Journal of Psychosomatic Research最新文献

{"title":"Depression profiles and hepatitis C treatment outcomes among people who inject drugs: The HERO study.","authors":"Irene Pericot-Valverde, Snehal S Lopes, Jessica Obeysekare, Abigail W Batchelder, Megan Groome, Lynn E Taylor, Kimberly Page, Judith I Tsui, Paula J Lum, Shruti H Mehta, Judith Feinberg, Arthur Y Kim, Brianna L Norton, Julia Arnsten, Anna Baker, Moonseong Heo, Alain H Litwin","doi":"10.1016/j.jpsychores.2025.112417","DOIUrl":"https://doi.org/10.1016/j.jpsychores.2025.112417","url":null,"abstract":"<p><strong>Background: </strong>Evidence suggests that depression profiles may be differentially associated with healthcare engagement. Relying solely on total scores may limit our understanding of depression among people who inject drugs (PWID) living with hepatitis C virus (HCV). This study aimed to (1) identify latent baseline depression symptom profiles and their correlates in HCV-infected PWID; (2) examine changes in depressive symptoms from baseline to follow-up by symptom profile and HCV cure status; and (3) examine the association between baseline depression symptom profiles and HCV treatment outcomes (adherence, completion, and sustained virologic response (SVR)).</p><p><strong>Methods: </strong>A secondary data analysis of the HERO Study was conducted with 498 PWID undergoing direct-acting antiviral (DAA) treatment. Latent class analysis classified participants into distinct baseline depression symptom profiles using the Patient Health Questionnaire-9 (PHQ-9). Changes in PHQ-9 scores and adherence were estimated using linear mixed-effects models, and logistic regression tested the impact of baseline depression symptom profile on treatment completion and SVR.</p><p><strong>Results: </strong>Three depression profiles were identified: Class 1 (n = 63/498) showed no symptoms. Class 2 (n = 148/498) was characterized by sleep difficulties, fatigue, and appetite changes. Class 3 (n = 287/498) endorsed all PHQ-9 items except suicidal thoughts and showed higher rates of urine toxicology tests positive for cocaine. Depression scores post-HCV treatment varied by SVR status, with those who did not achieve SVR showing persistent depression. Adherence, completion, and SVR did not differ across classes.</p><p><strong>Discussion: </strong>Severe depression among HCV-infected PWID underscores the critical importance of assessing, monitoring, and treating these symptoms during HCV treatment, particularly for those not achieving HCV cure.</p><p><strong>Clinical trials number: </strong>NCT02824640.</p>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"199 ","pages":"112417"},"PeriodicalIF":3.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlates of desire for hastened death in chronic illness: A cross-sectional network analysis","authors":"Eun-Jung Shim ,&nbsp;Donghee Jeong ,&nbsp;Saim Jung ,&nbsp;Bong-Jin Hahm","doi":"10.1016/j.jpsychores.2025.112407","DOIUrl":"10.1016/j.jpsychores.2025.112407","url":null,"abstract":"<div><h3>Objectives</h3><div>Desire to hasten death (DHD) may reflect complex physical and psychosocial suffering. This study examined psychosocial and cognitive-affective correlates of DHD in patients with chronic physical illness using cross-sectional network analysis.</div></div><div><h3>Methods</h3><div>This cross-sectional analysis included 366 patients with renal, cardiovascular, or cerebrovascular disease were recruited from two hospitals in South Korea. Participants completed validated measures of DHD, physical quality of life (QOL), perceived burdensomeness (PB), thwarted belongingness (TB), fearlessness about death, hopelessness, helplessness, loss of autonomy, depression, and anxiety. Gaussian graphical models were estimated, and centrality, predictability, and relative importance were analyzed. Subgroup and covariate-adjusted analyses were also conducted.</div></div><div><h3>Results</h3><div>Overall, 11.0 % of participants reported high DHD, defined as a Schedule of Attitudes toward Hastened Death Abbreviated score of 3 or higher. The network explained 43.1 % of the variance in DHD. PB showed the strongest direct association with DHD, followed by hopelessness, anxiety, and helplessness. Although depression was not directly linked to DHD, it emerged as the most central node in the network. Relative importance analysis confirmed that PB and anxiety were most strongly associated with DHD. Subgroup analyses indicated that anxiety was more salient in the renal disease, while PB ranked highest in the cardio/cerebrovascular disease. These findings remained robust after adjusted analyses.</div></div><div><h3>Conclusion</h3><div>PB and anxiety were the most robust correlates of DHD, whereas depression played a central role in the network. Addressing perceived burden and emotional distress may be relevant for understanding and managing DHD among individuals with chronic illness.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"199 ","pages":"Article 112407"},"PeriodicalIF":3.3,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Effectiveness and influence of mindfulness-based intervention on migraine patients: A systematic review and meta-analysis”","authors":"Jagriti Gairola ,&nbsp;Arvind Kumar ,&nbsp;Nivedita Nikhil Desai ,&nbsp;Dhanya Dedeepya","doi":"10.1016/j.jpsychores.2025.112406","DOIUrl":"10.1016/j.jpsychores.2025.112406","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"199 ","pages":"Article 112406"},"PeriodicalIF":3.3,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145289946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The fibromyalgia black box.","authors":"Sara Ceccatelli, Lorenzo Cosmi, Fiammetta Cosci","doi":"10.1016/j.jpsychores.2025.112402","DOIUrl":"https://doi.org/10.1016/j.jpsychores.2025.112402","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":" ","pages":"112402"},"PeriodicalIF":3.3,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What's in a name? Complex Regional Pain Syndrome, the ICD-11, and the power of taxonomy.","authors":"Constanze Hausteiner-Wiehle, Alexandra Melf-Marzi, Christopher Bass","doi":"10.1016/j.jpsychores.2025.112405","DOIUrl":"https://doi.org/10.1016/j.jpsychores.2025.112405","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":" ","pages":"112405"},"PeriodicalIF":3.3,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring biopsychosocial health outcomes in endometriosis and endometriosis with co-occurring irritable bowel syndrome - A prospective cohort study.","authors":"Suiyin Cheah, David Skvarc, Subhadra Evans, Leesa Van Niekerk, Antonina Mikocka-Walus","doi":"10.1016/j.jpsychores.2025.112404","DOIUrl":"https://doi.org/10.1016/j.jpsychores.2025.112404","url":null,"abstract":"<p><strong>Objective: </strong>To date there has been limited exploration of the impact of endometriosis with co-occurring irritable bowel syndrome (IBS) type symptoms on biopsychosocial health outcomes and wellbeing. This study aimed to prospectively investigate the changes and differences in biopsychosocial factors between individuals with endometriosis (EndoOnly) and individuals with endometriosis and co-occurring IBS-type symptoms (Endo+IBS) over a two-year period.</p><p><strong>Methods: </strong>610 adult women (EndoOnly; n = 352, Endo+IBS; n = 258), originally recruited via gyms, university sites and social media platforms, were identified from a longitudinal survey study exploring the physical and psychosocial impacts of pelvic pain. Health-related quality of life (HRQoL), psychological distress, pain, fatigue and menstrual symptoms data were collected at baseline, 12-months and 24-months using the World Health Organisation Quality of Life Assessment, Depression Anxiety and Stress Scale, pain severity numeric rating scale, Brief Pain Inventory, Pain Catastrophizing Scale (including rumination, magnification, and helplessness subscales), Fatigue Symptom Inventory and Menstrual Symptom Scale.</p><p><strong>Results: </strong>Using linear mixed models, results indicated that individuals with Endo+IBS were more likely to experience lower HRQoL and higher functional pain disability, fatigue, and menstrual symptoms compared to individuals with EndoOnly over three years. Results showed significant linear declines in rumination, total pain catastrophising, pain severity and helplessness for both groups; however, the rate of change for the Endo+IBS group tended to diminish and change direction over time. Further, individuals with Endo+IBS were inclined to exhibit more complex change trajectories in psychological distress, magnification, and fatigue, with a trend towards worse outcomes overall.</p><p><strong>Conclusion: </strong>Findings highlight the important implications of chronic disease co-morbidity and the need for interdisciplinary psychosocial healthcare, to help improve diagnosis, clinical management and health outcomes for individuals living with endometriosis and co-occurring IBS-type symptoms.</p>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"199 ","pages":"112404"},"PeriodicalIF":3.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145356667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental timing sets the clock for self- injury: A retrospective cohort study on stress asymmetry in early-menarche and depressive disorder girls","authors":"Xiaoyuan Han ,&nbsp;Ningning Liu ,&nbsp;Shifeng Song ,&nbsp;Zeyang Zhao ,&nbsp;Binpeng Zhang ,&nbsp;Lingming Hu ,&nbsp;Ming Cha","doi":"10.1016/j.jpsychores.2025.112403","DOIUrl":"10.1016/j.jpsychores.2025.112403","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the independent and interactive effects of menarche timing and stress exposure on non-suicidal self-injury (NSSI) in female depressive disorder adolescents, identifying risk factors and optimal intervention windows.</div></div><div><h3>Method</h3><div>106 female depressive disorder adolescents were stratified by menarche age (early:≤11 years, <em>n</em> = 32; normal:12–14 years, <em>n</em> = 74) and stress level (high/low). Generalized Linear Models and survival analysis compared NSSI incidence, onset age, and risk. Analyses were adjusted for potential confounders including body mass index (BMI) and depression severity.</div></div><div><h3>Result</h3><div>Early menarche independently increased NSSI risk HR = 4.68, and advanced the median self-injury age by 1.5 years. Critically, stress exhibited a selective, asymmetric effect: it significantly amplified NSSI risk exclusively in the early-menarche group, while showing no significant impact in the normal-menarche group. Survival curves further revealed distinct developmental risk windows, with the early-menarche group exhibiting a sharp increase in NSSI onset at age 12.0, compared to a later onset at 13.0 years in the normal-menarche group.</div></div><div><h3>Conclusion</h3><div>Menarche timing serves as a developmental clock for NSSI onset, while stress selectively exacerbates risk in early menarche individuals. The findings support the “development-environment mismatch” theory and suggest that early menarche females (≤11 years) should be prioritized for screening, with staged interventions tailored to developmental and stress profiles.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"198 ","pages":"Article 112403"},"PeriodicalIF":3.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145269674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional dissociative seizures: How do professionals in Buenos Aires, Argentina approach diagnosis and management?: A cross-sectional study","authors":"María Marta Areco Pico ,&nbsp;Mercedes Sarudiansky ,&nbsp;Camila Wolfzun ,&nbsp;Cristina Tenreyro ,&nbsp;Luciana D'Alessio ,&nbsp;Guido Pablo Korman","doi":"10.1016/j.jpsychores.2025.112400","DOIUrl":"10.1016/j.jpsychores.2025.112400","url":null,"abstract":"<div><h3>Objective</h3><div>Functional Dissociative Seizures (FDS), a subtype of Functional Neurological Disorders, are conditions originating from disruptions in nervous system function. Despite established diagnostic criteria, significant uncertainty persists among healthcare professionals regarding their diagnosis and management, particularly in low- and middle-income countries. This study examines how healthcare professionals in Buenos Aires, Argentina, perceive and approach FDS in clinical practice.</div></div><div><h3>Methods</h3><div>This cross-sectional, mixed-methods study recruited neurologists, primary care physicians, psychiatrists, and psychologists in Buenos Aires (2020−2023) through exponential snowball sampling. Participants completed an online instrument developed and expert-validated for this study, including a two-part clinical vignette. Quantitative data were analyzed descriptively, and qualitative responses underwent thematic analysis using Braun and Clarke's six steps.</div></div><div><h3>Results</h3><div>A total of 38 healthcare professionals participated. Diagnostic patterns varied by profession, with neurologists and psychiatrists leaning toward FDS, while psychologists more often diagnosed epilepsy with psychiatric comorbidities. Diagnoses were mainly based on seizure characteristics and mental health symptoms. Professionals prioritized further information on patients' backgrounds and seizure features. Treatment plans focused on neurological testing and referrals to neurology and mental health services. Challenges included limited training and low perceived competence, especially among psychologists. After receiving more case details, several participants—primarily psychologists—revised their diagnosis from epilepsy to FDS; all professional groups prioritized further exploration of mental health symptoms and disorders.</div></div><div><h3>Conclusions</h3><div>This study highlights challenges in FDS diagnosis and management in Argentina, including limited training and poor interdisciplinary coordination. Improving education and collaboration are essential to enhance diagnosis, treatment, and outcomes.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"198 ","pages":"Article 112400"},"PeriodicalIF":3.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145269060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of physical activity in the bidirectional association between depressive symptoms and chronic disease incidence: A prospective analysis of the Irish longitudinal study on ageing","authors":"André O. Werneck ,&nbsp;Felipe B. Schuch ,&nbsp;Davy Vancampfort ,&nbsp;Liye Zou ,&nbsp;José Francisco López-Gil ,&nbsp;Joseph Firth ,&nbsp;Nicola Veronese ,&nbsp;Nilufar Mossaheb ,&nbsp;Brendon Stubbs","doi":"10.1016/j.jpsychores.2025.112398","DOIUrl":"10.1016/j.jpsychores.2025.112398","url":null,"abstract":"<div><h3>Aim</h3><div>To examine the bidirectional associations between depressive symptoms and chronic disease incidence and to investigate the moderating role of physical activity in the above-presented associations.</div></div><div><h3>Methods</h3><div>Data from the Irish Longitudinal Study on Ageing were analyzed, including 7279 participants (55.7 % women, mean age = 62.5 ± 9.2 years) across four waves (2012–2018), comprising six years of follow-up. Depressive symptoms were assessed using the 8-item Center for Epidemiologic Studies Depression scale, while chronic disease incidence covered 13 self-reported conditions. Random-intercept cross-lagged panel models examined bidirectional associations, adjusting for confounders and stratifying by baseline physical activity levels.</div></div><div><h3>Results</h3><div>A significant bidirectional association was observed between depressive symptoms and incident chronic diseases. Depressive symptoms predicted future chronic disease incidence (unstandardized beta coefficient [<em>B</em>] = 0.005; 95 %CI: 0.001–0.008), while chronic disease incidence predicted future depressive symptoms (<em>B</em> = 0.216; 95 %CI: 0.100–0.331). Notably, these associations were only significant among participants with low and moderate baseline physical activity levels, where chronic diseases predicted depressive symptoms (Low baseline PA level: <em>B</em> = 0.006; 95 %CI = 0.001 to 0.012. Moderate baseline PA level: <em>B</em> <em>=</em> 0.008; 95 %CI = 0.002 to 0.014) and depressive symptoms predicted chronic disease incidence (Low baseline PA level: <em>B</em> = 0.234; 95 %CI = 0.002 to 0.466. Moderate baseline PA level: <em>B</em> = 0.318; 95 %CI = 0.126 to 0.511).</div></div><div><h3>Conclusion</h3><div>This study confirms bidirectional associations between depressive symptoms and chronic disease incidence. Physical activity may be a moderating factor as this bidirectional association was only significant among participants with low or moderate levels of physical activity.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"199 ","pages":"Article 112398"},"PeriodicalIF":3.3,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mentalizing in chronic conditions: A cross-sectional study of reflective functioning and adherence in transplant recipients","authors":"Benedetta Muzii ,&nbsp;Giorgia Margherita","doi":"10.1016/j.jpsychores.2025.112399","DOIUrl":"10.1016/j.jpsychores.2025.112399","url":null,"abstract":"<div><h3>Background</h3><div>Solid organ transplantation presents significant psychological challenges for recipients. While research has established relationships between psychological distress and medication non-adherence, the potential protective role of mentalization remains unexplored in transplant populations. This pilot study investigated whether reflective functioning moderates the relationship between psychopathological symptoms and medication adherence in transplant recipients.</div></div><div><h3>Methods</h3><div>This cross-sectional study examined 117 adult solid organ transplant recipients (kidney 57.3 %, liver 25.6 %, heart 11.1 %, lung 3.4 %, multiple organs 2.6 %). Participants completed validated measures assessing reflective functioning, medical adherence, psychopathological symptoms, perceived social support, and health-related quality of life. Hierarchical multiple regression analyses tested the proposed moderation model, controlling relevant demographic and clinical variables.</div></div><div><h3>Results</h3><div>Psychopathology negatively predicted medication adherence, while reflective functioning demonstrated a significant positive association with adherence behaviors. The interaction between psychopathology and reflective functioning was significant, indicating that the deleterious relationship between psychopathological symptoms and adherence was significantly stronger when reflective functioning was impaired but non-significant at high levels of reflective functioning.</div></div><div><h3>Conclusions</h3><div>These findings demonstrate that mentalization functions as a psychological buffer against non-adherence during periods of psychological distress in transplant recipients. Impaired reflective functioning represents a specific risk factor for medication non-adherence, particularly when recipients experience elevated psychopathological symptoms. Results support the development of mentalization-based interventions to enhance transplant recipients' psychological integration of the transplant experience and promote sustained adherence to immunosuppressive therapy.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"198 ","pages":"Article 112399"},"PeriodicalIF":3.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}