Luis Roberto Sinott, Cledia Silveira Flores da Silva, Alice Kunzgen Scheer, Amanda Barbosa Atrib, Augusto Schneider, Carlos Castilho Barros
{"title":"Effects of Resistance Training Combined with a Ketogenic Diet: A Systematic Review and Meta-Analysis","authors":"Luis Roberto Sinott, Cledia Silveira Flores da Silva, Alice Kunzgen Scheer, Amanda Barbosa Atrib, Augusto Schneider, Carlos Castilho Barros","doi":"10.1101/2024.06.19.24308878","DOIUrl":"https://doi.org/10.1101/2024.06.19.24308878","url":null,"abstract":"Weight loss treatments require adherence to physical exercise and diet. Restrictive diets have been proposed for obesity treatment, including a ketogenic diet that are high in lipids, moderate in proteins, and low in carbohydrates. In recent years, there has been criticism of this diet because of the reduction in fat-free mass and, consequently, a reduction in basal energy expenditure, which is considered negative in obesity treatment. However, resistance training is known to promote skeletal muscle hypertrophy. The hypothesis for this review was: \"Resistance training is sufficient to maintain lean mass during diets that cause ketosis.\" Despite the slight reduction in lean mass identified in the meta-analysis, some authors reported no loss in physical performance. Others suggested that this difference in lean mass is associated with water loss in the participants, which aligns with a few studies that reported a final phase with carbohydrate reintroduction into the diet. Our results indicated physical exercise was an important tool for maintaining lean mass in individuals who consumed carbohydrate-restricted diets that cause ketosis.\u0000Keywords: high-fat diet; carbohydrate-restricted diet; body composition; physical activity; muscle hypertrophy.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141503153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multiple Physiological and Behavioural Parameters Identification for Dietary Monitoring Using Wearable Sensors: A Feasibility Study Protocol","authors":"Mayue Shi, Jiaying Zhou, Mingzhu Cai","doi":"10.1101/2024.06.19.24309180","DOIUrl":"https://doi.org/10.1101/2024.06.19.24309180","url":null,"abstract":"Introduction: Traditional dietary intake assessment is labour- and time-consuming and prone to inaccuracies and biases. Emerging wearable sensing technology may offer a promising solution. This protocol paper describes a pilot study investigating the use of a customised wearable multi-sensor wristband, which is specifically designed to monitor multiple physiological and behavioural responses related to eating and digestion events for dietary monitoring.\u0000Methods and Analysis: This feasibility study will recruit 10 healthy volunteers from healthy volunteer databases and public advertisements, with informed consent required prior to participation. Participants will attend two main study visits at a clinical research facility, consuming pre-defined high- and low-calorie meals in a randomised order. Wearable sensors will be worn throughout the eating episodes to track hand-to-mouth movements and physiological changes, including skin temperature (Tsk), heart rate (HR), and oxygen saturation (SpO<sub>2</sub>). These sensor readings will be validated against a traditional bedside monitor which also measures blood pressure. Blood samples will be collected via intravenous cannula to measure blood glucose, insulin, and hormone levels. Relationship between eating episodes (e.g., occurrence, duration, use of cutlery, high- vs. low-calorie) with hand movement patterns, as well as physiological and blood biochemical responses, will be analysed. The results will inform the feasibility of using measures from wearable multi-sensors as indicators of food and energy intake.\u0000Ethics and Dissemination: Ethical approval has been granted by London - Westminster Research Ethics Committee. REC reference: 23/PR/1379. Written informed consent will be obtained from all participants. Findings will be disseminated through peer-reviewed journals, conferences, and seminar presentations. Protocol V.5. protocol date: 16 January 2024.\u0000Trial Registration Number: NCT06398340.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141503182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the factors associated with prelacteal feeding in Papua New Guinea: a population-based cross-sectional study","authors":"McKenzie Maviso, Elias Namosha, Georgia Guldan","doi":"10.1101/2024.06.18.24309085","DOIUrl":"https://doi.org/10.1101/2024.06.18.24309085","url":null,"abstract":"<strong>Objective</strong>\u0000Prelacteal feeds disrupt early breastfeeding initiation and exclusive breastfeeding and increase the risk of childhood illnesses and under-five mortality. Despite its negative health outcomes, prelacteal feeding prevails in Papua New Guinea (PNG). This study aimed to investigate the factors associated with prelacteal feeding among women in PNG.\u0000<strong>Design and setting</strong>\u0000A population-based cross-sectional study based on Demographic and Health Survey data\u0000<strong>Setting</strong>\u0000Papua New Guinea\u0000<strong>Participants</strong>\u0000A total weighted sample of 4399 women was included in the study.\u0000<strong>Main outcome measures</strong>\u0000Prelacteal feeding, modeled using multivariable logistic regression.\u0000<strong>Results</strong>\u0000About 10% (95% CI: 9 to 11) of women provided prelacteal feeds to their infants in PNG. The most frequently reported prelacteal feed was plain water (71.7%), followed by grains (eg, noodles) (47.1%), dark green leafy vegetables (42.1%), and soup (39.7%). Women with no formal (AOR 1.4, 95% CI: 1.0 to 3.0) or primary education (AOR 1.5, 95% CI: 1.0 to 2.9), from the Islands region (AOR 2.3, 95% CI: 1.5 to 3.5), who had a cesarean section (AOR 4.1, 95% CI: 2.4 to 7.2), and who had given birth at home or in the village (AOR 3.7, 95% CI: 2.1 to 6.8) had higher odds of providing prelacteal feeds. No statistically significant association was found between immediate newborn skin-to-skin contact after birth and prelacteal feeding.\u0000<strong>Conclusion</strong>\u0000Our study underscores the role of sociodemographic and healthcare system factors in prelacteal feeding. Strengthening healthcare providers' capacity to increase mothers' awareness of optimal breastfeeding and promote more health facility births is warranted. Comprehensive breastfeeding education should also be promoted at antenatal clinics and during outreach healthcare activities.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141503180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Estimating The Effect Of Adhering To Canada’s Food Guide 2019 Recommendations On Health Outcomes In Older Adults: A Target Trial Emulation Protocol","authors":"Didier Brassard, Nancy Presse, Stéphanie Chevalier","doi":"10.1101/2024.05.29.24308054","DOIUrl":"https://doi.org/10.1101/2024.05.29.24308054","url":null,"abstract":"<strong>Background</strong> The Canada’s Food Guide 2019 (CFG) provides universal recommendations to individuals aged 2 years or older. The extent to which these recommendations are appropriate for older adults is unknown. Although ideal, conducting a large randomized controlled trial is unrealistic in the short term. An alternative is the target trial emulation framework for causal inference using observational data.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141194137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benjamin D. Horne, Jeffrey L. Anderson, Heidi T. May, Tami L. Bair, Viet T. Le, Leslie Iverson, Kirk U. Knowlton, Joseph B. Muhlestein
{"title":"Weight Loss-Independent Changes in Human Growth Hormone During Water-Only Fasting: A Secondary Evaluation of a Randomized Controlled Trial","authors":"Benjamin D. Horne, Jeffrey L. Anderson, Heidi T. May, Tami L. Bair, Viet T. Le, Leslie Iverson, Kirk U. Knowlton, Joseph B. Muhlestein","doi":"10.1101/2024.05.28.24308055","DOIUrl":"https://doi.org/10.1101/2024.05.28.24308055","url":null,"abstract":"<strong>Introduction</strong> Water-only fasting for one day or more may provide health benefits independent of weight loss. Human growth hormone (HGH) may play a key role in multiple fasting-triggered mechanisms. Whether HGH changes during fasting are independent of weight loss and how basal HGH and HGH change relate to other fasting-induced changes are unknown.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141194130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marina Padilha, Victor N. Keller, Paula Normando, Raquel M. Schincaglia, Nathalia C. Freitas-Costa, Samary S. R. Freire, Felipe M. Delpino, Inês R. R. de Castro, Elisa M. A. Lacerda, Dayana R. Farias, Zachary Kroezen, Meera Shanmuganathan, Philip Britz-Mckibbin, Gilberto Kac
{"title":"Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019)","authors":"Marina Padilha, Victor N. Keller, Paula Normando, Raquel M. Schincaglia, Nathalia C. Freitas-Costa, Samary S. R. Freire, Felipe M. Delpino, Inês R. R. de Castro, Elisa M. A. Lacerda, Dayana R. Farias, Zachary Kroezen, Meera Shanmuganathan, Philip Britz-Mckibbin, Gilberto Kac","doi":"10.1101/2024.05.09.24307119","DOIUrl":"https://doi.org/10.1101/2024.05.09.24307119","url":null,"abstract":"<strong>Background</strong> The role of circulating metabolites on child development is understudied. We investigated associations between children’s serum metabolome and early childhood development (ECD).","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140942391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Ludlow, T. Harrington, R. Davidson, J. Davidson, K. Aikins, G. O’Grady, I. Bissett
{"title":"Evaluating the Efficacy and Safety of Neonatal Chyme Reinfusion Therapy: A Feasibility Study using a Novel Medical Device","authors":"E. Ludlow, T. Harrington, R. Davidson, J. Davidson, K. Aikins, G. O’Grady, I. Bissett","doi":"10.1101/2024.05.08.24306960","DOIUrl":"https://doi.org/10.1101/2024.05.08.24306960","url":null,"abstract":"<strong>Objectives</strong> Neonatal and pediatric intestinal failure related to enterostomy is an infrequent but burdensome condition associated with substantial morbidity and mortality. This study presents the development and clinical validation of a novel device to resolve these problems, by formalizing a safe and efficient enterostomy chyme reinfusion technique.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140925612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashley C. McCarthy, Ashleigh Angle, Sam Bliss, Farryl Bertmann, Emily H. Belarmino, Kelsey Rose, Meredith T. Niles
{"title":"Home and wild food procurement was associated with greater intake of fruits and vegetables during the COVID-19 pandemic in northern New England","authors":"Ashley C. McCarthy, Ashleigh Angle, Sam Bliss, Farryl Bertmann, Emily H. Belarmino, Kelsey Rose, Meredith T. Niles","doi":"10.1101/2024.05.02.24306758","DOIUrl":"https://doi.org/10.1101/2024.05.02.24306758","url":null,"abstract":"<strong>Objective</strong> This study examined the effect of home and wild food procurement (HWFP) activities (i.e., gardening, hunting, fishing, foraging, preserving food, raising livestock, and raising poultry for eggs) on food security status, fruit and vegetable intake, and meat consumption.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140886922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ishita Mostafa, Matthew C. Hibberd, Steven J. Hartman, Md Hasan Hafizur Rahman, Mustafa Mahfuz, S. M. Tafsir Hasan, Per Ashorn, Michael J. Barratt, Tahmeed Ahmed, Jeffrey I. Gordon
{"title":"A microbiota-directed complementary food intervention in 12-18-month-old Bangladeshi children improves linear growth","authors":"Ishita Mostafa, Matthew C. Hibberd, Steven J. Hartman, Md Hasan Hafizur Rahman, Mustafa Mahfuz, S. M. Tafsir Hasan, Per Ashorn, Michael J. Barratt, Tahmeed Ahmed, Jeffrey I. Gordon","doi":"10.1101/2024.04.29.24306564","DOIUrl":"https://doi.org/10.1101/2024.04.29.24306564","url":null,"abstract":"<strong>Background</strong> Globally, stunting affects ∼150 million children under five, while wasting affects nearly 50 million. Current interventions have had limited effectiveness in ameliorating long-term sequelae of undernutrition including stunting, cognitive deficits and immune dysfunction. Disrupted development of the gut microbiota has been linked to the pathogenesis of undernutrition, providing potentially new treatment approaches.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140886838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Domingos L. S. Rios, Márcia C. A. M. Oliveira, Sérgio Q. Braga, Matheus J. Chamorro, Beatriz L. B. Cunha, Ana C. R. Reis, Ana P. Guimarães, Ana D. N. Silva, Dandara A. R. Silva, Edilene M. Q. Araújo, Magno M. W. Pimentel
{"title":"Inpatient treatment for severe obesity: a retrospective cohort study in Brazil","authors":"Domingos L. S. Rios, Márcia C. A. M. Oliveira, Sérgio Q. Braga, Matheus J. Chamorro, Beatriz L. B. Cunha, Ana C. R. Reis, Ana P. Guimarães, Ana D. N. Silva, Dandara A. R. Silva, Edilene M. Q. Araújo, Magno M. W. Pimentel","doi":"10.1101/2024.04.28.24306514","DOIUrl":"https://doi.org/10.1101/2024.04.28.24306514","url":null,"abstract":"<strong>Introduction</strong> Very low-calorie diets with hospitalization have demonstrated promise as a viable therapeutic option for severe obesity and its associated comorbidities. However, large studies providing a comprehensive longitudinal observation of patients undergoing this therapy are lacking. We evaluated the effectiveness of treating severe obesity in hospitalized patients, using very low-calorie diets and clinical support to develop lifestyle changes.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140833307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}