Journal of Psychosomatic Research最新文献

{"title":"Trajectories of depressive symptoms and incident diabetes risk among middle-aged and older adults: A longitudinal cohort study","authors":"Le Zhao ,&nbsp;Yan Lou ,&nbsp;Yun Zou","doi":"10.1016/j.jpsychores.2025.112469","DOIUrl":"10.1016/j.jpsychores.2025.112469","url":null,"abstract":"<div><h3>Objectives</h3><div>Accumulating evidence links depressive symptoms to later diabetes risk, yet most studies assess depression at a single time point. This study examined the association between long-term depressive symptom trajectories and incident diabetes among middle-aged and older adults in the United States and the United Kingdom.</div></div><div><h3>Methods</h3><div>Data were derived from two nationally representative cohorts: the Health and Retirement Study (HRS, waves 4–7 for exposure, 8–12 for outcome; 1998–2014) and the English Longitudinal Study of Aging (ELSA, waves 1–4 for exposure, 5–9 for outcome; 2002–2018). Participants aged ≥50 years and free of diabetes at baseline were included. Depressive symptoms were measured using the 8-item Center for Epidemiologic Studies Depression Scale (CES<img>D). Total, somatic, and cognitive-affective symptom domains were classified into five trajectories: consistently low, decreasing, fluctuating, increasing, and consistently high. Incident diabetes was identified via self-reported physician diagnosis. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs).</div></div><div><h3>Results</h3><div>This study included 8741 adults to examine the association between depressive symptom trajectories and diabetes risk over 10 years. Compared with the consistently low group, participants in the increasing trajectory showed a significantly higher risk of diabetes across the overall (HR = 1.48, 95 % CI: 1.01–2.17), somatic (HR = 1.56, 95 % CI: 1.01–2.50), and cognitive-affective domains (HR = 2.15, 95 % CI: 1.39–3.32).</div></div><div><h3>Conclusions</h3><div>Rising depressive symptom trajectories, particularly in the cognitive-affective domain, were associated with increased diabetes risk. Sustained depression monitoring and early interventions targeting evolving depressive patterns may help prevent diabetes onset.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"200 ","pages":"Article 112469"},"PeriodicalIF":3.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological heterogeneity in functional neurological disorders: A systematic review of studies exploring psychopathological sub-types","authors":"Anna Mammì ,&nbsp;Kathryn Harper ,&nbsp;Cordelia Gray ,&nbsp;Markus Reuber ,&nbsp;Richard J. Brown","doi":"10.1016/j.jpsychores.2025.112473","DOIUrl":"10.1016/j.jpsychores.2025.112473","url":null,"abstract":"<div><h3>Background</h3><div>Functional Neurological Disorders (FND) are characterised by distressing neurological symptoms arising from altered brain network functioning rather than structural damage. FND were traditionally conceptualised as homogeneous (conversion) disorders despite the apparent heterogeneity of the condition.</div></div><div><h3>Objective</h3><div>In order to aid our understanding of the clinical spectrum of FND, this systematic review explores empirical evidence for psychological patient sub-groups.</div></div><div><h3>Methods</h3><div>OVID Medline/Embase/PsycINFO, Scopus and WoS were searched from 1980 to September 2025. We used the SURE quality appraisal process and an analytic process involving four steps of narrative synthesis.</div></div><div><h3>Results</h3><div>Of 10,414 articles screened, 13 papers met our inclusion criteria. Six non-exclusive and potentially interacting psychological themes were identified: “emotional dysregulation associated with high distress”, “constricted affect with low overt distress”, “presence of comorbid mental disorders”, “overt traumatisation”, “dissociation” and “lower intellectual abilities”.</div></div><div><h3>Conclusions</h3><div>This review confirms that there is an empirical basis for the perception of FND as aetiologically heterogeneous disorders. Six recurring psychological themes, often overlapping and interconnected, were identified. These findings emphasize the necessity of adopting a multidimensional framework for understanding FND. Further empirical validation may allow for FND treatment to be tailored to the specific psychological needs of this diverse patient group.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"200 ","pages":"Article 112473"},"PeriodicalIF":3.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type D personality and metabolic syndrome severity jointly predict 2-year MACE after acute coronary syndrome: A prospective cohort study","authors":"Bingji Huang ,&nbsp;Jiaxin Shi ,&nbsp;Mengru Sun ,&nbsp;Hui Tao ,&nbsp;Wenpei Liu ,&nbsp;Bo Yu ,&nbsp;Yini Wang ,&nbsp;Ping Lin","doi":"10.1016/j.jpsychores.2025.112453","DOIUrl":"10.1016/j.jpsychores.2025.112453","url":null,"abstract":"<div><h3>Objective</h3><div>To determine whether Type D personality and higher metabolic syndrome (MetS) severity jointly associate with 2-year major adverse cardiac events (MACE) after acute coronary syndrome (ACS).</div></div><div><h3>Methods</h3><div>This prospective cohort study included 5441 patients diagnosed with ACS between May 2021 and May 2023. Type D personality was assessed, and an age-sex-ethnicity-specific MetS scoring model (MetS score) was used to evaluate metabolic syndrome severity at baseline. MACE were analyzed after a 2-year follow-up period.</div></div><div><h3>Results</h3><div>During the 2-year follow-up period, 518 patients developed MACE. A nonlinear association was observed between MetS score and MACE risk (<em>p</em> for nonlinearity = 0.025). Compared with the Type D(−)/Low MetS risk group, the Type D(+)/High MetS risk group exhibited the highest risk of MACE (HR: 2.331, 95 % CI: 1.810–3.002). Subgroup analyses further revealed a pronounced sex difference: the association was strongest among women, with the Type D(+)/High MetS risk group showing the highest risk (HR: 3.505, 95 % CI: 2.092–5.872), whereas men in the same group also demonstrated elevated risk, though to a lesser degree (HR: 2.065, 95 % CI: 1.544–2.761).</div></div><div><h3>Conclusion</h3><div>Type D personality and higher MetS severity were jointly associated with increased 2-year MACE risk after ACS, with sex-specific patterns. These findings support integrated psychosocial and metabolic risk management, particularly among women with high MetS severity.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"200 ","pages":"Article 112453"},"PeriodicalIF":3.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of treatment credibility and expectancy on cognitive behavioral therapy for insomnia outcomes among cancer survivors","authors":"Brianna George ,&nbsp;Joshua Tulk ,&nbsp;Josée Savard ,&nbsp;Joshua A. Rash ,&nbsp;Christopher Quinn-Nilas ,&nbsp;Melanie Seal ,&nbsp;Robin Urquhart ,&nbsp;John Thoms ,&nbsp;Kara Laing ,&nbsp;Sheila N. Garland","doi":"10.1016/j.jpsychores.2025.112447","DOIUrl":"10.1016/j.jpsychores.2025.112447","url":null,"abstract":"<div><h3>Objectives</h3><div>Cognitive Behavioral Therapy for Insomnia (CBT-I) can effectively improve insomnia among cancer survivors. This secondary analysis explored what factors were associated with higher beliefs about credibility and expectancy and examined the impact of perceived treatment credibility and expectancy on outcomes.</div></div><div><h3>Methods</h3><div>As part of a randomized waitlist-controlled trial, cancer survivors (<em>N</em> = 132) with insomnia received 7 weekly virtual sessions of CBT-I. Credibility and expectancy beliefs were assessed at baseline for insomnia and perceived cognitive impairment (PCI) using the Credibility Expectancy Questionnaire. We examined which factors were associated with greater credibility and expectancy beliefs and whether credibility and expectancy moderated change in symptoms. Semi-structured interviews explored patient perceptions.</div></div><div><h3>Results</h3><div>Only younger age was associated with higher pre-treatment expectations for both insomnia and PCI (<em>p</em> = 0.009; <em>p</em> = 0.008). The magnitude of expectancy for insomnia and cognitive functioning were similar. Neither beliefs about credibility nor expectancy acted as moderators of change in symptoms of insomnia (<em>p</em> = 0.972; <em>p</em> = 0.502) or PCI (<em>p</em> = 0.143; <em>p</em> = 0.283), respectively. Qualitative results suggest credibility and expectancy can be optimized by: 1) promoting an understanding of sleep; 2) setting appropriate pre-treatment beliefs that foster optimism and mitigate skepticism; 3) promoting consistent engagement with treatment; and 4) fostering positive therapeutic relationships.</div></div><div><h3>Conclusion/implications</h3><div>CBT-I is effective regardless of pre-existing beliefs and expectations. While these factors may play a role in the decision to pursue CBT-I, our results suggest that clients are likely to see benefits if they engage in the therapy.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"200 ","pages":"Article 112447"},"PeriodicalIF":3.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering adolescents and young adults with somatoform disorders: A longitudinal pilot randomized controlled trial of a parent-focused mindfulness-based training versus support groups","authors":"Alexander Lassner ,&nbsp;Rosemarie Ahnert ,&nbsp;Jenny Dahringer ,&nbsp;Irina Papazova ,&nbsp;Michael Frühwald ,&nbsp;Alkomiet Hasan ,&nbsp;Sophie-Kathrin Greiner","doi":"10.1016/j.jpsychores.2025.112448","DOIUrl":"10.1016/j.jpsychores.2025.112448","url":null,"abstract":"<div><h3>Background</h3><div>In childhood somatoform disorders develop and persist through bio-psycho-social processes including family variables, substantially impacting the development of children, their school attendance, and well-being. Although intensive interdisciplinary pain treatment (IIPT) has demonstrated effectiveness, maintaining long-term outcomes remains challenging, particularly given children's increased risk of developing affective disorders. Since family dynamics influence disorder development and persistence, this study aimed to investigate the potential added value of addressing parents within the therapeutic process.</div></div><div><h3>Method</h3><div>This monocentric longitudinal pilot randomized controlled trial (RCT) (<em>N</em> = 31) investigated adjunct parent-focused interventions (mindfulness vs. support group) for families of children with somatoform disorders enrolled in IIPT. We assessed children's empowerment, pain related disability, affective pain perception, pain characteristics and parental catastrophizing at admission, discharge, and six-month follow-up. Regression models and repeated-measures ANOVAs evaluated intervention effects.</div></div><div><h3>Results</h3><div>Multiple regression analysis identified older age as predictor of empowerment at baseline (<em>β</em> = 0.63, <em>p</em> &lt; .01). IIPT plus parental intervention showed lasting treatment effects. Group allocation had no effect on empowerment, pain disability, affective pain perception, or parental catastrophizing, but allocation to the support group (<em>B</em> = -2.49, <em>p</em> = .009) and male sex (<em>B</em> = -2.29, <em>p</em> = .008) predicted greater reduction in average pain intensity.</div></div><div><h3>Conclusions</h3><div>This pilot RCT showed no superiority of the parent-focused mindfulness group over the support group when combined with IIPT. Yet, both interventions may enhance treatment efficacy, with some evidence suggesting additional benefits of the support group intervention in reducing average pain intensity. Further research is needed to examine underlying mechanisms and establish optimal parent intervention approaches in paediatric pain treatment.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"200 ","pages":"Article 112448"},"PeriodicalIF":3.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifying the role of somatic and depressive symptoms in suicide risk: Evidence from a cross-sectional analysis","authors":"Ronja Volz ,&nbsp;Robert Philipp Kosilek ,&nbsp;Carolin Haas ,&nbsp;Patricia Dolp ,&nbsp;Caroline Jung-Sievers ,&nbsp;Tobias Teismann ,&nbsp;Peter Henningsen ,&nbsp;Peter Falkai ,&nbsp;Jochen Gensichen ,&nbsp;Karoline Lukaschek ,&nbsp;for the POKAL Study Group","doi":"10.1016/j.jpsychores.2025.112468","DOIUrl":"10.1016/j.jpsychores.2025.112468","url":null,"abstract":"<div><h3>Background</h3><div>Somatic symptoms are common in psychiatric and primary care populations, and their relationship with depression and suicidal ideation is complex. This study investigates the association between somatic symptoms and suicidal ideation, accounting for comorbid depressive symptoms.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 521 in- and outpatient with PHQ-9 ≥ 6 or a positive response to item 9, indicative of suicidal thoughts. Somatic and depressive symptoms were assessed using the PHQ-15 and PHQ-2 or PHQ-9, respectively. Suicidal ideation was measured using the risk subscale of the SuPr-10; the protective subscale was included as a covariate. Associations were examined using correlation matrices and regression models.</div></div><div><h3>Results</h3><div>The sample was 68 % female with a mean age of 41 years; 52 % screened positive for suicidal ideation. PHQ-9 (mean = 14.8, SD = 5.0) and PHQ-15 scores (mean = 12.4, SD = 5.0) were moderately elevated. In a two-part regression model, higher depressive symptoms were associated with a reduced likelihood of reporting no suicidal ideation (OR = 0.50, 95 % CI: 0.41–0.62) and increased severity of suicidal ideation (IRR = 1.17, 95 % CI: 1.09–1.27). Somatic symptoms showed no meaningful direct effects but were indirectly associated with suicidal ideation via depressive symptoms (indirect effect OR = 1.05, 95 % CI: 1.03–1.07).</div></div><div><h3>Conclusions</h3><div>In individuals with somatic complaints, co-occurring depressive symptoms are strongly associated with suicidal ideation. Systematic depression screening is essential in somatically presenting patients.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"200 ","pages":"Article 112468"},"PeriodicalIF":3.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of age on prevalence of anxiety, depression and stress in patients with chronic obstructive pulmonary disease","authors":"Abebaw Mengistu Yohannes ,&nbsp;Mark T. Dransfield ,&nbsp;Richard Casaburi ,&nbsp;Nicola A. Hanania","doi":"10.1016/j.jpsychores.2025.112472","DOIUrl":"10.1016/j.jpsychores.2025.112472","url":null,"abstract":"<div><h3>Background</h3><div>Over 40 % of patients with chronic obstructive pulmonary disease (COPD) suffer from mood and anxiety disorders. However, little is known about the impact of age on the prevalence of anxiety, depression and stress in patients with COPD. We examined the prevalence of depression, anxiety and stress in patients with COPD aged 65 years and older compared to less than 65 years old and their relation to quality of life (QoL), dyspnea, lung function and exercise capacity.</div></div><div><h3>Methods</h3><div>From our research database, we examined 993 clinically stable COPD patients recruited from 2013 to 2019, before entering pulmonary rehabilitation (PR). At baseline, COPD patients completed: dyspnea measured by modified Medical Research Council (mMRC) scale, exercise capacity by incremental shuttle walk test (ISWT), QoL by St. George's Respiratory Questionnaire (SGRQ), and psychological distress by Depression Anxiety Stress Scale (DASS).</div></div><div><h3>Results</h3><div>Seven-hundred-sixty-seven patients with COPD ≥65 years with mean age (SD) 75 (6) years were compared to 226 patients with COPD &lt;65 years with mean age 58 (6) years. Patients &lt;65 years compared to patients ≥65 years with COPD had higher scores for DASS-depression ≥10, (61 % vs. 38 %), DASS-anxiety ≥8 (73 % vs 51 %) and DASS-stress ≥15 (45 % vs. 25 %) all (<em>p</em> &lt; 0.001). Younger patients with COPD had poorer QoL, elevated dyspnea, and lower FEV₁ percentage predicted, (all p &lt; 0.001). No significant difference in exercise capacity was seen between the two groups (<em>p</em> = 0.58).</div></div><div><h3>Conclusion</h3><div>Younger COPD patients exhibited higher levels of depression, anxiety and stress, with poorer QoL and elevated symptoms of dyspnea compared to older patients.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"200 ","pages":"Article 112472"},"PeriodicalIF":3.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain patterns in patients with irritable bowel symptoms – A longitudinal observational time series approach","authors":"B. Wild ,&nbsp;T. Stadnitski ,&nbsp;S. Benz-Sahnoun ,&nbsp;V. Guenther ,&nbsp;A. Korn ,&nbsp;M. Rämisch ,&nbsp;L. Keefer ,&nbsp;F. Engel","doi":"10.1016/j.jpsychores.2025.112442","DOIUrl":"10.1016/j.jpsychores.2025.112442","url":null,"abstract":"<div><h3>Background</h3><div>Patients with IBS frequently present with a long history of abdominal pain, and high psychosocial burden. The aim of this study was to analyze pain patterns of IBS patients and to identify different pain phenotypes.</div></div><div><h3>Methods</h3><div>The study used a longitudinal design. At the beginning IBS patients filled in a series of validated questionnaires. Subsequently, during 7 weeks <em>n</em> = 81 patients answered questions daily regarding somatic and psychological variables using an online diary. Cluster analysis was applied to determine pain phenotypes. Vector autoregressive modelling (VAR) was used to analyze the diary data.</div></div><div><h3>Results</h3><div>Three groups could be determined according to their pain patterns: high persistent pain (HPP), occasional pain (OP), and moderate changing pain (MCP). Pain phenotypes were independent of gender and age and occurred across all IBS subtypes. The OP group scored significantly lower (<em>p</em> &lt; .05) in psychosomatic burden compared to the other two groups. The HPP group exhibited the highest levels across all psychosomatic symptoms with significant differences to the OP group. However, HPP did not differ from the MCP group regarding all psychosomatic questionnaire scores, except for hypochondriasis.</div><div>Diary data showed that, all concurrent correlations between abdominal pain, depression, and anxiety were significant, ranging from 0.24 to 0.62, Lagged correlations between abdominal pain and psychological times series were observed in 35 % of the patients, with no differences between the three groups.</div></div><div><h3>Conclusion</h3><div>We identified three different pain phenotypes in IBS patients. Further studies could explore whether the three pain phenotypes would benefit from different treatment approaches.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"200 ","pages":"Article 112442"},"PeriodicalIF":3.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EAPM 2026 Florence","authors":"","doi":"10.1016/S0022-3999(25)00450-7","DOIUrl":"10.1016/S0022-3999(25)00450-7","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"200 ","pages":"Article 112486"},"PeriodicalIF":3.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute and chronic fatigue after COVID-19: The impact of depression and somatic distress","authors":"Kamiar K. Rückert ,&nbsp;Julia Petersen ,&nbsp;Philipp S. Wild ,&nbsp;Thomas Münzel ,&nbsp;Jochem König ,&nbsp;Karl J. Lackner ,&nbsp;Isabel Heinrich ,&nbsp;Julia Weinmann-Menke ,&nbsp;Christian Dresel ,&nbsp;Marc Bodenstein ,&nbsp;Michael Kreuter ,&nbsp;Felix Rausch ,&nbsp;Manfred E. Beutel ,&nbsp;Jasmin Ghaemi Kerahrodi","doi":"10.1016/j.jpsychores.2025.112456","DOIUrl":"10.1016/j.jpsychores.2025.112456","url":null,"abstract":"<div><h3>Objective</h3><div>Fatigue is the most frequent and burdensome symptom following COVID-19. The contribution of biopsychosocial factors remains unclear, particularly with respect to symptom duration. This exploratory study investigated the prevalence of acute and chronic fatigue after COVID-19 and examined biopsychosocial correlations.</div></div><div><h3>Methods</h3><div>Cross-sectional data from 452 participants of the Gutenberg Post-COVID Study were analyzed. All individuals had a previous Sars-CoV-2 infection. Participants were categorized into three groups (1) no fatigue during assessment, (2) fatigue lasting 1–&lt;6 months at assessment, and (3) fatigue lasting 6 months or more at assessment. Fatigue was assessed using the Chalder Fatigue Questionnaire (CFQ) and classified as acute (&lt;6 months) or chronic (≥ 6 months). The modified PHQ-9 (mPHQ-9, excluding the fatigue item) measured depressivity. SSD-12 measured the somatic symptom burden. Associations were examined using multivariable regression analyses.</div></div><div><h3>Results</h3><div>51.6 % reported no fatigue, 13.9 % showed acute fatigue, 34.5 % displayed chronic fatigue. Vaccination status was not associated with fatigue. The severity of the infection was associated with acute fatigue. No significant associations were observed with chronic fatigue. When psychological variables (mPHQ-9, SSD-12) were introduced, associations with somatic pre-morbid conditions disappeared, except for body mass index. Higher levels of depressiveness and somatic distress increased the likelihood of both forms of fatigue, while lower social status was associated specifically with chronic fatigue.</div></div><div><h3>Conclusion</h3><div>Depressiveness and somatic distress are strongly linked to post-COVID fatigue, particularly its chronic form. These findings underscore the importance of a biopsychosocial framework and the need for interdisciplinary treatment approaches in post-COVID care.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"200 ","pages":"Article 112456"},"PeriodicalIF":3.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}