{"title":"房颤的遗传和分子基础","authors":"Mason E. Sweat, WIlliam T. Pu","doi":"10.1038/s44325-024-00035-5","DOIUrl":null,"url":null,"abstract":"Atrial fibrillation (AF) increases stroke and heart failure risks. This review examines genetic and molecular mechanisms underlying AF. We review genes linked to AF and mechanisms by which they alter AF risk. We highlight gene expression differences between atrial and ventricular cardiomyocytes, regulatory mechanisms responsible for these differences, and their contribution to AF. Understanding AF mechanisms through the lens of atrial gene regulation is crucial for developing targeted AF therapies.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":" ","pages":"1-17"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44325-024-00035-5.pdf","citationCount":"0","resultStr":"{\"title\":\"Genetic and molecular underpinnings of atrial fibrillation\",\"authors\":\"Mason E. Sweat, WIlliam T. Pu\",\"doi\":\"10.1038/s44325-024-00035-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Atrial fibrillation (AF) increases stroke and heart failure risks. This review examines genetic and molecular mechanisms underlying AF. We review genes linked to AF and mechanisms by which they alter AF risk. We highlight gene expression differences between atrial and ventricular cardiomyocytes, regulatory mechanisms responsible for these differences, and their contribution to AF. Understanding AF mechanisms through the lens of atrial gene regulation is crucial for developing targeted AF therapies.\",\"PeriodicalId\":501706,\"journal\":{\"name\":\"npj Cardiovascular Health\",\"volume\":\" \",\"pages\":\"1-17\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-12-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.nature.com/articles/s44325-024-00035-5.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"npj Cardiovascular Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44325-024-00035-5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"npj Cardiovascular Health","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44325-024-00035-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Genetic and molecular underpinnings of atrial fibrillation
Atrial fibrillation (AF) increases stroke and heart failure risks. This review examines genetic and molecular mechanisms underlying AF. We review genes linked to AF and mechanisms by which they alter AF risk. We highlight gene expression differences between atrial and ventricular cardiomyocytes, regulatory mechanisms responsible for these differences, and their contribution to AF. Understanding AF mechanisms through the lens of atrial gene regulation is crucial for developing targeted AF therapies.
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