Journal of Psychosomatic Research最新文献

{"title":"A systematic review and meta-analysis of the relationship between emotion regulation, pain, depressive symptoms and quality of life in women with endometriosis","authors":"Sérgio A. Carvalho,&nbsp;Inês Eulálio,&nbsp;Raquel Guiomar","doi":"10.1016/j.jpsychores.2025.112205","DOIUrl":"10.1016/j.jpsychores.2025.112205","url":null,"abstract":"<div><h3>Background</h3><div>Endometriosis is a chronic gynecological condition with a broad spectrum of symptomatology resulting from a complex pathophysiology and biopsychosocial etiology, to which emotion regulation (ER) seems to contribute. This systematic review aims to summarize and meta-analyse the empirical evidence for the relationship between (mal)adaptive ER strategies, pain (intensity and impact), depressive symptoms, and quality of life of women with endometriosis.</div></div><div><h3>Design and methods</h3><div>After registering to PROSPERO (ID: CRD42023427936; redacted), four databases were searched (PubMed, PsycINFO, Web of Knowledge, Scopus) from inception until 30th May 2025. All screening steps were performed by two researchers independently. The quality of the studies was examined using the National Heart, Lung and Blood Institute tool, and statistical analyses were performed on R.</div></div><div><h3>Results</h3><div>Sixteen studies (<em>N</em> = 3687) were included. Pooled correlations found ER to be significantly correlated with all outcomes, with adaptive (e.g., acceptance, mindfulness, self-compassion) and maladaptive (e.g., rumination, catastrophizing) ER strategies being associated with the outcomes in the expected direction. Age moderated the association between ER and quality of life, showing that ER especially moderates quality of life in younger women with endometriosis.</div></div><div><h3>Conclusions</h3><div>This meta-analysis provides evidence that adaptive ER skills might positively influence symptomatology in younger women with endometriosis. To foster mental health and pain coping, psychological management with a focus on emotion regulation may help the field further.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112205"},"PeriodicalIF":3.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health literacy scale for women with polycystic ovary syndrome (HL-PCO): Instrument development and cross-sectional validation study","authors":"Minhui Guan ,&nbsp;Rong Li ,&nbsp;Guangpeng Wang ,&nbsp;Ziyan Li ,&nbsp;Quan Shen ,&nbsp;Enuo Peng ,&nbsp;Jia Qu ,&nbsp;Jun Lei ,&nbsp;Bing Fu","doi":"10.1016/j.jpsychores.2025.112200","DOIUrl":"10.1016/j.jpsychores.2025.112200","url":null,"abstract":"<div><h3>Background</h3><div>Health literacy is crucial in shaping health outcomes for individuals with polycystic ovary syndrome (PCOS), influencing their disease perceptions, treatment adherence, and self-management behaviors. Women with PCOS often face challenges due to inadequate health literacy, leading to delayed diagnosis and low treatment compliance. However, there is a lack of specific tools to measure health literacy within the context of PCOS, hindering accurate assessments and targeted interventions.</div></div><div><h3>Method</h3><div>To address this gap, a health literacy scale for women with PCOS (HL-PCO) was developed and validated. The initial items were generated through a comprehensive literature review, in-depth interviews, and the Delphi method. A cross-sectional validation study was conducted at a tertiary hospital in Changsha, China, using classical test theory (CTT) and item response theory (IRT) for item selection. Reliability was assessed using Cronbach's α coefficient and split-half reliability, while validity was evaluated through various analyses.</div></div><div><h3>Result</h3><div>The HL-PCO scale retained 17 items across four factors: Acquisition, Understanding, Appraisal, and Application. Confirmatory factor analysis exhibited acceptable goodness-of-fit indices, and the Item Content Validity Index values surpassed 0.833. Robust results were also demonstrated through analyses of convergent validity, discriminant validity, and concurrent validity. The Cronbach's α coefficient for the HL-PCO was 0.930, and the split-half reliability coefficient amounted to 0.836.</div></div><div><h3>Conclusion</h3><div>The refined HL-PCO scale, comprising 17 items across four factors, has been rigorously validated as a reliable instrument. Its implementation has the potential to enhance health literacy assessment and improvement among women with PCOS, facilitating more effective health education interventions and ultimately improving patient outcomes.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112200"},"PeriodicalIF":3.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the causal influence of herpesvirus infections on the risk of depression phenotypes: A Mendelian randomization study","authors":"Yi Li ,&nbsp;Zhenqiu Liu ,&nbsp;Hong Fan ,&nbsp;Sijie Tao ,&nbsp;Haili Wang ,&nbsp;Xin Zhang ,&nbsp;Sheng Wu ,&nbsp;Yiyun Xu ,&nbsp;Tianye Wang ,&nbsp;Ying Yang ,&nbsp;Tiejun Zhang","doi":"10.1016/j.jpsychores.2025.112194","DOIUrl":"10.1016/j.jpsychores.2025.112194","url":null,"abstract":"<div><h3>Objective</h3><div>Previous findings of associations between herpesvirus infections and depression were mixed and did not implicate causality. This study used two-sample Mendelian randomization (MR) to clarify the causal impact of four symptomatic herpesvirus infections (shingles, chicken pox, cold sores, and mononucleosis) on three depression phenotypes, including depressive symptoms (DS), number of episodes with depressed mood (NEDM), and major depressive disorder (MDD).</div></div><div><h3>Methods</h3><div>Eligible SNPs were selected as instrumental variables (IVs). MR estimates were primarily based on the inverse variance weighted (IVW) method. Cochran's Q, MR-Egger intercept tests, and leave-one-out analyses were performed to assess the robustness of the results. False discovery rates (FDR) were calculated to correct the bias of multiple testing. Sensitivity analyses were performed by repeating the above process using IVs meeting a more relaxed threshold.</div></div><div><h3>Results</h3><div>Estimates of the main MR analyses suggested that shingles was associated with an increased risk of DS (IVW β = 0.040, <em>FDR</em> = 0.008) and NEDM (IVW β = 0.056, <em>FDR</em> = 0.003), which was supported by the sensitivity analyses. The effects of chicken pox on DS and NEDM were non-significant in the main analyses, whereas significant in the sensitivity analyses (for DS: IVW β = 0.063, <em>FDR</em> = 0.027; for NEDM: IVW β = 0.151, <em>FDR</em> = 0.039). None of the four herpesvirus infections was linked to MDD.</div></div><div><h3>Conclusion</h3><div>Our findings provide evidence that shingles is causally linked to specific depression phenotypes. Enhancing antiviral treatments and vaccination programs may promote the prevention of depression.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112194"},"PeriodicalIF":3.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health service use among individuals with traumatic brain injury: Exploring the role of social support, employment, and insurance","authors":"Altaf Saadi ,&nbsp;Mario Cruz-Gonzalez ,&nbsp;Lulu Zhang ,&nbsp;Margarita Alegría","doi":"10.1016/j.jpsychores.2025.112195","DOIUrl":"10.1016/j.jpsychores.2025.112195","url":null,"abstract":"<div><h3>Introduction</h3><div>This study assessed 1) differences in mental health service use among those with and without traumatic brain injury (TBI), 2) whether social supports, employment, and insurance moderated the TBI-mental health service use relationship, and 3) racial and ethnic differences in these associations.</div></div><div><h3>Methods</h3><div>In an analytic sample of 1018 participants, we used propensity score matching and inverse probability of treatment weighting to assess differences in both lifetime and past 12-month mental health service use among those with and without TBI. We used a logistic regression model for the moderation analyses.</div></div><div><h3>Results</h3><div>Those with TBI reported greater depressive, anxiety, and PTSD symptoms than those without TBI, as well as higher probability of both lifetime and past 12-month mental health service use. After adjusting for the propensity score, those with TBI were about 10.5 % more likely to use mental health services compared to those without TBI. Higher levels of social support were associated with a three-fold increase in the odds of using mental health services in individuals with TBI. Employment and insurance did not significantly moderate the TBI-mental health service use relationship, but insurance was independently associated with grater odds of both lifetime and past 12-month mental health service use.</div></div><div><h3>Conclusion</h3><div>Greater psychiatric symptoms in individuals with TBI, along with their increased use of mental health services, highlight the need for a multidisciplinary approach to TBI care. Interventions could also target social relationships, as lower social support represents a potential pathway for differences in mental health service use for those with TBI.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112195"},"PeriodicalIF":3.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsychosocial prognostic indicators in Functional Neurological Disorder: A systematic review","authors":"Edwina R. Sekine ,&nbsp;Richard A. Kanaan ,&nbsp;Janine McMillan ,&nbsp;Sarah Oxford ,&nbsp;Ross A. Iles","doi":"10.1016/j.jpsychores.2025.112201","DOIUrl":"10.1016/j.jpsychores.2025.112201","url":null,"abstract":"<div><h3>Background</h3><div>Functional Neurological Disorder (FND) may result in significant disability. Biopsychosocial and contextual factors contributing to health outcomes in FND remain unclear.</div></div><div><h3>Purpose</h3><div>To ascertain the current evidence relating to biopsychosocial and contextual factors of prognostic relevance in adults with FND.</div></div><div><h3>Methods</h3><div>A systematic review was conducted. Studies of adults with FND were included. Methodological quality was assessed using the Joanna Briggs Institute checklist for cohort studies. A best-evidence synthesis approach was applied to consider the quantity and consistency of findings. Outcomes measured were mapped to the biopsychosocial domains of the International Classification of Functioning, Disability and Health framework.</div></div><div><h3>Findings</h3><div>The search yielded 6019 references. Thirty studies (3000 participants) examining 2309 people with FND met inclusion criteria. Ten were deemed high methodological quality and 17 medium quality. Biologically, age was unrelated to outcomes. Psychologically, a history of psychiatric treatment, somatisation and alexithymia were associated with negative outcomes. Socially, there was strong evidence that workforce participation was associated with better outcomes. Seizure frequency and illness duration were characteristics unrelated to outcomes. Factors associated with an individual were examined more often than broader systemic contextual factors.</div></div><div><h3>Conclusions</h3><div>This review summarises existing knowledge around biopsychosocial prognostic indicators of recovery in adults with FND. Workforce participation is associated with better health outcomes in FND. A change in seizure frequency may not translate to participation in life roles. There was limited research investigating the impact of systemic contextual factors. A more consistent approach in this research area would further reveal the true state of phenomena.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112201"},"PeriodicalIF":3.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cluster analysis of psychological variables to identify profiles of Nociplastic pain: A cross-sectional study in women with fibromyalgia, chronic headache and vulvodynia","authors":"Filippo Maria Nimbi ,&nbsp;Luigi Palla ,&nbsp;Sara Bottiroli ,&nbsp;Lorys Castelli ,&nbsp;Piercarlo Sarzi-Puttini ,&nbsp;Federica Galli","doi":"10.1016/j.jpsychores.2025.112203","DOIUrl":"10.1016/j.jpsychores.2025.112203","url":null,"abstract":"<div><h3>Background</h3><div>Nociplastic pain (NP) arises from altered nociceptive processing without detectable tissue damage and is common in conditions such as fibromyalgia (FM), vulvodynia (VU), and chronic headaches (CH).</div></div><div><h3>Objectives</h3><div>This study aimed to identify subgroups of NP patients using cluster analysis based on psychological variables, including central sensitivity syndrome manifestations, environmental sensitivity, traumatic experiences, personality traits, defense mechanisms, and alexithymia. A secondary aim was to compare these clusters with clinical diagnoses (FM, CH, VU, and comorbid cases) to explore potential overlaps between psychological profiles and conditions.</div></div><div><h3>Methods</h3><div>A total of 895 Italian women were recruited via snowball sampling through patient associations. Participants completed a web survey featuring self-administered psychological measures assessing central sensitivity, environmental sensitivity, traumatic experiences, personality traits, defense mechanisms, and alexithymia.</div></div><div><h3>Results</h3><div>Cluster analysis identified three meaningful groups—“severe,” “moderate,” and “mild” psychological impairment—based on 20 psychological variables. A one-way MANOVA revealed significant differences among clusters, with central sensitization, alexithymia, and personality traits contributing most to the variance. Chi-square analysis showed significant differences in the distribution of NP conditions across clusters. FM and comorbid cases were associated with “moderate” and “severe” impairment clusters, indicating more compromised psychological profiles compared to other conditions.</div></div><div><h3>Conclusions</h3><div>These findings highlight the presence of distinct psychological profiles within NP conditions, supporting the need for a multidimensional approach to assessment and treatment. Tailored psychological interventions addressing these profiles could improve outcomes for NP patients.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112203"},"PeriodicalIF":3.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type D personality, insomnia severity, perceived stress, and health-related quality of life in inflammatory bowel disease: A case–control study","authors":"Hassan Mohammed Sonbol ,&nbsp;Mona Metwally El-Sayed ,&nbsp;Mahmoud Abdelwahab Khedr ,&nbsp;Mohamad Abulhassan Ibrahim ,&nbsp;Manar Osama ,&nbsp;Asmaa Adel Abdel-Sattar ,&nbsp;Hiam Fathy Elsaied ,&nbsp;Eman Abdeen Ali ,&nbsp;Shorouk Mohsen ,&nbsp;Alaa Salah Abdel Mawgoud","doi":"10.1016/j.jpsychores.2025.112199","DOIUrl":"10.1016/j.jpsychores.2025.112199","url":null,"abstract":"<div><h3>Background</h3><div>Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is associated with significant psychological distress. This study aimed to investigate the relationships between Type D personality, insomnia severity, and perceived stress in IBD patients and a matched control group.</div></div><div><h3>Methods</h3><div>A case–control study was conducted with 132 patients with IBD and 132 age- and sex-matched controls at the outpatient IBD clinic of Main Internal Medicine University Hospitals, Egypt. The participants completed the DS14 (Type D Personality Scale), PSS-10 (Perceived Stress Scale), ISI (Insomnia Severity Index), SIBDQ (Short Inflammatory Bowel Disease Questionnaire), and GSRS (Gastrointestinal Symptom Rating Scale). For disease severity assessment, the DSI (Disease Severity Index) was employed. Logistic regression analysis was conducted only among IBD patients to identify independent predictors of perceived stress and insomnia.</div></div><div><h3>Results</h3><div>Compared with controls, patients with IBD presented significantly higher Type D personality scores (total score: 28 vs. 9, <em>p</em> &lt; 0.001), increased insomnia severity (severe insomnia: 9.1 % vs. 3.1 %, p &lt; 0.001), and higher perceived stress levels (high stress: 34.1 % vs. 6.8 %, p &lt; 0.001). Logistic regression revealed that Type D personality (OR: 30.9, 95 % CI: 5.9–160.1, p &lt; 0.001) and urban residency (OR: 3.1, 95 % CI: 1.5–6.7, <em>p</em> = 0.001) were significant predictors of perceived stress, whereas Crohn's disease was associated with greater insomnia severity (OR: 3.6, 95 % CI: 1.6–7.9, p = 0.001).</div></div><div><h3>Conclusion</h3><div>The findings highlight the significant impact of Type D personality, insomnia, and perceived stress on patients with IBD. These results emphasize the need for integrated care approaches that address both psychological and physical health to improve patient outcomes and quality of life.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112199"},"PeriodicalIF":3.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relative importance of key life domains in explaining life satisfaction among older adults","authors":"Udeni De Silva Perera ,&nbsp;Nicolau Martin-Bassols ,&nbsp;Gang Chen","doi":"10.1016/j.jpsychores.2025.112202","DOIUrl":"10.1016/j.jpsychores.2025.112202","url":null,"abstract":"<div><h3>Objective</h3><div>Life satisfaction is a key element contributing to successful aging. Limited empirical studies have specifically explored the nature of the relationship between domain-specific satisfaction and global life satisfaction among older adults. Furthermore, the existing literature is mainly based on cross-sectional analyses. This study aims to use longitudinal data to quantify the relative importance of key life domains in explaining global life satisfaction among older adults.</div></div><div><h3>Methods</h3><div>Data was drawn from the Health and Retirement Study in the US, including a total of 12,046 respondents (aged 50 years or older) followed for up to 3 waves. Global life satisfaction was measured using the Satisfaction with Life Scale. Five key life domains were studied. Hierarchical linear mixed-effects model, longitudinal dominance analyses, and mixed-effects random forests machine learning approach were used to identify the relative importance of five life domains in explaining global life satisfaction. Potential population heterogeneity is examined using sub-samples based on a number of current and early-life socio-demographic characteristics.</div></div><div><h3>Results</h3><div>“Daily life and leisure activities” domain was found to have the strongest explanatory power for global life satisfaction, followed by “Financial situation”, “Family life”, “Health”, whilst “Conditions of the place where you live” was relatively the least important domain. Heterogeneity was evident on sub-samples according to disability or health status, as well as exposure to early-life adverse events.</div></div><div><h3>Conclusions</h3><div>The findings enriched our understanding of what matters the most for older adults, and are relevant for informing more effective policy interventions to improve global life satisfaction for successful aging.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112202"},"PeriodicalIF":3.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stanford study of the validity of the pre-interventional preventive risk assessment (PIPRA) tool for at-risk elderly patients undergoing elective orthopedic surgery","authors":"Matthew Gunther ,&nbsp;Derek Pipolo ,&nbsp;Shixie Jiang ,&nbsp;Tyler Zahrli ,&nbsp;Jon Sole ,&nbsp;Charles Cloughly ,&nbsp;Jose R. Maldonado","doi":"10.1016/j.jpsychores.2025.112196","DOIUrl":"10.1016/j.jpsychores.2025.112196","url":null,"abstract":"<div><h3>Introduction</h3><div>Post-operative delirium (POD) is a frequent complication in older adults following surgery, leading to higher morbidity and mortality. This study evaluates the validity of the Pre-Interventional Preventive Risk Assessment (PIPRA) tool in predicting POD in an elderly orthopedic population.</div></div><div><h3>Methods</h3><div>We enrolled 250 patients aged 65 or over undergoing elective orthopedic surgery (knee or hip arthroplasties). Delirium was assessed using the Confusion Assessment Method (CAM) and additional DSM-5 based neuropsychiatric evaluations. The PIPRA tool was applied retroactively to generate delirium risk scores based on nine validated risk factors found within the patient's electronic medical record (EMR).</div></div><div><h3>Results</h3><div>Of 241 patients, 13 (5.4 %) developed POD. The median PIPRA score for delirious patients was significantly higher (24.3) compared to non-delirious patients (8.95). Logistic regression identified age (OR = 1.12) and history of cognitive impairment (OR = 10.38) as significant predictors of POD. The PIPRA tool demonstrated an area under the curve (AUC) of 0.748.</div></div><div><h3>Discussion</h3><div>Our study supports PIPRA's validity in assessing delirium risk using readily available clinical parameters from patients' EMRs. When integrated into clinical workflows, this model can preoperatively stratify delirium risk, enabling targeted interventions to prevent its onset.</div></div><div><h3>Conclusion</h3><div>The PIPRA tool presents an innovative approach to evaluating POD risk in surgical populations. By identifying at-risk patients, PIPRA can facilitate informed consent discussions and the implementation of effective preventive measures. Future research should validate its performance across diverse surgical cohorts to refine predictive capabilities and optimize delirium prevention strategies.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112196"},"PeriodicalIF":3.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144469965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and inflammatory markers associated with metabolic dysfunction-associated fatty liver disease in a cohort of individuals with chronic schizophrenia (FACE-SZ)","authors":"Rudy Tokarski ,&nbsp;Susana Barbosa ,&nbsp;Baptiste Pignon ,&nbsp;Bruno Aouizerate ,&nbsp;Christelle Andrieu ,&nbsp;Myrtille Andre ,&nbsp;Wahid Boukouaci ,&nbsp;Delphine Capdevielle ,&nbsp;Isabelle Chereau ,&nbsp;Clément Dondé ,&nbsp;Julie Clauss Kobayashi ,&nbsp;J.M. Dorey ,&nbsp;Caroline Dubertret ,&nbsp;Eric Fakra ,&nbsp;Guillaume Fond ,&nbsp;Tudy Goze ,&nbsp;Sylvain Leignier ,&nbsp;Pierre-Michel Llorca ,&nbsp;Jasmina Mallet ,&nbsp;David Misdrahi ,&nbsp;Ophelia Godin","doi":"10.1016/j.jpsychores.2025.112192","DOIUrl":"10.1016/j.jpsychores.2025.112192","url":null,"abstract":"<div><h3>Aims</h3><div>Recent studies on Metabolic dysfunction-associated fatty liver (MAFLD) in schizophrenia show inconsistent findings, often based on small or specific samples. This study aims to assess the prevalence of MAFLD and its sociodemographic, clinical, and treatment-related risk factors in a large cohort of chronic patients with schizophrenia. A secondary goal is to identify an immuno-inflammatory signature associated with MAFLD.</div></div><div><h3>Methods</h3><div>1009 stable outpatients with schizophrenia were included in the cross-sectional analysis. Individuals with liver disease, hepatitis B/C, or current alcohol use disorder were excluded. MAFLD was screened using the Fatty Liver Index (FLI), with FLI &gt; 60 indicating MAFLD. Risk factors were assessed using multivariate logistic regression, and inflammatory markers were analysed with penalized logistic regression.</div></div><div><h3>Results</h3><div>In a sample of 1009 individuals with schizophrenia, MAFLD prevalence was 36.6 %, higher in men than in women (38.3 % vs 32.0 %, <em>p</em> &lt; 0.0001). Multivariate analysis identified male gender, older age, current smokers, mood stabilizers, antidepressant, clozapine, olanzapine and quetiapine as risk factors for MAFLD. The use of risperidone was associated with a lower risk of MAFLD (0.63 (0.42–0.94). Elevated levels of inflammatory markers such as TNF-α, CRP, and IL-12/IL-23p40 were also linked to a higher likelihood of MAFLD.</div></div><div><h3>Conclusion</h3><div>Although not generalizable to all patients with schizophrenia, this study confirms the high prevalence of MAFLD in individuals with schizophrenia. Psychiatrists should promote healthy lifestyle changes, such as weight control, improved diet, better sleep, and increased physical activity, to improve both physical health and quality of life in these patients.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"195 ","pages":"Article 112192"},"PeriodicalIF":3.5,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144469962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}