Journal of Psychosomatic Research最新文献

{"title":"The first on the dark side of the moon: Revisiting the first nonblind placebo trial","authors":"Jens Gaab ,&nbsp;Antje Frey Nascimento ,&nbsp;Clara Wehlage ,&nbsp;Lee C. Park","doi":"10.1016/j.jpsychores.2026.112565","DOIUrl":"10.1016/j.jpsychores.2026.112565","url":null,"abstract":"<div><div>Open-label placebos have been studied extensively and with rigor for about 15 years, and clinically meaningful effects have been replicated in experiments and clinical trials since then, across countries, with different populations, with differing methodologies. But are open-label placebos the first to harness placebo effects in an ethically manner? Not quite. About 60 years ago, Lee C. Park and Lino Covi conducted a study using so-called nonblind placebos in psychiatric patients, with striking effect. But how was this study possible as there were hardly any antecedents as much as there were no discernible subsequents for 45 years, i.e. until 2010. When one of the authors (AFN) received a short email in March 2025, it was to our surprise and joy to find it written by no other that Lee C. Park himself, 60 years to the month after the publication of the “Nonblind placebo trial”. Between July and October 2025, a vivid email dialogue emerged on how the idea of using placebos with full disclosure evolved and how it has been received by patients and colleagues at the time, including the discussion of ethical and practical issues. This also included the relationship between psychotherapy and placebos and why the placebo effect also may be better labeled as <em>a brief psychotherapy effect</em>.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"204 ","pages":"Article 112565"},"PeriodicalIF":3.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146154201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Holistic needs assessment for hospitalized patients: A cross-sectional study","authors":"Chuan-Ya Lee ,&nbsp;Shu-Fen Chen ,&nbsp;Chien-Ling Su ,&nbsp;Tze-Wah Kao ,&nbsp;Yun-Yun Chou ,&nbsp;Tzu-Tung Kuo ,&nbsp;Sam H. Ahmedzai ,&nbsp;Li-Sin Hsiao ,&nbsp;Ka-Wai Tam","doi":"10.1016/j.jpsychores.2026.112583","DOIUrl":"10.1016/j.jpsychores.2026.112583","url":null,"abstract":"<div><h3>Background</h3><div>Disease affects physical, psychological, spiritual, and social well-being, underscoring the need for holistic care. This study assesses the severity of holistic needs among hospitalized patients by using the Sheffield Profile for Assessment and Referral for Care–Taiwan version (SPARC-T)—a multidimensional, self-report questionnaire.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted at a medical center in Taiwan, where the SPARC-T has been implemented across various departments between January 2023 and June 2024. The severity of holistic needs among hospitalized patients was assessed across psychological, spiritual, and social domains; referral thresholds for individual domains were established through discussions among the clinical team. Furthermore, sensitivity and specificity of the SPARC-T in psychological screening using were compared with those of the Brief Symptom Rating Scale (BSRS), with psychiatric consultations used as the reference standard.</div></div><div><h3>Results</h3><div>Over 17 months, 10,948 patients completed the SPARC-T, of whom 6304 valid responses were included in the analysis. These responses enabled the identification of department-specific variations in holistic needs. Notably, after exceeding domain-specific referral thresholds, 118, 207, and 111 patients directly received psychiatric, social work, and discharge planning consultations, respectively. The SPARC-T also demonstrated higher sensitivity (53.85%) than the BSRS (27.27%) and exhibited a specificity of 83.33% in detecting psychological concerns.</div></div><div><h3>Conclusion</h3><div>Holistic assessment is integral to patient care, as patients' needs vary across departments. The SPARC-T effectively identifies patients requiring support and exhibits excellent sensitivity in detecting holistic needs, it is a valuable tool for hospital-wide holistic screening and can be integrated into comprehensive care settings.</div></div><div><h3>Structured abstract</h3><div>Addressing inpatients’ physical, psychological, spiritual and social needs is essential for providing holistic care. This study indicated that SPARC-T questionnaire effectively identified department-specific patient needs. Moreover, the SPARC-T questionnaire exhibited greater sensitivity in evaluating psychological needs than did the BSRS-5. This study highlights the department-specific variations in patients’ holistic needs and can help clinicians provide targeted support.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"204 ","pages":"Article 112583"},"PeriodicalIF":3.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intentional nonadherence to self-administered cancer medications: Identifying key factors for tailored interventions","authors":"Kate Perry ,&nbsp;Jane Choi ,&nbsp;John Weinman ,&nbsp;Keith J. Petrie","doi":"10.1016/j.jpsychores.2026.112582","DOIUrl":"10.1016/j.jpsychores.2026.112582","url":null,"abstract":"<div><h3>Background</h3><div>Self-administered cancer treatments are increasingly common. While these treatments are often perceived as more convenient, intentional nonadherence – when patients deliberately choose not to take medication as prescribed – remains a significant challenge and is influenced by a range of motivational factors.</div></div><div><h3>Objective</h3><div>To identify key reasons for intentional nonadherence to self-administered cancer medications, to inform the development of personalised interventions.</div></div><div><h3>Methodology</h3><div>A cross-sectional e-survey of 126 adults with cancer was conducted. Adherence was assessed using the Medication Adherence Report Scale (MARS-5). Reasons for intentional nonadherence were measured with the Intentional Non-Adherence Scale (INAS). Principal component analysis was conducted, specifying a four-factor structure based on recent studies. Independent samples <em>t</em>-tests compared factor scores between adherent and nonadherent participants.</div></div><div><h3>Results</h3><div>Half the sample (50.0%) had a diagnosis of breast cancer, followed by thyroid cancer (16.7%), blood cancer (7.1%), and male urologic cancer (6.3%). Fifty-six percent of participants were classified as nonadherent. The most frequently endorsed reasons for intentional nonadherence were “Because I don't like the side effects” (32%) and “Because I want to think of myself as a healthy person again” (28%). Four INAS factors – Sensitivity to Medicines, Testing Treatment, Inconvenience, and Resisting Illness and Medication accounted for 79% of the variance and demonstrated high internal consistency (Cronbach's α = 0.90–0.96). Nonadherent participants scored significantly higher on all factors compared to adherent participants (<em>p</em> &lt; 0.001).</div></div><div><h3>Discussion</h3><div>Intentional nonadherence to self-administered cancer medications is driven by diverse motivational factors, including concerns about side effects and illness identity, highlighting the need for tailored interventions.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"204 ","pages":"Article 112582"},"PeriodicalIF":3.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindfulness-based stress reduction for functional neurological disorder: A feasibility study","authors":"Rosa Michaelis ,&nbsp;Jörg Meibert ,&nbsp;Nicole Alimov ,&nbsp;Christoph Kleinschnitz ,&nbsp;Stoyan Popkirov","doi":"10.1016/j.jpsychores.2026.112581","DOIUrl":"10.1016/j.jpsychores.2026.112581","url":null,"abstract":"<div><h3>Background</h3><div>Functional neurological disorder (FND) is common and associated with substantial disability, yet evidence-based treatment options remain limited. Because maladaptive attentional processes are central to FND pathophysiology, mindfulness-based interventions may be beneficial. Mindfulness-Based Stress Reduction (MBSR) has strong empirical support across physical and mental health conditions, but evidence in FND is sparse.</div></div><div><h3>Objectives</h3><div>To assess feasibility, acceptability, and preliminary clinical outcomes of MBSR for patients with FND.</div></div><div><h3>Methods</h3><div>In this monocentric, single-arm feasibility study, German-speaking adults with confirmed FND were recruited from a specialized outpatient clinic. Participants completed an 8-week standardized MBSR program across three course cycles (two in-person, one online). Primary outcomes included recruitment, retention, attendance, and self-reported home practice; acceptability was assessed via recommendation likelihood. Secondary outcomes included health-related quality of life (WHODAS 2.0), functional impairment (WSAS), depressive (PHQ-9) and anxiety symptoms (GAD-7), and FND symptom burden (FNSQ). Assessments occurred at baseline, post-intervention, and three-month follow-up.</div></div><div><h3>Results</h3><div>Of 57 eligible patients, 24 enrolled (42%); 22 completed the course (92%). Recommendation likelihood was high. Statistically significant pre–post improvements were observed in WHODAS 2.0 (d = −0.56) and WSAS (d = −0.67), with comparable values at three-month follow-up. Post-intervention PHQ-9 scores improved (d = −0.75), FNSQ symptom count decreased (d = −0.68), whereas GAD-7 changes were nonsignificant. Online delivery demonstrated particularly strong adherence without dropouts.</div></div><div><h3>Conclusions</h3><div>MBSR for FND is feasible and well-accepted. A randomized controlled trial is warranted to determine efficacy. Future research could serve as a model for transforming patient-centered care in the digital era.</div><div><strong>Clinical trial registration number:</strong> German Clinical Trials Register (DRKS00034806).</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"204 ","pages":"Article 112581"},"PeriodicalIF":3.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stressful life events, PTSD symptoms and mental health in people living with HIV","authors":"Oscar Royuela ,&nbsp;Francesco Oliva ,&nbsp;Joana Bucker ,&nbsp;Cristina De Córdoba Gil ,&nbsp;Marta Fontana-McNally ,&nbsp;Daniela L. Gatto ,&nbsp;Daniel Guinart ,&nbsp;Hernando Knobel-Freud ,&nbsp;Pablo Knobel ,&nbsp;Walter Lupo ,&nbsp;Cristina Macias ,&nbsp;Mila Montero ,&nbsp;Ana Moreno-Alcázar ,&nbsp;Johannes Wolf ,&nbsp;Frank Padberg ,&nbsp;Benedikt L. Amann ,&nbsp;Alicia Valiente-Gómez ,&nbsp;Bridget Hogg","doi":"10.1016/j.jpsychores.2026.112545","DOIUrl":"10.1016/j.jpsychores.2026.112545","url":null,"abstract":"<div><h3>Background</h3><div><strong>People living with human immunodeficiency virus (HIV; PLWH) can perceive aspects of the disease as traumatic. Objectives:</strong> 1) This study examined the trauma profile and sociodemographic and clinical correlates of HIV-related trauma; 2) to compare the impact of a post-traumatic stress disorder (PTSD) on clinical variables and biological markers in PLWH with HIV-related trauma; 3) to investigate the factors associated with PTSD; 4) to examine the relationship between childhood maltreatment, dissociation, and psychopathology.</div></div><div><h3>Methods</h3><div>93 Hospital del Mar Barcelona outpatient adults living with HIV with HIV-related trauma were included in this cross-sectional study. Participants were assessed with validated scales for PTSD, trauma, psychopathology, quality of life, functionality, and HIV-related stigma. CD4/CD8 ratio was also collected. PLWH with and without PTSD were compared in terms of clinical and sociodemographic factors and a pathway analysis was conducted.</div></div><div><h3>Results</h3><div>PLWH with PTSD reported significantly more anxious, depressive, and general psychiatric symptoms, poorer health-related quality of life and more stigma related to HIV compared to those with trauma symptoms only (all <em>p</em> &lt; 0.0024). Age (OR = 1.08, <em>p</em> = 0.045) and previous psychiatric disorder (OR = 15.57, <em>p</em> = 0.010) can predict a PTSD diagnosis. PLWH with PTSD showed stronger correlations between childhood maltreatment, dissociation, and psychiatric symptoms than those with trauma symptoms only.</div></div><div><h3>Conclusions</h3><div>PTSD is associated with more psychiatric symptoms, lower quality of life and increased HIV-related stigma. Dissociation and PTSD were identified as a potential mechanism linking childhood maltreatment and mental health outcomes, suggesting a target for intervention. These findings support the need for PTSD screening and trauma-focused treatments in HIV care settings.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"204 ","pages":"Article 112545"},"PeriodicalIF":3.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression severity and major cardiovascular events: Findings from German insurance claims data","authors":"Caroline Märtens ,&nbsp;Britta Stapel ,&nbsp;Ivo Heitland ,&nbsp;Jan Zeidler ,&nbsp;Johann Bauersachs ,&nbsp;Jona T. Stahmeyer ,&nbsp;Kai G. Kahl","doi":"10.1016/j.jpsychores.2026.112579","DOIUrl":"10.1016/j.jpsychores.2026.112579","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have linked depression and depressive symptoms to major adverse cardiovascular events (MACE, i.e. stroke and acute myocardial infarction (AMI)) and mortality. However, data on the association of diagnosed depressive disorders and MACE in large samples are scarce. In the present study, we aim to assess the association of depression diagnoses and depression severity with the risk for MACE and all-cause mortality.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included health insurance data from 1,314,289 individuals in Germany. Depressive disorders and depression severity were defined by ICD-10 codes. Patients with MACE during a three-year pre-observation period were excluded. Incident MACE and all-cause deaths were recorded over a six-year follow-up. Adjusted hazard ratios (HR) and 95% confidence intervals (95%CI) were computed by cox proportional hazard models with confounders age, sex, cardiometabolic- and substance use disorders.</div></div><div><h3>Results</h3><div>Depression was significantly associated with increased risk for MACE (HR 1.16, 95%CI 1.14–1.18), reflected by heightened risk for AMI (HR 1.10, 95%CI 1.06–1.13) and stroke (HR 1.20, 95%CI 1.17–1.23). MACE risk increased with greater depression severity (mild: HR 1.09, 95%CI 1.05–1.13; moderate: HR 1.19, 95%CI 1.15–1.23; severe: HR 1.19, 95%CI 1.14–1.24). Similarly, depression was significantly linked to augmented mortality risk (HR 1.20, 95%CI 1.18–1.21), depending on depression severity (mild: HR 1.07, 95%CI 1.05–1.09; moderate: HR 1.21, 95%CI 1.18–1.23; severe: HR 1.29, 95%CI 1.26–1.32).</div></div><div><h3>Conclusion</h3><div>This study demonstrates a significant association between depression and increased risk for MACE and mortality in a large German health insurance claims sample. Additionally, it highlights that depression severity is linked to both, MACE and mortality risk, underscoring the urgent need for targeted cardiovascular disease prevention strategies in patients with clinical depression.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"204 ","pages":"Article 112579"},"PeriodicalIF":3.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trauma, resilience, and posttraumatic growth.","authors":"Ulrich Schnyder","doi":"10.1016/j.jpsychores.2026.112683","DOIUrl":"https://doi.org/10.1016/j.jpsychores.2026.112683","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":" ","pages":"112683"},"PeriodicalIF":3.3,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"The relationship between self-reported interoception and depression: A systematic review and multilevel meta-analysis\" Journal of Psychosomatic Research (2026) 205, 112632.","authors":"Paul M Jenkinson, Rodolfo Leuzzi, Charlotte E Dean, Aaron T Clarke, Joanna Mash, Keith R Laws","doi":"10.1016/j.jpsychores.2026.112680","DOIUrl":"https://doi.org/10.1016/j.jpsychores.2026.112680","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":" ","pages":"112680"},"PeriodicalIF":3.3,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing factitious disorder through an addiction-informed lens: Harm reduction first.","authors":"Cédric Lemogne, Guillaume Airagnes","doi":"10.1016/j.jpsychores.2026.112676","DOIUrl":"https://doi.org/10.1016/j.jpsychores.2026.112676","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":" ","pages":"112676"},"PeriodicalIF":3.3,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147700645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbid DSM-5 mental disorders and chronic pain: What kind of relationship? Findings from the P3 cross-sectional study","authors":"Lorenzo Pelizza ,&nbsp;Simona Pupo ,&nbsp;Camilla Barbi ,&nbsp;Marika Alessia Incardona ,&nbsp;Giovanni Musetti ,&nbsp;Marco Menchetti","doi":"10.1016/j.jpsychores.2026.112549","DOIUrl":"10.1016/j.jpsychores.2026.112549","url":null,"abstract":"<div><h3>Purpose</h3><div>Mental disorders and chronic pain frequently co-occur. The prevalence of this comorbidity varies widely across investigations and is certainly overestimated using screening self-reports. The main aim of this cross-sectional research was to calculate prevalence rates of mental disorders in a chronic pain population during their first consultation in an Italian specialized pain clinic using the narrow diagnostic criteria of the DSM-5. Additionally, we examined the relationship between this psychiatric comorbidity and a broad range of socio-demographic and clinical parameters related to chronic pain.</div></div><div><h3>Procedures</h3><div>174 participants were enrolled in the Pain Therapy Service at the Parma University Hospital. They completed the Structured Clinical Interview for DSM-5 mental disorders (SCID-5) and the Brief Pain Inventory (BPI). Associations between psychiatric comorbidity and other parameters were explored using regression analyses.</div></div><div><h3>Main findings</h3><div>57 (32.7%) subjects with chronic pain had DSM-5 psychiatric comorbidity, particularly major depression and anxiety disorders. This comorbid psychopathology showed significant associations with BPI pain severity and interference scores, as well as with the presence of widespread chronic pain (including fibromyalgia) and the prescription of anti-neuropathic medication at entry. Notably, only a minority (<em>n</em> = 18; 31.6%) of these participants with current comorbid mental disorders were treated in psychiatric services.</div></div><div><h3>Conclusions</h3><div>A large portion of chronic pain patients with comorbid psychiatric syndromes remain undiagnosed and undertreated. The presence of mental health operators in multidisciplinary chronic pain teams is justified and recommended.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"203 ","pages":"Article 112549"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146081107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}