medRxiv - Nutrition最新文献

{"title":"Randomized dose–response trial of n–3 fatty acids in hormone receptor negative breast cancer survivors—impact on breast adipose oxylipin and DNA methylation patterns","authors":"David E Frankhouser, Todd DeWess, Isabel F Snodgrass, Rachel M Cole, Sarah Steck, Danielle Thomas, Chidimma Kalu, Martha A Belury, Steven K Clinton, John W Newman, Lisa D Yee","doi":"10.1101/2024.09.16.24313691","DOIUrl":"https://doi.org/10.1101/2024.09.16.24313691","url":null,"abstract":"Background: Increasing evidence suggests the unique susceptibility of estrogen receptor and progesterone receptor negative (ERPR-) breast cancer to dietary fat amount and type. Dietary n-3 polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), may modulate breast adipose fatty acid profiles and downstream bioactive metabolites to counteract pro-inflammatory, pro-carcinogenic signaling in the mammary microenvironment. Objective: To determine effects of ~1 to 5 g/d EPA+DHA over 12 months on breast adipose fatty acid and oxylipin profiles in women with ERPR(-) breast cancer, a high-risk molecular subtype.\u0000Methods: We conducted a 12-month randomized controlled, double-blind clinical trial of ~5g/d vs ~1g/d DHA+EPA supplementation in women within 5 years of completing standard therapy for ERPR(-) breast cancer Stages 0-III. Blood and breast adipose tissue specimens were collected every 3 months for biomarker analyses including fatty acids by gas chromatography, oxylipins by LC-MS/MS, and DNA methylation by reduced-representation bisulfite sequencing (RRBS).\u0000Results: A total of 51 participants completed the 12-month intervention. Study treatments were generally well-tolerated. While both doses increased n-3 PUFAs from baseline in breast adipose, erythrocytes, and plasma, the 5g/d supplement was more potent (n =51, p <0.001). The 5g/d dose also reduced plasma triglycerides from baseline (p =0.008). Breast adipose oxylipins at 0, 6, and 12 months showed dose-dependent increases in unesterified and esterified DHA and EPA metabolites (n =28). Distinct DNA methylation patterns in adipose tissue after 12 months were identified, with effects unique to the 5g/d dose group (n =17).\u0000Conclusions: Over the course of 1 year, EPA+DHA dose-dependently increased concentrations of these fatty acids and their derivative oxylipin metabolites, producing differential DNA methylation profiles of gene promoters involved in metabolism-related pathways critical to ERPR(-) breast cancer development and progression. These data provide evidence of both metabolic and epigenetic effects of n-3 PUFAs in breast adipose tissue, elucidating novel mechanisms of action for high-dose EPA+DHA-mediated prevention of ERPR(-) breast cancer.\u0000Clinicaltrials.gov identifier NCT02295059","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advertising ultra-processed foods around urban and rural schools in Kenya","authors":"Caroline Hiuko Karugu, Gershim Asiki, Milka Wanjohi, Veronica Ojiambo, Richard Sanya, Amos Laar, Michelle Holdsworth, Stefanie Vandevijvere, Charles Agyemang","doi":"10.1101/2024.09.10.24313437","DOIUrl":"https://doi.org/10.1101/2024.09.10.24313437","url":null,"abstract":"Background: Marketing of ultra-processed foods (UPFs) can influence purchase intentions and consumption of such foods, especially among children. There is limited evidence on the extent to which UPFs are marketed around schools in low- and middle-income countries (LMICs), including Kenya. We assessed the extent, content, and type of advertising of ultra-processed/unhealthy foods around schools in urban and rural settings in Kenya.\u0000Methods: This cross-sectional study assessed advertising of food and beverages within a 250m radius around schools in Kenya between June to July 2021. We conducted the study in three counties (Nairobi-urban, Mombasa-coastal urban city, and Baringo-rural). Each county was stratified into high and low socioeconomic status (SES) sub-counties. Within each, we randomly selected schools and collected detailed information on advertising around the schools. The information gathered included the location, type of food and beverage product advertised, and the promotional techniques used. We used the NOVA classification and International Network for Food and Obesity/NCDs Research Monitoring and Action Support (INFORMAS) methods to categorize the food and beverages advertised based on processing level and core (healthy)/non-core(unhealthy) groups. We determined the extent of advertisements using descriptive analysis frequencies, and median (interquartile ranges). Poisson regression was used to determine the factors associated with UPF advertisements.\u0000Results: In total, 2300 food and beverage advertisements were mapped around the 500 schools. There was a higher median number of advertisements in urban areas (median=25, Interquartile range (IQR)=25,160) compared to rural areas (median=10, IQR= 4, 13). Of these advertisements, approximately 48.0% were UPFs. The most common promotional strategy used was cartoon and company-owned characters, while the most frequent premium offer was price discounts. In the multivariate analysis, there was a significantly higher rate of advertisements of UPFs in Baringo County (prevalence rate ratios (PRR): 1.17, 95% CI: 1.01-1.36) compared to the urban Nairobi County, and in lower compared to higher SES settings (PRR: 1.10, 95% CI: 1.01-1.20).\u0000Conclusion: UPFs are frequently advertised around schools with promotional strategies that may be appealing to children. There is a need to restrict the marketing of unhealthy foods around schools to children in Kenya.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimated morbimortality and costs attributable to child and adolescent obesity in Brazil from 2024 to 2060: a multistate life table study","authors":"Eduardo Augusto Fernandes Nilson, Ana Carolina Rocha de Oliveira, Bruna Gusmao, Raphael Barreto da Conceicao Barbosa","doi":"10.1101/2024.08.29.24312725","DOIUrl":"https://doi.org/10.1101/2024.08.29.24312725","url":null,"abstract":"Introduction\u0000Childhood obesity is a major global public health issue globally and in Brazil. The impacts of childhood obesity include higher risk of disease during childhood and of obesity and non-communicable diseases in adulthood and represent an important epidemiological and economic burden to countries.\u0000Methods\u0000This study is based on the multistate life table modeling of different scenarios of change3s in the child and adolescent obesity on the estimated costs attributable to obesity and the epidemiological burden of obesity-related diseases.\u0000Results\u0000According to this study, if the current trends in childhood and adolescent obesity in Brazil continue, the prevalence will significantly increase across different age subgroups and for both sexes by 2060 and obesity among adults will nearly double, resulting in R$3.84 billion costs attributable to childhood and adolescent obesity to the Brazilian Unified Health System during this period. Alternatively, if obesity prevalence among children and adolescents is reduced and remains constant these direct costs could be reduced by R$1.05 to R$1.27 billion by 2060 and up to 244,600 incident cases and 70,800 deaths from obesity-related diseases could be prevented.\u0000Conclusion\u0000This study highlights that the costs of childhood obesity are not limited to the impacts on adult health and represent a relevant economic burden to the Brazilian National Health System and to families because of additional costs during childhood. Therefore, the prevention and control of childhood obesity is a public health priority that demands immediate and robust policies.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Qualitative Study on Food Taboos Among Rural Pregnant Women in Bangladesh: Motivators for Adherence and Influencers of Taboo-Breaking Behavior","authors":"Shahrin Emdad Rayna, Fahmida Afroz Khan, Sharraf Samin, Saiqa Siraj, Saika Nizam, Syed Shariful Islam, Md. Khalequzzaman","doi":"10.1101/2024.09.09.24313362","DOIUrl":"https://doi.org/10.1101/2024.09.09.24313362","url":null,"abstract":"Understanding the influence of cultural practices on maternal health is crucial in addressing the nutritional challenges faced by pregnant women in rural Bangladesh. Despite significant improvements in maternal and child health indicators, food taboos remain prevalent, impacting the nutritional well-being and health outcomes of vulnerable populations. This study explored food taboos and factors related to their adherence or violation, among rural pregnant women in four districts of Bangladesh: Habiganj, Bhola, Rajshahi, and Cumilla. A qualitative cross-sectional study was conducted with 90 participants through 29 in-depth interviews and 11 focus group discussions. Participants included 21 pregnant women, 23 mothers-in-law, 20 husbands, and 26 healthcare workers. The data were thematically coded and the narrative was analyzed. All participants identified at least one food item restricted by family elders, often based on beliefs about the negative effects of certain foods on pregnancy and the baby’s health. Commonly restricted animal source foods included white carp, trout, duck meat, and mutton, due to fears of convulsions, speech disorders, or undesirable traits in the baby. Raw papayas and pineapples were avoided due to beliefs they could cause miscarriage. Adherence to these taboos was related to the pregnant mother’s preference for vaginal delivery, desire to avoid harm to her child, and profound respect for her elders. Factors enabling the breaking of food taboos included nutritional counseling by health care workers, increased family understanding of maternal nutrition, reduced reinforcement of taboos, and the lack of negative consequences from consuming tabooed foods. The findings highlight the importance of utilizing scientific evidence to challenge food taboos by developing new strategies or updating community-based nutritional counseling programs. Furthermore, including family members and community elders in these efforts is crucial for creating a conducive environment that facilitates dietary changes for pregnant women.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142225716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating co-design into formative research for a SBCC entry-point platform for nutrition-sensitive social protection programs in low -and middle-income country settings.","authors":"Tahir Turk, Rina Paul, Nilofer Fatimi Safdar, Syed Mahbubul Alam, Sohel Reza Choudhury, Kashif Shafique, Zaeema Ahmer, Anthony J Wenndt, Hamidullah Khan Babar, Tannaza Sadaf, Moniruzzaman Bipul","doi":"10.1101/2024.09.08.24313037","DOIUrl":"https://doi.org/10.1101/2024.09.08.24313037","url":null,"abstract":"Background: Achieving adequate nutrition for vulnerable populations is an objective of the Sustainable Development Goals. Nutrition-sensitive social protection programs, including those that promote nutrition through Social and Behaviour Change Communication (SBCC), have the potential to reduce malnutrition and provide social supports to those most in need. Country-level needs assessments can clarify key issues. When supported by co-design approaches, program formative research may provide more culturally contextualised SBCC for the improved delivery of nutrition social protection to vulnerable groups. This formative study from Pakistan and Bangladesh, integrated co-design to more fully explore program beneficiary knowledge, attitudes and perceptions toward nutrition social protection to inform the design of SBCC key messages and an entry-point platform to ensure effective message dissemination. Methods: Qualitative formative research was conducted to support findings from a systematic review. Thirty semi-structured interviews with program stakeholders and 12 focus group discussions (134 participants) were conducted with program beneficiaries in Bangladesh and Pakistan. Co-design sessions supplemented the needs assessment protocol. A COREQ checklist ensured best practice approaches in research design, analysis and reporting. NVIVO 2023 qualitative software supported the thematic analysis. Results: Four organising themes were identified: 1. Barriers to Program Engagement, 2. Opportunities for Program Improvement, 3. Knowledge Attitudes and Practices, and 4. Target Groups, Messaging and SBCC Entry-Points, with 21 sub-themes emerging under the four organising themes. Main barriers related to resource constraints and maladministration of SPPs while opportunities identified greater integration of cash transfers with nutritious food provision, increased engagement with key influencers in vulnerable communities, and identification of culturally nuanced messages with dissemination through preferred channels. Integrating co-design sessions provided greater ownership, participation and engagement by program beneficiaries and more pragmatic SBCC solutions to challenges identified. Conclusion: The needs assessments and integrated co-design sessions highlighted the benefits of close consultation with program beneficiaries in the design of culturally appropriate SBCC interventions to support nutrition-sensitive social protection programs. A SBCC entry-point platform was developed from participant recommendations to provide options for programmers on message designs, advocacy approaches and dissemination channels with the approaches applicable for a number of low -and middle-income countries where malnutrition is a major challenge.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian meal timing is heritable and associated with insulin sensitivity","authors":"Janna Vahlhaus, Beeke Peters, Silke Hornemann, Anne-Cathrin Ost, Michael Kruse, Andreas Busjahn, Andreas F.H. Pfeiffer, Olga Pivovarova-Ramich","doi":"10.1101/2024.09.04.24312795","DOIUrl":"https://doi.org/10.1101/2024.09.04.24312795","url":null,"abstract":"Background: Although the contribution of the circadian clock to metabolic regulation is widely recognized, the role of meal timing in glucose metabolism and diabetes risk remains insufficiently studied. This study aimed (i) to investigate the link between individual circadian meal timing pattern and glucose homeostasis and (ii) to explore the contribution of genetic and environmental factors to meal timing parameters. Methods: In the German NUtriGenomic Analysis in Twins (NUGAT) cohort, which includes 92 adult twins, glucose metabolism parameters were assessed using fasting samples and the oral glucose tolerance test (OGTT). Parameters of meal timing pattern (meal timing itself, daily calorie distribution, and meal number) were extracted from five-day food records. Circadian eating timing was determined relative to the individual’s chronotype (MSFsc) assessed by the Munich chronotype questionnaire. The heritability of meal timing components was estimated using the ACE model. Results: Multiple meal timing components showed associations with glucose metabolism parameters. Most associations were found for the calorie midpoint defined as the time point at which 50% of daily calories were consumed. Indices of insulin sensitivity, ISI Stumvoll (β = 0.334, p = 2.9 x 10^-4) and HOMA-IR (β = -0.276, p = 0.007), as well as fasting insulin levels were significantly associated with the circadian caloric midpoint even after the model adjustment for gender, age, energy intake, and sleep duration. BMI and waist circumference also demonstrated robust associations with circadian caloric midpoint. High or moderate heritability was shown for all meal timing components. Meal timing pattern was also strongly related to individual sleep timing and chronotype, both of which also showed a marked genetic impact. Conclusion: Circadian meal timing is associated with insulin sensitivity and shows significant genetic influences, sharing a common genetic architecture with sleep behaviour. Shifting the main calorie intake to earlier circadian time might protect against diabetes, although this could be challenging due to the high heritability of meal timing components.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in hypothalamic subunits volume and their association with metabolic parameters and gastrointestinal appetite-regulating hormones following bariatric surgery","authors":"Amélie Lachance, Justine Daoust, Mélissa Pelletier, Alexandre Caron, André C. Carpentier, Laurent Biertho, Josefina Maranzano, André Tchernof, Mahsa Dadar, Andréanne Michaud","doi":"10.1101/2024.08.30.24312638","DOIUrl":"https://doi.org/10.1101/2024.08.30.24312638","url":null,"abstract":"<strong>Background</strong> Some nuclei of the hypothalamus are known for their important roles in maintaining energy homeostasis and regulating food intake. Moreover, obesity has been associated with hypothalamic inflammation and morphological alterations, as indicated by increased volume. However, the reversibility of these changes after bariatric surgery-induced weight loss remains underexplored.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammation during fasting and postprandial states: a comprehensive study of key determinants in a deeply characterized cohort of young adults","authors":"Parvaneh Ebrahimi, David Horner, David Burgner, Nicklas Brustad, Tingting Wang, Mina Ali, Liang Chen, Ann-Marie M Schoos, Klaus Bønnelykke, Jakob Stokholm, Evrim Acar, Nilo Vahman, Bo Chawes, Morten A. Rasmussen","doi":"10.1101/2024.08.30.24312659","DOIUrl":"https://doi.org/10.1101/2024.08.30.24312659","url":null,"abstract":"Systemic inflammation contributes to the pathogenesis of many noncommunicable diseases. Additionally, postprandial inflammation can exacerbate systemic inflammation. These emphasize the need to examine inflammation in both fasting and postprandial states, to identify modifiable factors to alleviate inflammation. This study investigated a comprehensive list of factors spanning from foetal stage to young-adulthood against inflammation levels at fasting (chronic inflammation) and postprandial states (meal-induced transient inflammation). A meal challenge was undertaken in 18-year-olds <em>(n</em> = 298), and inflammation was assessed using the robust GlycA biomarker. Associations between inflammation and various factors were observed, some of which were sex-specific; e.g. the associations of alcohol consumption and smoking with inflammation were significantly stronger in females. Moreover, novel associations from gestation and early life (e.g. pregnancy smoking) were identified. Our findings highlight factors that should inform dietary and lifestyle interventions for reducing systemic inflammation and highlight the importance of considering inflammation in precision nutrition practices.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimum Days Estimation for Reliable Dietary Intake Information: Findings from a Digital Cohort","authors":"Rohan Singh, Mathieu Théo Eric Verest, Marcel Salathé","doi":"10.1101/2024.08.29.24312779","DOIUrl":"https://doi.org/10.1101/2024.08.29.24312779","url":null,"abstract":"Accurate dietary assessment is crucial for understanding diet-health relationships, but variability in daily food intake poses challenges in capturing precise data. This study leveraged data from 958 participants of the “Food &amp; You“ digital cohort to determine the minimum number of days required for reliable dietary intake estimation. Participants tracked meals using the AI-assisted MyFoodRepo app, providing a comprehensive dataset of over 315,000 dishes across 23,335 participant days. We employed multiple analytical approaches, including Linear Mixed Models (LMM), Intraclass Correlation Coefficient (ICC), and Coefficient of Variation (CV) methods. LMM analysis revealed significant day-of-week effects, with increased energy, carbohydrate, and alcohol intake on weekends, particularly pronounced in younger individuals and those with higher BMI. ICC and CV analyses demonstrated that the required number of days varies considerably among nutrients and food groups. Water, coffee, and total food quantity by weight could be reliably estimated (ICC&gt;0.9) with just 1-2 days of data. Most macronutrients, including carbohydrates, protein, and fat, achieved good reliability (ICC&gt;0.75 or r=0.8) with 3-4 days of data. Micronutrients and some food groups like meat and vegetables typically required 4-5 days for highly reliable estimation. Optimal day combinations often included both weekdays and weekend days. Our findings largely align with and refine FAO recommendations, suggesting that 3-4 days, typically non-consecutive and including a weekend day, are generally sufficient for reliable estimation of energy and macronutrient intake. However, our results provide more nuanced, nutrient-specific guidelines that can inform the design of future nutritional studies.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catastrophic Hunger in Gaza: Unprecedented Levels of Hunger Post-October 7th. A Real Population-Based Study from the Gaza Strip","authors":"MoezAlIslam Faris, Ayman S. Abutair, Reham M. Elfarra, Nida. A. Barqawi, Amal M. Firwana, Rawan M. Firwana, Madleen M. AbuHajjaj, Shaimaa A. Shamaly, Samar S. AbuSamra, Hanan S. Bashir, Noor A. Abedalrahim, Noor A. Nofal, Mhran K. Alshawaf, Rania M. Al Shatali, Kafa I. Ghaben, Moayad I. Alron, Sara S. Alqeeq, Aya O. Al-Nabahin, Reem A. Badawi","doi":"10.1101/2024.08.21.24312386","DOIUrl":"https://doi.org/10.1101/2024.08.21.24312386","url":null,"abstract":"<strong>Background</strong> The Gaza Strip, spanning approximately 365 square kilometers, has been a focal point of geopolitical tensions and humanitarian crises. The military escalation on October 7^th exacerbated existing vulnerabilities, notably food security and hunger, with an estimated 85,750 deaths due to Israeli attacks, representing about 8% of the 2.34 million population. This research aims to inform policymakers and humanitarian organizations about strategies to mitigate hunger and improve food security in Gaza amidst this damaging war.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}