Journal of Psychosomatic Research最新文献

{"title":"Exploring the role of psychedelic-assisted therapy in enhancing spirituality and mystical experiences in patients with life-threatening illnesses: A systematic review","authors":"Ana Esteves Ferreira ,&nbsp;Paulo Reis-Pina","doi":"10.1016/j.jpsychores.2024.112020","DOIUrl":"10.1016/j.jpsychores.2024.112020","url":null,"abstract":"<div><h3>Introduction</h3><div>Psychedelic-Assisted Therapy (PAT) is gaining traction as a novel approach to addressing the psychological and existential distress experienced by patients.</div></div><div><h3>Objectives</h3><div>This systematic review aimed to investigate the impact of PAT on spirituality, mystical experiences, and spiritual well-being (SpWB) in patients with life-threatening, incurable, or terminal illnesses.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted across PubMed, Web of Science, and Cochrane databases to identify relevant studies published between 2013 and 2023. The study population comprised patients diagnosed with life-threatening illnesses. Various forms of PAT, encompassing both typical and atypical psychedelic substances, were considered as interventions, with no specific comparators outlined. The primary outcomes of interest included spirituality, mystical experience, and SpWB. Risk of bias assessment was performed using Cochrane's tools.</div></div><div><h3>Results</h3><div>Six studies with a high risk of bias were included in the review, all conducted in the United States of America, involving 140 patients, the majority of whom had cancer (99 %). PAT, especially with psilocybin, demonstrated significant enhancements in spirituality, mystical experiences, and SpWB. Notably, SpWB showed improvements in all studies which assessed this spiritual outcome following PAT. Mystical experiences were correlated with improvements in spirituality in one study.</div></div><div><h3>Conclusions</h3><div>This systematic review underscores the potential of PAT to address unmet spiritual needs and enhance SpWB in patients with life-threatening illnesses. However, further research is needed to elucidate the mechanisms underlying these therapeutic effects. Rigorous evaluation of healthcare practitioners' role in guiding patients through PAT protocols is essential to ensure safe and effective implementation in palliative care settings.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112020"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-occurrence of mental distress and insomnia associates with more severe musculoskeletal pain – Northern Finland Birth Cohort 1966 study","authors":"Joel Hoffrén ,&nbsp;Juhani Määttä ,&nbsp;Jaro Karppinen ,&nbsp;Petteri Oura ,&nbsp;Eveliina Heikkala","doi":"10.1016/j.jpsychores.2024.112026","DOIUrl":"10.1016/j.jpsychores.2024.112026","url":null,"abstract":"<div><h3>Objective</h3><div>This cross-sectional study demonstrates the differences in the dimensions of musculoskeletal (MSK) pain between participants with mental distress and/or insomnia among general population with MSK pain within the past 12 months.</div></div><div><h3>Methods</h3><div>Participants of Northern Finland Birth Cohort 1966 (NFBC1966) were studied (<em>n</em> = 4316). They were divided into groups based on their mental distress and insomnia status (co-occurring mental distress and insomnia [CMI], isolated mental distress [M] and insomnia [I], and absence of both [AMI]). The AMI group was used as a reference for the main analyses. The dimensions of MSK pain included frequency, bothersomeness (Numerical Rating Scale [NRS] 0–10), intensity of pain (NRS), and number of pain sites (1–8). Multinomial and general linear regression analyses were used to study the associations, and adjustments were made for sex, education, number of somatic diseases, and physical activity.</div></div><div><h3>Results</h3><div>The CMI group was associated with more severe pain in every dimension when contrasted to all other groups (daily pain adjusted OR 5.08, 95 % CI 3.43–7.51; bothersomeness adjusted β 1.7, 95 % CI 1.5–2.0; intensity adjusted β 1.4, 95 % CI 1.2–1.7; number of pain sites adjusted β 1.2, 95 % CI 1.0–1.4). Compared to AMI, I and M groups also had relationships with all pain dimensions, but with lower magnitude compared to the CMI group.</div></div><div><h3>Conclusions</h3><div>The results suggest that insomnia and mental distress co-exist with more severe MSK pain, and when co-occurring, MSK pain severity tends to increase. Therefore, contemplating insomnia and mental distress are important to consider when comprehensively evaluating MSK pain symptoms.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112026"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Side effects following administration of open-placebos: A randomized controlled trial","authors":"Kate Faasse ,&nbsp;Chiara Gasteiger ,&nbsp;Anna Borgmann ,&nbsp;Jane Choi ,&nbsp;Keith J. Petrie","doi":"10.1016/j.jpsychores.2024.112028","DOIUrl":"10.1016/j.jpsychores.2024.112028","url":null,"abstract":"<div><h3>Objective</h3><div>To assess whether individuals reported more side effects and decreased mood after receiving an open-label placebo compared to a control group that received no treatment.</div></div><div><h3>Methods</h3><div>We randomized participants to receive an open placebo or no treatment. The primary outcome was reported side effects on the Side effect Attribution Scale (SEAS) at 15 min and at 24-h. We also examined negative mood as a secondary outcome and whether psychological variables influenced symptom reporting.</div></div><div><h3>Results</h3><div>At both 15 min and 24-h, participants who took the open-placebo reported a significantly higher number of symptoms (<em>M</em> = 2.03, <em>SE</em> = 0.42) than the control group (<em>M</em> = 1.14, <em>SE</em> = 0.20). Across both time points, participants who took the placebo also reported significantly greater negative mood (<em>M</em> = 6.28, <em>SE</em> = 0.27) than the control group (<em>M</em> = 5.59, <em>SE</em> = 0.16). There was no significant group by time interaction for symptoms or mood (<em>ps</em> &gt; 0.32). Symptom reporting after taking the placebo was not correlated with baseline anxiety, perceived sensitivity to medicines, or modern health worries at either 15 min or 24-h (<em>p</em>s &gt; 0.11).</div></div><div><h3>Conclusions</h3><div>The act of taking a treatment, even knowing it is a placebo, resulted in an increase in symptoms and negative mood reported immediately following pill-taking and 24 h later. These findings have implications for the use of open-label placebos and the prescription of medicines in general, as they suggest the process of taking a medicine may result in increased symptoms and an increase in negative mood.</div></div><div><h3>Trial registration</h3><div>The trial was preregistered at the Australian New Zealand Clinical Trials Registry (12622001570774).</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112028"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and factor associated with depressive symptoms in patients with osteoarthritis: A cross-sectional study","authors":"Zehua Wang ,&nbsp;Xingjia Mao ,&nbsp;Zijian Guo ,&nbsp;Hui Huang ,&nbsp;Guoyu Che ,&nbsp;Tao Li","doi":"10.1016/j.jpsychores.2024.112018","DOIUrl":"10.1016/j.jpsychores.2024.112018","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is a prevalent degenerative joint condition. Among OA patients, depressive symptoms are the most frequent psychiatric disorder, negatively impacting both prognosis and quality of life. This study analyzed the independent factors associated with the development of depressive symptoms in patients with OA and constructed a nomogram to assess the risk of developing depressive symptoms.</div></div><div><h3>Methods</h3><div>An analysis was conducted on data from 2093 OA patients in the NHANES database, covering 2007 to 2014. A training set and a validation set were randomly assigned to participants in a 7:3 ratio. Variables significantly associated with depressive symptoms in OA patients were identified using the least absolute shrinkage and selection operator (LASSO) and multivariable logistic regression analyses and nomograms were constructed. Its performance and clinical relevance were assessed using receiver operating characteristic (ROC) curves, C indices, calibration curves, and decision curves.</div></div><div><h3>Results</h3><div>Among the 2093 OA patients, 357 were assessed as having depressive symptoms. There are eight independent relevant factors, which are gender, age, poverty-to-income ratio (PIR), race, educational attainment, smoking status, diabetes, and sleep disorder. The AUC values of the training and validation sets were 0.718 (95 %CI: 0.683–0.752) and 0.733 (95 %CI: 0.678–0.788). Calibration and decision curve analyses showed that this nomogram exhibits high accuracy, good discrimination, and potential clinical benefits on both training and validation sets.</div></div><div><h3>Conclusions</h3><div>We screened to obtain factors associated with depressive symptoms in patients with OA. Dynamic nomograms enable the combination of individual relevant factors for better assessing and managing high-risk OA groups.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112018"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent pain in older age: A cross-sectional network analysis of biopsychosocial-existential interactions","authors":"Nadezhda Golovchanova ,&nbsp;Xiang Zhao ,&nbsp;Ida Flink ,&nbsp;Christiana Owiredua ,&nbsp;Katja Boersma","doi":"10.1016/j.jpsychores.2024.112016","DOIUrl":"10.1016/j.jpsychores.2024.112016","url":null,"abstract":"<div><h3>Objective</h3><div>Chronic pain is a prevalent condition in older adults, associated with substantial distress. For many older people, chronic pain interferes with their daily life which is reflected in various life domains. This study aimed to investigate whether interactions among self-reported indicators of biological, psychological, social, and existential life domains differ for older adults with no pain, with non-interfering pain, and with interfering pain.</div></div><div><h3>Method</h3><div>The study was based on the cross-sectional 65+ and Safe Study data (<em>N</em> = 622; age range 64–106 years; 60.6 % women). Network analysis was used to assess the inter-variable associations for older adults reporting no pain, non-interfering pain, and interfering pain separately. Network visualization and centrality tests were performed. Permutation-based analyses were conducted to investigate the connections among variables in three subgroups.</div></div><div><h3>Results</h3><div>We identified a structural difference between the networks of older adults with no pain and interfering pain, suggesting differences in connectivity among the life domains. The strength centrality metrics showed the central role of presence of meaning in the networks of older adults with no pain and with non-interfering pain, while for older adults with interfering pain, anxiety appeared to be dominant.</div></div><div><h3>Conclusion</h3><div>The findings illuminated that anxiety regulation and meaning-enhancement are potentially important intervention targets for older adults with recurrent pain. Overall, the study highlighted the value of a holistic biopsychosocial-existential approach for understanding and managing pain in older adults.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112016"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic evidence of the causal relationships between psychiatric disorders and cardiovascular diseases","authors":"Yanchao Wen ,&nbsp;Xingyu Wang ,&nbsp;Liufei Deng ,&nbsp;Guiming Zhu ,&nbsp;Xinyu Si ,&nbsp;Xue Gao ,&nbsp;Xiangfeng Lu ,&nbsp;Tong Wang","doi":"10.1016/j.jpsychores.2024.112029","DOIUrl":"10.1016/j.jpsychores.2024.112029","url":null,"abstract":"<div><h3>Objective</h3><div>Our primary objective is to investigate the causal relationships between 12 psychiatric disorders (PDs) and atrial fibrillation (AF), coronary artery disease (CAD), myocardial infarction (MI), and heart failure (HF).</div></div><div><h3>Methods</h3><div>Firstly, we used linkage disequilibrium score regression to calculate the genetic correlations between 12 PDs and 4 cardiovascular diseases (CVDs). Subsequently, we performed two-sample and bidirectional Mendelian randomization (MR) analyses of phenotypes with significant genetic correlations to explore the causal relationships between PDs and CVDs. Inverse variance weighted with modified weights (MW-IVW), Robust Adjusted Profile Score, Inverse Variance Weighted, weighted median and weighted mode were used to evaluate causal effects, with MW-IVW being the main analysis method. And to validate the MR results, we conducted the replicate analyses using data from the FinnGen database.</div></div><div><h3>Results</h3><div>Conducting MR analyses in phenotypes with significant genetic correlations, we identified bidirectional causal relationships between depression (DEP) and MI (DEP as exposure: OR = 1.1324, 95 % confidence interval (CI): 1.0984–1.1663, <em>P</em> &lt; 0.0001; MI as exposure: OR = 1.0268, 95 % CI: 1.0160–1.0375, <em>P</em> &lt; 0.0001). Similar relationships were observed in Attention Deficit/Hyperactivity Disorder (ADHD) and HF (ADHD as exposure: OR = 1.0270, 95 % CI: 1.0144–1.0395, <em>P</em> &lt; 0.0001; HF as exposure: OR = 1.0980, 95 % CI: 1.0502–1.1458, <em>P</em> &lt; 0.0001).</div></div><div><h3>Conclusions</h3><div>In our study, we conducted the comprehensive analyses between 12 PDs and CVDs. By bidirectional MR analysis, we observed significant causal relationships between MI and DEP, HF and ADHD. These findings suggest possible complex causal relationships between PDs and CVDs.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112029"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction of chronic diseases and levels of mastery on the course of depression","authors":"Delphine A. Ambe ,&nbsp;Richard C. Oude Voshaar ,&nbsp;Radboud M. Marijnissen ,&nbsp;Heidi de Kam ,&nbsp;Nathaly Rius-Ottenheim ,&nbsp;Almar A.L. Kok ,&nbsp;Didi Rhebergen","doi":"10.1016/j.jpsychores.2024.112000","DOIUrl":"10.1016/j.jpsychores.2024.112000","url":null,"abstract":"<div><h3>Background</h3><div>Chronic diseases may negatively interfere with the course of depression. Our aim was to examine whether the association between chronic disease and course of depression is moderated by mastery.</div></div><div><h3>Method</h3><div><em>N</em> = 1146 persons, aged 18–88, with depressive disorder according to DSM-IV criteria were followed for two years. Outcomes were change in depression severity (change in IDS-SR) (<em>n</em> = 945), chronic course (life chart interview) (<em>n</em> = 971), depression at follow-up (DSM-diagnosis) (n = 971), and time to remission (life chart interview) (<em>n</em> = 799). Predictors were number of chronic somatic diseases and mastery. Regression models (linear, logistic and Cox) were used, adjusted for depression severity, sociodemographics, loneliness, smoking and alcohol use. Next, an interaction term (chronic diseases*mastery) was added to the models.</div></div><div><h3>Results</h3><div>We only found significant interaction between mastery and chronic diseases (<em>p</em> = 0.02), when outcome was defined as change in depression severity. In analyses, stratified for level of mastery, chronic diseases were significantly associated with chronic course in persons with moderate (B = 1.03; <em>p</em> = 0.03) and high (B = 1.10; <em>p</em> = 0.02) mastery levels. In unstratified analyses, mastery was associated with both chronic course (B = -0.18, p = 0.03) and time to remission (B = 1.03; <em>p</em> &lt; 0.001). Chronic diseases did not reach significance in three outcomes.</div></div><div><h3>Conclusion</h3><div>While impact of chronic diseases on depression trajectories was less consistent than expected, when present, this association was moderated by mastery, suggesting that persons with higher levels of mastery may have difficulties coping with somatic illnesses. In clinical practice, attention to the impact of somatic diseases and coping strategies, in persons with higher levels of mastery, is warranted.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112000"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to a healthy sleep pattern and the risk of kidney stone disease: A prospective study of UK biobank","authors":"Han Cong ,&nbsp;Zhibiao Li ,&nbsp;Jiahao Zhang ,&nbsp;Zeyao Xu ,&nbsp;Zhicheng Tang ,&nbsp;Yuxin Qian ,&nbsp;Juan Wang ,&nbsp;Haoliang Wu ,&nbsp;Hanxiong Zheng ,&nbsp;Zhaohui He ,&nbsp;Fucai Tang","doi":"10.1016/j.jpsychores.2024.111999","DOIUrl":"10.1016/j.jpsychores.2024.111999","url":null,"abstract":"<div><h3>Purpose</h3><div>This research seeks to assess the connection between healthy sleep patterns and the occurrence of kidney stone disease (KSD) by analyzing data obtained from a large-scale cohort study.</div></div><div><h3>Methods</h3><div>We examined 313,870 initial participants without KSD from the UK Biobank. Five healthy sleep factors were assessed: no frequent excessive daytime sleepiness, early chronotype, no snoring, sleeping 7–8 h daily, and never or rarely experiencing insomnia at baseline. A healthy sleep score between 0 and 5 was assigned to participants according to these criteria. We utilized Cox proportional hazards models to calculate hazard ratios (HR) and 95 % confidence intervals (CI) between a healthy sleep score and the occurrence of KSD.</div></div><div><h3>Results</h3><div>During the follow-up period, 3818 new cases of KSD were recorded. After comprehensive adjustments, every 1-point rise in the healthy sleep score was associated with an HR of 0.93 (95 % CI: 0.90–0.96). Additionally, individuals with a healthy sleep score of 5 had a 20 % lower risk of KSD compared to those with scores between 0 and 2.</div></div><div><h3>Conclusions</h3><div>Our study results indicate that adhering to a healthy sleep pattern can reduce the risk of KSD.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 111999"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antenatal socioeconomic status of childhood family and the risk of pain spreading (ROPS) in early and mid-adulthood - a descriptive study from the northern Finland birth cohort 1966","authors":"Eveliina Heikkala ,&nbsp;Ina Rissanen ,&nbsp;Christophe Tanguay-Sabourin ,&nbsp;Etienne Vachon-Presseau ,&nbsp;Jeremy Rui Chang ,&nbsp;Arnold Yu Lok Wong ,&nbsp;Jaro Karppinen ,&nbsp;Petteri Oura","doi":"10.1016/j.jpsychores.2024.112014","DOIUrl":"10.1016/j.jpsychores.2024.112014","url":null,"abstract":"<div><h3>Objective</h3><div>The Risk of Pain Spreading (ROPS) is a six-item tool capturing key data-driven prognostic factors for chronic pain and its spreading. Higher values on the ROPS indicate a higher risk. Early factors potentially associated with the ROPS are unknown. We aimed to examine the associations between antenatal socioeconomic status of childhood family (antenatal SES) and ROPS at ages 31 and 46 years.</div></div><div><h3>Methods</h3><div>The study was based on the Northern Finland Birth Cohort 1966 and previously formulated latent clusters of antenatal family SES: Highest status (the reference), Small, Larger, Average wealth, and Rural families. The ROPS ranged from zero (the reference) to two or more points out of six. A multinomial regression model was used to identify antenatal SES clusters associated with ROPS.</div></div><div><h3>Results</h3><div>At 31 years (<em>n</em> = 8252), only the Larger families cluster was associated with having accumulated points (two or more) (Odds ratio [OR]: 1.46, 95 % Confidence Interval [CI]: 1.14–1.87) on the ROPS compared to the Highest status families cluster. Corresponding finding was observed at 46 years (<em>n</em> = 6245), but the Small families and Average wealth families clusters were also associated with this outcome. The association of Larger families cluster was, however, the strongest (OR 1.48, 95 % CI 1.16–1.89).</div></div><div><h3>Conclusions</h3><div>Offspring born into families with ≥5 members are likely to accumulate higher sums of key data-driven prognostic factors for worse pain across the life course until middle age. In future, associations between antenatal SES and pain would be important to be examined in a light of the ROPS.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112014"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The myth of a cancer-specific temperament: An analysis of affective temperament in cancer patients","authors":"Elisabeth L. Zeilinger ,&nbsp;Matthias Knefel ,&nbsp;Andreas Erfurth ,&nbsp;Denise Andrzejewski ,&nbsp;Otto Lesch ,&nbsp;Caterina Sturtzel ,&nbsp;Matthias Unseld ,&nbsp;Simone Lubowitzki ,&nbsp;Rupert Bartsch ,&nbsp;Thorsten Fuereder ,&nbsp;Ulrich Jäger ,&nbsp;Barbara Kiesewetter ,&nbsp;Maria T. Krauth ,&nbsp;Gerald Prager ,&nbsp;Markus Raderer ,&nbsp;Philipp B. Staber ,&nbsp;Peter Valent ,&nbsp;Alexander Gaiger","doi":"10.1016/j.jpsychores.2024.112015","DOIUrl":"10.1016/j.jpsychores.2024.112015","url":null,"abstract":"<div><h3>Objective</h3><div>We investigate the prevalence of five affective temperaments (depressive, cyclothymic, hyperthymic, irritable, and anxious) in a large sample of cancer patients and associations of temperament with cancer site as well as the impact of temperament on overall survival of cancer patients.</div></div><div><h3>Methods</h3><div>Data for this prospective cohort study was collected in the outpatient clinic of a large cancer center. We used the <em>Temperament Evaluation in Memphis, Pisa and San Diego – Münster Version</em> (TEMPS-M) and recorded patient data. The sample consisted of 2531 patients with seven different cancer/disease-sites. Kruskal-Wallis tests and pairwise Wilcoxon rank sum test were applied to compare temperament scales across disease groups. For analyzing survival time, we used a Cox regression model and log-rank tests.</div></div><div><h3>Results</h3><div>The five affective temperaments were similarly distributed across all disease groups. We found higher levels of depressive, cyclothymic, and anxious temperament in women and higher levels of hyperthymic and irritable temperament in men. Temperament was mostly not predictive of survival, with only two significant results in the regression models. Here, cyclothymic temperament was predictive of mortality in the full sample and hyperthymic temperament was predictive of the pancreatic cancer subsample.</div></div><div><h3>Conclusions</h3><div>Our study provides evidence to debunk the myth of a cancer-specific temperament. Neither did we find a temperament profile that was different from studies with general population samples, nor were there any disease-specific profiles differentiating various types of cancer.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112015"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}