Mechanisms and implications of vascular-homing CD8 T cells in atherosclerosis.

Abstract

CD8 T cells likely contribute to atherosclerosis. Here, we review the relationship of vascular-homing CD8 T cells to atherosclerotic cardiovascular disease, with discussions of atherogenic and atheroprotective CD8 T cell subsets, encompassing their origin, activation, antigen-specificity, trafficking, and functionality. Furthermore, we explore factors that promote CD8 T cell vascular-homing phenotypes, such as infections and inflammation, and describe innovative therapeutic strategies targeting vascular-homing CD8 T cells in people with atherosclerosis.