npj Cardiovascular Health最新文献_第4页

Strategies for chronic coronary disease: A brief guide for clinicians 慢性冠心病策略：临床医生简明指南

npj Cardiovascular Health Pub Date : 2024-06-04 DOI: 10.1038/s44325-024-00006-w

Chayakrit Krittanawong, Muzamil Khawaja, Hafeez Ul Hassan Virk, Johao Escobar, Umair Khalid, Yochai Birnbaum, Carl J. Lavie, Samin Sharma, Hani Jneid, Sunil Rao, Salim S. Virani

{"title":"Strategies for chronic coronary disease: A brief guide for clinicians","authors":"Chayakrit Krittanawong, Muzamil Khawaja, Hafeez Ul Hassan Virk, Johao Escobar, Umair Khalid, Yochai Birnbaum, Carl J. Lavie, Samin Sharma, Hani Jneid, Sunil Rao, Salim S. Virani","doi":"10.1038/s44325-024-00006-w","DOIUrl":"10.1038/s44325-024-00006-w","url":null,"abstract":"The 2023 Multisociety Guidelines for the Management of Patients with Chronic Coronary Disease (CCD) is a collaborative effort between the American Heart Association (AHA) and the American College of Cardiology (ACC) that provides recommendations on the management of this condition. Efficient management of CCD involves non-pharmaceutical interventions that promote healthier lifestyles, such as increasing physical activity, adopting a balanced diet, and addressing tobacco misuse. These changes are critical to improving cardiovascular outcomes for individuals with CCD. In addition to lifestyle modifications, pharmacological and revascularization treatments also play an essential role in managing CCD. These treatments target the complex mechanisms of the disease, optimize cardiac function, and decrease the risk of adverse events. The combination of lifestyle changes and medicine-based medications enhances the quality of life and lowers mortality rates among individuals with CCD. This article review emphasizes the importance of non-pharmacological and pharmacological strategies that align with the AHA/ACC guidelines. In addition, the primary objective of this study is to enhance comprehension of the approaches that have led to better cardiovascular results for patients diagnosed with CCD.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":" ","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44325-024-00006-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141246222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota metabolism disturbance is associated with postoperative atrial fibrillation after coronary artery bypass grafting 肠道微生物群代谢紊乱与冠状动脉旁路移植术后心房颤动有关

npj Cardiovascular Health Pub Date : 2024-06-03 DOI: 10.1038/s44325-024-00003-z

Yuhua Liu, Zhiyong Du, Yingyuan Lu, Ying Ma, Yunxiao Yang, Florian Osmanaj, Yifan Zhang, Xiaoyu Guo, Yanwen Qin, Xiubin Yang, Kun Hua

{"title":"Gut microbiota metabolism disturbance is associated with postoperative atrial fibrillation after coronary artery bypass grafting","authors":"Yuhua Liu, Zhiyong Du, Yingyuan Lu, Ying Ma, Yunxiao Yang, Florian Osmanaj, Yifan Zhang, Xiaoyu Guo, Yanwen Qin, Xiubin Yang, Kun Hua","doi":"10.1038/s44325-024-00003-z","DOIUrl":"10.1038/s44325-024-00003-z","url":null,"abstract":"Postoperative atrial fibrillation (POAF) is a common complication after coronary artery bypass grafting (CABG) surgery. Gut microbiota and its metabolites have been implicated in the development of AF. However, whether the gut–host metabolic interaction contributes to POAF is still unknown. This study aimed to investigate the POAF-associated gut microbiota metabolism biomarkers and related risk model. The POAF (N = 30) patients and non-POAF (N = 60) patients from the discovery cohort exhibited significantly different microbiome and metabolome profiles. The differentiated features were mainly implicated in the bile acids (BAs) and short-chain fatty acids metabolism, inflammation, and oxidative stress. Random forest analysis identified the combination of five secondary BAs showed a powerful performance on predicting POAF in the discovery cohort, highlighting significant values of area under the curve (AUC = 0.954) and correct classification rate (CCR, 93.3%). In addition, the five secondary BAs-based risk model also exhibited good performance in differentiating the POAF (N = 114) and non-POAF individuals (N = 253) in an independent validation cohort (AUC = 0.872; CCR = 90.4%). This work revealed perturbed microbial and metabolic traits in POAF, providing potential avenues for the prediction and prevention of POAF after CABG.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44325-024-00003-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141246181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous coronary artery dissection: a clinically oriented narrative review 自发性冠状动脉夹层：以临床为导向的叙述性综述

npj Cardiovascular Health Pub Date : 2024-05-10 DOI: 10.1038/s44325-024-00004-y

Quan Dang, Sonya Burgess, Peter J. Psaltis, Sarah Fairley, Jacqueline Saw, Sarah Zaman

引用次数: 0

Different cardiovascular risks associated with elevated creatinine-based eGFR and cystatin C-based eGFR 基于肌酐的 eGFR 和基于胱抑素 C 的 eGFR 升高会带来不同的心血管风险

npj Cardiovascular Health Pub Date : 2024-05-02 DOI: 10.1038/s44325-024-00005-x

Mengyi Liu, Ziliang Ye, Panpan He, Qimeng Wu, Sisi Yang, Yanjun Zhang, Chun Zhou, Yuanyuan Zhang, Fan Fan Hou, Xianhui Qin

{"title":"Different cardiovascular risks associated with elevated creatinine-based eGFR and cystatin C-based eGFR","authors":"Mengyi Liu, Ziliang Ye, Panpan He, Qimeng Wu, Sisi Yang, Yanjun Zhang, Chun Zhou, Yuanyuan Zhang, Fan Fan Hou, Xianhui Qin","doi":"10.1038/s44325-024-00005-x","DOIUrl":"10.1038/s44325-024-00005-x","url":null,"abstract":"To compare the association of elevated estimated glomerular filtration rate (eGFR) based on creatinine (eGFRcr) and cystatin C (eGFRcys) with the risk of cardiovascular diseases (CVD) and chronic kidney diseases (CKD). 372,060 participants free of CVD and CKD in the UK Biobank were included. Participants were categorized into low, normal and high eGFR groups according to the age- and sex-specific 5th and 95th percentiles of eGFR. The primary outcome was incident CVD, defined as a combination of ischemic heart disease, stroke, heart failure, and atrial fibrillation. Thresholds for high eGFR varied with age and sex, ranging from 96.5 to 116.0 mL/min/1.73 m2 and 100.3 to 120.1 mL/min/1.73 m2 for eGFRcr and eGFRcys, respectively. During a median follow-up of 12.4 years, 39,855 (10.7%) participants developed CVD. Compared with normal eGFR levels, high eGFRcr levels were associated with a higher risk of CVD (HR, 1.19; 95% CI: 1.14–1.25), while high eGFRcys levels were associated with a lower risk of CVD (HR, 0.90; 95% CI: 0.85–0.95). Compared to normal eGFR levels, both high eGFRcr and high eGFRcys levels were related to a lower risk of CKD. Elevated eGFRcr levels were associated with a higher risk of CVD, and elevated eGFRcys levels were associated with a lower risk of CVD.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":" ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44325-024-00005-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140819054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of prematurity on lifelong cardiovascular health: structural and functional considerations 早产对终生心血管健康的影响：结构和功能方面的考虑因素

npj Cardiovascular Health Pub Date : 2024-04-05 DOI: 10.1038/s44325-024-00002-0

Ryan P. Sixtus, Rebecca M. Dyson, Clint L. Gray

{"title":"Impact of prematurity on lifelong cardiovascular health: structural and functional considerations","authors":"Ryan P. Sixtus, Rebecca M. Dyson, Clint L. Gray","doi":"10.1038/s44325-024-00002-0","DOIUrl":"10.1038/s44325-024-00002-0","url":null,"abstract":"The aetiology of preterm cardiovascular disease formation appears different from that of traditional population. Within the ‘traditional’ population cardiovascular disease formation is driven by functional stressors (e.g., diet, smoking). Whereas preterm cardiovascular disease risk is driven by structural changes incurred at birth. Much of the proliferative growth in the developing heart and major vessels ceases at birth, leading to permanently reduced dimensions compared to their term-born cohort. These structural changes take a back seat to functional and clinical complications within the neonatal period, but become increasingly pronounced from adolescence, at which point functional decompensation can be observed. While the cause may differ from ‘traditional’ populations, the eventual disease outcomes do not, leading them to be an overlooked population. This means that aetiology, and thus, treatment options may be very different due to the underlying mechanisms. Here, we propose that the structural cause of preterm-associated cardiovascular disease is apparent and observable early in life. Understanding the differences in cardiovascular disease aetiology may therefore aid in the early treatment of preterm-associated cardiovascular disease risk.","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44325-024-00002-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140348862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between brachial-ankle pulse wave velocity and the risk of new-onset atrial fibrillation: A report from Kailuan prospective cohort study 肱踝关节脉搏波速度与新发心房颤动风险之间的关系：开滦前瞻性队列研究报告

npj Cardiovascular Health Pub Date : 2024-03-06 DOI: 10.1038/s44325-023-00001-7

Wenhua Song, Zongshuang Song, Nan Zhang, Meijuan Zhang, Gary Tse, Oscar Hou In Chou, Guangping Li, Gan-Xin Yan, Gregory Y. H. Lip, Shouling Wu, Tong Liu

{"title":"Association between brachial-ankle pulse wave velocity and the risk of new-onset atrial fibrillation: A report from Kailuan prospective cohort study","authors":"Wenhua Song, Zongshuang Song, Nan Zhang, Meijuan Zhang, Gary Tse, Oscar Hou In Chou, Guangping Li, Gan-Xin Yan, Gregory Y. H. Lip, Shouling Wu, Tong Liu","doi":"10.1038/s44325-023-00001-7","DOIUrl":"10.1038/s44325-023-00001-7","url":null,"abstract":"One marker of arterial stiffness (AS) is the brachial-ankle pulse wave velocity (baPWV). We aim to investigate the predictive value of baPWV with regard to new-onset atrial fibrillation (AF). All participants without AF from 2010 to 2020 in the Kailuan cohort were included. The primary endpoint was new-onset AF. Participants were categorized into three study groups based on baPWV, with a normal baPWV group as a reference. The predictive value of baPWV was analyzed as a continuous variable. Multivariable Cox proportional hazard regression models were used to investigate the association. A total of 49,872 subjects (mean age: 47.57 years old, 74.2% male) were included with a mean follow-up of 6.17 (3.95–8.46) years. The risk of AF increased as the baseline baPWV increased, whereby the adjusted hazard ratio (aHR) of the borderline AS group and the elevated AS group were 1.82 (95% confidence interval [CI]: 1.18–2.80) and 2.08 (95% CI: 1.31–3.30), respectively. When considered as a continuous variable, each 361 cm/s increase in baseline baPWV, increased the risk of AF by 21.7% (aHR: 1.22; 95% CI: 1.08–1.37). In the subgroup analysis of non-hypertensive patients, the risks of AF were significantly higher in the borderline AS group (aHR: 3.16, 95% CI: 1.74–5.74) and elevated AS group (aHR: 2.26, 95% CI: 1.02–5.05). For patients with elevated BMI, the risk of AF in the elevated AS group was significantly higher (aHR: 1.69, 95% CI: 1.00–2.83). Baseline baPWV was associated with new-onset AF after adjustments. (Trial registration site and registration number are, respectively, http://www.chictr.org.cn/index.aspx and ChiCTR-TNRC-11001489).","PeriodicalId":501706,"journal":{"name":"npj Cardiovascular Health","volume":" ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44325-023-00001-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140043204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0