Journal of Pediatric Ophthalmology & Strabismus最新文献

{"title":"Surgical Treatment of Strabismus in Children With Developmental Delay: A Review of the Literature and Results of Personal Experience.","authors":"Aldo Vagge, Andrea Lembo, Paolo Nucci","doi":"10.3928/01913913-20241001-01","DOIUrl":"10.3928/01913913-20241001-01","url":null,"abstract":"<p><strong>Purpose: </strong>To review the current literature, to provide a foundation of knowledge on strabismus surgery in patients with developmental delay, and to present results from the authors' personal experience.</p><p><strong>Methods: </strong>The following terms were searched on PubMed: strabismus surgery, mental delay, developmental delay, Down syndrome, Angelman syndrome, cerebral palsy, hydrocephalus, Williams syndrome, fragile X syndrome, and fetal alcohol syndrome. Surgical outcomes were analyzed and discussed; only English articles were included. Medical records of 183 patients with developmental delay who underwent strabismus correction surgery from 2001 to 2020 were examined and discussed.</p><p><strong>Results: </strong>Articles were reviewed and analyzed, categorized based on the disease. The authors' experience included 183 patients with various diseases or syndromes: 44 Down syndrome, 40 fetal alcohol syndrome, 36 Williams syndrome, 9 fragile X syndrome, 12 Angelman syndrome, 11 Cohen syndrome, and 31 cerebral palsy. Surgical results at 3 and 18 months of follow-up were analyzed. Regarding esotropia surgery, 83.9% had a deviation of less than 8 prism diopters at 3 months and 53.8% at 18 months of follow-up. Hypocorrection was seen in 7.7% and 3.5% and hypercorrection was observed in 8.4% and 52.7% at 3 and 18 months, respectively. For exotropia, 60% had a deviation of less than 8 prism diopters at 3 months and 22.5% at 18 months. Hypocorrection occurred in 35% and 75%, whereas hypercorrection was found in 5% and 2.5%, respectively.</p><p><strong>Conclusions: </strong>A higher prevalence of strabismus was found in these patients and the surgical outcomes were more difficult to predict. Patients with esotropia were more hypercorrected, whereas those with exotropia were more hyporcorrected. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2025;62(2):96-104.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"96-104"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability in the Evaluation and Treatment of Healthy Neonates With Uncomplicated Conjunctivitis.","authors":"Camden Nelson, Bailee J Deshler, Brittany Bernstein, Stephen Aronoff","doi":"10.3928/01913913-20241121-04","DOIUrl":"10.3928/01913913-20241121-04","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the current state of diagnosis and management of neonatal conjunctivitis.</p><p><strong>Methods: </strong>Cosmos, an EHR-based, de-identified data set including more than 200 million patients, was used for this study. Neonates born between January 1, 2016 and December 31, 2022, discharged from the hospital by day 3 of life, and with an ambulatory visit within the first 4 weeks of life associated with a new diagnosis of neonatal conjunctivitis (SNOMED) or conjunctivitis (ICD-10 H10.*) were included. Cosmos slicer/dicer software was used to extract demographic, diagnostic, etiologic, and therapeutic data.</p><p><strong>Results: </strong>A total of 1,870 of 7,325,276 (0.0255%) neonates with a hospital stay of 3 days or less met criteria for inclusion: 96.5% were from the United States, 16.2% were admitted to the hospital, and bacterial cultures were obtained from 21.3%. Congenital lacrimal duct stenosis was causative in 2.7% of patients. Important infectious agents included staphylococcal, streptococcal, or enterococcal species (2.5%), <i>Neisseria gonorrhoeae</i> (1.6%), and <i>Chlamydia trachomatis</i> (0.6%). No herpesviral or <i>Pseudomonas</i> infections were identified. Antimicrobial agents were prescribed to 93.7% of patients and given ophthalmically (79.5%), orally (11.4%), and parenterally (7.7%).</p><p><strong>Conclusions: </strong>The evaluation and management of neonatal conjunctivitis within United States ambulatory settings are highly variable. Diagnostic studies are underused, resulting in limited etiologic data and a lack of susceptibility-guided treatment. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2025;62(2):143-149.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"143-149"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Options for Intermittent Exotropia.","authors":"Darron Bacal, Alina Dumitrescu, Daniel Weaver, Rudolph S Wagner","doi":"10.3928/01913913-20241210-01","DOIUrl":"https://doi.org/10.3928/01913913-20241210-01","url":null,"abstract":"","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"62 2","pages":"81-83"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravitreal Methotrexate and CAR-T Therapy for Anterior Segment B-Cell Acute Lymphoblastic Leukemia Relapse.","authors":"Chathuranka De Silva, Alan Connor, Wing Roberts","doi":"10.3928/01913913-20250117-01","DOIUrl":"10.3928/01913913-20250117-01","url":null,"abstract":"<p><p>The authors present a child with a rare case of unilateral pseudo-hypopyon and raised intraocular pressure as the only manifestation of acute lymphoblastic leukemia recurrence. This was treated with intravitreal methotrexate and chimeric antigen receptor T-cell therapy (CAR-T) with subsequent remission. This case demonstrates intravitreal methotrexate is a safe and effective adjunct to use with CAR-T therapy for relapsing acute lymphoblastic leukemia with ocular involvement. Further research should be sought on both CAR-T therapy and intravitreal methotrexate for acute lymphoblastic leukemia with ocular involvement. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2025;62(2):e18-e21.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"62 2","pages":"e18-e21"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"YouTube as a Source of Knowledge for Childhood Glaucoma.","authors":"Mohamed M Khodeiry, Qais A Dihan, Taher K Eleiwa, Amr K Hassan, Mohamed A Hassan, Tom Kornhauser, Mohamed S Sayed, Abdelrahman M Elhusseiny","doi":"10.3928/01913913-20241105-04","DOIUrl":"10.3928/01913913-20241105-04","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the quality and reliability of patient-targeted videos about childhood glaucoma on the YouTube platform.</p><p><strong>Methods: </strong>On March 1, 2024, a search was performed on YouTube (www.youtube.com) using the keywords \"Infantile glaucoma,\" \"childhood glaucoma,\" \"paediatric glaucoma,\" \"congenital glaucoma,\" \"juvenile glaucoma,\" \"buphthalmos,\" and \"pediatric glaucoma.\" For each video, the time since the upload date (days), duration of the videos (minutes), number of likes, dislikes, and comments, the view ratio (number of views/time since the upload date), like ratio (likes × 100) /(likes+dislikes), view power index ([like ratio × view ratio] /100), and upload source (whether it was uploaded by medical organization versus uploaded by patients or commercial organization) were recorded. Two independent reviewers blindly evaluated the patient-targeted videos using DISCERN, the <i>Journal of American Medical Association</i> (JAMA), and the Global Quality Score (GQS) criteria.</p><p><strong>Results: </strong>Twenty-five videos were analyzed, and 19 (64%) of them were uploaded by physicians or medical organizations. The overall median (interquartile range) scores for DISCERN, JAMA, and GQS criteria were 2.5 (1.8 to 3.0), 2.5 (2.0 to 2.5), and 3.5 (2.5 to 4.0), respectively. No significant differences in scoring were noted between the two reviewers. The duration of the videos was significantly correlated with the GQS; however, no other video parameters were correlated to the quality scorings.</p><p><strong>Conclusions: </strong>YouTube videos of patient education about childhood glaucoma were of moderate quality and reliability. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2025;62(2):116-121.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"116-121"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mini Lens for Mini Eyes: Management of Congenital Cataract With Microcornea.","authors":"Karthika R Chandran, Shailja Tibrewal, Soveeta Rath, Suma Ganesh","doi":"10.3928/01913913-20250227-01","DOIUrl":"10.3928/01913913-20250227-01","url":null,"abstract":"<p><p>Management of congenital cataract associated with microcornea is challenging, often due to limited options for intraocular lens implantation. This case report describes the use of a small posterior-fixated iris claw lens for optical rehabilitation of cataract with microcornea, which resulted in significant improvement in the child's visual acuity. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2025;62(3):e27-e30.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"62 2","pages":"e27-e30"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total Retinal Detachment With an Intraocular Mass in a Young Girl.","authors":"Haley M Evans, Rolika Bansal, Michael J Shapiro, Carol L Shields","doi":"10.3928/01913913-20241105-02","DOIUrl":"10.3928/01913913-20241105-02","url":null,"abstract":"","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"151"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Cystinosis Experience in Southwestern Ontario.","authors":"Edward Tran, Inas Makar, Joanne Grimmer, Sapna Sharan","doi":"10.3928/01913913-20241001-02","DOIUrl":"10.3928/01913913-20241001-02","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate ocular treatment adherence and its impact on clinical outcomes in patients with cystinosis in southwestern Ontario, where the disease incidence is higher due to a founder effect in the Old Order Amish population.</p><p><strong>Methods: </strong>This was a retrospective case series of patients with ocular cystinosis seen at Victoria Hospital and the Ivey Eye Institute at St Joseph's Health Care in London, Ontario, Canada, from 2008 to 2023. The authors investigated the demographics, ocular manifestations, and visual outcomes and characteristics in pediatric patients with ocular cystinosis. They also conducted qualitative analysis to characterize medication compliance and identify treatment barriers to compliance.</p><p><strong>Results: </strong>This study included 14 patients with ocular cystinosis. In southwestern Ontario, the incidence of cystinosis is approximately 1 in 4,700 live births. Most patients were Old Order Amish, with a family history of cystinosis and consanguineous parents. During treatment, patients were typically asymptomatic, but photophobia was the most reported symptom. Slit-lamp examination revealed cystine crystals in the cornea of all patients; however, best corrected visual acuity and intraocular pressure were unremarkable in every case. A Fisher's exact test revealed a trend toward lower compliance in Amish patients compared to non-Amish patients (odds ratio: 0.067, <i>P</i> = .103). Significant treatment barriers for patients with ocular cystinosis were identified, including compliance issues with frequent eye drop regimens, educational and financial burdens, and geographical and cultural challenges, all impacting patient care and follow-up.</p><p><strong>Conclusions: </strong>This study highlights the need for improved strategies to improve treatment compliance and overcome barriers to care for patients with ocular cystinosis, particularly within the Old Order Amish population in southwestern Ontario, to ensure better clinical outcomes and quality of life. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2025;62(2):105-115.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"105-115"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Ophthalmological Manifestations of Claes-Jensen Syndrome Without Intellectual Disability: A Case Report.","authors":"Felipe A Murati, Juan B Yepez, Michele Petitto, Igor Kozak, J Fernando Arevalo","doi":"10.3928/01913913-20250227-02","DOIUrl":"10.3928/01913913-20250227-02","url":null,"abstract":"<p><p>An 8-year-old boy with prenatal-onset short stature, ophthalmological abnormalities, and dysmorphic features had a KDM5C variant typically linked to Claes-Jensen syndrome with intellectual disability, which he did not have. This atypical presentation highlights the importance of ophthalmological assessments in X-linked syndromes with variable expressivity, even without classic features. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2025;62(2):e22-e26.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"62 2","pages":"e22-e26"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing Inquiries About the Management of Retinopathy of Prematurity.","authors":"Rudolph S Wagner","doi":"10.3928/01913913-20250220-01","DOIUrl":"https://doi.org/10.3928/01913913-20250220-01","url":null,"abstract":"","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"62 2","pages":"80"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}