npj Cardiovascular Health最新文献_第2页

Assessing the feasibility of using smartphone data to identify risk of idiopathic pulmonary arterial hypertension. 评估使用智能手机数据识别特发性肺动脉高压风险的可行性。

npj Cardiovascular Health Pub Date : 2026-03-25 DOI: 10.1038/s44325-026-00114-9

Juan A Delgado-SanMartin, Merve Keles, Niamh Errington, Narayan Schuetz, Anders Johnson, Varsha Gupta, Steve Hershman, Mark Toshner, Martin R Wilkins, David G Kiely, Roger Thompson, Euan Ashley, Dennis Wang, Allan Lawrie

{"title":"Assessing the feasibility of using smartphone data to identify risk of idiopathic pulmonary arterial hypertension.","authors":"Juan A Delgado-SanMartin, Merve Keles, Niamh Errington, Narayan Schuetz, Anders Johnson, Varsha Gupta, Steve Hershman, Mark Toshner, Martin R Wilkins, David G Kiely, Roger Thompson, Euan Ashley, Dennis Wang, Allan Lawrie","doi":"10.1038/s44325-026-00114-9","DOIUrl":"10.1038/s44325-026-00114-9","url":null,"abstract":"Idiopathic pulmonary arterial hypertension (IPAH) is a progressive, life-limiting condition often diagnosed late due to non-specific symptoms and requirement of invasive right heart catheterisation. This pilot study explores the feasibility of using real-world physical activity data from wearable devices and a smartphone app (My Heart Counts) to aid earlier detection. We analysed up to eight years of retrospective data from 109 UK participants, including patients with IPAH, disease controls, and healthy individuals. A classifier trained on pre-diagnostic activity and heart rate, distinguished individuals with IPAH from healthy and disease controls with an ROC AUC of 0.87, improving to 0.94 with in-app questionnaire input. Validation in a matched US cohort yielded an ROC AUC of 0.74. Wearable-derived metrics correlated with clinical 6MWD supporting their potential to complement traditional risk assessment. These pilot findings suggest that digital health tools may support earlier detection and remote monitoring of IPAH warranting larger scale studies.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13018193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short- and long-term outcomes of systemic semilunar valve replacement in neonates and infants. 新生儿和婴儿全身性半月瓣置换术的短期和长期疗效。

npj Cardiovascular Health Pub Date : 2026-03-23 DOI: 10.1038/s44325-026-00109-6

Abdelrahman Masri, Caroline Yunhua Shi, Brent Winemiller, Haya Alsarrawi, Lazaros K Kochilas, Brian Reemtsen, Amna Qasim, Taufiek Konrad Rajab

{"title":"Short- and long-term outcomes of systemic semilunar valve replacement in neonates and infants.","authors":"Abdelrahman Masri, Caroline Yunhua Shi, Brent Winemiller, Haya Alsarrawi, Lazaros K Kochilas, Brian Reemtsen, Amna Qasim, Taufiek Konrad Rajab","doi":"10.1038/s44325-026-00109-6","DOIUrl":"10.1038/s44325-026-00109-6","url":null,"abstract":"Systemic semilunar valve replacement in neonates and infants is rare and usually a last resort. We analyzed Pediatric Cardiac Care Consortium data for patients undergoing Ross, aortic valve replacement (AVR), or truncal valve replacement (TVR) from 1982-2011 across 35 centers, with mortality tracked via the US National Death Index through 2022. Among 167 patients, in-hospital mortality was 23% for Ross, 49% for AVR, and 52% for TVR. Twenty-five-year survival was 59%, 29%, and 41%, respectively. Neonatal age (vs. infant) was associated with increased in-hospital and long-term mortality (OR 2.5, 3.9, respectively), while higher surgical weight was protective (OR 0.67, 0.61 per kg, respectively). The earlier surgical era was associated with higher in-hospital mortality (OR 3.4). AVR had over threefold in-hospital and long-term mortality (OR 3.2, 3.4, respectively). These results highlight the historically high risk of systemic semilunar valve replacement in this population and the need for innovative surgical approaches.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A scoping review exploring women's experiences of cardiometabolic pregnancy complications and future cardiovascular health implications. 一项范围审查，探讨妇女的心脏代谢妊娠并发症的经验和未来的心血管健康的影响。

npj Cardiovascular Health Pub Date : 2026-03-23 DOI: 10.1038/s44325-026-00107-8

Wentong Xu, Monique Wisnewski, Caroline Kindsvater, Helena Teede, Lisa J Moran, Sarah Lang

{"title":"A scoping review exploring women's experiences of cardiometabolic pregnancy complications and future cardiovascular health implications.","authors":"Wentong Xu, Monique Wisnewski, Caroline Kindsvater, Helena Teede, Lisa J Moran, Sarah Lang","doi":"10.1038/s44325-026-00107-8","DOIUrl":"10.1038/s44325-026-00107-8","url":null,"abstract":"Women who develop cardiometabolic pregnancy complications including gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR) and preterm birth (PTB) are at increased risk of type 2 diabetes and cardiovascular disease. This scoping review explores the extent, range and nature of qualitative research investigating experiences of women at-risk of or diagnosed with cardiometabolic pregnancy complications. Original research (n = 623) and review (n = 66) articles with qualitative data from women, partners, healthcare professionals and community and professional stakeholders were included. Studies involving women with GDM (n = 342, 49.6%), HDP (n = 163, 23.7%) and FGR (n = 17, 2.5%) primarily explored lifestyle, medical or pharmacotherapy interventions during pregnancy, whereas studies regarding PTB (n = 198, 28.7%) primarily explored psychosocial health postpartum. Risk of future diabetes or cardiovascular disease were prevalent concepts in GDM and HDP literature. Extensive qualitative research exists relating to maternal cardiometabolic health. Understanding women's experiences may guide cardiovascular disease prevention and screening initiatives.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and preclinical results of a transcatheter aortic valve implant with novel polymeric leaflets. 新型聚合物小叶经导管主动脉瓣植入物的研制及临床前结果。

npj Cardiovascular Health Pub Date : 2026-03-23 DOI: 10.1038/s44325-026-00112-x

J Ryan Stanfield, Garrett Johnson, Nelson Belais, Isaac George, Steven Yakubov

{"title":"Development and preclinical results of a transcatheter aortic valve implant with novel polymeric leaflets.","authors":"J Ryan Stanfield, Garrett Johnson, Nelson Belais, Isaac George, Steven Yakubov","doi":"10.1038/s44325-026-00112-x","DOIUrl":"10.1038/s44325-026-00112-x","url":null,"abstract":"Current transcatheter aortic valve implantation (TAVI) systems use glutaraldehyde-fixed tissue leaflets, which are prone to structural valve degeneration. Polymeric valves may improve durability, hemocompatibility, and manufacturability. We designed, produced, and evaluated a self-expanding nitinol-framed TAVI device with siloxane poly(urethane-urea) (SiPUU) leaflets and an electrospun SiPUU skirt. Bench testing included frame fatigue to 200 million cycles, hydrodynamics per ISO 5840-3, and flow visualization using particle image velocimetry. Biocompatibility was assessed per ISO 10993. Preclinical evaluation involved nine ovine implants with serial imaging and histology to 90 days. In vitro tests showed EOAs of 1.3-1.5 cm² and 1.7-2.1 cm² (21 and 24 mm annulus, respectively, simulating under expansion), regurgitant fraction <6%, and preserved coaptation. Six animals completed follow-up with stable hemodynamics, no hemolysis, no PVL at implant, and no calcification at explant. The SiPUU-based TAVI demonstrated favorable durability, hydrodynamics, and biocompatibility, supporting further testing and delivery refinement toward first-in-human evaluation. Clinical Trial: N/A.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision percutaneous coronary intervention. 精确经皮冠状动脉介入治疗。

npj Cardiovascular Health Pub Date : 2026-03-23 DOI: 10.1038/s44325-026-00111-y

Travis M Wilson, Uzair Munaf, Nafhat Shaikh, Affan Rizwan, Riyan Siddiqui, Hafeez Ul Hassan Virk, Mahboob Alam, Umair Khalid, Muzamil Khawaja, Tanawat Attachaipanich, Larisa H Cavallari, Tania Ahuja, Michael G Nanna, Samin K Sharma, Lloyd W Klein, Gary S Mintz, Chayakrit Krittanawong

引用次数: 0

Economic modeling of polygenic risk prediction of coronary artery disease in childhood. 儿童冠状动脉疾病多基因风险预测的经济模型。

npj Cardiovascular Health Pub Date : 2026-03-23 DOI: 10.1038/s44325-026-00110-z

Fouad Bitar, Rana Zareef, Hussain Ismaeel, Roukoz Abou-Karam, Mariam Arabi, Ziad Bulbul, Fadi F Bitar, Akl C Fahed

{"title":"Economic modeling of polygenic risk prediction of coronary artery disease in childhood.","authors":"Fouad Bitar, Rana Zareef, Hussain Ismaeel, Roukoz Abou-Karam, Mariam Arabi, Ziad Bulbul, Fadi F Bitar, Akl C Fahed","doi":"10.1038/s44325-026-00110-z","DOIUrl":"10.1038/s44325-026-00110-z","url":null,"abstract":"Risk factors and subclinical pathophysiology of coronary artery disease (CAD) begin in childhood, yet identifying candidates for primordial prevention remains challenging. Polygenic risk scores (PRS) provide a DNA-based risk marker from birth that can stratify children by lifetime CAD risk. We evaluated the potential clinical utility and cost-effectiveness of PRS-guided CAD prevention in children using health economic modeling. A Markov model compared PRS-guided prevention with standard prevention in a hypothetical group of 10,000 children. Children in the top 20% of PRS (n = 2000) were assumed to receive behavioral interventions. Assuming a 10-year CAD incidence of 12% during adulthood among those in the top 20% of the PRS distribution and a conservative 30% relative risk reduction with preventive intervention, PRS-guided prevention was projected to prevent 72 CAD events among 2000 high-risk children (3.6% absolute event reduction), yielding a return on investment of 3614%. PRS enables early, targeted prevention, improving outcomes, and lowering lifetime costs.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network meta-analysis to compare the efficacies of three surgical techniques in rheumatic mitral valve disease. 网络荟萃分析比较三种手术技术治疗风湿性二尖瓣疾病的疗效。

npj Cardiovascular Health Pub Date : 2026-02-20 DOI: 10.1038/s44325-026-00106-9

Chuang Liu, Song-Hao Jia, Mao-Zhou Wang, Ming-Xuan Zhang, Xiao-Long Wang, Hong-Jia Zhang, Wen-Jian Jiang

引用次数: 0

Development and validation of AI-Enhanced auscultation for valvular heart disease screening through a multi-centre study. 通过一项多中心研究开发和验证人工智能增强听诊用于瓣膜性心脏病筛查。

npj Cardiovascular Health Pub Date : 2026-02-10 eCollection Date: 2026-01-01 DOI: 10.1038/s44325-026-00103-y

Andrew McDonald, Mark Gales, Bushra S Rana, Matthew Shun-Shin, Benito F Lukban, Rita Adrego, Alexandros Papachristidis, Fatima Hajee, Len Shapiro, Joanna Wilson, Tony Prothero, Andrew Kennedy, Saul Myerson, Bernard Prendergast, Patrik Bachtiger, Mihir A Kelshiker, Nicholas Peters, Richard Steeds, Anurag Agarwal

{"title":"Development and validation of AI-Enhanced auscultation for valvular heart disease screening through a multi-centre study.","authors":"Andrew McDonald, Mark Gales, Bushra S Rana, Matthew Shun-Shin, Benito F Lukban, Rita Adrego, Alexandros Papachristidis, Fatima Hajee, Len Shapiro, Joanna Wilson, Tony Prothero, Andrew Kennedy, Saul Myerson, Bernard Prendergast, Patrik Bachtiger, Mihir A Kelshiker, Nicholas Peters, Richard Steeds, Anurag Agarwal","doi":"10.1038/s44325-026-00103-y","DOIUrl":"10.1038/s44325-026-00103-y","url":null,"abstract":"Valvular heart disease (VHD) is a growing public health concern, yet over half of cases remain undiagnosed due to late symptom onset, limited public awareness, and low sensitivity of traditional stethoscope-based screening. Current AI-enabled tools rely on murmur detection as a proxy for VHD but lack sensitivity for common subtypes like mitral regurgitation and are limited by small datasets. This study presents a novel neural network that directly predicts clinically significant VHD from stethoscope recordings, trained using echocardiographic targets rather than heart murmur labels. A diverse dataset of 1767 patients across UK primary care and hospital settings was developed, combining stethoscope recordings with echocardiographic labels. The trained recurrent neural network achieved an AUROC of 0.83, outperforming general practitioners and demonstrating exceptional sensitivity for severe aortic stenosis (98%) and severe mitral regurgitation (94%). This algorithm shows promise as a scalable, low-cost screening tool, enabling earlier diagnosis and timely referral for intervention. This research was registered with ClinicalTrials.gov (CAIS: NCT04445012 registered on 2020-06-21, DUO-EF: NCT04601415 registered on 2020-10-19).","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":"3 ","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12890582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146184030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can AI help with the hardest thing: pro health behavior change. 人工智能能帮助解决最难的问题吗：改变健康行为。

npj Cardiovascular Health Pub Date : 2026-02-02 DOI: 10.1038/s44325-025-00101-6

D Douglas Miller

引用次数: 0

A narrative review of impacts of apolipoproteins on atherosclerotic coronary plaques. 载脂蛋白对冠状动脉粥样硬化斑块影响的叙述性综述。

npj Cardiovascular Health Pub Date : 2026-02-02 DOI: 10.1038/s44325-026-00104-x

Tatsuya Fukase, Tomotaka Dohi

引用次数: 0