease prevention in Scotland.","authors":"Yuanqing Xia, Kathy Leung, Jie V Zhao","doi":"10.1038/s44325-026-00121-w","DOIUrl":"https://doi.org/10.1038/s44325-026-00121-w","url":null,"abstract":"We aim to estimate and compare the cost-effectiveness of statins, berberine, and their combined use for primary cardiovascular disease (CVD) prevention. The Scottish CVD Policy Model was used to predict long-term health and cost outcomes in Scottish adults aged 40 years or older without pre-existing CVD. Intervention and cost inputs were sourced from published literature and health service cost data. The primary outcome measure was the lifetime incremental cost-effectiveness ratio (ICER), evaluated as cost per quality-adjusted life year (QALY) gained. Five strategies were analyzed for individuals with ASSIGN risk scores ≥20% and ≥10%: no intervention, atorvastatin 20 mg/day, berberine 1000 mg/day, simvastatin 20 mg plus berberine 1500 mg/day, and simvastatin 20 mg plus berberine 900 mg/day. All intervention strategies were cost-effective, compared to no intervention, at the threshold of ICER of £20,000 per QALY. Compared to statins, berberine was less cost-effective, but the combined interventions remained cost-effective. Notably, when using drug costs from China (reflecting lower berberine prices), berberine and the combined interventions were preferable to statins alone. Statins, berberine, and combined interventions are all cost-effective options for primary CVD prevention. Berberine could be considered a valuable alternative or complementary therapy, particularly if its price decreases below that of statins.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13106774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal assessment of arterial stiffness using photoplethysmography and laser Doppler flowmetry. 利用光容积脉搏图和激光多普勒血流仪评估动脉僵硬度。

npj Cardiovascular Health Pub Date : 2026-04-09 DOI: 10.1038/s44325-026-00115-8

Parmis Karimpour, Redjan Ferizoli, James M May, Panicos A Kyriacou

{"title":"Multimodal assessment of arterial stiffness using photoplethysmography and laser Doppler flowmetry.","authors":"Parmis Karimpour, Redjan Ferizoli, James M May, Panicos A Kyriacou","doi":"10.1038/s44325-026-00115-8","DOIUrl":"10.1038/s44325-026-00115-8","url":null,"abstract":"Age-related deterioration of vascular elasticity contributes to cardiovascular disease (CVD), the leading cause of death worldwide, making early detection in primary care essential. This study investigated the feasibility of photoplethysmography (PPG) and laser Doppler flowmetry (LDF) in an in vitro vascular system, examining independent and combined use. Custom femoral vessel-tissue phantoms replicated healthy (0.82 MPa), intermediate (1.48 MPa) and unhealthy (2.06 MPa) arterial stiffness. Two blood-mimicking fluids (BMFs) with scattering agents (intralipid and LPFS) evaluated modality performance. Extracted features included area, slope ratio and datum-based PPG metrics, plus LDF DC mean flux, statistically analysed using the Kruskal-Wallis test. The intralipid-based BMF produced larger reductions in LDF DC flux. Multiclass classification improved prediction when combining signals, yielding 100% holdout accuracy for red and infra-red (IR) PPG and 95.24% for green PPG with intralipid. These findings demonstrate technical feasibility for stiffness discrimination and motivate in vivo validation against clinical markers.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scoping review of preclinical and clinical studies on the role of HMGB1 in heart disease. HMGB1在心脏病中的作用的临床前和临床研究的范围综述。

npj Cardiovascular Health Pub Date : 2026-04-09 DOI: 10.1038/s44325-026-00119-4

Shih-Hsuan Mao, Roger Guan-Jie Luo, Carl Lee, Jia-Ling Ruan, Lynn Williams, Alvaro Viñals Guitart, Kat Steiner, James K K Chan, Juan Enrique Berner, Andrew J M Lewis, Paul R Riley, Jagdeep Nanchahal

{"title":"Scoping review of preclinical and clinical studies on the role of HMGB1 in heart disease.","authors":"Shih-Hsuan Mao, Roger Guan-Jie Luo, Carl Lee, Jia-Ling Ruan, Lynn Williams, Alvaro Viñals Guitart, Kat Steiner, James K K Chan, Juan Enrique Berner, Andrew J M Lewis, Paul R Riley, Jagdeep Nanchahal","doi":"10.1038/s44325-026-00119-4","DOIUrl":"10.1038/s44325-026-00119-4","url":null,"abstract":"High Mobility Group Box 1 (HMGB1) is a critical regulator of cardiac injury and repair. However, there is conflicting evidence regarding whether HMGB1 is beneficial or deleterious. We evaluated and synthesised available evidence regarding the molecular functions as well as the clinical and therapeutic utility of HMGB1 in heart disease. We found that overall, the effects depend on the redox state and subcellular location, although most studies failed to identify these parameters clearly. Nuclear upregulation or exogenous administration of fully reduced HMGB1 was beneficial. The partially oxidised form of HMGB1 (dsHMGB1) in the cytoplasm depleted intranuclear HMGB1, and extracellular dsHMGB1 was proinflammatory. Clinically, elevated circulating HMGB1 levels correlate with disease severity and may be a useful prognostic biomarker. Future research should specify the subcellular location and redox state of HMGB1. The development of methods to identify the different redox isoforms would help uncover the therapeutic potential of this multifaceted protein.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enabling ankle-brachial index prediction from doppler sounds using deep learning. 利用深度学习从多普勒声音中预测踝臂指数。

npj Cardiovascular Health Pub Date : 2026-04-09 DOI: 10.1038/s44325-026-00116-7

Adrit Rao, Kevin Battenfield, Arash Fereydooni, Akshay Chaudhari, Oliver Aalami

{"title":"Enabling ankle-brachial index prediction from doppler sounds using deep learning.","authors":"Adrit Rao, Kevin Battenfield, Arash Fereydooni, Akshay Chaudhari, Oliver Aalami","doi":"10.1038/s44325-026-00116-7","DOIUrl":"10.1038/s44325-026-00116-7","url":null,"abstract":"The ability to perform accurate point-of-care assessment of limb perfusion is critical for safe clinical decision-making. A formal ankle-brachial index (ABI) is typically required prior to supervised exercise therapy (SET) for peripheral arterial disease (PAD) or compression therapy for venous stasis ulcers. However, ABI measurements cannot be reported in patients with calcified, non-compressible tibial vessels. In this study, we introduce AutoABI, a deep learning algorithm that classifies ABI categories directly from circulatory Doppler sounds to improve the accessibility of point-of-care ABI assessment. AutoABI was trained and tested on a limited size dataset of 791 recordings from 198 patients and predicts ABI categories of <0.5, 0.5-0.7, 0.7-0.9, and >0.9. The algorithm achieved strong discriminatory performance with average areas under the receiver operating characteristic curve (AUCs) of 0.95, 0.96, 0.94, and 0.97 for the respective ABI ranges. Additional testing demonstrated the ability to predict ABI categories in patients with non-compressible arteries, offering a promising solution for more accessible and reliable PAD assessments.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A view-flexible deep learning framework for automated analysis of 2D echocardiography. 用于二维超声心动图自动分析的视图灵活的深度学习框架。

npj Cardiovascular Health Pub Date : 2026-04-01 DOI: 10.1038/s44325-025-00100-7

D M Anisuzzaman, Jeffrey G Malins, John I Jackson, Eunjung Lee, Jwan A Naser, Behrouz Rostami, Jared G Bird, Dan Spiegelstein, Talia Amar, Christie C Ngo, Jae K Oh, Patricia A Pellikka, Jeremy J Thaden, Francisco Lopez-Jimenez, Timothy J Poterucha, Paul A Friedman, Sorin V Pislaru, Garvan C Kane, Zachi I Attia

{"title":"A view-flexible deep learning framework for automated analysis of 2D echocardiography.","authors":"D M Anisuzzaman, Jeffrey G Malins, John I Jackson, Eunjung Lee, Jwan A Naser, Behrouz Rostami, Jared G Bird, Dan Spiegelstein, Talia Amar, Christie C Ngo, Jae K Oh, Patricia A Pellikka, Jeremy J Thaden, Francisco Lopez-Jimenez, Timothy J Poterucha, Paul A Friedman, Sorin V Pislaru, Garvan C Kane, Zachi I Attia","doi":"10.1038/s44325-025-00100-7","DOIUrl":"10.1038/s44325-025-00100-7","url":null,"abstract":"Echocardiography traditionally requires experienced operators to select and interpret clips from specific viewing angles. Clinical decision-making is therefore limited for handheld cardiac ultrasound (HCU), which is often collected by novice users. In this study, we developed a view-flexible deep learning framework to estimate left ventricular ejection fraction (LVEF), patient age, and patient sex from any of several views containing the left ventricle. Model performance was: (1) consistently strong across retrospective transthoracic echocardiography (TTE) datasets; (2) comparable between prospective HCU versus TTE (625 patients; LVEF r2 0.80 vs. 0.86, LVEF [> or ≤40%] AUC 0.981 vs. 0.993, age r2 0.85 vs. 0.87, sex classification AUC 0.985 vs. 0.996); (3) comparable between prospective HCU data collected by experts versus novice users (100 patients; LVEF r2 0.77 vs. 0.64, LVEF AUC 0.983 vs. 0.968). This approach may broaden the clinical utility of echocardiography by lessening the need for user expertise in image acquisition. Created in BioRender. Malins, J. (2026) https://BioRender.com/lhw4pb1 .","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular health in pregnancy according to Life's Essential 8 score. 根据生命基本8分，怀孕期间的心血管健康状况。

npj Cardiovascular Health Pub Date : 2026-04-01 DOI: 10.1038/s44325-026-00117-6

Krishin Yerabolu, Harshvir S Bal, Abdulla Shahid, Nehal Vekariya, Naman S Shetty, Mokshad Gaonkar, Nirav Patel, Peng Li, Pankaj Arora, Garima Arora

引用次数: 0

Berberine signature and cardiometabolic diseases using randomized controlled trial, cohort study and Mendelian randomization. 小檗碱特征与心脏代谢疾病的随机对照试验、队列研究和孟德尔随机化。

npj Cardiovascular Health Pub Date : 2026-03-25 DOI: 10.1038/s44325-026-00113-w

Jie V Zhao, Vishal Sarsani, Bing Chen, Huan Yun, Jie Hu, Liming Liang

{"title":"Berberine signature and cardiometabolic diseases using randomized controlled trial, cohort study and Mendelian randomization.","authors":"Jie V Zhao, Vishal Sarsani, Bing Chen, Huan Yun, Jie Hu, Liming Liang","doi":"10.1038/s44325-026-00113-w","DOIUrl":"10.1038/s44325-026-00113-w","url":null,"abstract":"Berberine lowers both lipids and glucose, yet its role on cardiometabolic disease risk remain unclear. Based on a randomized controlled trial of berberine (registered in ClinicalTrials.gov on Dec 2018, NCT03770325), leveraging proteomics and sex hormones data, we built a signature reflecting response to berberine using elastic net regression. We then assessed its associations with ischemic heart disease (IHD) and diabetes in UK Biobank using logistic regression and for causal relationship, using bi-directional Mendelian randomization (MR), and estimates of each protein/hormone. The signature was related to lower IHD and diabetes risks (OR for IHD 0.85, 95% CI 0.79-0.91; diabetes 0.88, 0.80-0.96 using MR). SHBG and PRSS2 might explain the beneficial association with IHD; testosterone, SHBG, CCL5, CNDP1, F11, LCN2, and THBS4 might explain the association with diabetes, which provides insights for drug development. Our study suggests beneficial associations of berberine with IHD and diabetes, which requires confirmation in large clinical trials.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13018313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0