Journal of Psychosomatic Research最新文献

{"title":"Characterization of psychiatric admissions in Huntington disease: A retrospective review","authors":"Shuhei Shiino ,&nbsp;Sarah Moroz ,&nbsp;Jeffrey Stovall ,&nbsp;William M. Petrie ,&nbsp;Daniel O. Claassen ,&nbsp;Katherine E. McDonell","doi":"10.1016/j.jpsychores.2025.112331","DOIUrl":"10.1016/j.jpsychores.2025.112331","url":null,"abstract":"<div><h3>Objective</h3><div>Neuropsychiatric symptoms are common clinical features of Huntington disease (HD) that can result in mental health emergencies. However, there are no established guidelines for inpatient psychiatric treatment in HD. In this study, the investigators reviewed psychiatric hospitalizations in a large medical center to better understand the mental health needs of patients with HD and identify potential gaps in care.</div></div><div><h3>Methods</h3><div>Charts were reviewed to identify patients with HD at Vanderbilt University Medical Center who were admitted to psychiatry between 2013 and 2020. Clinical data and demographic information were obtained from the electrical health record along with the indication for each psychiatric admission, actions taken during the admission, and follow-up care.</div></div><div><h3>Results</h3><div>Among this cohort, 32 of 287 patients (11.1 %) were admitted to inpatient psychiatry at least once. Age at first admission ranged from 17 to 74 years, with 84.4 % of patients in the motor-manifest stage. The most common reasons for admission were suicidal ideation or attempt (57.6 %), psychosis (39.4 %), and aggression (36.4 %). Most patients were able to return to their previous level of care, although readmissions were common.</div></div><div><h3>Conclusions</h3><div>These results emphasize the frequency and severity of psychiatric crises in HD and support the need for expanded access to emergency psychiatry care across the disease course. Further research is warranted to develop an integrated, disease-specific approach to early recognition and management of psychiatric symptoms in HD.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"196 ","pages":"Article 112331"},"PeriodicalIF":3.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with anxiety and depression symptoms among women with endometriosis: A cross-sectional study within the ComPaRe-Endometriosis cohort","authors":"Zélia Breton ,&nbsp;Solène Gouesbet ,&nbsp;Hélène Amazouz ,&nbsp;Hélèna Schoefs ,&nbsp;Viet-Thi Tran ,&nbsp;Bruno Falissard ,&nbsp;Emmanuelle Corruble ,&nbsp;Marina Kvaskoff","doi":"10.1016/j.jpsychores.2025.112329","DOIUrl":"10.1016/j.jpsychores.2025.112329","url":null,"abstract":"<div><h3>Context and objectives</h3><div>Women with endometriosis report higher anxiety and depression levels compared with the general population. While numerous studies focused on chronic pain, few have investigated broader potential correlates of mental well-being in patients with endometriosis. This cross-sectional study aimed to highlight the factors associated with higher anxiety and depression symptoms in women with endometriosis.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional analysis among 2394 participants of the ComPaRe-Endometriosis e-cohort. Symptoms of anxiety and depression were assessed via GAD-7 and PHQ-9 scales at baseline. We used polytomous logistic regression modeling to explore the factors associated with anxiety and depression symptoms severity after adjustment for age, body mass index (BMI), number of comorbidities, diagnostic delay, and age at first symptoms.</div></div><div><h3>Results</h3><div>Overall, 32 % and 45 % of participants had moderate-to-severe anxiety and depression symptoms respectively. Factors positively associated with higher anxiety/depression symptom severity included lower education, poor sleep quality, reduced quality of life, severity of pelvic/abdominal pain, number of comorbidities, higher BMI, number of medical consultations to diagnosis, and use of complementary medicine. In contrast, older age, a financial situation perceived as comfortable, lack of pain treatment or less frequent transvaginal ultrasound follow-ups were associated with lower anxiety and depression symptoms.</div></div><div><h3>Conclusion</h3><div>This study identified several sociodemographic and medical factors associated with higher severity of anxiety and depression symptoms in women with endometriosis. If confirmed in future studies, these results could guide preventive strategies, enhance healthcare provider training, and optimize treatments for improved patient-centered care.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"196 ","pages":"Article 112329"},"PeriodicalIF":3.5,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When silence hurts: Menstrual stigma, mental health, and service gaps among Indonesian adolescents","authors":"Erma Pratiwi Nufi","doi":"10.1016/j.jpsychores.2025.112327","DOIUrl":"10.1016/j.jpsychores.2025.112327","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"196 ","pages":"Article 112327"},"PeriodicalIF":3.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of non-pharmacological interventions on psychological well-being in stable COPD: A systematic review and network meta-analysis","authors":"Yujie Xue ,&nbsp;Kaiwen Tang ,&nbsp;Huimin Liu ,&nbsp;Xueqin Jin","doi":"10.1016/j.jpsychores.2025.112324","DOIUrl":"10.1016/j.jpsychores.2025.112324","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to compare the efficacy of multiple non-pharmacological interventions to improve anxiety and depression in chronic obstructive pulmonary disease (COPD) patients by network meta-analysis and to determine the optimal intervention.</div></div><div><h3>Methods</h3><div>PubMed, Embase, Cochrane Library, CINAHL, PsycINFO, and Web of Science databases were searched for randomized controlled trials (RCTs) related to the study objectives. The search spanned from database inception to January 2025. Two reviewers independently selected the literature, extracted data, and assessed the risk of bias in the included studies. A random-effects model based on a frequency framework was applied using Stata 18.0 software to perform network meta-analysis. Publication bias was evaluated using funnel plots.</div></div><div><h3>Results</h3><div>This study included 41 RCTs involving 5055 participants, and seven different intervention categories were involved. Network meta-analysis revealed that mind-body therapy (MBT) [SMD = -0.59, 95 %CI (−0.88, −0.30)], exercise (EX) [SMD = -0.44, 95 %CI (−0.84, −0.05)], and biopsychosocial approach (BA) [SMD = -0.42, 95 %CI (−0.69, −0.15)] significantly outperformed the control group in improving anxiety. For depression relief, MBT [SMD = -0.72, 95 %CI (−1.03, −0.40)] and EX [SMD = -0.68, 95 %CI (−1.08, −0.27)] significantly surpassed the control group. The ranked probabilities indicated that mind-body therapy was the most effective, followed by exercise, in reducing depression and anxiety in patients with COPD. The funnel plot suggested a potential risk of publication bias.</div></div><div><h3>Conclusion</h3><div>Our network meta-analysis highlights the superior efficacy of mind-body therapy and exercise interventions in improving anxiety and depression among COPD patients. However, given the low certainty of the evidence, additional high-quality trials are needed to confirm these findings.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"196 ","pages":"Article 112324"},"PeriodicalIF":3.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of suicide and suicide attempts following a diagnosis of cancer: A nationwide study using Danish registry data","authors":"Erik Christiansen ,&nbsp;Jesper Hallas ,&nbsp;Elsebeth Stenager ,&nbsp;Mette Reilev","doi":"10.1016/j.jpsychores.2025.112326","DOIUrl":"10.1016/j.jpsychores.2025.112326","url":null,"abstract":"<div><h3>Background</h3><div>Suicide is a significant global health issue, with elevated risks observed in individuals diagnosed with severe somatic diseases, including cancer.</div></div><div><h3>Aim</h3><div>The study aims to elucidate patterns of suicidal behavior relative to cancer diagnosis, providing both absolute and relative risk estimates.</div></div><div><h3>Methods</h3><div>A nationwide cohort study utilized Danish registry data (2012−2021). Two cohorts were established: cancer cases (<em>n</em> = 300,803) and an age- and sex-matched comparison group. Suicidal behavior was assessed over seven years (two years pre-diagnosis and five years post-diagnosis) using Poisson regression and Generalized Estimating Equations to calculate incidence rates and incidence rate ratios (IRR).</div></div><div><h3>Results</h3><div>Suicide rates peaked during the quarter following cancer diagnosis, with IRRs up to 4.3 (CI: 1.3–13.8). Elevated risks for suicide attempts persisted for two years post-diagnosis, decreased thereafter but remained higher than the comparison group. Risk patterns varied by cancer type, sex, and age, with older males exhibiting the highest suicide rates and younger individuals displaying more suicide attempts.</div></div><div><h3>Conclusions</h3><div>Suicidal behavior significantly increased around the time of cancer diagnosis, highlighting critical periods for intervention. These findings emphasize the importance of integrated mental health support for cancer patients, particularly in the early stages after diagnosis.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"196 ","pages":"Article 112326"},"PeriodicalIF":3.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interoceptive sensibility in stroke patients: Latent profile analysis and influencing factors","authors":"Yunmei Guo,&nbsp;Xueya Feng,&nbsp;Yu Shan,&nbsp;Shouwen Peng,&nbsp;Xin Yan,&nbsp;Qian Zhou","doi":"10.1016/j.jpsychores.2025.112313","DOIUrl":"10.1016/j.jpsychores.2025.112313","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to explore the latent categories of interoceptive sensibility in patients with stroke and analyze its influencing factors.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted using a convenience sample of 417 patients with stroke in a tertiary hospital in Zunyi from June to October 2024. Socio-demographic information and interoceptive sensibility of participants were obtained using a general information questionnaire and the multidimensional assessment of the interoceptive awareness scale. Latent profile analysis was used to analyze the latent categories of interoceptive sensibility in patients with stroke. In the multiple logistic regression analysis, the latent categories of interoceptive sensibility derived from latent profile analysis were used as the dependent variable to identify factors influencing these categories.</div></div><div><h3>Results</h3><div>The average interoceptive sensibility score of patients with stroke was 90.46 ± 44.93. Interoceptive sensibility in patients with stroke was classified as low (C1, 34.4 %), moderate (C2, 26.3 %), and high types (C3, 39.3 %). Multiple logistic regression demonstrated that self-efficacy, health literacy, self-care capability, and family monthly income were predictors of the participants' latent categories of interoceptive sensibility.</div></div><div><h3>Conclusion</h3><div>In patients with stroke, interoceptive sensibility can be categorized into three distinct profiles: high, moderate and low-interoceptive sensibility group. Intervention measures are implemented according to their different demographic characteristics to improve their ability to interpret internal body signals and improve self-management and recovery.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"196 ","pages":"Article 112313"},"PeriodicalIF":3.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of panic disorder on severe asthma and chronic rhinosinusitis with nasal polyps: A comparative clinical study","authors":"Daniela Caldirola ,&nbsp;Silvia Daccò ,&nbsp;Francesca Puggioni ,&nbsp;Matilde Crebelli ,&nbsp;Massimiliano Grassi ,&nbsp;Alessandra Alciati ,&nbsp;Luca Malvezzi ,&nbsp;Enrico Heffler ,&nbsp;Giampaolo Perna","doi":"10.1016/j.jpsychores.2025.112325","DOIUrl":"10.1016/j.jpsychores.2025.112325","url":null,"abstract":"<div><h3>Objective</h3><div>We cross-sectionally compared outpatients with severe asthma (SA), chronic rhinosinusitis with nasal polyps (CRSwNP), or both, grouped by current, past, or absent panic disorder (PD) history, to assess clinical differences. Published data on this topic are limited in SA and absent in CRSwNP.</div></div><div><h3>Methods</h3><div>Between February and March 2024, outpatients at the Personalized Medicine Asthma and Allergy Clinic, Humanitas Research Hospital, were consecutively recruited during follow-up visits. All were previously enrolled in the SANI (Severe Asthma Network Italy) or RINET (Rhinosinusitis Italian Network) registries. Participants completed a self-report survey assessing sociodemographics, lifestyle, medical history, asthma control, nasal obstruction, physical symptoms, cognitive-emotional factors, and quality of life. Provisional diagnoses of PD (PPD) and, additionally, major depressive episode (PMDE) were based on the Patient Health Questionnaire (PHQ). Analyses included Kruskal-Wallis, Dunn's post-hoc, and Fisher's exact tests with Holm's correction (α = 0.05).</div></div><div><h3>Results</h3><div>Among 79 patients (58.2 % women), 7 (8.9 %) had current PPD and 12 (15.2 %) had past PPD. Four (5.1 %) had a PMDE. PPD significantly correlated with poorer asthma control, more severe nasal obstruction, increased dyspnea and physical symptoms, greater asthma-related catastrophizing, focus on bodily sensations, avoidance of activities, and reduced quality of life.</div></div><div><h3>Conclusions</h3><div>PPD is more prevalent in SA and/or CRSwNP than in the general population. Panic comorbidity links to greater respiratory severity and symptom burden, supporting screening and integrated care. The study is novel in including CRSwNP, advanced-treatment patients, evaluating current and past PPD, and exploring multiple previously unexamined clinical aspects. Further research is warranted.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"196 ","pages":"Article 112325"},"PeriodicalIF":3.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of self-compassion in protecting psychological wellbeing and health-related quality of life in those with endometriosis: A prospective study","authors":"Chelsea M. Skinner,&nbsp;Roeline G. Kuijer","doi":"10.1016/j.jpsychores.2025.112322","DOIUrl":"10.1016/j.jpsychores.2025.112322","url":null,"abstract":"<div><h3>Objective</h3><div>Endometriosis negatively impacts psychological wellbeing and health-related quality of life (HRQoL). Emerging research suggests that self-compassion may be a protective resource, although the mechanisms through which it influences functioning in endometriosis are not well understood. This study examined the relationship between self-compassion, psychological distress, and HRQoL over a six-month period. Pain catastrophising, pain acceptance, and resilience were examined as potential mediators.</div></div><div><h3>Methods</h3><div>264 individuals with endometriosis completed questionnaires twice over a 6-month period assessing self-compassion (T1 only), psychological distress (depression, anxiety, and stress), HRQoL, pain catastrophising, pain acceptance (activity engagement, pain willingness), resilience, and endometriosis-related information (T1 and T2). Bootstrapped mediation analyses were conducted to examine the relationship between the key variables cross-sectionally and over time (two-wave mediation).</div></div><div><h3>Results</h3><div>Psychological wellbeing and HRQoL was significantly impaired in this sample. Higher self-compassion was associated with less impairment on all outcome variables at T1 <em>(r</em> &gt; −0.25, <em>p</em> &lt; .001) and improvements in depression (<em>b</em> = −0.28, <em>p</em> &lt; .01) and stress (<em>b</em> = −0.21, <em>p</em> &lt; .05) over the study period. Cross-sectionally, pain catastrophising mediated the relationship between self-compassion and all outcome variables. Prospectively, higher self-compassion at baseline was related to a decrease in pain catastrophising over the study period, which in turn was related to a decrease in depression, anxiety, stress, and HRQoL impairment over the study period. Pain willingness, activity engagement, and resilience were less consistent mediators at baseline and did not mediate the relationship between self-compassion and the outcome variables prospectively.</div></div><div><h3>Conclusion</h3><div>Future research should consider interventions that address self-compassion and pain catastrophising to reduce impairment in psychological wellbeing and HRQoL in individuals with endometriosis.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"196 ","pages":"Article 112322"},"PeriodicalIF":3.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological distress after COVID-19 recovery and subsequent prolonged post-acute COVID-19 syndrome: A longitudinal study with one-year follow-up in Japan","authors":"Megumi Hazumi ,&nbsp;Mayumi Kataoka ,&nbsp;Zui Narita ,&nbsp;Kentaro Usuda ,&nbsp;Emi Okazaki ,&nbsp;Daisuke Nishi","doi":"10.1016/j.jpsychores.2025.112323","DOIUrl":"10.1016/j.jpsychores.2025.112323","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the longitudinal association between psychological distress in the post-acute phase and the subsequent prolonged post-acute COVID-19 syndrome (PACS) symptoms among individuals with PACS symptoms.</div></div><div><h3>Methods</h3><div>An online longitudinal survey was conducted from July to September 2021 (Time 1, T1) and from July to September 2022 (Time 2, T2). Individuals who were 20 years or older had a positive polymerase chain reaction test, were one-month post-infection, and did not select “Nothing” to a question about PACS symptoms were included. The primary outcome was any PACS symptoms at T2. General and respiratory symptoms at T2 were also examined among participants with those symptoms at T1. Exposure was psychological distress, defined as Kessler Distress Scale ≥13 at T1. Logistic regression analyses were conducted to examine associations between psychological distress and PACS symptoms, general and respiratory symptoms among participants with relevant symptoms at T1.</div></div><div><h3>Results</h3><div>Of 1674 participants, 671 completed T2, and 109 of them reported psychological distress. Psychological distress was associated with higher odds of any PACS (odds ratio [OR] = 1.79, 95 % confidence interval [CI] = 1.07–2.98, <em>p</em> = 0.03), general symptoms (OR = 1.92, 95 % CI = 1.01–3.67, <em>p</em> = 0.046), and respiratory symptoms (OR = 2.73, 95 % CI = 1.02–6.44, <em>p</em> = 0.02) at T2.</div></div><div><h3>Conclusion</h3><div>Psychological distress in the post-acute phase may contribute to the persistence of PACS symptoms, mainly general and respiratory symptoms, at the one-year follow-up in individuals with PACS symptoms.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"196 ","pages":"Article 112323"},"PeriodicalIF":3.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomic arousal and heart rate variability in functional somatic disorder - a cross-sectional population-based study","authors":"Lise Gormsen ,&nbsp;Henning Mølgaard ,&nbsp;Thomas Meinertz Dantoft ,&nbsp;Anne Arendt Bjerregaard ,&nbsp;Per Fink ,&nbsp;Marie Weinreich Petersen","doi":"10.1016/j.jpsychores.2025.112193","DOIUrl":"10.1016/j.jpsychores.2025.112193","url":null,"abstract":"<div><h3>Objective</h3><div>The bodily distress syndrome (BDS) checklist has proven to be useful diagnostic aid and as screening tool for functional somatic disorder (FSD). It has been hypotheses that the symptoms clusters of the checklist represent autonomic activity. This study aims to investigate associations between autonomic activity (Heart rate variability, HRV) and somatic symptoms profiles measured by the BDS checklist and diagnoses of FSD based on interviews.</div></div><div><h3>Methods</h3><div>This cross-sectional population-based study included 6891 men and women aged 18–72 years. Somatic symptom profiles were measured by the 25-item BDS checklist, and five short-term HRV measures (MeanRR, RMSSD, LF, HF, and LF/HF) were obtained. In a stratified subsample (<em>n</em> = 1590), diagnoses of FSD was established by diagnostic interviews, performed by trained family physicians. Associations were tested with regression models. Measures of associations were mean difference with 95 % confidence intervals (CIs) for Mean RR and median ratio and 95 % CI for RMSS, LF, HF, and LF/HF.</div></div><div><h3>Results</h3><div>Overall, higher BDS checklist scores were associated with lower HRV, particularly reduced mean RR intervals (−0.86, 95 % CI: −0,24;-0,49 for the total sum score). The strongest associations were seen for the cardiopulmonary symptom cluster (−3.58, 95 % CI: −0,05;-2.10). Clinically diagnosed FSD cases also showed lower mean RR compared to non-cases (−23.12, 95 % CI: −41.17;-5.07), especially the multi-organ type (−39.44, 95 % CI: −75.49;-3.39).</div></div><div><h3>Conclusions</h3><div>The study indicate that the symptom clusters of the BDS checklist are associated with autonomic arousal as measured by HRV. Further that individuals with FSD, especially the multi-organ type, had an increased sympathetic neural and neurohormonal activity, suggesting this may be an important physiological mechanism in FSD.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"196 ","pages":"Article 112193"},"PeriodicalIF":3.5,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}