正念干预对偏头痛患者的有效性和影响：系统回顾和荟萃分析

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2025-08-22 DOI:10.1016/j.jpsychores.2025.112366

Yu-Chi Liao , Wen-Shuan Chen , Winda Putri Diah Restya , Yu-Chun Liao , Yi-Chun Lin , Ro-Ting Lin

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引用次数: 0

摘要

移民是全球致残的主要原因之一，通常采用可能产生不利影响的药物治疗。基于正念的干预（MBIs）已经成为一种很有前途的非药物方法，然而现有的研究报告了不同的结果。本荟萃分析旨在阐明MBIs在改善成人偏头痛患者疼痛、心理和功能结局方面的有效性。方法：我们对临床诊断为偏头痛的成人（≥18岁）随机对照试验（rct）进行了系统回顾和荟萃分析。从1982年至2025年7月检索了medline、CINAHL、Scopus和ProQuest central四个数据库。使用Cochrane RoB 2.0工具评估偏倚风险。采用综合meta分析软件Version 4和r进行meta分析。结果纳入14项随机对照试验，共1027名受试者。mbi与疼痛强度（标准化平均差：0.23 [95% CI: 0.11-0.35]）和疼痛频率（0.33[0.11-0.54]）的显著降低以及生活质量的改善（0.24[0.08-0.40]）相关。心理结果显著改善，包括焦虑（0.37[0.14-0.61]）、抑郁（0.26[0.06-0.45]）和疼痛灾难化（0.57[0.35-0.80]）。活动相关残疾（0.18[−0.01-0.38]）或使用镇痛药物（0.07[−0.06-0.20]）和曲坦类药物（0.04[−0.13-0.21]）均未发现显著影响。结论中药可作为偏头痛药物治疗的有效补充。它们显著降低疼痛强度、发作频率和心理症状，同时适度改善生活质量。这些发现支持将正念练习整合到偏头痛的常规护理中，以促进心理健康并减轻症状负担。

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Effectiveness and influence of mindfulness-based intervention on migraine patients: A systematic review and meta-analysis

Purpose

Migraines are among the top causes of global disability and are often managed with pharmacological treatments, which may produce adverse effects. Mindfulness-based interventions (MBIs) have emerged as promising non-pharmacological approaches, yet existing studies report mixed findings. This meta-analysis aimed to clarify the effectiveness of MBIs in improving pain, psychological, and functional outcomes among adults with migraine.

Methods

We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) involving adults (≥18 years) with a clinical diagnosis of migraine. Four databases—Medline, CINAHL, Scopus, and ProQuest Central—were searched from 1982 to July 2025. Risk of bias was assessed using the Cochrane RoB 2.0 tool. Meta-analyses were performed using Comprehensive Meta-Analysis Software Version 4 and R.

Results

Fourteen RCTs with 1027 participants were included. MBIs were associated with significant reductions in pain intensity (standardized mean difference: 0.23 [95 % CI: 0.11–0.35]) and pain frequency (0.33 [0.11–0.54]), as well as improvements in quality of life (0.24 [0.08–0.40]). Psychological outcomes improved significantly, including anxiety (0.37 [0.14–0.61]), depression (0.26 [0.06–0.45]), and pain catastrophizing (0.57 [0.35–0.80]). No significant effects were found for activity-related disability (0.18 [−0.01–0.38]) or use of analgesic medications (0.07 [−0.06–0.20]) and triptans (0.04 [−0.13–0.21]).

Conclusions

MBIs may serve as effective complements to pharmacological treatments for migraine. They significantly reduce pain intensity, attack frequency, and psychological symptoms, while modestly improving quality of life. These findings support integrating mindfulness practices into routine migraine care to promote psychological well-being and reduce symptom burden.

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.