Journal of Psychosomatic Research最新文献

{"title":"Estimating cardiovascular mortality in patients with hypertension using machine learning: The role of depression classification based on lifestyle and physical activity","authors":"Xingyu Liu ,&nbsp;Zeyu Luo ,&nbsp;Fengshi Jing ,&nbsp;Hao Ren ,&nbsp;Changjin Li ,&nbsp;Lei Wang ,&nbsp;Tao Chen","doi":"10.1016/j.jpsychores.2024.112030","DOIUrl":"10.1016/j.jpsychores.2024.112030","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aims to harness machine learning techniques, particularly the Random Survival Forest (RSF) model, to assess the impact of depression on cardiovascular disease (CVD) mortality among hypertensive patients. A key objective is to elucidate the interplay between mental health, lifestyle, and physical activity while comparing the effectiveness of the RSF model against the traditional Cox proportional hazards model in predicting CVD mortality.</div></div><div><h3>Methods</h3><div>Data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007 to 2014 were used for comprehensive depression screening. The Patient Health Questionnaire-9 (PHQ-9) was employed to categorize depression severity levels among participants. The final cohort included 9271 participants, selected after excluding those with incomplete data. Participants were followed up for a median of 7.1 years, and cardiovascular mortality was assessed up to December 31, 2019. We employed the RSF model to predict cardiovascular mortality with high effectiveness and precision. And to ensure comparability, we developed the traditional Cox proportional hazards model using the same set of predictors.</div></div><div><h3>Results</h3><div>RSF model outperformed the Cox proportional hazards model in predicting cardiovascular mortality among hypertensive patients with varying depression levels. The RSF model's integrated area under the curve (iAUC) scores were 0.842, 0.893, and 0.760 for none, mild, and severe depression, respectively, surpassing the Cox model's scores of 0.826, 0.805, and 0.746.</div></div><div><h3>Conclusion</h3><div>The RSF model provides a more accurate prediction of CVD mortality among hypertensive patients with varying degrees of depression, offering a valuable tool for personalized patient care. Its ability to stratify patients into risk categories can assist healthcare professionals in making informed decisions, underscoring the potential of machine learning in public health and clinical settings. This model demonstrates particular utility in settings where detailed, patient-specific risk assessments are critical for managing long-term health outcomes. Future research should focus on external validation and integration of more diverse variables to enhance predictive power.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112030"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint effects of depressive symptoms and triglyceride-glucose index on cardiovascular events in acute coronary syndrome patients: The mediating role of TyGi","authors":"Chengqian Xu ,&nbsp;Di Wang ,&nbsp;Mengru Sun ,&nbsp;Bingji Huang ,&nbsp;Yini Wang ,&nbsp;Ping Lin","doi":"10.1016/j.jpsychores.2024.112034","DOIUrl":"10.1016/j.jpsychores.2024.112034","url":null,"abstract":"<div><h3>Objective</h3><div>Our aim was to explore the joint impacts of depressive symptoms along with triglyceride-glucose index (TyGi) on major adverse cardiovascular events (MACE) in patients who have acute coronary syndrome (ACS) and investigate whether the impact of depressive symptoms on MACE is mediated through the TyGi.</div></div><div><h3>Methods</h3><div>This extensive cohort study included 3681 ACS patients. Depressive symptoms and TyGi were assessed at baseline, and the patients were subsequently followed for two years to monitor the occurrence of MACE.</div></div><div><h3>Results</h3><div>Throughout the two-year monitoring period, 387 (10.5 %) patients with ACS experienced MACE. The TyGi was positively correlated with MACE risk (hazard ratio [HR]: 1.301, 95 % confidence interval [CI]: 1.112–1.522, <em>p</em> = .001). A nonlinear relation was observed between the TyGi and MACE (<em>p</em> for nonlinearity = 0.04). Joint analyses revealed that, unlike the non-depression &amp; TyG low group, the depression &amp; TyG low group had a two-fold elevation in MACE risk (HR: 2.108, 95 % CI: 1.499–2.966), while the depression &amp; TyG high group represented an even higher risk (HR: 2.442, 95 % CI: 1.786–3.339). The mediation analysis results showcased that the TyGi was a significant mediator of the interplay between depressive symptoms and MACE.</div></div><div><h3>Conclusion</h3><div>Depressive symptoms and the TyGi jointly influence MACE risk in ACS patients, with the TyGi mediating this relation. Close monitoring and management of depressive symptoms and the TyGi are crucial during ACS rehabilitation.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112034"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal study of resilience and social function in patients with colorectal cancer and stomas","authors":"Min Wang ,&nbsp;Yanhua Xu ,&nbsp;Bing Xiang Yang ,&nbsp;Dan Luo ,&nbsp;Hao Hou ,&nbsp;Qian Liu","doi":"10.1016/j.jpsychores.2024.112013","DOIUrl":"10.1016/j.jpsychores.2024.112013","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the dynamic changes, influencing factors, and relationships between resilience and social function in patients with colorectal cancer (CRC) and stomas at different postoperative stages, and to inform precise psychosocial rehabilitation interventions.</div></div><div><h3>Methods</h3><div>A longitudinal study was conducted at a tertiary hospital in eastern China from January 2021 to June 2023. Patients completed a self-designed socio-demographic questionnaire one month post-surgery, and the Connor and Davidson Resilience Scale (CD-RISC) and Social Dysfunction Screening Scale (SDSS) at 1, 3, and 5 months post-surgery. Data were analyzed using repeated measures ANOVA, Spearman correlation, group-based trajectory modeling, and binary logistic regression.</div></div><div><h3>Results</h3><div>A total of 131 patients were included in the analysis. Resilience showed an initial increase followed by a decline, while social function consistently improved. A moderate negative correlation between social dysfunction and resilience was observed at all time points. Influencing factors for resilience and social function varied across different postoperative stages. Significant differences in resilience trajectories were observed based on education and family income. Resilience trajectories significantly impacted social function trajectories (OR 19.39, 95 % CI 2.46–152.91, <em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>This study identifies distinct trajectories of resilience and social function in patients with colorectal cancer and stomas. Low resilience is linked to severe social function deficits. Stage-specific interventions are crucial to enhance social adaptation and improve overall quality of life. Tailored support is needed throughout recovery to address the unique challenges faced by these patients.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112013"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained improvements in sick leave, fatigue and functional status following a concentrated micro-choice based treatment for patients with long COVID: A 1 year prospective uncontrolled study","authors":"Bente Frisk ,&nbsp;Marte Jürgensen ,&nbsp;Birgitte Espehaug ,&nbsp;Eirik Søfteland ,&nbsp;Gerd Kvale","doi":"10.1016/j.jpsychores.2024.112023","DOIUrl":"10.1016/j.jpsychores.2024.112023","url":null,"abstract":"<div><h3>Background</h3><div>Long COVID has affected approximately 200 million people globally, with substantial consequences for the individuals, healthcare systems and society. Treatment guidelines lack clear recommendations regarding increased activity. This study aimed to evaluate primary outcomes as patients' satisfaction, illness perception and patient activation. In addition, potential changes in functional levels, sick leave, fatigue, dyspnea, and exercise capacity from baseline to 12-month follow-up after a concentrated micro-choice-based intervention in patients with long COVID.</div></div><div><h3>Methods</h3><div>This prospective interventional study, study start 26 May 2021, with 12-month follow-up included 78 patients with long COVID aged 19–67 years, mean age 40.3 ± 12.0 years. The intervention was structured into three equally important phases: pre-treatment preparation, a 3-day concentrated micro-choice-based intervention and integrating the changes into everyday living.</div></div><div><h3>Results</h3><div>At 3 and 12-month follow-ups, 71 (91 %) and 65 (83 %) patients, respectively completed questionnaires and physical tests. The patients reported significant enhancements in illness perception and health activation. Sick leave decreased significantly from 63 % at baseline to 43 % and 23 % at 3 and 12-month, respectively (<em>p</em> &lt; 0.001). Fatigue decreased significantly at 3-month (mean difference (MD) = −5.5, 95 % CI: −6.6 to −4.3) and at 12-month (MD = −7.0, CI: −8.3 to −5.7). Functional level and exercise capacity increased (p &lt; 0.001), and dyspnea decreased (p &lt; 0.001), at both follow-ups regardless of baseline fatigue severity.</div></div><div><h3>Conclusion</h3><div>The micro-choice-based intervention for patients with long COVID was safe, highly satisfactory and significantly enhanced health activation alongside rapid improvements in functional levels and fatigue which continued improving throughout the follow-up year, together with significant reduction in sick leave.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112023"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health anxiety in cancer patients, assessed with the Whiteley Index","authors":"Andreas Hinz ,&nbsp;Mareike Ernst ,&nbsp;Thomas Schulte ,&nbsp;Markus Zenger ,&nbsp;Michael Friedrich ,&nbsp;Nadja Dornhöfer","doi":"10.1016/j.jpsychores.2024.112017","DOIUrl":"10.1016/j.jpsychores.2024.112017","url":null,"abstract":"<div><h3>Objective</h3><div>Health anxiety (HA) is frequently observed in patients suffering from a severe disease such as cancer. This study aimed to test the psychometric properties of the Whiteley Index-7 (WI-7) measuring HA and to identify prognostic factors for heightened HA in cancer patients.</div></div><div><h3>Methods</h3><div>A sample of 1723 cancer patients, treated in a German rehabilitation clinic, completed the Whiteley Index-7, the Generalized Anxiety Disorder screener GAD-7, the Patient Health Questionnaire PHQ-9, the Fear of Progression questionnaire FoP-Q-12, the Concerns About Cancer Recurrence questionnaire CARQ-4, and two subscales of the EORTC QLQ-SURV100.</div></div><div><h3>Results</h3><div>The internal consistency of the WI-7 was good (Cronbach's α = 0.85), and the correlations between the WI-7 and other scales were as follows: 0.64 (GAD-7), 0.63 (PHQ-9), 0.75 (FoP-Q-12), 0.71 (CARQ-4), 0.66 (SURV-HD), and 0.75 (SURV-NHO). Women showed markedly higher levels of HA than men (effect size: <em>d</em> = 0.40), and patients aged 60 years and above reported lower levels of HA than younger patients (<em>d</em> = −0.32). Melanoma patients showed the highest HA mean score (M = 10.9), and patients receiving antibody therapy showed heightened levels of HA (M = 10.7). When considering age and sex, the effects of tumor type and treatment become smaller than in the univariate analyses.</div></div><div><h3>Conclusion</h3><div>The WI-7 is a suitable instrument for assessing HA in cancer patients. When evaluating the effects of cancer type or treatment on HA, one has to take into account the age and sex distribution. Younger patients and women deserve special attention regarding HA.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112017"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing autonomic nervous system function in patients with functional somatic syndromes, stress-related syndromes and healthy controls","authors":"Maaike Van Den Houte ,&nbsp;Indra Ramakers ,&nbsp;Lukas Van Oudenhove ,&nbsp;Omer Van den Bergh ,&nbsp;Katleen Bogaerts","doi":"10.1016/j.jpsychores.2024.112025","DOIUrl":"10.1016/j.jpsychores.2024.112025","url":null,"abstract":"<div><h3>Background</h3><div>The goal of this study was to examine autonomic nervous system function by measuring heart rate (HR), heart rate variability (HRV), skin conductance levels (SCL), and peripheral skin temperature (ST) in response to and during recovery from psychosocial stressors in patients with functional somatic syndromes (FSS; fibromyalgia and/or chronic fatigue syndrome), stress-related syndromes (SRS; overstrain or burn-out), and healthy controls (HC).</div></div><div><h3>Methods</h3><div>Patients with FSS (<em>n</em> = 26), patients with SRS (<em>n</em> = 59), and HC (<em>n</em> = 30) went through a standardized psychosocial stress test consisting of a resting phase (120 s), the STROOP color word task (120 s), a mental arithmetic task (120 s) and a stress talk (120 s), each followed by a 120 s recovery period. HR, HRV, SCL, and ST were monitored continuously.</div></div><div><h3>Results</h3><div>Average HR and SCL were higher, and HRV was lower, in both patient groups compared to HC during rest (0.50 &lt; Cohen's d &lt; 0.97). A larger SC response to psychosocial stress was found in FSS compared to HC (d = 0.71). However, HR increased less during psychosocial stress and showed a smaller reduction during recovery in both patient groups compared to HC (0.68 &lt; d &lt; 0.98). HRV was lower in both patient groups compared to HC during recovery (0.91 &lt; d &lt; 0.98). There were no differences in ST levels or responses between groups.</div></div><div><h3>Conclusions</h3><div>Our results indicate a dominance of the sympathetic nervous system in both patient groups compared to controls, suggesting that autonomic nervous system dysfunction is a transdiagnostic feature for stress-related and functional somatic syndromes.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112025"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diminished salivary cortisol response to mental stress predict all-cause mortality in general population","authors":"Han Yin ,&nbsp;Zihan Gao ,&nbsp;Mengyang Jia ,&nbsp;Cheng Jiang ,&nbsp;Yuanhao Wang ,&nbsp;Dahui Xue ,&nbsp;Jingnan Huang ,&nbsp;Huhao Feng ,&nbsp;Nana Jin ,&nbsp;Jingjin Liu ,&nbsp;Lixin Cheng ,&nbsp;Qingshan Geng","doi":"10.1016/j.jpsychores.2024.112031","DOIUrl":"10.1016/j.jpsychores.2024.112031","url":null,"abstract":"<div><h3>Objectives</h3><div>To characterize individuals with a diminished salivary cortisol response to mental stress, assess its association with all-cause mortality, and quantify the mediating effects of the most relevant and modifiable factors to identify potential target for prevention.</div></div><div><h3>Methods</h3><div>Data from MIDUS II study with a 16-year follow-up, were used to categorize 1129 participants as responders or non-responders based on the existence of increase in salivary cortisol under mental stress. LASSO-logistics analysis identified the most relevant factors. Cox regression models and restricted cubic splines evaluated the prognostic impact. Further analyses examined the mediating effects of identified factors on prognosis.</div></div><div><h3>Results</h3><div>After employing Inverse Probability of Treatment Weighting to adjust for demographic differences between groups, individuals with diminished cortisol responses were found to have higher levels of depressive symptoms (<em>p</em> = 0.050), increased inflammation (IL-6, 2.30 [1.41, 3.79] vs. 1.96[1.33, 3.31], <em>p</em> = 0.011), and were less likely to regularly exercise (74.3 % vs. 79.9 %, <em>p</em> = 0.030). IL-6 (OR: 1.25 [1.04, 1.52]，<em>p</em> = 0.021) and regularly exercising (OR 0.71 [0.51, 0.97], <em>p</em> = 0.032) emerged as significant modifiable factors in multivariate analysis. A notable prognostic association of diminished cortisol response with all-cause mortality (HR = 1.33 [1.01–1.76], <em>p</em> = 0.046) was observed, consistent across various subgroups and supported by non-linear model analysis. Approximately 13 % of the mortality risk associated with diminished cortisol response was mediated by increased IL-6 levels (<em>p</em> = 0.043).</div></div><div><h3>Conclusion</h3><div>Diminished salivary cortisol response is linked to an increased risk of all-cause mortality, significantly mediated by elevated IL-6. This study offers a new perspective on prognostic prediction while highlighting potential avenues for intervention.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112031"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional study on the impact of adverse childhood experiences on psychological distress in patients with an implantable cardioverter-defibrillator","authors":"Marc Dörner ,&nbsp;Roland von Känel ,&nbsp;Aju P. Pazhenkottil ,&nbsp;Rahel Altwegg ,&nbsp;Noelle König ,&nbsp;Ladina Nager ,&nbsp;Veronica Attanasio ,&nbsp;Lisa Guth ,&nbsp;Sina Zirngast ,&nbsp;Anna Menzi ,&nbsp;Mary Princip ,&nbsp;Claudia Zuccarella-Hackl","doi":"10.1016/j.jpsychores.2024.112033","DOIUrl":"10.1016/j.jpsychores.2024.112033","url":null,"abstract":"<div><div>Objective: Previous studies implied detrimental effects of adverse childhood experiences (ACE) on cardiovascular disease and mental health. Still, data on the influence of ACE on psychological distress in patients with an implantable cardioverter-defibrillator (ICD) are lacking. Methods: We prospectively recruited 423 patients with an ICD. To determine associations between ACE (ACE questionnaire, cut-off ≥4), depression (Patient Health Questionnaire-8), anxiety (Generalized Anxiety Disorder-7 scale), and post-traumatic stress disorder (PTSD) symptoms (Post-Traumatic Stress Diagnostic Scale), we conducted a binary logistic regression analysis. Regression models were adjusted for conventional risk factors of psychological distress in ICD patients. To identify indirect mediating effects of resilience (Resilience Scale) on ACE and psychological distress, we applied the PROCESS regression path analysis modeling tool. Results: 49.1 % of all patients reported at least one ACE, and 9.7 % experienced even four or more ACE. A high-risk ACE profile (≥ 4) was associated with higher levels of anxiety (OR 3.68, 95 % CI 1.37–9.84, <em>p</em> = 0.009), depression (OR 4.08, 95 % CI 1.67–9.97, <em>p</em> = 0.002), and PTSD symptoms (OR 2.20, 95 % CI 1.03–5.21, <em>p</em> = 0.041). Greater resilience partially mediated the relationship between ACE and depression (indirect effect 0.11, 95 % CI 0.01–0.26) as well as anxiety (indirect effect 0.08, 95 % CI 0.008–0.19). Conclusions: The current study suggests an association between ACE and psychological distress in patients with an ICD. However, resilience could mitigate the adverse effects of ACE. Future studies should strive to unravel the complex mechanisms of ACE and its effects on cardiovascular and mental health in ICD patients.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112033"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of depressive symptom trajectories with chronic kidney disease in middle-aged and older adults","authors":"Longyang Han ,&nbsp;Yiqun Li ,&nbsp;Minglan Jiang ,&nbsp;Xiao Ren ,&nbsp;Wenyan Wu ,&nbsp;Xiaowei Zheng","doi":"10.1016/j.jpsychores.2024.112036","DOIUrl":"10.1016/j.jpsychores.2024.112036","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to investigate the association between trajectories of depressive symptoms and the subsequent risk of chronic kidney disease (CKD) by measuring depressive symptoms repeatedly in older adults with normal renal function.</div></div><div><h3>Methods</h3><div>A total of 9650 participants, comprising community-dwelling middle-aged and older adults from the China Health and Retirement Longitudinal Study, were included. Depressive symptoms were assessed at three time points: Wave 1 (2011−2012), Wave 2 (2013–2014), and Wave 3 (2015–2016). Trajectories of depressive symptoms were determined using latent mixed models, and the association between these trajectories and CKD was verified using COX proportional hazards models.</div></div><div><h3>Results</h3><div>Five trajectory patterns of depressive symptoms were identified: low CESD-10 score (Low-Stable, 3702 participants, 38.36 %), moderate CESD-10 score (Moderate-Stable, 3602 participants, 37.33 %), continuously increasing CESD-10 score from moderate initiation (Moderate-Increasing, 825 participants, 8.55 %), continuously decreasing CESD-10 score from high initiation (High-Decreasing, 1032 participants, 10.69 %), and stable high CESD-10 score (High-stable, 489 participants, 5.07 %). During the two-year follow-up period from Wave 3 to Wave 4 (2017–2018), 420 CKD events occurred. Participants in the Moderate-Stable, Moderate-Increasing, High-Decreasing, and High-Stable groups had an increased risk of developing CKD compared to those in the Low-Stable group, with multivariable-adjusted hazard ratios (95 % confidence interval) were 1.32 (1.02–1.71), 1.68 (1.15–2.45), 2.26 (1.63–3.13), and 3.73 (2.57–5.43), respectively, comparted to those with low-stable trajectory.</div></div><div><h3>Conclusion</h3><div>Middle-aged and older adults with increasing (Moderate-Increasing) and persistent depressive symptoms (including Moderate-Stable, High-Decreasing, and High-Stable) face a higher risk of developing CKD over time.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112036"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meaning in life as a pathway to longevity and better health outcomes","authors":"Rizky Andana Pohan ,&nbsp;Ririn Dwi Astuti ,&nbsp;Nining Maizura ,&nbsp;Putri Bunga Aisyah Pohan ,&nbsp;Erfan Ramadhani ,&nbsp;Rikas Saputra","doi":"10.1016/j.jpsychores.2024.112035","DOIUrl":"10.1016/j.jpsychores.2024.112035","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112035"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}