Journal of Psychosomatic Research最新文献

{"title":"Biopsychosocial complexity and compulsory admission to the psychiatric ward: A retrospective observational study","authors":"Mattia Marchi ,&nbsp;Gianluca Fiore ,&nbsp;Gloria Bizzarri ,&nbsp;Ilaria Corbellini ,&nbsp;Alessia Mancini ,&nbsp;Isabella Riguzzi ,&nbsp;Erjon Radheshi ,&nbsp;Roberto Salati ,&nbsp;Giulia Ferrazzi ,&nbsp;Luca Pingani ,&nbsp;Gian Maria Galeazzi ,&nbsp;Silvia Ferrari","doi":"10.1016/j.jpsychores.2025.112204","DOIUrl":"10.1016/j.jpsychores.2025.112204","url":null,"abstract":"<div><h3>Background</h3><div>The INTERMED scale is a tool used to assess the biopsychosocial (BPS) complexity through a semi-structured interview that explores the psychological, biological, social and health-system domains. The objective of this study was to investigate the use of the INTERMED scale as a predictor of Compulsory Admission (CA) in patients with psychiatric disorders.</div></div><div><h3>Method</h3><div>Sociodemographic and clinical information, including INTERMED and HoNOS scores, was collected retrospectively on patients admitted to the hospital psychiatric ward under both CA and Voluntary Admission (VA). The correlations between these variables and admission type were analysed using descriptive statistics and Chi² and <em>t</em>-test. Then, univariate logistic regression was used to estimate Odds Ratios (ORs) with 95% confidence intervals (95% CIs) for CA based on different predictors, including the INTERMED score, as a measure of BPS complexity.</div></div><div><h3>Results</h3><div>The entire sample of 332 CA and VA patients exhibited considerable BPS complexity (mean INTERMED total score 25.8 ± 8.4), but this was higher among CA patients (all INTERMED scores but the biological domain one); further significant differences were observed between CA and VA patients, e.g. diagnosis at discharge or dosage of antipsychotic medications. Moreover, high scores on the INTERMED scale were identified as predictors of CA, particularly the total score (OR:1.05[95% CI:1.02;1.08]), the psychological domain score (OR:1.30[95% CI:1.18;1.44]) and the health-system domain score (OR:1.15[95% CI:1.05;1.25]).</div></div><div><h3>Conclusions</h3><div>This study found significant associations between some INTERMED dimensions and CA. INTERMED may be a useful screening instrument to identify specific areas of vulnerability in patients with psychiatric disorders, that could support clinical strategies to reduce hospitalization and CA.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"196 ","pages":"Article 112204"},"PeriodicalIF":3.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis of the relationship between emotion regulation, pain, depressive symptoms and quality of life in women with endometriosis","authors":"Sérgio A. Carvalho,&nbsp;Inês Eulálio,&nbsp;Raquel Guiomar","doi":"10.1016/j.jpsychores.2025.112205","DOIUrl":"10.1016/j.jpsychores.2025.112205","url":null,"abstract":"<div><h3>Background</h3><div>Endometriosis is a chronic gynecological condition with a broad spectrum of symptomatology resulting from a complex pathophysiology and biopsychosocial etiology, to which emotion regulation (ER) seems to contribute. This systematic review aims to summarize and meta-analyse the empirical evidence for the relationship between (mal)adaptive ER strategies, pain (intensity and impact), depressive symptoms, and quality of life of women with endometriosis.</div></div><div><h3>Design and methods</h3><div>After registering to PROSPERO (ID: CRD42023427936; redacted), four databases were searched (PubMed, PsycINFO, Web of Knowledge, Scopus) from inception until 30th May 2025. All screening steps were performed by two researchers independently. The quality of the studies was examined using the National Heart, Lung and Blood Institute tool, and statistical analyses were performed on R.</div></div><div><h3>Results</h3><div>Sixteen studies (<em>N</em> = 3687) were included. Pooled correlations found ER to be significantly correlated with all outcomes, with adaptive (e.g., acceptance, mindfulness, self-compassion) and maladaptive (e.g., rumination, catastrophizing) ER strategies being associated with the outcomes in the expected direction. Age moderated the association between ER and quality of life, showing that ER especially moderates quality of life in younger women with endometriosis.</div></div><div><h3>Conclusions</h3><div>This meta-analysis provides evidence that adaptive ER skills might positively influence symptomatology in younger women with endometriosis. To foster mental health and pain coping, psychological management with a focus on emotion regulation may help the field further.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112205"},"PeriodicalIF":3.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of sleep disturbances and its associated factors in patients with generalised anxiety disorder: A systematic review and meta-analysis","authors":"Chotiman Chinvararak ,&nbsp;Kimberley Goldsmith ,&nbsp;Trudie Chalder","doi":"10.1016/j.jpsychores.2025.112208","DOIUrl":"10.1016/j.jpsychores.2025.112208","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to study the prevalence of sleep disturbances in patients with generalised anxiety disorder (GAD) and to identify the factors related to sleep disturbances.</div></div><div><h3>Methods</h3><div>We conducted a systematic review of factors associated with sleep disturbances and a meta-analysis of the pooled prevalence of sleep disturbances in GAD patients. A box-score method was employed to quantify the relationships between the identified factors associated with sleep disturbances and GAD. Cochran's Q-test and I2 statistics were used to evaluate the heterogeneity of the studies. We employed a random-effects meta-analysis model to estimate the pooled prevalence of sleep disturbances, combining the data using the Freeman-Tukey double arcsine method. Publication bias was evaluated by a funnel plot and Egger's test.</div></div><div><h3>Results</h3><div>We identified eight eligible papers for systematic review; five were included in the meta-analysis. Five studies involved 5875 GAD patients; most participants were females aged 18 to 94. The pooled prevalence of sleep disturbance was 72 % (95 % CI: 28–99 %). The associated factors of sleep disturbances included sex, body mass index, GAD severity, Hamilton Anxiety Rating Scale score, Hamilton Depression Rating Scale score, Beck Depression Inventory score, Brief Pain Inventory score, cigarette consumption, Health-related quality of life and parathyroid hormone and vitamin D levels.</div></div><div><h3>Conclusion</h3><div>Sleep disturbances are prevalent in GAD patients and associated with several factors, including individual characteristics and measures of mood and health. Interventions focused onmodifiable factors may benefit GAD patients.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112208"},"PeriodicalIF":3.5,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expectations, conditioning, and the placebo effect do not differ between fibromyalgia patients and healthy controls but might be differently associated","authors":"Galia Emergui ,&nbsp;Mariana Agostinho ,&nbsp;Rita Canaipa ,&nbsp;Roi Treister","doi":"10.1016/j.jpsychores.2025.112207","DOIUrl":"10.1016/j.jpsychores.2025.112207","url":null,"abstract":"<div><h3>Introduction</h3><div>Individuals with chronic pain such as fibromyalgia (FM) are often experiencing disappointing outcomes from clinical therapies, which theoretically should condition them to experience low placebo analgesia. However, no consistent differences in the placebo effect were found between healthy controls (HC) and chronic pain patients. This study examined the expectations, conditioning, and placebo effect in HC and FM, and the relationships between these factors in both groups.</div></div><div><h3>Methods</h3><div>Female HC and FM patients were recruited, provided demographic and clinical information and underwent the experimental placebo paradigm. This paradigm has the advantage of measuring expectations (baseline, reinforced, and after placebo), conditioning, and placebo effect. Mixed factorial ANCOVAs, correlational analysis, stepwise and moderation regression analysis were employed.</div></div><div><h3>Results</h3><div>Thirty-seven HC and 32 FM patients participated. Three Mixed factorial ANCOVAs showed no main effects of group or interactions for expectations (<em>p</em> = .692), conditioning (<em>p</em> = .357), or placebo effect (<em>p</em> = .819). Reinforced expectations predicted the conditioning strength (<em>r</em> = .48, <em>p</em> = .008) and placebo effect (<em>r</em> = .44, <em>p</em> = .014) in HC but not in FM participants. In FM, duration of pain predicted the reinforced expectations (<em>r</em> = −.38, <em>p</em> = .035) and moderated the prediction of the placebo effect by the conditioning strength (b = .04, <em>p</em> = .011).</div></div><div><h3>Conclusion</h3><div>While the classical placebo theorem is supported in healthy controls, with conditioning influencing expectations, which in turn predict the placebo effect, these associations are not observed in fibromyalgia, where prior clinical experience plays a more significant role. These findings underscore the impact of previous negative clinical experiences on the placebo effect and, possibly, on responses to effective treatments.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112207"},"PeriodicalIF":3.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between allostatic load and trouble sleeping in U.S. adults","authors":"Shanshan Yang ,&nbsp;Yujie Ma ,&nbsp;Hang Fu ,&nbsp;Chengzeng Wang ,&nbsp;Yafeng Zhang","doi":"10.1016/j.jpsychores.2025.112206","DOIUrl":"10.1016/j.jpsychores.2025.112206","url":null,"abstract":"<div><h3>Objective</h3><div>This study examined the association between allostatic load and trouble sleeping and assessed whether this relationship varies based on allostatic load score (ALS) criteria.</div></div><div><h3>Methods</h3><div>This cross-sectional survey utilized nationally representative data from the National Health and Nutrition Examination Survey (NHANES). ALS was derived using empirical and clinical criteria based on eight biomarkers reflecting cardiovascular, metabolic, and immune function. Weighted multivariate logistic regression was employed to analyze the association between ALS and trouble sleeping, with subgroup analyses conducted to assess gender-specific differences.</div></div><div><h3>Results</h3><div>Of 5331 participants included in this study, 1485 (29 %) reported trouble sleeping. In multivariate-adjusted logistic regression, higher ALS was associated with increased odds of trouble sleeping (empirical ALS: OR 1.13 [95 % CI 1.07–1.18]; clinical ALS: OR 1.08 [95 % CI 1.04–1.13]). Subgroup analyses confirmed the consistency of this association across genders.</div></div><div><h3>Conclusion</h3><div>This study provides robust evidence of a significant association between ALS and trouble sleeping, supported by observed OR of 1.13 (empirical) and 1.08 (clinical). The consistency of findings across both empirical and clinical ALS underscores the potential role of physiological dysregulation in sleep health, highlighting the need for integrated approaches to stress and sleep management.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"196 ","pages":"Article 112206"},"PeriodicalIF":3.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing labels for persistent physical symptoms: A cross-sectional study among lay participants and healthcare professionals","authors":"Héloïse Lebrun ,&nbsp;Ingrid Zablith ,&nbsp;Jon Stone ,&nbsp;Alexandra Vasilache ,&nbsp;Clément Gouraud ,&nbsp;Agathe Ancellin-Geay ,&nbsp;Alexandra Kachaner ,&nbsp;Brigitte Ranque ,&nbsp;Cédric Lemogne ,&nbsp;Victor Pitron","doi":"10.1016/j.jpsychores.2025.112197","DOIUrl":"10.1016/j.jpsychores.2025.112197","url":null,"abstract":"<div><h3>Context</h3><div>Numerous labels are used to describe physical symptoms that remain for at least several months and cause significant distress (i.e., persistent physical symptoms, PPS). This study aims to assess attitudes associated with various labels among lay participants and healthcare professionals.</div></div><div><h3>Methods</h3><div>Participants recruited via mailing lists of volunteers completed an online questionnaire assessing their views on underlying physical and mental causations for ten diagnostic labels accounting for PPS. Lay participants rated their feelings of offence associated with each label, and healthcare professionals their willingness to take care of a patient diagnosed with each label. Mixed regression models investigated the factors associated with feelings of offence and willingness to care.</div></div><div><h3>Results</h3><div>266 lay participants (mean age: 43; 70 % women) and 126 healthcare professionals (mean age: 42; 69 % women) were included. Labels rated high on perceived mental causation tended to be rated low on physical causation and vice versa in both populations, although this effect was stronger in lay participants. “Long COVID”, “persistent physical symptoms” and “functional symptoms” were rated with higher physical causation by lay participants compared to health professionals (<em>p</em> &lt; 0.001), whereas “somatic symptom disorder” and “psychosomatic” were rated with higher mental causation. Regression models showed that perceived mental causation was associated with feelings of offence in lay participants, while perceived physical causation was associated with less offence. Perceived physical causation was associated with willingness to care among healthcare professionals.</div></div><div><h3>Discussion</h3><div>Some diagnostic labels provoke negative attitudes, both among lay participants and healthcare professionals, probably hindering clinician/patient relationships and treatment.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112197"},"PeriodicalIF":3.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health literacy scale for women with polycystic ovary syndrome (HL-PCO): Instrument development and cross-sectional validation study","authors":"Minhui Guan ,&nbsp;Rong Li ,&nbsp;Guangpeng Wang ,&nbsp;Ziyan Li ,&nbsp;Quan Shen ,&nbsp;Enuo Peng ,&nbsp;Jia Qu ,&nbsp;Jun Lei ,&nbsp;Bing Fu","doi":"10.1016/j.jpsychores.2025.112200","DOIUrl":"10.1016/j.jpsychores.2025.112200","url":null,"abstract":"<div><h3>Background</h3><div>Health literacy is crucial in shaping health outcomes for individuals with polycystic ovary syndrome (PCOS), influencing their disease perceptions, treatment adherence, and self-management behaviors. Women with PCOS often face challenges due to inadequate health literacy, leading to delayed diagnosis and low treatment compliance. However, there is a lack of specific tools to measure health literacy within the context of PCOS, hindering accurate assessments and targeted interventions.</div></div><div><h3>Method</h3><div>To address this gap, a health literacy scale for women with PCOS (HL-PCO) was developed and validated. The initial items were generated through a comprehensive literature review, in-depth interviews, and the Delphi method. A cross-sectional validation study was conducted at a tertiary hospital in Changsha, China, using classical test theory (CTT) and item response theory (IRT) for item selection. Reliability was assessed using Cronbach's α coefficient and split-half reliability, while validity was evaluated through various analyses.</div></div><div><h3>Result</h3><div>The HL-PCO scale retained 17 items across four factors: Acquisition, Understanding, Appraisal, and Application. Confirmatory factor analysis exhibited acceptable goodness-of-fit indices, and the Item Content Validity Index values surpassed 0.833. Robust results were also demonstrated through analyses of convergent validity, discriminant validity, and concurrent validity. The Cronbach's α coefficient for the HL-PCO was 0.930, and the split-half reliability coefficient amounted to 0.836.</div></div><div><h3>Conclusion</h3><div>The refined HL-PCO scale, comprising 17 items across four factors, has been rigorously validated as a reliable instrument. Its implementation has the potential to enhance health literacy assessment and improvement among women with PCOS, facilitating more effective health education interventions and ultimately improving patient outcomes.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112200"},"PeriodicalIF":3.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the causal influence of herpesvirus infections on the risk of depression phenotypes: A Mendelian randomization study","authors":"Yi Li ,&nbsp;Zhenqiu Liu ,&nbsp;Hong Fan ,&nbsp;Sijie Tao ,&nbsp;Haili Wang ,&nbsp;Xin Zhang ,&nbsp;Sheng Wu ,&nbsp;Yiyun Xu ,&nbsp;Tianye Wang ,&nbsp;Ying Yang ,&nbsp;Tiejun Zhang","doi":"10.1016/j.jpsychores.2025.112194","DOIUrl":"10.1016/j.jpsychores.2025.112194","url":null,"abstract":"<div><h3>Objective</h3><div>Previous findings of associations between herpesvirus infections and depression were mixed and did not implicate causality. This study used two-sample Mendelian randomization (MR) to clarify the causal impact of four symptomatic herpesvirus infections (shingles, chicken pox, cold sores, and mononucleosis) on three depression phenotypes, including depressive symptoms (DS), number of episodes with depressed mood (NEDM), and major depressive disorder (MDD).</div></div><div><h3>Methods</h3><div>Eligible SNPs were selected as instrumental variables (IVs). MR estimates were primarily based on the inverse variance weighted (IVW) method. Cochran's Q, MR-Egger intercept tests, and leave-one-out analyses were performed to assess the robustness of the results. False discovery rates (FDR) were calculated to correct the bias of multiple testing. Sensitivity analyses were performed by repeating the above process using IVs meeting a more relaxed threshold.</div></div><div><h3>Results</h3><div>Estimates of the main MR analyses suggested that shingles was associated with an increased risk of DS (IVW β = 0.040, <em>FDR</em> = 0.008) and NEDM (IVW β = 0.056, <em>FDR</em> = 0.003), which was supported by the sensitivity analyses. The effects of chicken pox on DS and NEDM were non-significant in the main analyses, whereas significant in the sensitivity analyses (for DS: IVW β = 0.063, <em>FDR</em> = 0.027; for NEDM: IVW β = 0.151, <em>FDR</em> = 0.039). None of the four herpesvirus infections was linked to MDD.</div></div><div><h3>Conclusion</h3><div>Our findings provide evidence that shingles is causally linked to specific depression phenotypes. Enhancing antiviral treatments and vaccination programs may promote the prevention of depression.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112194"},"PeriodicalIF":3.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health service use among individuals with traumatic brain injury: Exploring the role of social support, employment, and insurance","authors":"Altaf Saadi ,&nbsp;Mario Cruz-Gonzalez ,&nbsp;Lulu Zhang ,&nbsp;Margarita Alegría","doi":"10.1016/j.jpsychores.2025.112195","DOIUrl":"10.1016/j.jpsychores.2025.112195","url":null,"abstract":"<div><h3>Introduction</h3><div>This study assessed 1) differences in mental health service use among those with and without traumatic brain injury (TBI), 2) whether social supports, employment, and insurance moderated the TBI-mental health service use relationship, and 3) racial and ethnic differences in these associations.</div></div><div><h3>Methods</h3><div>In an analytic sample of 1018 participants, we used propensity score matching and inverse probability of treatment weighting to assess differences in both lifetime and past 12-month mental health service use among those with and without TBI. We used a logistic regression model for the moderation analyses.</div></div><div><h3>Results</h3><div>Those with TBI reported greater depressive, anxiety, and PTSD symptoms than those without TBI, as well as higher probability of both lifetime and past 12-month mental health service use. After adjusting for the propensity score, those with TBI were about 10.5 % more likely to use mental health services compared to those without TBI. Higher levels of social support were associated with a three-fold increase in the odds of using mental health services in individuals with TBI. Employment and insurance did not significantly moderate the TBI-mental health service use relationship, but insurance was independently associated with grater odds of both lifetime and past 12-month mental health service use.</div></div><div><h3>Conclusion</h3><div>Greater psychiatric symptoms in individuals with TBI, along with their increased use of mental health services, highlight the need for a multidisciplinary approach to TBI care. Interventions could also target social relationships, as lower social support represents a potential pathway for differences in mental health service use for those with TBI.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112195"},"PeriodicalIF":3.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsychosocial prognostic indicators in Functional Neurological Disorder: A systematic review","authors":"Edwina R. Sekine ,&nbsp;Richard A. Kanaan ,&nbsp;Janine McMillan ,&nbsp;Sarah Oxford ,&nbsp;Ross A. Iles","doi":"10.1016/j.jpsychores.2025.112201","DOIUrl":"10.1016/j.jpsychores.2025.112201","url":null,"abstract":"<div><h3>Background</h3><div>Functional Neurological Disorder (FND) may result in significant disability. Biopsychosocial and contextual factors contributing to health outcomes in FND remain unclear.</div></div><div><h3>Purpose</h3><div>To ascertain the current evidence relating to biopsychosocial and contextual factors of prognostic relevance in adults with FND.</div></div><div><h3>Methods</h3><div>A systematic review was conducted. Studies of adults with FND were included. Methodological quality was assessed using the Joanna Briggs Institute checklist for cohort studies. A best-evidence synthesis approach was applied to consider the quantity and consistency of findings. Outcomes measured were mapped to the biopsychosocial domains of the International Classification of Functioning, Disability and Health framework.</div></div><div><h3>Findings</h3><div>The search yielded 6019 references. Thirty studies (3000 participants) examining 2309 people with FND met inclusion criteria. Ten were deemed high methodological quality and 17 medium quality. Biologically, age was unrelated to outcomes. Psychologically, a history of psychiatric treatment, somatisation and alexithymia were associated with negative outcomes. Socially, there was strong evidence that workforce participation was associated with better outcomes. Seizure frequency and illness duration were characteristics unrelated to outcomes. Factors associated with an individual were examined more often than broader systemic contextual factors.</div></div><div><h3>Conclusions</h3><div>This review summarises existing knowledge around biopsychosocial prognostic indicators of recovery in adults with FND. Workforce participation is associated with better health outcomes in FND. A change in seizure frequency may not translate to participation in life roles. There was limited research investigating the impact of systemic contextual factors. A more consistent approach in this research area would further reveal the true state of phenomena.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112201"},"PeriodicalIF":3.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}