Angelina R. Sutin , Martina Luchetti , Selin Karakose , Yannick Stephan , Antonio Terracciano
{"title":"Meaning in life and all-cause and cause-specific mortality in the UK Biobank","authors":"Angelina R. Sutin , Martina Luchetti , Selin Karakose , Yannick Stephan , Antonio Terracciano","doi":"10.1016/j.jpsychores.2024.111971","DOIUrl":"10.1016/j.jpsychores.2024.111971","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the association between meaning in life and all-cause and cause-specific mortality, and whether associations vary by depression or sociodemographic factors.</div></div><div><h3>Methods</h3><div>Participants were UK Biobank cohort members who reported on their meaning in life in the mental health assessment from October 2016 to July 2017 (<em>N</em> = 153,505). All-cause mortality and cause-specific mortality were identified from ICD-10 codes from national death registries through December 2022.</div></div><div><h3>Results</h3><div>Over the up to six-year follow-up, every standard deviation higher in meaning in life was associated with a 15 % decreased risk of death from any cause (HR = 0.87, 95 % CI = 0.85–0.90, <em>p</em> < .001). The association was attenuated but remained significant accounting for socioeconomic, clinical, and behavioral risk factors (HR = 0.91, 95 % CI = 0.88–0.94, <em>p</em> < .001). Meaning in life was associated with reduced risk of death from 7 of the 8 cause-specific deaths examined: external cause (47 %), respiratory (41 %), nervous (32 %), digestive (25 %), or circulatory (15 %) systems, COVID-19 (28 %), and cancer (8 %). Depression concurrent with the meaning assessment did not explain or moderate these associations, which indicated that meaning was similarly protective when concurrently experiencing psychological distress. The association between meaning and all-cause mortality was similar across age, ethnicity, and socioeconomic status but slightly stronger among female than male participants.</div></div><div><h3>Conclusion</h3><div>Feeling that one's life has meaning is associated with lower risk of mortality, particularly causes of death due to the respiratory system, nervous system, or COVID-19. Given that meaning in life can be modified through intervention, future research could address whether it could be a useful target of intervention.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"188 ","pages":"Article 111971"},"PeriodicalIF":3.5,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A cultural adaptation and validation study of the Intentional Nonadherence Scale (INAS) among people with type 2 diabetes in Singapore","authors":"Vivien Teo , John Weinman , Kai Zhen Yap","doi":"10.1016/j.jpsychores.2024.111969","DOIUrl":"10.1016/j.jpsychores.2024.111969","url":null,"abstract":"<div><h3>Aims</h3><div>To examine the psychometric properties of the Intentional Non-adherence Scale (INAS) among people with type 2 diabetes mellitus (PwT2D) in Singapore.</div></div><div><h3>Methods</h3><div>This study consisted of Phase 1: translation and adaptation of the questionnaire into local Mandarin and English and Phase 2: a longitudinal validation study at the outpatient clinics of a hospital in Singapore. In Phase 1, cognitive interviews were conducted with 20 PwT2D and healthcare providers to examine the content validity of the INAS. In Phase 2, 290 PwT2D were recruited. Fifty-three of them were involved in test-retest reliability analysis, while 185 were followed-up in 3–6 months to assess the predictive validity of the INAS. The INAS was also evaluated for its structural validity, construct validity and internal reliability.</div></div><div><h3>Results</h3><div>Exploratory factor analysis revealed four factors, namely “<em>Resisting illness and medication”, “Sensitivity to medication”, “Testing treatment”</em> and “<em>Inconvenience”.</em> All INAS factors showed good internal consistency (Cronbach's alpha = 0.84–0.94) and moderate test-retest reliability (intraclass correlation coefficient = 0.50–0.62). Construct validity of the INAS was demonstrated in its relationship with medication adherence, glycated haemoglobin (HbA1c), beliefs about medications, illness perception and mood. Quantile and linear regression for medication adherence and HbA1c in 3–6 months did not show statistical associations with the INAS after adjusting for potential confounders.</div></div><div><h3>Conclusions</h3><div>Our study supports the reliability and most aspects of validity of the INAS, which revealed new factors that may affect medication adherence and HbA1c. In clinical settings, healthcare providers may consider using this questionnaire to evaluate potential intentional nonadherence.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"188 ","pages":"Article 111969"},"PeriodicalIF":3.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qian Li , Ngan Yin Chan , Liping Zhang , Samuel Yeung-shan Wong , Xue Yang
{"title":"Mapping the 9-year sleep trajectory and its implications for chronic disease risks among middle-aged and older adults","authors":"Qian Li , Ngan Yin Chan , Liping Zhang , Samuel Yeung-shan Wong , Xue Yang","doi":"10.1016/j.jpsychores.2024.111967","DOIUrl":"10.1016/j.jpsychores.2024.111967","url":null,"abstract":"<div><h3>Objective</h3><div>To identify the 9-year trajectories of sleep duration and to assess the relationship between time-dependent sleep duration and sleep trajectories with 14 chronic diseases in adults.</div></div><div><h3>Methods</h3><div>This study used five waves of data of the China Health and Retirement Longitudinal Survey. Participants with complete sleep duration data and at least one record of 14 chronic diseases were included. The group-based trajectory model was used to identify sleep trajectories from 2011 to 2020. Time-dependent survival analysis and logistic regression were used to examine the relationship between time-dependent sleep duration and sleep trajectories with chronic diseases.</div></div><div><h3>Results</h3><div>A total of 9063 participants were included, with a mean (standard deviation, SD) sleep duration of 6.37 (1.83) h/d. Sleeping <7 h/d predicted higher risks of 11 chronic diseases at follow-up, with hazard ratios (HR) and 95 % confidence intervals (CI) ranging from 1.71 (1.26–2.33) for psychiatric disease to 1.15 (1.04–1.27) for dyslipidemia. Five sleep trajectories were identified and labeled as group 1–5 based on ascending order of sleep duration. Consistently sleeping <4 h/d (group 1) and 4–6 h/d predicted higher risks of most chronic diseases, with the highest HR (95 %CI) of 3.50 (1.73–6.92) and 2.94 (1.82–4.49) for psychiatric diseases, respectively. Consistently sleeping 6–7 h/d (group 3) predicted higher risks of digestive diseases and arthritis. Decreasing sleep (group 4) predicted higher risks of psychiatric diseases and memory-related diseases.</div></div><div><h3>Conclusions</h3><div>Consistently sleeping <6 h/d predicted higher risks of most chronic diseases, especially psychiatric diseases. Digestive disease and arthritis were more sensitive to consistently inadequate sleep.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"188 ","pages":"Article 111967"},"PeriodicalIF":3.5,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandra Litzenburger , Yannick Rothacher , Kay-Uwe Hanusch , Ulrike Ehlert , Urs M. Nater , Susanne Fischer
{"title":"Network structure of functional somatic symptoms","authors":"Alexandra Litzenburger , Yannick Rothacher , Kay-Uwe Hanusch , Ulrike Ehlert , Urs M. Nater , Susanne Fischer","doi":"10.1016/j.jpsychores.2024.111968","DOIUrl":"10.1016/j.jpsychores.2024.111968","url":null,"abstract":"<div><h3>Objective</h3><div>The overlap among functional somatic syndromes (FSS) is substantial, which is why various empirical attempts at an improved understanding of related symptoms have been undertaken. Network analyses are particularly valuable from a clinical point of view, since they focus on the extent to which symptoms expression is co-dependent. The aim of this study was to provide the first estimation of the network structure of symptoms in 17 FSS.</div></div><div><h3>Methods</h3><div><em>N</em> = 3054 young adults participated in an online survey. The Questionnaire on Functional Somatic Syndromes (FSSQ) was used to diagnose FSS and to assess related symptoms. The Patient Health Questionnaire (PHQ-9) was used to assess (comorbid) depression. Various R packages were used for network analysis, which yielded correlations between symptoms (edges), symptom groups (communities), and measures of centrality for individual symptoms (e.g., node strength).</div></div><div><h3>Results</h3><div>The final network had a relatively small number of edges, with small (46.5 %) or small- to medium-sized (47.1 %) correlations. Ten communities were identified: cognitive problems/fatigue/depression, sensory problems, facial pain, head/neck/upper back pain, dizziness/nausea, throat pain/problems with swallowing, chest pain, widespread pain, abdominal pain/problems with digestion, and genital pain. The highest node strength in the network was found for the symptoms “tired”, “down, depressed, or hopeless”, and “tired after minimal exertion”.</div></div><div><h3>Conclusions</h3><div>The network analyses pointed to ten distinct groups of moderately associated symptoms in individuals with FSS. Fatigue and depression emerged as important symptoms connecting groups. Future studies should test whether (transdiagnostic) interventions specifically targeting these symptoms are particularly potent in alleviating FSS.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"188 ","pages":"Article 111968"},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stephen Gallagher , Aoife Bowman Grangel , Ailbhe Dempsey , Siobhán Howard
{"title":"Caregiving, caring intensity, and allostatic load: A comparison of caring to others inside and outside the home","authors":"Stephen Gallagher , Aoife Bowman Grangel , Ailbhe Dempsey , Siobhán Howard","doi":"10.1016/j.jpsychores.2024.111966","DOIUrl":"10.1016/j.jpsychores.2024.111966","url":null,"abstract":"<div><h3>Objective</h3><div>Caregiving to a sick or disabled relative is a key chronic stress model in health psychology. However, caregiving is not uniformly stressful, and this study tested whether caregiving effects on life satisfaction and allostatic load varies by caring intensity, i.e., caring within the home, outside the own home, or both (e.g. Dual caring).</div></div><div><h3>Method</h3><div>Using data from the UK Understanding Society Wave 2, a sample of non-caregivers (<em>N</em> = 3149) and caregivers (<em>N</em> = 562) met inclusion criteria and completed measures of life satisfaction and provided blood samples for capturing endocrine, cardiovascular and immune parameters for assessment of allostatic load.</div></div><div><h3>Results</h3><div>Dual caregivers had lower life satisfaction compared to non-carers, and other caregiver groups. Further, dual caregivers had higher levels of allostatic load compared to non-carers and those caring within the home and those caring outside the home. These group differences withstood adjustment for several co-variates including gender, education, income and lifestyle factors.</div></div><div><h3>Conclusions</h3><div>These results confirm that caregiving is not uniformly stressful with dual caring, an index of caring intensity being more damaging for health. The findings are also discussed in relation to the caregiver-control model of chronic stress.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111966"},"PeriodicalIF":3.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ajeng Ayu Widiastuti , Adi Atmoko , Nur Eva , Henni Anggraini , Aryudho Widyatno , Riza Amalia , Beny Dwi Pratama
{"title":"The role of self-efficacy and tangible support in managing depression in fibromyalgia: Expanding social support strategies","authors":"Ajeng Ayu Widiastuti , Adi Atmoko , Nur Eva , Henni Anggraini , Aryudho Widyatno , Riza Amalia , Beny Dwi Pratama","doi":"10.1016/j.jpsychores.2024.111964","DOIUrl":"10.1016/j.jpsychores.2024.111964","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111964"},"PeriodicalIF":3.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Renzo Bianchi , Elin Lindsäter , Tonje Erevik Vollan , Rune Tesaker , Håkon Homme Mathisen , Sigrid Hovdal Øyangen , Benjamin Ek , Una Wen Bø , Emilie Sofie Eilertsen , Tonje Hauglie-Hanssen , Jenny Sofie Hunvik , Maja Hansen Rasul , Irvin Sam Schonfeld
{"title":"Most people do not attribute their burnout symptoms to work","authors":"Renzo Bianchi , Elin Lindsäter , Tonje Erevik Vollan , Rune Tesaker , Håkon Homme Mathisen , Sigrid Hovdal Øyangen , Benjamin Ek , Una Wen Bø , Emilie Sofie Eilertsen , Tonje Hauglie-Hanssen , Jenny Sofie Hunvik , Maja Hansen Rasul , Irvin Sam Schonfeld","doi":"10.1016/j.jpsychores.2024.111962","DOIUrl":"10.1016/j.jpsychores.2024.111962","url":null,"abstract":"<div><div>A prevailing belief among researchers is that burnout is a work-specific syndrome induced by intractable job stress. The validity of this belief, however, remains unclear. This cross-sectional study compared burnout with two general conditions, nonspecific psychological distress (NSPD) and exhaustion, in terms of (a) causal attributions to work and (b) associations with 11 job variables (e.g., job satisfaction). The study involved 813 individuals employed in Norway (70.5 % female). Burnout was assessed with the Burnout Assessment Tool; NSPD, with the K6; and exhaustion, with the Karolinska Exhaustion Disorder Scale. Results showed that only 27.7 % of participants with burnout symptoms attributed these symptoms to work. The proportions of individuals ascribing their symptoms to work were similar for NSPD (26.9 %) and exhaustion (27.5 %). The higher one's burnout score, the higher the likelihood of attributing one's burnout, NSPD, and exhaustion symptoms to work. Overall, burnout shared more variance with job variables than did NSPD and exhaustion. Coworker support, job security, and job autonomy constituted notable exceptions. In multiple regression analyses, seven of the 11 job variables predicted NSPD; five predicted burnout and exhaustion. An a posteriori analysis of a nationally balanced quota sample of 591 U.S. employees (48.2 % female) replicated our main finding—only 35.9 % of participants attributed their burnout symptoms to work. This study invites stakeholders to exercise more caution when making etiological inferences about burnout. Assuming that symptoms experienced at work are necessarily caused by work may hinder our ability to mitigate these symptoms. Our findings further question work-centric views of burnout.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111962"},"PeriodicalIF":3.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ann Xiuli Chicoine , Howard Chertkow , Jean-Claude Tardif , David Busseuil , Bianca D'Antono
{"title":"Childhood maltreatment, cognitive performance, and cognitive decline in middle-aged and older adults with chronic disease: A prospective study","authors":"Ann Xiuli Chicoine , Howard Chertkow , Jean-Claude Tardif , David Busseuil , Bianca D'Antono","doi":"10.1016/j.jpsychores.2024.111965","DOIUrl":"10.1016/j.jpsychores.2024.111965","url":null,"abstract":"<div><h3>Objectives</h3><div>Childhood maltreatment (CM) may increase the risk for cognitive deficits and dementia later in life. However, most research has been cross-sectional in nature, has typically focused on specific types of CM, and rarely examined individual differences. The objectives are to evaluate 1) if CM predicts poorer cognitive performance and greater cognitive decline over a 5-year follow-up in older men and women with coronary artery disease (CAD) or other non-cardiovascular (non-CVD) chronic disease, and whether 2) sex and CAD status influence these relations.</div></div><div><h3>Methods</h3><div>Men and women (<em>N</em> = 1254; 39.6 % women; 65.6 ± 7.0 years old) with CAD or other non-CVD chronic diseases completed the Childhood Trauma Questionnaire Short Form (CTQ-SF). The Montreal Cognitive Assessment (MoCA) was administered twice at 5-year intervals. Main analyses included bivariate correlations, hierarchical analyses and moderation analyses controlling for sociodemographic and health parameters.</div></div><div><h3>Results</h3><div>CM was experienced by 32 % of the sample, while scores suggestive of cognitive deficits were obtained by 32.7 % and 40.2 % at study onset and follow-up, respectively. CM was associated with significantly lower MoCA scores at study onset (b = −0.013, <em>p</em> = 0.020), but not with change in MoCA over time (b = −0.002, <em>p</em> = 0.796). While MoCA scores did differ as a function of sex and CAD status, the latter did not influence the relations between maltreatment and MoCA.</div></div><div><h3>Conclusions</h3><div>CM predicted poorer cognitive functioning among older individuals with chronic diseases but did not play a role in any further cognitive decline over the follow-up period. Further research is needed to help understand the mechanisms implicated.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111965"},"PeriodicalIF":3.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unlike other medical conditions, type 2 diabetes is a risk factor for new-onset major depression after COVID-19","authors":"Matthieu Gasnier , Anne-Lise Lecoq , Tài Pham , Luc Morin , François Radiguer , Eugénie Gosset-Grainville , Marie Quinque , Wassim Najib Alaoui , Eric Deflesselle , Walid Choucha , Samy Figueiredo , Mohamad Zaidan , Laurent Savale , David Montani , Xavier Monnet , Laurent Becquemont , Emmanuelle Corruble , Romain Colle","doi":"10.1016/j.jpsychores.2024.111963","DOIUrl":"10.1016/j.jpsychores.2024.111963","url":null,"abstract":"<div><h3>Objective</h3><div>It is unclear whether pre-COVID medical conditions are risk factors for post-COVID major depressive episode (MDE). We aimed to determine which pre-COVID medical conditions are risk factors for post-COVID MDE after a hospitalization for COVID-19.</div></div><div><h3>Methods</h3><div>We conducted a nested retrospective case-cohort study within a cohort of 650 patients evaluated six months after hospitalization for COVID-19 at Bicêtre hospital, France. Nine medical conditions present before COVID-19 (High blood pressure, obesity, type 2 diabetes, cardiac, respiratory and renal disease, immune deficiency, neoplasia and liver disease) were extracted from medical records. MDE was assessed using the Structured Clinical Interview for DSM-5 Disorders-Clinician Version (SCID-5-CV). Bivariate and multivariable analyses were performed to determine which pre-COVID medical conditions are independent risk factors for post-COVID new-onset MDE.</div></div><div><h3>Results</h3><div>Patients mean age was 62.8 (15.8), 258 (39.7 %) were women; 301 (46.3 %) had high blood pressure, 205 (32.4 %) had obesity, and 186 (28.6 %) had type 2 diabetes. Thirty-six (5.5 %) patients were diagnosed with a new-onset MDE. In contrast to other medical conditions, type 2 diabetes was significantly associated with new-onset MDE (OR = 2.51 [1.19–5.29]).</div></div><div><h3>Conclusion</h3><div>Unlike other pre-COVID medical conditions, type 2 diabetes is a risk factor for post-COVID MDE. Patients with type 2 diabetes should be screened for MDE after a hospitalization for COVID-19.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111963"},"PeriodicalIF":3.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Weekend sleep duration, weekday sleep characteristics and the risk of prediabetes and diabetes","authors":"Tomoyuki Kawada","doi":"10.1016/j.jpsychores.2024.111959","DOIUrl":"10.1016/j.jpsychores.2024.111959","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111959"},"PeriodicalIF":3.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}