A microbiota-directed complementary food intervention in 12-18-month-old Bangladeshi children improves linear growth

Ishita Mostafa, Matthew C. Hibberd, Steven J. Hartman, Md Hasan Hafizur Rahman, Mustafa Mahfuz, S. M. Tafsir Hasan, Per Ashorn, Michael J. Barratt, Tahmeed Ahmed, Jeffrey I. Gordon
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Abstract

Background Globally, stunting affects ∼150 million children under five, while wasting affects nearly 50 million. Current interventions have had limited effectiveness in ameliorating long-term sequelae of undernutrition including stunting, cognitive deficits and immune dysfunction. Disrupted development of the gut microbiota has been linked to the pathogenesis of undernutrition, providing potentially new treatment approaches.
对 12-18 个月大的孟加拉国儿童进行微生物指导的辅食干预可改善线性生长
背景 全球有 1.5 亿五岁以下儿童发育迟缓,近 5000 万儿童消瘦。目前的干预措施在改善营养不良的长期后遗症(包括发育迟缓、认知缺陷和免疫功能障碍)方面效果有限。肠道微生物群的发育紊乱与营养不良的发病机制有关,这可能提供新的治疗方法。
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