Journal of Psychosomatic Research最新文献

{"title":"Progressive muscle relaxation technique improves sleep quality and mental health: A systematic review and meta-analysis of randomized controlled trials","authors":"Kenzo Ogasawara Donato ,&nbsp;Luciano Falcão ,&nbsp;André Nishizima ,&nbsp;Adriane Santos Oliveira ,&nbsp;João Victor Gonzalez ,&nbsp;Natália Napoli Ribeiro ,&nbsp;Caio Abbud ,&nbsp;Gabriel Augustus Braga ,&nbsp;Gustavo Garrido ,&nbsp;Akio Ogasawara Donato ,&nbsp;Alan Eckeli ,&nbsp;Miguel Meira e Cruz ,&nbsp;Cristina Salles","doi":"10.1016/j.jpsychores.2026.112563","DOIUrl":"10.1016/j.jpsychores.2026.112563","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the effectiveness of Progressive Muscle Relaxation (PMR) in improving sleep quality and mental health in adults.</div></div><div><h3>Methods</h3><div>This systematic review and meta-analysis followed PRISMA 2020 guidelines. Randomized controlled trials assessing PMR's effect on sleep quality were included. Databases searched included PubMed, Embase, Cochrane and Web of Science. Outcomes included sleep quality, anxiety, and quality of life. Effect sizes were pooled using Standard Mean Difference (SMD) or Mean Difference (MD), and heterogeneity was assessed with the I². Subgroup analysis was performed according to the duration of PMR intervention in weeks. Statistical analysis was conducted with Rstudio version 4.4.1.</div></div><div><h3>Results</h3><div>Thirty-one RCTs involving 2277 patients were included. PMR significantly improved sleep quality compared to the control group, with a SMD of −1.74 (95% CI -2.14 to −1.34; I² = 92.1%). Pittsburgh Sleep Quality Index (PSQI) showed a mean difference of −3.79 (95% CI -4.78 to −2.79; I² = 94.2%), also indicating statistical significance. Furthermore, PMR significantly reduced anxiety, with an SMD of −1.11 (95% CI -1.69 to −0.53; I² = 85%), and improved quality of life, which had an SMD of 1.32 (95% CI 0.53 to 2.12; I² = 83%). Subgroup analysis by PMR duration showed effectiveness across all intervention periods. Despite the high heterogeneity, sensitivity analyses confirmed consistent beneficial effects across all outcomes.</div></div><div><h3>Conclusion</h3><div>PMR is a non-pharmacological intervention that improves sleep quality and mental health in adults, with effects that vary across populations and settings.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"203 ","pages":"Article 112563"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal co-occurrence and shared exposure profiles of adolescent depressive disorders and asthma worldwide and in China (GBD 2021, 1990–2021): an ecological study with bidirectional two-sample Mendelian randomization","authors":"Xiaoxi Liu ,&nbsp;Luhua Zhao ,&nbsp;Wei Wu ,&nbsp;Yonggui Yuan ,&nbsp;Zhaojun Yan","doi":"10.1016/j.jpsychores.2026.112542","DOIUrl":"10.1016/j.jpsychores.2026.112542","url":null,"abstract":"<div><h3>Background</h3><div>Depressive disorders and asthma frequently co-occur in adolescence, but global co-patterning and shared population-level risk signals remain unclear.</div></div><div><h3>Methods</h3><div>Using Global Burden of Disease (GBD) 2021 estimates for ages 10–19 years (1990–2021), we characterized global and China-specific trends and sex disparities in incidence, prevalence, and disability-adjusted life years (DALYs) using joinpoint regression. We constructed a 2021 incidence-quartile co-occurrence typology, estimated typology-stratified coupling (Spearman rank correlation coefficient, ρ) using pooled country–year observations (1990/2000/2011/2021), prioritized shared summary exposure value (SEV) correlates using Shapley additive explanations (SHAP)-informed multiclass random forests and negative binomial models, and evaluated bidirectional genetic directionality using two-sample Mendelian randomization (MR).</div></div><div><h3>Results</h3><div>The burden of depressive disorders remained broadly stable but started to increase from 2019 onward, with persistent female excess. Asthma DALY rates declined overall, whereas incidence and prevalence were largely stable globally, with modest recent increases in North America. In 2021, typology membership showed marked income gradients and positive within-typology coupling (ρ = 0.408–0.925). Ambient particulate matter ≤2.5 μm (PM2.5) and household air pollution from solid fuels were consistently prioritized as shared ecological correlates and showed marked socioeconomic gradients. Two-sample MR supported a modest depressive disorders-to-asthma signal (inverse-variance weighted (IVW) odds ratio (OR) = 1.18, 95% confidence interval (CI) 1.02–1.36), whereas reverse-direction estimates were weaker and more heterogeneous.</div></div><div><h3>Conclusions</h3><div>Adolescent depressive disorders and asthma exhibit divergent long-term trajectories but cluster into income-patterned co-occurrence typologies with shared ecological risk signals. These findings reflect population-level correlates and do not directly estimate intervention or policy effects.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"203 ","pages":"Article 112542"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of optimism training on atherosclerotic biomarkers in coronary artery disease: A randomized controlled trial","authors":"Masoumeh Sadeghi ,&nbsp;Nasim Kakavand ,&nbsp;Mohammadesmaeil Aramesh Boroujeni ,&nbsp;Hamidreza Roohafza ,&nbsp;Narges Mohammadi ,&nbsp;Alireza Aghayousefi ,&nbsp;Mohammad Kermani-Alghoraishi","doi":"10.1016/j.jpsychores.2026.112529","DOIUrl":"10.1016/j.jpsychores.2026.112529","url":null,"abstract":"<div><h3>Background</h3><div>Atherosclerosis, a chronic inflammatory condition, is the leading cause of cardiovascular disease (CVD) morbidity and mortality worldwide. Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are key mediators of leukocyte-endothelial interactions and drivers of atherosclerotic progression. While optimism-based psychological interventions have demonstrated beneficial effects on several inflammatory biomarkers, their impact on adhesion molecules remains unclear.</div></div><div><h3>Methods</h3><div>We conducted a randomized controlled trial involving 61 outpatients with stable coronary artery disease (CAD) who had completed cardiac rehabilitation. Participants were randomized to an eight-week group-based optimism training program or an attention-matched cardiac education control. Changes in plasma ICAM-1 and VCAM-1 levels were measured by ELISA at baseline and 16 weeks as well as psychological measures of depression, anxiety, and negative affect.</div></div><div><h3>Results</h3><div>The optimism intervention significantly improved psychological outcomes, with reductions in depression, anxiety, and negative affect compared to controls (<em>p</em> &lt; 0.05). While post-intervention adhesion molecule levels showed significant between-group differences, effect sizes were small and inconclusive, with no significant group-by-time interactions. Correlation analyses found no significant link between changes in optimism and adhesion molecule levels.</div></div><div><h3>Conclusions</h3><div>Optimism-based interventions yield meaningful psychological benefits in patients with CAD, though changes in adhesion molecule biomarkers were small and uncertain. High variability in biomarker levels and limited detectable effect sizes highlight the need for larger studies to clarify the clinical significance of these findings.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"203 ","pages":"Article 112529"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146081106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between sleep trajectories throughout pregnancy and postpartum pain in individuals with overweight or obesity: A prospective cohort study","authors":"Marquis S. Hawkins ,&nbsp;Danielle A.N. Chapa ,&nbsp;Grace Lim ,&nbsp;Andrea B. Goldschmidt ,&nbsp;Michelle L. Meyer ,&nbsp;Forgive Avorgbedor ,&nbsp;Michele D. Levine","doi":"10.1016/j.jpsychores.2026.112535","DOIUrl":"10.1016/j.jpsychores.2026.112535","url":null,"abstract":"<div><div><u>Background</u>: Pain after childbirth impacts maternal and infant outcomes. While sleep affects pain in adult populations, research during the perinatal period is limited. This study examines the association between sleep quality and duration before delivery and throughout pregnancy with pain during postpartum hospitalization. <u>Methods</u>: This analysis included 118 pregnant individuals with a pre-pregnancy BMI ≥ 25 kg/m². Group-based trajectory models identified patterns of self-reported sleep quality and duration at six prenatal visits. Pain was assessed every 8 h during the three-day postpartum hospitalization using a 0–10 numeric rating scale. The Area Under the Curve (AUC) for these assessments reflects cumulative pain burden; log-transformed AUC, exponentiated for interpretation. Linear regression analyzed the relationship between sleep (trajectories and before pregnancy) and cumulative pain burden. <u>Results</u>: Two trajectories for sleep quality and two for sleep duration were identified. The “Consistently poor” group showed increasing PSQI scores from 9 to 11, while the “Late worsening” group's scores increased from 4 to 6. The “Late decreasing” duration group consistently slept 6–7 h, while the “Consistently short” group maintained 5–6 h nightly. No statistically significant associations were found between sleep quality (expβ = 0.70, 95% CI: 0.45 to 1.10) or sleep duration trajectories (expβ = 0.68, 95% CI: 0.41 to 1.13) throughout pregnancy and cumulative pain burden. <u>Conclusions</u>: Sleep quality and duration changes during pregnancy were not associated with postpartum pain in this cohort. Future research should explore sleep's impact on pain later in the postpartum period when chronic pain may develop.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"203 ","pages":"Article 112535"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146015594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom expectations as a clinical target in somatic symptom disorder: Cross-sectional evidence from the SOMA.SSD study","authors":"Stefanie Hahn ,&nbsp;Franz Pauls ,&nbsp;Henrike Wittenbecher ,&nbsp;Kerstin Maehder ,&nbsp;Bernd Löwe ,&nbsp;Kristina Blankenburg ,&nbsp;Anne Toussaint ,&nbsp;Yvonne Nestoriuc","doi":"10.1016/j.jpsychores.2026.112546","DOIUrl":"10.1016/j.jpsychores.2026.112546","url":null,"abstract":"<div><h3>Background</h3><div>Symptom expectations influence symptom severity in patients with pain disorders through nocebo and placebo mechanisms. Similar associations have been suggested for patients with somatic symptom disorder (SSD). While evidence underlines the significance of expectations for symptom experience, yet little is known about the nature of these expectations in SSD or about the psychological and biological factors that shape them.</div></div><div><h3>Methods</h3><div>Patients diagnosed with SSD participated in a structured on-site assessment at the psychosomatic outpatient clinic of the University Medical Center Hamburg-Eppendorf. The assessment included standardized questionnaires, a physical examination, and a clinical interview. Descriptive statistics and multiple regression analyses were conducted on symptom impairment expectation and symptom-specific expectation measures.</div></div><div><h3>Results</h3><div>A total of <em>N</em> = 241 patients participated in this study. The majority of patients (66.8% female, mean age = 44.5 years) reported negative short-term symptom expectations (54%). Patients with more negative expectations also reported greater somatic symptom severity, higher depression and anxiety severity, increased symptom-related distress, and higher symptom-related disability. Symptom-related disability was found to have the largest association with symptom impairment expectations (short-term: β = 0.46, <em>p</em> &lt; 0.001, long-term: β = 0.26, <em>p</em> &lt; 0.001), whereas symptom severity was associated with symptom-specific expectations the most (β = 0.66, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Negative symptom expectations are associated with elevated psychological burden in patients with SSD, indicating a clinically relevant subgroup that may benefit from expectation-focused interventions.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"203 ","pages":"Article 112546"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146015595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a personality-based psychoeducational booklet aligned with openness-related characteristics on health-related quality of life in pulmonary rehabilitation: A randomized controlled trial","authors":"Sébastien Kuss ,&nbsp;Nelly Héraud ,&nbsp;François Alexandre ,&nbsp;Espérance Moine ,&nbsp;Benjamin Eichenauer ,&nbsp;Lorie Thomas ,&nbsp;Laura Brandon ,&nbsp;Perrine Sanchez ,&nbsp;Brice Canada","doi":"10.1016/j.jpsychores.2026.112560","DOIUrl":"10.1016/j.jpsychores.2026.112560","url":null,"abstract":"<div><h3>Objectives</h3><div>Five-Factor Model personality traits differ in their associations with health outcomes after therapeutic interventions. In the specific context of inpatient pulmonary rehabilitation (PR), higher levels of openness to experience have been associated with greater risk of non-response in terms of health-related quality of life. This study aimed to examine the effect of psychoeducational information aligned with characteristics associated with higher levels of openness on health-related quality of life in inpatient PR.</div></div><div><h3>Methods</h3><div>A single-blind multicenter randomized controlled trial was conducted in the context of inpatient PR with 136 participants diagnosed with chronic respiratory disease. Participants in the intervention group received an openness-based psychoeducational booklet, while the control group received a neutral booklet. Health-related quality of life was measured at baseline and at PR completion using the St George's Respiratory Questionnaire (SGRQ), which includes a total score and three sub-dimensions (i.e., <em>symptoms</em>, <em>activities</em>, <em>impact</em>). Mixed ANOVA was conducted to investigate group differences in changes in health-related quality of life.</div></div><div><h3>Results</h3><div>While no significant difference in SGRQ total score was found between the groups, the intervention group exhibited significantly greater improvement in the SGRQ “<em>activities</em>” sub-dimension compared to the control group (<em>η</em>²ₚ = 0.04, <em>p</em> &lt; .05). Exploratory analyses showed that this effect was not moderated by participants' level of openness.</div></div><div><h3>Conclusions</h3><div>This study highlights that an openness-based intervention can improve a sub-dimension of health-related quality of life in inpatient PR and offers valuable insights for the conception of future personality-based interventions in PR.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"203 ","pages":"Article 112560"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Report on the 12th annual EAPM conference in Munich, Germany","authors":"Peter Henningsen ,&nbsp;Michael Sharpe","doi":"10.1016/j.jpsychores.2026.112578","DOIUrl":"10.1016/j.jpsychores.2026.112578","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"203 ","pages":"Article 112578"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146167672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse childhood experiences and cancer pain: A national cross-sectional analysis of survivors' pain outcomes","authors":"Fares Qeadan,&nbsp;Max Moroz,&nbsp;Benjamin Tingey","doi":"10.1016/j.jpsychores.2026.112556","DOIUrl":"10.1016/j.jpsychores.2026.112556","url":null,"abstract":"<div><h3>Context</h3><div>Adverse childhood experiences (ACEs) are linked to long-term health impacts, including increased pain prevalence. However, the relationship between ACEs and pain presence and pain control among cancer survivors is not well understood.</div></div><div><h3>Objectives</h3><div>To examine the association between cumulative ACE exposure and (1) the presence of cancer-related physical pain and (2) the current perceived adequacy of pain control among adult survivors in the United States.</div></div><div><h3>Methods</h3><div>Behavioral Risk Factor Surveillance-System (BRFSS) data from 2019 to 2023 were analyzed, including 19,046 adults with self-reported cancer diagnoses and complete ACE data. Modified Poisson regression estimated crude and adjusted prevalence ratios (PRs, aPRs) for pain presence and pain control. Subgroup analyses were stratified by cancer type. Random forest models assessed ACE domain importance.</div></div><div><h3>Results</h3><div>A clear dose-response was found between ACEs and pain presence. Each additional ACE was associated with a 6% higher prevalence of pain (aPR = 1.058; 95% CI: 1.005–1.113). Pain prevalence increased from 7.2% (0 ACEs) to 25.4% (8 ACEs). ACEs were not significantly associated with pain control in adjusted models (aPR = 0.994; 95% CI: 0.973–1.016). Stratified analyses revealed stronger associations in certain cancer types, particularly leukemia, pharyngeal, and bladder. Random forest models identified household dysfunction and emotional/sexual abuse as key predictors of pain presence and pain control.</div></div><div><h3>Conclusion</h3><div>ACEs are significantly associated with pain presence, but not with perceived pain control. These findings underscore the need for ACE-informed screening and trauma-informed care in survivorship planning to address cancer pain.</div></div><div><h3>Key message</h3><div>Cancer survivors with adverse childhood experiences report higher prevalence of pain, but not significantly lower prevalence of adequate pain control. This study emphasizes the need for trauma-informed care to address the lasting influence of early adversity on cancer-related symptom burden.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"203 ","pages":"Article 112556"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146025726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective cross-sectional study comparing health-related quality-of-life in females with lipoedema and bilateral leg lymphoedema","authors":"Rhiannon Stellmaker ,&nbsp;Belinda Thompson ,&nbsp;Helen Mackie ,&nbsp;Vincent Singh Paramanandam ,&nbsp;Kerry A. Sherman ,&nbsp;Louise Koelmeyer","doi":"10.1016/j.jpsychores.2026.112562","DOIUrl":"10.1016/j.jpsychores.2026.112562","url":null,"abstract":"<div><h3>Background</h3><div>Lipoedema is a condition of abnormal accumulation of painful adipose tissue, usually in the lower body of women. The disproportionate subcutaneous adipose tissue may negatively impact health-related quality of life (HRQoL). There are currently no patient reported outcome measures (PROM) specifically designed to assess the HRQoL in individuals with lipoedema. The aim of this study was to compare scores on validated lower limb lymphoedema PROMs between females with lipoedema and lymphoedema.</div></div><div><h3>Methods</h3><div>In a private lymphoedema clinic in Australia between 1 October 2021 and 22 August 2023, individuals assigned female at birth, aged 18 years and older who consented to the entry of de-identified data into a research databank and completed the Lymphoedema Quality of Life tool (LYMQOL-leg) and/or Lymphoedema Symptoms Intensity and Distress Survey (LSIDS-L) for the legs were included in this study. Between group analysis was conducted on 151 participants who were either diagnosed with lipoedema <em>(N</em> <em>= 90)</em> or bilateral leg lymphoedema <em>(N</em> <em>= 61)</em>. Participants with both conditions were excluded.</div></div><div><h3>Results</h3><div>Participants with lipoedema reported significantly higher burden scores for symptoms (<em>p</em> = 0.003), appearance (p = 0.003) and mood (<em>p</em> = 0.011) in the LYMQOL-leg survey when compared to participants with bilateral leg lymphoedema. Participants with lipoedema also reported significantly worse LSIDS-L scores for neurological sensation (p = 0.003), biobehavioral (<em>p</em> = 0.016) and resource (<em>p</em> = 0.008) questions compared to participants with lymphoedema.</div></div><div><h3>Conclusions</h3><div>This study highlights that although females with lipoedema and lymphoedema experience similar symptoms, their experiences differ in specific outcomes that influence their HRQoL. These findings warrant further investigation into the HRQoL concerns of individuals with lipoedema.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"203 ","pages":"Article 112562"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Number of group psychotherapy sessions predicts inflammation changes in patients with coronary artery disease and comorbid depression","authors":"Joram Ronel ,&nbsp;Elisabeth Olliges ,&nbsp;Christoph Herrmann-Lingen ,&nbsp;Christian Albus ,&nbsp;Birgitt Marten-Mittag ,&nbsp;Siegmund L. Braun ,&nbsp;Hans Christian Deter ,&nbsp;Marie-Christine Federle ,&nbsp;Katharina Franz ,&nbsp;Kurt Fritzsche ,&nbsp;Jana Jünger ,&nbsp;Matthias Michal ,&nbsp;Lena Schambeck ,&nbsp;Roland Schmidt ,&nbsp;Wolfgang Söllner ,&nbsp;Frank Vitinius ,&nbsp;Cora S. Weber ,&nbsp;Martina de Zwaan ,&nbsp;Katja Petrowski ,&nbsp;Karl-Heinz Ladwig","doi":"10.1016/j.jpsychores.2026.112539","DOIUrl":"10.1016/j.jpsychores.2026.112539","url":null,"abstract":"<div><h3>Objective</h3><div>Inflammation contributes to the bidirectional relationship between depression and coronary artery disease (CAD). However, the impact of group psychotherapy on inflammatory levels in CAD patients with comorbid depression has not been elucidated.</div></div><div><h3>Methods</h3><div>A total of 337 patients (average age 59.2 years ±9.4, 80.4% male) from the SPIRR-CAD trial provided results of questionnaires and inflammatory data at baseline (T₀) and the 18-month follow-up (T₃) of a group psychotherapy program, with a maximum of 25 sessions vs. usual care.</div></div><div><h3>Results</h3><div>At baseline, inflammatory parameters were elevated for high-sensitivity C-reactive protein (hsCRP) in 41.2%, tumor necrosis factor-α (TNF-α) in 33.2% and interleukin-6 (IL-6) in 21.1% of all patients. From T₀ to T₃, prevalences of elevated hsCRP (<em>p</em> = .027), TNF-α (<em>p</em> = .013) and depression scores (measured with the Hamilton Depression Rating-Scale; (<em>p</em> = .002) significantly decreased in all patients. Additionally, an inflammatory factors score (IFS), calculated from the inflammatory parameters showed a significant decrease between T₀ and T₃ (<em>p</em> = .046) in all patients. A blockwise multivariate logistic regression analysis revealed a 4.59-fold higher chance of IFS reduction (or stable low values) for patients with a higher number (10–25) of group psychotherapy sessions (OR = 4.59, 95% CI: 1.39–15.1, <em>p</em> = .012) compared to patients with 1–9 sessions, even after adjusting for comorbidities or pharmacological antidepressant treatment.</div></div><div><h3>Conclusion</h3><div>This analysis demonstrates a significant impact of group psychotherapy sessions on IFS changes in CAD patients with persistently elevated depression scores. Beyond the influence of the absence of diabetes mellitus, a higher number of group psychotherapy sessions reduces the risk of inflammatory burden.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"203 ","pages":"Article 112539"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}