Journal of Psychosomatic Research最新文献

{"title":"Combined influence of healthy lifestyles, nutritional and inflammatory status on mortality among US adults with depression","authors":"Jumei Yin ,&nbsp;Lan Jiang ,&nbsp;Huan Zhang ,&nbsp;Jinming Zhang ,&nbsp;Ju Zhang ,&nbsp;Nuo Yao ,&nbsp;Yongquan Shi ,&nbsp;Zheyi Han","doi":"10.1016/j.jpsychores.2025.112131","DOIUrl":"10.1016/j.jpsychores.2025.112131","url":null,"abstract":"<div><h3>Objective</h3><div>Healthy lifestyles, nutritional and inflammatory status are interrelated and influence mortality. This study aimed to evaluate their separate and combined effects on all-cause and cause-specific mortality in individuals exhibiting depression.</div></div><div><h3>Methods</h3><div>6143 individuals with depression (median age 47) were recruited from the US National Health and Nutrition Examination Survey (NHANES 2005–2018), with mortality followed up through December 31, 2019. A healthy lifestyle score (0–5) was constructed based on current non-smoking, low-to-moderate alcohol consumption, adequate sleep, sufficient physical activity and healthy diet. Higher scores indicated healthier lifestyles. The Advanced Lung Cancer Inflammation Index (ALI), a composite marker of inflammation and nutritional status, was calculated as Body Mass Index (BMI) (kg/m²) × albumin (g/dl)/Neutrophil-to-Lymphocyte Ratio (NLR). Higher ALI values denoted lower inflammation and better nutrition. Weighted Cox proportional-hazards models were used to estimate mortality hazard ratios.</div></div><div><h3>Results</h3><div>Healthier lifestyles significantly lowered all-cause (hazard ratio [HR] 0.72, 95 % confidence interval [CI] 0.66–0.78), cardiovascular (HR 0.70, 95 % CI 0.58–0.83), and non-cardiovascular mortality (HR 0.72, 95 % CI 0.64–0.81). High ALI reduced all-cause (HR 0.70, 95 % CI 0.54–0.91) and cardiovascular mortality (HR 0.46, 95 % CI 0.28–0.77) compared with low ALI. Joint analyses showed that individuals with both healthy lifestyle scores ≥3 and high ALI had the lowest risk of all-cause, cardiovascular, and non-cardiovascular mortality (HR 0.44, 95 % CI 0.33–0.60; 0.32, 95 % CI 0.16–0.63; 0.49, 95 % CI 0.35–0.68).</div></div><div><h3>Conclusion</h3><div>The joint presence of healthy lifestyles and high ALI was significantly associated with lower risk of mortality among individuals with depression.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"193 ","pages":"Article 112131"},"PeriodicalIF":3.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of obsessive beliefs on fibromyalgia: The mediating role of emotional dysfunction and obsessive-compulsive symptoms","authors":"Burak Okumus ,&nbsp;Makbule Esen Oksuzoglu ,&nbsp;Nihal Yılmaz ,&nbsp;Hande Gunal Okumus","doi":"10.1016/j.jpsychores.2025.112128","DOIUrl":"10.1016/j.jpsychores.2025.112128","url":null,"abstract":"<div><h3>Background</h3><div>The role of obsessive beliefs in the development and maintenance of Fibromyalgia syndrome (FMS) remains unclear. This study aims to compare patients with FMS and controls in terms of obsessive beliefs, quality of life, and comorbid psychiatric symptoms. In addition, this study uses structural equation modelling (SEM) to examine whether obsessive beliefs influence FMS symptom severity directly or through mediating factors.</div></div><div><h3>Method</h3><div>This study was conducted at Uşak Training and Research Hospital, Turkey, involving 116 adults, including 76 FMS patients (mean age = 43.2) and 40 controls (mean age = 45.8). Both groups completed the Short Form 12 Health Survey (SF-12), Obsessive Beliefs Questionnaire (OBQ) and Symptom Checklist-90 Revised (SCL-90-R), with the FMS group additionally completing the Fibromyalgia Impact Questionnaire (FIQ). SEM was applied to examine the direct and indirect effects of obsessive beliefs on FMS symptom severity.</div></div><div><h3>Results</h3><div>In the FMS group, SF-12 subscale scores were lower, while OBQ-44 and SCL-90-R subscale scores (except for anger-hostility, phobic anxiety, and paranoid ideation) were higher compared to controls (all <em>p &lt; .05).</em> The final model showed that the OBQ-Total Score negatively predicted SF-12 Role Emotional (β = −0.22, <em>p</em> = .042) and positively predicted SCL-90 Obsessive-Compulsive (β = 0.25, <em>p</em> = .013). SF-12 Role Emotional negatively predicted both the FIQ (β = −0.50, <em>p</em> &lt; .001) and SCL-90 Obsessive-Compulsive (β = −0.40, <em>p</em> = .001), while SCL-90 Obsessive-Compulsive positively predicted the FIQ (β = 0.39, <em>p</em> = .002).</div></div><div><h3>Conclusions</h3><div>Our findings highlight the role of obsessive beliefs and emotional dysfunction in FMS severity, suggesting that targeting these factors may help alleviate symptoms. Future research should examine targeted therapies to enhance emotional regulation and cognitive flexibility in FMS.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112128"},"PeriodicalIF":3.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between menstrual pain in adolescence and mental health in adolescence and early adulthood","authors":"Lauren Cameron ,&nbsp;Antonina Mikocka-Walus ,&nbsp;Katherine Stanley ,&nbsp;Laura A. Payne ,&nbsp;Marilla Druitt ,&nbsp;Sonia Grover ,&nbsp;Subhadra Evans","doi":"10.1016/j.jpsychores.2025.112122","DOIUrl":"10.1016/j.jpsychores.2025.112122","url":null,"abstract":"<div><h3>Objectives</h3><div>Approximately 70 % of adolescents worldwide experience menstrual pain (dysmenorrhea), with significant impacts on quality of life. This prospective study aimed to explore the relationship between mental health and dysmenorrhea in Australian adolescents.</div></div><div><h3>Design</h3><div>Female adolescents in a nationally representative sample of Australian children (the Longitudinal Study of Australian Children) recruited in 2004 were included in the Kinder cohort (aged 4–5 years at enrolment).</div></div><div><h3>Participants</h3><div>Survey data for 1600 participants from Wave 4 (age 10) to Wave 9C2 (age 21) were included in this study. Parents and adolescents completed questionnaires and interviews at each wave.</div></div><div><h3>Main outcome measures</h3><div>For this study, questions included age of menstruation onset, dysmenorrhea severity, symptoms of anxiety and/or depression (parent-report and adolescent-report), and psychological distress (adolescent-report).</div></div><div><h3>Results</h3><div>Adolescents with dysmenorrhea were more likely to have anxiety (odds ratios 1.75–1.82) and more likely to have depression (odds ratios 2.03–2.89) than adolescents without dysmenorrhea at ages 14, 16, and 18. Adolescents with dysmenorrhea at ages 14, 16, and 18 reported higher levels of psychological distress, with scores 2.99 to 3.34 points higher on a self-report measure (K10) in early adulthood than adolescents without dysmenorrhea (<em>p</em> &lt; 0.001). Longitudinal analyses revealed that adolescents with dysmenorrhea were more likely to develop mental health concerns in later adolescence and early adulthood (χ² = 17.26, <em>p</em> &lt; 0.001), while those with mental health concerns were not more likely to develop dysmenorrhea (χ² = 0.49, <em>p</em> = 0.48).</div></div><div><h3>Conclusion</h3><div>This study highlights that adolescents who experience dysmenorrhea are at significantly greater risk of experiencing mental health problems both in adolescence and in early adulthood. Improved treatment for dysmenorrhea, menstrual education, mental health monitoring, and early intervention are essential to reduce this risk.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112122"},"PeriodicalIF":3.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143835205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of consultation liaison services on postoperative psychotropic drug use","authors":"Riki Kitaoka ,&nbsp;Nobutaka Ayani ,&nbsp;Takahiro Uramatsu ,&nbsp;Eriko Yamazoe ,&nbsp;Tomoya Okazaki ,&nbsp;Kyohei Ogawa ,&nbsp;Takato Yokoi ,&nbsp;Keisuke Takeda ,&nbsp;Koju Nakai ,&nbsp;Nozomu Oya ,&nbsp;Takeshi Nakamura ,&nbsp;Go Horiguchi ,&nbsp;Jin Narumoto","doi":"10.1016/j.jpsychores.2025.112123","DOIUrl":"10.1016/j.jpsychores.2025.112123","url":null,"abstract":"<div><h3>Objective</h3><div>In clinical practice, most cases of postoperative delirium are treated by an attending surgeon who is not a specialist in delirium treatment. We investigated the postoperative use of psychotropic drugs with and without psychiatric consultation liaison service (CLS).</div></div><div><h3>Method</h3><div>Patients who received specific psychotropic drugs postoperatively under general anesthesia were included. The participants were divided into two groups, with and without CLS intervention. The type and dosage of psychotropic drugs used, presence of delirium, and adverse drug events (ADEs) caused by psychotropic drugs administered postoperatively were investigated.</div></div><div><h3>Results</h3><div>Of the 509 patients who were newly prescribed the psychotropic drugs postoperatively, 67 patients (13 %) received CLS intervention. In the non-CLS group, 65 % (43/66) of patients who received antipsychotics after surgery did not have delirium, which was significantly higher than in the CLS group (65 % vs 22 %, <em>p</em> &lt; 0.01). Haloperidol was the most commonly used antipsychotic postoperatively, and the median daily dose was significantly higher in the non-CLS group (0.22 mg/day vs 0.38 mg/day, <em>p</em> = 0.04).</div></div><div><h3>Conclusion</h3><div>CLS interventions may contribute to a reduction in unnecessary administration of antipsychotic drugs and dosages.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112123"},"PeriodicalIF":3.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143835204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of buccal acupuncture therapy on the incidence of postoperative delirium in older adults undergoing orthopedic lower limb surgery: A randomized controlled trial","authors":"Shilei Fang ,&nbsp;Xiang Wang ,&nbsp;Chen Chen ,&nbsp;Wenjin Sun ,&nbsp;Yanyan Ji ,&nbsp;Donghua Shao ,&nbsp;Caixia Sun","doi":"10.1016/j.jpsychores.2025.112129","DOIUrl":"10.1016/j.jpsychores.2025.112129","url":null,"abstract":"<div><h3>Objective</h3><div>This study evaluated the effect of perioperative buccal acupuncture therapy on the incidence of postoperative delirium in elderly patients who underwent orthopedic lower limb surgery.</div></div><div><h3>Methods</h3><div>This was a single-center, prospective, randomized controlled trial. A total of 120 elderly patients (aged ≥65 years) scheduled for elective orthopedic lower limb surgery were randomly assigned to the intervention group (<em>n</em> = 60, buccal acupuncture 30 min before anesthesia induction until the end of surgery and for 30 min each day for the first 2 postoperative days) or the control group (<em>n</em> = 60, no buccal acupuncture). The primary outcome was delirium during the first 7 postoperative days. The secondary outcomes included delirium severity, duration, and subtype; intraoperative total consumption rate of sufentanil and remifentanil; interleukin-6, interleukin-8, and norepinephrine in venous blood; the total number of electronic analgesia pump compressions; nausea and vomiting in 48 h; postoperative pain score; postoperative hospital stay, and postoperative adverse event rates.</div></div><div><h3>Results</h3><div>The data of 120 patients were collected. The incidence of delirium during the first 7 postoperative days was significantly lower in the intervention group than in the control group (27 % [16/60] <em>vs.</em> 12 % [7/60]; relative risk, 0.44; 95 % confidence interval, 0.19–0.99; <em>P</em> = 0.037). Intraoperative total consumption rate of sufentanil and remifentanil, postoperative pain scores, and the incidence of postoperative nausea and vomiting were significantly lower in the intervention group.</div></div><div><h3>Conclusion</h3><div>Buccal acupuncture can reduce the incidence of postoperative delirium in elderly patients who undergo orthopedic lower limb surgery.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112129"},"PeriodicalIF":3.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short report: Early-onset health anxiety: Insights from a cross-sectional study on adults diagnosed with severe health anxiety","authors":"Rebecca Nyengaard ,&nbsp;Katrine Ingeman ,&nbsp;Lisbeth Frostholm ,&nbsp;Charlotte Ulrikka Rask","doi":"10.1016/j.jpsychores.2025.112127","DOIUrl":"10.1016/j.jpsychores.2025.112127","url":null,"abstract":"<div><h3>Objective</h3><div>The knowledge of early-onset health anxiety (HA) (i.e. onset before age 18) is limited. This retrospective study aimed to investigate 1) the age of onset of HA and 2) potential clinical factors associated with early- compared with late-onset HA in adult patients with severe HA.</div></div><div><h3>Methods</h3><div>The study sample consisted of 126 adults (aged 20–60 years) diagnosed with severe HA and referred to specialized treatment. All underwent semi-structured diagnostic interviews assessing psychiatric disorders and functional somatic disorders. The interview also included a detailed illness history with a chronological listing of HA symptom onset. Self-reports were obtained on current HA symptoms, illness perceptions, and treatment expectations.</div></div><div><h3>Results</h3><div>Early onset of HA was reported by 40 participants (32 %, 95 % CI: 24 %–41 %) with a mean age at symptom onset of 11.6 years (SD: 4.0, range: 5–17), and 23 participants reported onset before age 13 (57.5 %). Early-onset HA was significantly associated with more negative perceptions of consequences of symptoms (Cohen's d = 0.41, <em>p</em> = 0.04) and stronger psychological attributions (Cohen's d = 0.33, <em>p</em> = 0.03), and the group with early onset were more often diagnosed with severe functional somatic disorders (Cramer's V = 0.17, <em>p</em> = 0.06) and reported more negative treatment expectations (Cramer's V = 0.17, p = 0 0.06), although these results were non-significant.</div></div><div><h3>Conclusion</h3><div>Early onset of HA may be common and associated with more negative illness perceptions in adulthood. These results need replication but highlight the need for further research on HA in youth.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112127"},"PeriodicalIF":3.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who benefits the most from cognitive behavior therapy for health anxiety? Secondary analysis of a randomized controlled trial of internet-delivered vs. face-to-face treatment in primary care","authors":"Erland Axelsson ,&nbsp;Erik Andersson ,&nbsp;Daniel Björkander ,&nbsp;Maria Hedman-Lagerlöf ,&nbsp;Susanna Österman ,&nbsp;Jonna Hybelius ,&nbsp;Erik Hedman-Lagerlöf","doi":"10.1016/j.jpsychores.2025.112130","DOIUrl":"10.1016/j.jpsychores.2025.112130","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate who benefits most from exposure-focused cognitive behavior therapy (CBT) for pathological health anxiety.</div></div><div><h3>Methods</h3><div>This was a secondary study based on a randomized controlled trial of Internet-delivered versus face-to-face CBT (<em>N</em> = 204) delivered in primary care for participants with pathological health anxiety and a primary diagnosis of either somatic symptom disorder or illness anxiety disorder. Linear mixed effects regression models were fitted on 13 weekly 18-item Health Anxiety Inventory assessments over the treatment phase. The time×variable coefficient was tested as indicative of a predictive effect, regardless of treatment format. The treatment format (Internet versus face-to-face) was then added to the model, and the time×format×variable coefficient was tested as indicative of moderation of the between-format effect. The following pre-treatment variables were evaluated: age, gender, education, health anxiety, subtypes of health anxiety behaviors, anxiety sensitivity, intolerance of uncertainty, depression symptoms, experience of psychotherapy, noncommunicable disease, treatment preference, and path of referral.</div></div><div><h3>Results</h3><div>Regardless of delivery format, a larger reduction in health anxiety was predicted by higher pre-treatment health anxiety, bodily preoccupation/checking, prevention/planning, anxiety sensitivity, and depression symptoms. Most effects were small. None of the candidate variables were significant moderators of the relative effect of Internet-delivered and face-to-face CBT.</div></div><div><h3>Conclusion</h3><div>This study replicates that higher pre-treatment health anxiety and anxiety sensitivity are predictive of a larger reduction in health anxiety regardless of CBT format. So far, no robust moderators of the relative effect of Internet-delivered versus face-to-face CBT for health anxiety have been identified.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112130"},"PeriodicalIF":3.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Amalia et al. “Health anxiety, academic procrastination, and the SDGs: A call for longitudinal research and global collaboration”","authors":"Charlotte Steen Duholm","doi":"10.1016/j.jpsychores.2025.112126","DOIUrl":"10.1016/j.jpsychores.2025.112126","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112126"},"PeriodicalIF":3.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and tinnitus: Evidence from a nationally representative observational study","authors":"Ying Cui ,&nbsp;Wenjie Miao ,&nbsp;Tong Wu ,&nbsp;Chenyang Liu ,&nbsp;Lin Chen","doi":"10.1016/j.jpsychores.2025.112114","DOIUrl":"10.1016/j.jpsychores.2025.112114","url":null,"abstract":"<div><h3>Background</h3><div>Tinnitus, a condition with substantial psychological and physical implications, significantly impacts quality of life; however, its relationship with lipid metabolism remains underexplored.</div></div><div><h3>Methods</h3><div>This population-based observational study included 4991 participants. Weighted multivariate logistic regression and restricted cubic spline (RCS) analyses were employed to assess the relationship between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and tinnitus. Subgroup and sensitivity analyses were conducted to evaluate the consistency and robustness of findings across sociodemographic and health-related subgroups.</div></div><div><h3>Results</h3><div>A total of 791 participants reported tinnitus, with a prevalence of 15.85 %. A significant positive association was observed between NHHR and tinnitus risk. In the final model with all covariates adjusted, when NHHR increased by one unit, the risk of tinnitus would increase by 12 % (odds ratio [OR] = 1.12, 95 % confidence interval (CI), 1.02–1.22, <em>P</em> = 0.022). Compared to the lowest NHHR tertile, the highest NHHR tertile had a higher risk of tinnitus (OR = 1.46; 95 % CI, 1.02–2.07, <em>P</em> = 0.040). RCS analysis revealed that NHHR was linearly associated with tinnitus (<em>P</em> for nonlinearity = 0.923). Subgroup analyses confirmed that this association remained stable across various sociodemographic and health subgroups (<em>P</em> for interaction &gt;0.05).</div></div><div><h3>Conclusions</h3><div>These findings suggest that NHHR is positively and linearly associated with tinnitus risk, highlighting the essential role of NHHR in the development of tinnitus. The findings underscore the need for integrated metabolic and psychosomatic approaches in tinnitus prevention and management.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112114"},"PeriodicalIF":3.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between graves’ disease and mental disorders: A bidirectional Mendelian randomization study","authors":"Yuanyuan Deng ,&nbsp;Zejin Hao ,&nbsp;Wen Chen ,&nbsp;Junping Zhang ,&nbsp;Yun Zou ,&nbsp;Jie Zhang ,&nbsp;Yanhua Xi ,&nbsp;Jixiong Xu","doi":"10.1016/j.jpsychores.2025.112124","DOIUrl":"10.1016/j.jpsychores.2025.112124","url":null,"abstract":"<div><h3>Objective</h3><div>Many patients with Graves' disease (GD) also suffer from mental disorders in clinical practice, but their causal relationship remains unclear. This study aims to investigate the causal relationship between GD and common mental disorders using a bidirectional Mendelian randomization (MR)approach.</div></div><div><h3>Methods</h3><div>We derived genome-wide association study (GWAS) data for common mental disorders, including major depressive disorder (MDD), anxiety disorders, bipolar disorder, and attention-deficit/hyperactivity disorder (ADHD), from the Psychiatric Genomics Consortium consortium. GWAS data for GD were obtained from the FinnGen consortium. Subsequently, a bidirectional MR analysis was conducted, with the inverse-variance weighted (IVW) methods as the primary MR analysis method. Sensitivity analysis used Cochran's Q test, MR-Egger intercept test, and leave-one-out method.</div></div><div><h3>Results</h3><div>IVW results in MR demonstrated a positive association between genetic susceptibility to GD and bipolar disorder (OR = 1.073, 95 % CI: 1.042–1.105, <em>p</em> = 2.882 × 10⁻⁶). Similar causal estimates were obtained through MR-Egger regression and the weighted median method. Additionally, both Cochran's Q test and MR-Egger intercept test indicated no evidence of heterogeneity or pleiotropy. However, no causal associations were demonstrated between GD and MDD, anxiety disorders, or ADHD. Furthermore, a causal relationship between genetic susceptibility to common mental disorders and GD was not evidenced.</div></div><div><h3>Conclusions</h3><div>This bidirectional MR study supports the role of GD in the causal association with an increased risk of bipolar disorder, which guides us to pay attention to the mental diseases of GD patients in the clinic.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112124"},"PeriodicalIF":3.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}