Journal of Pediatric Ophthalmology & Strabismus最新文献

{"title":"Long-term, Low-Dose Oral Azithromycin Treatment for Chronic Severe Bilateral Blepharokeratoconjunctivitis in Pediatric Patients.","authors":"Esin Sogutlu Sari, Ahmet Tuncer Ozmen, Meral Yildiz, Berna Akova, Mehmet Baykara, Shole Hasanova","doi":"10.3928/01913913-20240508-06","DOIUrl":"10.3928/01913913-20240508-06","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy and safety of oral azithromycin treatment combined with topical antibiotic and anti-inflammatory agents in pediatric patients with chronic severe bilateral blepharokeratoconjunctivitis.</p><p><strong>Methods: </strong>Patients younger than 14 years with chronic and severe bilateral blepharokeratoconjunctivitis were reviewed retrospectively. Consecutive patients receiving oral azithromycin treatment were included. All patients received oral azithromycin (5 mg/kg/single dose daily) for at least 4 weeks combined with topical antibiotic and anti-inflammatory agents. Before and after the treatment, clinical symptoms were noted, and corneal and conjunctival fluorescein staining and corneal neovascularization were graded. Meibomian gland secretion and meibomian gland plugging were also assessed. All patients completed at least 3 months of follow-up after completion of the oral azithromycin treatment. Patients' clinical data at the time of diagnosis and last follow-up visit were statistically compared.</p><p><strong>Results: </strong>Twenty-nine children (58 eyes, mean age of 6.51 years) were included. The mean time of oral azithromycin use was 5.87 weeks (range: 4 to 10 weeks). Clinical symptoms and signs and visual acuity were significantly improved after treatment. The mean fluorescein staining and corneal neovascularization grades and meibomian gland secretion and meibomian gland plugging scores also improved after treatment (<i>P</i> < .001). Eyelid distortion or fornix shortening was not observed. At the last follow-up visit, all patients were stable with treatment only with daily eyelid hygiene, topical cyclosporine, and artificial tears.</p><p><strong>Conclusions: </strong>Long-term, low-dose oral azithromycin combined with topical antibiotic and anti-inflammatory agents is an effective treatment option for pediatric patients with chronic severe bilateral blepharokeratoconjunctivitis. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2024;61(5):358-364.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"358-364"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Botulinum Toxin A Injection in Horizontal Nystagmus: Effect on the Frequency of the Oscillation on a Pediatric Population.","authors":"Daiane Bergamim, Thaís Christine Dos Santos Surgik, Mariana Tosato Zinher, Teresa Cristina Nogueira de Lassus","doi":"10.3928/01913913-20240409-02","DOIUrl":"10.3928/01913913-20240409-02","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of botulinum toxin A injection on the frequency of horizontal nystagmus in children.</p><p><strong>Methods: </strong>This was a non-randomized before-and-after clinical trial evaluating a cohort of children with horizontal nystagmus before and after treatment with botulinum toxin A. The toxin was injected under general anesthesia with spontaneous ventilation without intubation using the Mendonça forceps and the effect was evaluated by analyzing the frequency of the oscillation in Hertz (Hz) on video registrations before and after treatment.</p><p><strong>Results: </strong>The current study found a statistically significant difference on the frequency of the nystagmus in children before and after the injection of botulinum toxin A, with the mean frequency decreasing from 1.55 ± 0.94 Hz before treatment to 1.04 ± 0.87 Hz at 1 month post-injection (<i>P</i> < .001) and to 1.27 ± 0.87 Hz at 6 months post-injection (<i>P</i> = .002). When comparing the data 1 and 6 months post-injection, this study found a significant increase (<i>P</i> = .001) in the frequency of the nystagmus.</p><p><strong>Conclusions: </strong>The injection of botulinum toxin A is effective in reducing the frequency of oscillations in children with horizontal nystagmus both 1 and 6 months after the procedure, and can be used as a first-line, less invasive treatment aiming to decrease the frequency of oscillation. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2024;61(5):365-370.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"365-370"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cataract Formation in a Child Receiving Dabrafenib and Trametinib Therapy.","authors":"Elaine Botros, Yasmin Bradfield, Nicholas Pytel","doi":"10.3928/01913913-20240722-01","DOIUrl":"10.3928/01913913-20240722-01","url":null,"abstract":"<p><p>The authors report a case of bilateral cataract in a 9-year-old girl after being treated with a combination of the targeted therapy drugs dabrafenib and trametinib. Although adverse effects have been reported with this treatment, this report is the first documented case of cataract as a complication. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2024;61(5):e47-e49.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"61 5","pages":"e47-e49"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Accuracy and Readability of ChatGPT in Providing Information to Patients With Keratoconus.","authors":"Elishai Assayag, David Zadok, Liron Berkovitz, Yishay Weill","doi":"10.3928/01913913-20240718-01","DOIUrl":"https://doi.org/10.3928/01913913-20240718-01","url":null,"abstract":"<p><p>Patients with keratoconus may lack sufficient understanding of their illness. The authors assessed the accuracy and readability of ChatGPT (OpenAI) responses to common questions regarding keratoconus and found that the provided data are precise, with minor inaccuracies. The complexity of responses requires a high reading level, which may be unsuitable for many patients. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2024;61(5):e43-e46.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"61 5","pages":"e43-e46"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eye Mobile Units and Their Effect on Access to Pediatric Eye Care.","authors":"Leonard B Nelson","doi":"10.3928/01913913-20240909-01","DOIUrl":"https://doi.org/10.3928/01913913-20240909-01","url":null,"abstract":"","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"61 5","pages":"304"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prematurity May Affect the Postoperative Sensory Results in Children With Strabismus.","authors":"Leyla Niyaz, Nurullah Kocak, Mustafa Subası, Ozlem Eski Yucel","doi":"10.3928/01913913-20240208-02","DOIUrl":"10.3928/01913913-20240208-02","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the motor and sensory outcomes of strabismus surgery in children born preterm (premature group) and full-term (control group).</p><p><strong>Methods: </strong>The study was performed at a tertiary university hospital. Children who underwent strabismus surgery between 2012 and 2019 were retrospectively reviewed. The success of surgery, postoperative over-correction and undercorrection rates, and stereopsis and fusion test results were compared between the premature and control groups.</p><p><strong>Results: </strong>There were 70 patients in the premature group (mean gestational age: 31.25 weeks; range: 24 to 35 weeks) and 242 patients in the control group. The amounts of preoperative and postoperative deviations and overcorrection, undercorrection, and success rates were similar between the premature and control groups (<i>P</i> > .05). Stereopsis improved from 560 to 300 arc/sec postoperatively in the premature group (<i>P</i> = .066) and from 1,156 to 685 arc/sec in the control group (<i>P</i> < .001). The rate of fusion increased from 12.5% to 25% in the premature group (<i>P</i> = .50) and from 17% to 47% in the control group (<i>P</i> < .001). The analysis of strabismus subgroups revealed significant improvement of fusion in full-term patients (<i>P</i> < .001) and not in preterm patients (<i>P</i> = .50) with esotropia. Preoperative amount of deviation was the only risk factor for surgical success (<i>P</i> < .001). Age, sex, history of prematurity, and spherical equivalent refraction were not correlated with undercorrection (<i>P</i> > .05).</p><p><strong>Conclusions: </strong>Regardless of the type of strabismus, although the functional results after strabismus surgery were similar in preterm and full-term patients, the gain of stereopsis and central fusion was significantly higher in full-term patients compared to preterm patients. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2024;61(4):267-272.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"267-272"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory Function of Children With Strabismus After Epiblepharon Surgery.","authors":"Heejeong You, Helen Lew","doi":"10.3928/01913913-20240118-02","DOIUrl":"10.3928/01913913-20240118-02","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effect of epiblepharon surgery on motor and sensory function in children with epiblepharon and concomitant strabismus.</p><p><strong>Methods: </strong>Among 564 patients who underwent epiblepharon correction surgery from May 2016 to April 2023, 45 children who were examined for strabismus were included in the study. Preoperative and postoperative visual acuity, refraction, and angle of deviation were analyzed. For those with significant angle of deviation, additional stereopsis, sensory fusion, and returning time were retrospectively investigated. The angle of deviation was examined by one examiner at distance and near.</p><p><strong>Results: </strong>The mean age of 45 children (18 boys and 27 girls) was 6.8 ± 2.9 years. Fifteen had significant strabismus at the time of epiblepharon surgery. Visual acuity improved in both the total and strabismus groups. Improvement in stereopsis and fusion was also observed in the strabismus group. The angle of deviation showed no difference in both groups.</p><p><strong>Conclusions: </strong>Epiblepharon could affect ocular manifestations of strabismus as shown in this study. The authors suggest strabismus treatment be continued after epiblepharon surgery, with improved sensory function. Further evaluation with larger groups is needed in the future. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2024;61(4):257-261.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"257-261"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroretinogram as a Screening Tool to Assess Vigabatrin-Induced Retinal Toxicity in Children With Infantile Spasms.","authors":"Suruthi Nagarajan, Rajesh Prabu, Nikulaa Parachuri, Mithun Thulasidas","doi":"10.3928/01913913-20240215-01","DOIUrl":"10.3928/01913913-20240215-01","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the utility of electroretinogram (ERG) as a screening tool for vigabatrin-induced retinal toxicity in children with infantile spasms.</p><p><strong>Methods: </strong>This was an observational cohort study including children with infantile spasms receiving treatment with vigabatrin. A 30-Hz flicker potential ERG, using the RETeval system (LKC Technologies), was done at baseline before starting vigabatrin at 6 months and 1 year. The amplitudes were recorded.</p><p><strong>Results: </strong>Eleven children were included in the study. The most common etiologic factor for infantile spasms was tuberous sclerosis (36.4%) followed by West syndrome (27.3%). The mean age of the children was 7.14 ± 2.9 months, with a range of 3 to 16 months. The mean difference in amplitude was 3.21 ± 2.45 and 5.72 ± 4.18 µV at 6 and 12 months follow-up, respectively (<i>P</i> < .001). Eight of the 11 children (72.7%) showed vigabatrin-induced retinal toxicity, and all 8 children were receiving vigabatrin for more than 6 months.</p><p><strong>Conclusions: </strong>ERG can be used for vigabatrin-induced retinal toxicity monitoring in children with infantile spasms. Vigabatrin-induced retinal toxicity is related to the duration of treatment rather than cumulative dosage. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2024;61(4):273-278.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"273-278"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Report on the Epidemiology of Pediatric Dog Bite-Associated Ocular Injuries.","authors":"Siri Uppuluri, Julia Nguyen, Aditya Uppuluri, Paul D Langer, Neelakshi Bhagat","doi":"10.3928/01913913-20240620-04","DOIUrl":"https://doi.org/10.3928/01913913-20240620-04","url":null,"abstract":"","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"61 4","pages":"296-297"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric-Type Follicular Lymphoma of the Conjunctiva in Two Adolescents.","authors":"Julie M Shabto, Alejandro A Gru, Craig R Soderquist, James Yip, Amy Chadburn, Yue Gu, Brian Marr, Lauren Yeager, Lora R Dagi Glass","doi":"10.3928/01913913-20240517-01","DOIUrl":"https://doi.org/10.3928/01913913-20240517-01","url":null,"abstract":"<p><p>The authors present two cases of conjunctival pediatric-type follicular lymphoma. A 14-year-old Black boy and 14-year-old Black girl were each referred for evaluation of a painless salmon-colored conjunctival lesion. Both patients underwent excisional biopsy. Histopathology demonstrated follicles with germinal centers composed of atypical B-cells with high Ki67 proliferation index, positive staining for CD20, CD10, and BCL6, and negative for BCL2. This series contributes two cases to the limited literature and presents the first case reported in a female. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2024;61(4):e33-e38.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"61 4","pages":"e33-e38"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}