Journal of Psychosomatic Research最新文献

{"title":"Somatic symptom disorder in patients with irritable bowel syndrome or ulcerative colitis – Cross-sectional baseline findings from the SOMA.GUT-RCT","authors":"Luisa Peters ,&nbsp;Anna Matysiak ,&nbsp;Sina Hübener ,&nbsp;Ansgar W. Lohse ,&nbsp;Yvonne Nestoriuc ,&nbsp;Kerstin Maehder ,&nbsp;Bernd Löwe","doi":"10.1016/j.jpsychores.2025.112395","DOIUrl":"10.1016/j.jpsychores.2025.112395","url":null,"abstract":"<div><h3>Background</h3><div>Somatic symptom disorder (SSD) is characterised by distressing somatic symptoms accompanied by excessive symptom-related thoughts, emotions, or behaviour. While initial evidence supports SSD's relevance in gastrointestinal conditions like irritable bowel syndrome (IBS) and ulcerative colitis (UC), structured interview-based data are lacking. This study examined SSD frequency and its associations with biopsychosocial variables in patients with IBS or UC recruited in the context of a psychological intervention trial.</div></div><div><h3>Methods</h3><div>Cross-sectional baseline data from a randomised controlled trial of patients with UC or IBS were analysed. SSD was diagnosed using structured DSM-5-based diagnostic interviews. Measures included illness-related anxiety (WI-7), neuroticism (BFI-10), illness perceptions (B-IPQ), symptom-related disability (adapted PDI), and gastrointestinal symptom severity (IBS-SSS). Between-group comparisons and multiple logistic regression analysis were conducted.</div></div><div><h3>Results</h3><div>SSD was diagnosed in 41.5 % (95 % CI 35.6–47.9) out of 236 patients, including 125 patients with UC and 111 with IBS (73.7 % female; M_age = 40.14, SD = 13.8). SSD was more frequent in IBS (55.0 %; 95 % CI 44.4–64.9) than in UC (29.6 %; 95 % CI 21.7–37.1) (χ²(1) = 15.67, <em>p</em> &lt; .001), and linked to higher illness-related anxiety, negative illness perceptions, and symptom-related disability in both groups. Gastrointestinal symptom severity was highest in patients with IBS and SSD. Regression analysis showed IBS diagnosis, illness-related anxiety, and neuroticism correlated with SSD.</div></div><div><h3>Conclusions</h3><div>A substantial number of patients with IBS or UC met SSD criteria in structured interviews. SSD occurred more commonly in IBS and was associated with psychological distress in both conditions. Findings highlight SSD's diagnostic relevance in functional and inflammatory bowel diseases. Future studies should investigate whether targeted SSD diagnosis and treatment in these conditions could improve clinical outcomes.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"198 ","pages":"Article 112395"},"PeriodicalIF":3.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145222647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring loneliness in individuals with diabetes – The role of childhood abuse and neglect, and personality functioning: Findings from a German population-based sample","authors":"Sandra Zara ,&nbsp;Johannes Kruse ,&nbsp;Elmar Brähler ,&nbsp;Mareike Ernst ,&nbsp;Jörg M. Fegert ,&nbsp;Astrid Lampe ,&nbsp;Tobias Nolte ,&nbsp;Miriam Rassenhofer ,&nbsp;David Riedl ,&nbsp;Hanna Kampling","doi":"10.1016/j.jpsychores.2025.112390","DOIUrl":"10.1016/j.jpsychores.2025.112390","url":null,"abstract":"<div><h3>Background</h3><div>This study examines 1) loneliness frequency in individuals with diabetes, 2) associated factors, and 3) personality functioning and the epistemic stance as underlying mechanisms linking childhood abuse and neglect, and loneliness.</div></div><div><h3>Methods</h3><div>Using representative population data (<em>N</em> = 2428), loneliness (UCLA-LS) was assessed in individuals with self-reported diabetes (<em>n</em> = 206) and compared to those without. Regression analyses tested age, sex, relationship status, childhood abuse and neglect (ICAST-R), depression and anxiety (PHQ-4), personality functioning (OPD-SQS), and the epistemic stance (ETMCQ-12) as predictors. Structural equation modeling (SEM) investigated personality functioning and the epistemic stance as mediators between childhood abuse and neglect, and loneliness.</div></div><div><h3>Results</h3><div>In the total sample, 12.4 % reported loneliness, and loneliness was more frequent in individuals with diabetes (24.8 %) than those without (11.3 %). Higher loneliness was linked to being single, greater depression and anxiety symptoms, and impaired personality functioning. While childhood abuse and neglect were initially associated with loneliness, this became nonsignificant when personality functioning was included as a mediator, increasing the explained variance from 3.4 % to 42.0 %.</div></div><div><h3>Conclusions</h3><div>Nearly a quarter of individuals with diabetes experience loneliness, particularly linked to emotional abuse. Impaired personality functioning, associated with interpersonal difficulties, appears as a shared mechanism for diabetes and loneliness. Considering loneliness and impairments in personality functioning might be highly important in research and clinical practice.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"198 ","pages":"Article 112390"},"PeriodicalIF":3.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145222646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of internet use between ADL disability and depressive symptoms in Chinese middle-aged and older adults: Evidence from a longitudinal study","authors":"Ruirui Guo ,&nbsp;Yixuan Liu ,&nbsp;Xuyang Zhao ,&nbsp;Yibing Chen ,&nbsp;Ranran Li ,&nbsp;Xinyu Gao ,&nbsp;Jiamin Feng ,&nbsp;Cuiping Wang ,&nbsp;Bingyang Nian ,&nbsp;Hongjian Liu ,&nbsp;Xiumin Zhang","doi":"10.1016/j.jpsychores.2025.112394","DOIUrl":"10.1016/j.jpsychores.2025.112394","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to explore the role of internet use between ADL disability and depressive symptoms onset and the effect of age on association mentioned above.</div></div><div><h3>Methods</h3><div>The participants who are 45 years old and above from the China Health and Retirement Longitudinal Study (CHARLS) were included in the 2018 baseline and 2020 follow-up research. Logistic regression analysis was used to investigate the association between ADL disability in 2018 and depressive symptoms in 2020. Interaction testing and stratified analyses were used to assess the role of internet use between them.</div></div><div><h3>Results</h3><div>There were 6784 subjects included in the study and 1503 (22.2 %) participants developed depressive symptoms in follow-up. ADL disability was associated with an increased risk of depressive symptoms in all participants after adjusting for all covariates (OR: 1.530, 95 %CI: 1.301, 1.797). This association remained in participants not using the internet (OR: 1.532, 95 %CI: 1.294, 1.811), but this association was not found in participants using the internet (OR: 1.242, 95 %CI: 0.638, 2.290). In addition, the role of internet use varied by age groups. Internet use may attenuate the association between ADL disability and depressive symptoms in middle-aged adults and younger older adults, but not in older adults aged 70 years and above.</div></div><div><h3>Conclusions</h3><div>ADL disability positively associated with depressive symptoms in middle-aged and older adults and internet use may attenuate the association between them especially in middle-aged and younger older adults.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"198 ","pages":"Article 112394"},"PeriodicalIF":3.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACT for postsurgical pain and dysfunction in at-risk veterans: Multisite, double-blind, cluster RCT","authors":"Lilian Dindo ,&nbsp;Katherine Hadlandsmyth ,&nbsp;Lauren Garvin ,&nbsp;James Marchman ,&nbsp;M. Bridget Zimmerman ,&nbsp;Joseph A. Buckwalter IV ,&nbsp;David M. Green ,&nbsp;John K. Wollaeger ,&nbsp;Andrea Strayer ,&nbsp;Kyung Soo Kim ,&nbsp;Wen Liu ,&nbsp;Jennie Embree ,&nbsp;Merlyn Rodrigues ,&nbsp;Barbara A. Rakel","doi":"10.1016/j.jpsychores.2025.112393","DOIUrl":"10.1016/j.jpsychores.2025.112393","url":null,"abstract":"<div><div>Persistent postsurgical pain (PPSP) and functional limitations after total knee arthroplasty (TKA) often vary in severity and duration, with higher levels seen in individuals at elevated risk. This multisite, double-blinded randomized controlled trial compared Acceptance and Commitment Therapy (ACT) to an active educational plus support attention control (AC), in Veterans “at-risk” for PPSP following TKA. Veterans indicated for unilateral TKA and at-risk for PPSP completed a 1-day (5 h) group workshop prior to surgery and at least 1 postoperative phone booster session. 336 patients who underwent TKA were randomized to ACT (<em>N</em> = 173) or to AC (<em>N</em> = 163). Of these, 95 % in the ACT group and 97 % in the AC group received at least 1 booster session. Primary outcomes included self-reported pain severity, Activities of Daily Living (ADL), and Quality of Life (QoL). The secondary outcome was time to opioid cessation. Both groups showed significant reductions in pain severity across time points: at 3 months, ACT participants had greater pain reduction (−2.78) than AC (−2.50), suggesting an earlier advantage. ADL function also improved significantly in both groups (6-month scores: ACT 31.4, AC 29.9). Median time to opioid cessation was similar overall: 2.71 weeks in both groups. Among participants without postoperative complications, ACT showed a non-significant trend toward earlier cessation (2.36 vs. 2.80 weeks). These findings suggest that brief, preoperative group-based interventions—whether ACT or educational support—can improve pain and function following TKA. ACT may offer additional early benefits in pain reduction and opioid tapering in Veterans at elevated risk for PPSP.</div><div><strong>Trial Registration:</strong> <span><span>Clinicaltrials.gov</span><svg><path></path></svg></span> under the number <span><span>NCT03965897</span><svg><path></path></svg></span></div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"198 ","pages":"Article 112393"},"PeriodicalIF":3.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing depressive symptom representation between individuals with cancer, non-cancer controls and healthy individuals: A network approach","authors":"Judith Hirschmiller ,&nbsp;Mareike Ernst ,&nbsp;Tamara Schwinn ,&nbsp;Elmar Brähler ,&nbsp;Jörg Wiltink ,&nbsp;Rüdiger Zwerenz ,&nbsp;Philipp S. Wild ,&nbsp;Thomas Münzel ,&nbsp;Jochem König ,&nbsp;Karl J. Lackner ,&nbsp;Norbert Pfeiffer ,&nbsp;Manfred E. Beutel ,&nbsp;GHS Research Consortium,&nbsp;Lina Krakau","doi":"10.1016/j.jpsychores.2025.112376","DOIUrl":"10.1016/j.jpsychores.2025.112376","url":null,"abstract":"<div><h3>Introduction</h3><div>Individuals affected by cancer are vulnerable to depression, but prevalence rates vary greatly between studies. The preponderance of somatic rather than psychological symptoms, overlapping with cancer-related symptoms, has spurred controversy on depressive symptom assessment in cancer. This work moves beyond sum scores of symptoms and explores symptom interrelations in individuals affected by cancer (compared to non-cancer and healthy controls) to deepen the understanding of depressive symptom expression in the context of cancer. It also compares the symptom network of individuals with cancer to a) non-cancer and b) healthy controls.</div></div><div><h3>Methods</h3><div>Network analyses and comparisons were conducted on 3512 participants from the Gutenberg-Health-Study (1230 with cancer; 1230 non-cancer controls; 1230 healthy individuals). Gaussian graphical models were estimated for each group, and network structures were compared regarding symptom predictability and centrality of PHQ-9 items.</div></div><div><h3>Results</h3><div>Depressive symptoms were more frequent in individuals affected by cancer than in non-cancer controls (<em>d</em> = 0.131) and healthy individuals (<em>d</em> = 0.172), but network structures did not differ. Mean predictability (amount of symptom variance explained through all other symptoms) ranged between 25 % and 29 %; with <em>depressed mood</em> highest in individuals with cancer and <em>energy loss</em> highest in non-cancer and healthy controls. Both symptoms were the most central nodes in all groups.</div></div><div><h3>Conclusion</h3><div>Symptom structure did not differ between individuals affected by cancer, non-cancer controls and healthy individuals. While somatic symptoms were more frequent in individuals with cancer, they were as closely associated with other symptoms as in the control populations. Along with psychological symptoms, somatic symptoms should be considered in screening as well as targeted by interventions in those with cancer.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"198 ","pages":"Article 112376"},"PeriodicalIF":3.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and clinimetric validation of the Brief Brain Fog Scale (BBFS) for post-COVID cognitive symptoms","authors":"Yubo Zhang ,&nbsp;Chenguang Jiang ,&nbsp;Wenhao Jiang ,&nbsp;Yucheng Yuan ,&nbsp;Dong Cao ,&nbsp;Yonggui Yuan","doi":"10.1016/j.jpsychores.2025.112380","DOIUrl":"10.1016/j.jpsychores.2025.112380","url":null,"abstract":"<div><h3>Objectives</h3><div>To develop and clinimetrically validate the Brief Brain Fog Scale (BBFS), a concise self-report tool for assessing post-COVID-19 cognitive symptoms, and to evaluate its structural validity, reliability and precision.</div></div><div><h3>Methods</h3><div>The BBFS was generated from literature and expert review and finalized as five items targeting core brain-fog symptoms.A total of 844 participants completed an online cross-sectional survey, including 686 with self-reported post-COVID brain fog and 158 healthy controls. Rasch modeling and Mokken scaling were used to examine unidimensionality, item fit, person reliability, and item scalability. Local independence and differential item functioning (DIF) were assessed across age, sex, and education groups.</div></div><div><h3>Results</h3><div>The BBFS fit Rasch model expectations (χ² = 44.6, df = 60, <em>p</em> = 0.928) and showed strong scalability (Mokken H = 0.679). Reliability was high (PSI = 0.846; WLE reliability = 0.846; EAP reliability = 0.852), with optimal precision in the moderate symptom range. All items had acceptable Infit MNSQ values (0.5–1.5), though several exhibited elevated Outfit in the highest response category. Local independence was largely supported; one pair marginally exceeded the indicative Q3^⁎ threshold (0.204), and none exceeded 0.30. Uniform DIF was identified across age, sex, and education. Two items showed lower thresholds in older respondents, two showed higher thresholds in females, and four showed lower thresholds in postgraduate respondents. ‘Forgetful’ did not exhibit education-related DIF.</div></div><div><h3>Conclusions</h3><div>The BBFS is a reliable, unidimensional instrument for post-COVID brain fog, with robust measurement properties supported by Rasch and Mokken analyses. Although some items showed demographic sensitivity, the total scale functioned consistently across groups. The BBFS represents a potentially valid and practical screening instrument. Future work should examine longitudinal responsiveness, cross-cultural generalizability, and item refinements.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"198 ","pages":"Article 112380"},"PeriodicalIF":3.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angry body, angry mind – mediation analysis of anger suppression, psychopathology and quality of life in bodily distress","authors":"Stefan M. Kahnert ,&nbsp;Nora Kämpfer ,&nbsp;Markus Ramm ,&nbsp;Franziska Geiser ,&nbsp;Rupert Conrad","doi":"10.1016/j.jpsychores.2025.112381","DOIUrl":"10.1016/j.jpsychores.2025.112381","url":null,"abstract":"<div><h3>Background</h3><div>Bodily distress is highly prevalent in the adult population and those affected exhibit a decreased quality of life (QoL). What contributes to this decreased QoL is incompletely understood. As bodily distress has been associated both with comorbidities and alterations in emotion regulation, in particular anger suppression, the relation between suppressed anger, psychopathology and QoL was studied.</div></div><div><h3>Methods</h3><div>In a cross-sectional study of adult psychosomatic outpatients presenting with bodily distress classified as somatoform disorders, anger suppression (Anger-In scale from the State-Trait Anger Expression Inventory), psychopathology (Symptom Checklist 90-R) and QoL (short version of the World Health Organization's Quality of Life Questionnaire) were assessed. Firstly, the association between anger suppression and different domains of QoL was examined. Secondly, mediation analyses were employed to test whether the relationship between anger suppression and QoL was mediated by the level of psychopathological symptoms.</div></div><div><h3>Results</h3><div>Data from 539 patients (63.1 % female, mean age 41.3 (SD: 15) years) were analysed. Higher Anger-In was associated with decreased QoL in all four domains (<em>p</em> &lt; 0.001). Mediation analysis showed a direct effect of anger suppression on decreased psychological and social QoL. For the physical and environmental domains of QoL, however, this relationship was fully mediated by psychopathology (depression, somatisation).</div></div><div><h3>Conclusion</h3><div>Anger suppression was strongly associated with decreased QoL in patients with bodily distress. While this was partly explained through basic psychopathology, there were some direct effects of anger suppression, in particular on social and psychological QoL. Anger management might hence be integrated in the treatment of bodily distress.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"198 ","pages":"Article 112381"},"PeriodicalIF":3.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antenatal anxiety symptoms and its contributing factors: The case in urban areas of Ethiopia","authors":"Koku S. Tamirat ,&nbsp;Sara Shishehgar ,&nbsp;Abel F. Dadi","doi":"10.1016/j.jpsychores.2025.112379","DOIUrl":"10.1016/j.jpsychores.2025.112379","url":null,"abstract":"<div><h3>Background</h3><div>Mental health challenges, such as depression and anxiety, commonly affect pregnant women and can have adverse health consequences for both the mother and the fetus. Despite their significant impact, anxiety symptoms in pregnant women are often inadequately addressed. This study aims to determine the prevalence of anxiety symptoms during pregnancy and identify contributing factors, with the goal of informing effective interventions.</div></div><div><h3>Methods</h3><div>We conducted a community-based cross-sectional study. We used a cluster sampling technique to recruit 940 study participants from selected clusters (sub-cities) in Gondar, Ethiopia. We assessed Anxiety symptoms using a set of three questions (Q 3, 4, &amp; 5) from the Edinburgh Postnatal Depression Scale (EPDS-3 A). We fitted a binary logistic regression model and computed the Adjusted Odds Ratio (AOR) with its 95 % Confidence Interval (CI).</div></div><div><h3>Result</h3><div>111 (11.9 %) of pregnant women had anxiety symptoms (95 %CI: 9.91 to 14.15). Compared to women with no formal education, those with secondary schooling had twice the odds of antenatal anxiety (AOR 2.05; 95 % CI 1.08–3.88). Likewise, women who faced food access problems in the past three months had 4.60 times the odds of anxiety compared with those without food issues (95 % CI 2.34–9.05); women with unplanned pregnancies had 2.53 times the odds relative to those with planned pregnancies (95 % CI 1.56–4.10); and those in their third trimester had 1.75 times the odds compared to women in the first trimester (95 % CI 1.10–2.79).</div></div><div><h3>Conclusions</h3><div>This study offers insight into the factors that play a role in the development of antenatal anxiety symptoms. Healthcare professionals should be well-informed about these factors and implement universal psychosocial screening for all pregnant women—ensuring timely identification of those at risk and enabling interventions that enhance their mental well-being.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"197 ","pages":"Article 112379"},"PeriodicalIF":3.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased use of psychiatric medication following incident celiac autoimmunity","authors":"Quinn Goddard ,&nbsp;Gilaad G. Kaplan ,&nbsp;Stephanie Coward ,&nbsp;Tyler Williamson ,&nbsp;Scott Patten ,&nbsp;Marcia Bruce ,&nbsp;Jenny Godley ,&nbsp;Rita Henderson ,&nbsp;Tara A. Whitten ,&nbsp;Araba Chintoh ,&nbsp;James A. King","doi":"10.1016/j.jpsychores.2025.112377","DOIUrl":"10.1016/j.jpsychores.2025.112377","url":null,"abstract":"<div><h3>Background</h3><div>Celiac disease is associated with an increased risk of psychiatric disorders, yet little is known about formal treatment for such conditions among patients.</div></div><div><h3>Methods</h3><div>Using administrative healthcare data, we conducted a population-based cohort study of individuals newly positive for celiac autoimmunity (tTG) between 2015 and 2023 in Alberta, Canada. Individuals were linked to medication dispensations to assess use of antidepressants, anxiolytics, and antipsychotics. We calculated the proportion of days covered (PDC) by psychiatric medication as the number of days for which medication was prescribed. We conducted identical sub-analyses for individuals with anxiety and/or depression-related healthcare encounters prior to their positive tTG test.</div></div><div><h3>Results</h3><div>Among 14,323 newly tTG-positive individuals, a greater proportion dispensed antidepressants (22.5 % vs 27.6 %) and antipsychotics (4.6 % vs 6.0 %) post-tTG, while a lower proportion dispensed anxiolytics post-tTG (15.4 % vs 11.4 %), all <em>p</em> &lt; 0.001. We observed higher odds of being dispensed psychiatric medication post-tTG (OR = 1.22; 95 % CI = 1.14, 1.31). Median PDC also significantly increased post-tTG test for antidepressants (2.8 % vs 21.1 %) and antipsychotics (0.4 % vs 6.3 %), <em>p</em> &lt; 0.001. However, a decreased odds of medication dispensation (OR = 0.42; 95 % CI: 0.32, 0.56) and median PDC post-tTG (45.1 % vs. 10.1 %, <em>p</em> &lt; 0.001) were observed among those with a previous depression/anxiety-related healthcare encounter.</div></div><div><h3>Conclusion</h3><div>These findings highlight a need for increased screening for and/or monitoring of psychiatric comorbidities in the celiac population, and further investigation into what may be underpinning greater use of psychiatric medications after tTG positivity.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"198 ","pages":"Article 112377"},"PeriodicalIF":3.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle factors, metabolic syndrome and apolipoprotein E in monozygotic twins with, at risk of and without affective disorders, as predictors of onset or recurrence of affective episodes, a seven-years follow-up study","authors":"Maj Vinberg ,&nbsp;Jon Dyg Sperling ,&nbsp;Ruth Frikke-Schmidt ,&nbsp;Thomas Scheike ,&nbsp;Lars Vedel Kessing ,&nbsp;Kamilla Miskowiak","doi":"10.1016/j.jpsychores.2025.112378","DOIUrl":"10.1016/j.jpsychores.2025.112378","url":null,"abstract":"<div><h3>Introduction</h3><div>This study explores lifestyle factors, metabolic syndrome (MetS), apolipoprotein E genotype (APOE), and plasma concentrations of apoE as predictors for the onset and recurrence of affective disorders.</div></div><div><h3>Methods</h3><div>We examined these factors in a seven-year follow-up study of 201 monozygotic twins (MZ) with unipolar or bipolar disorder (affected), their unaffected co-twins (high-risk), and twins with no personal or familial risk of affective disorder (low-risk).</div></div><div><h3>Results</h3><div>Higher body mass index (hazard ratio (HR) = 1.29, 95 % CI 1.11–1.50) and higher apoE plasma concentrations (HR = 1.09, 95 % CI 1.02–1.17) were significant predictors of onset. The APOE genotypes ε22 (HR = 2.85, 95 % CI 1.52–5.36) and ε43 + ε44 (HR = 2.42, 95 % CI 1.42–4.11) were predictors of onset or recurrence in the total sample. The ε22 genotype increased the HR = 5.04(95 % CI 2.25–11.31) in the affected group, while ε43 + ε44 genotypes predicted onset in the high-risk group (HR = 7.42, 95 % CI 1.76–31.36). Smoking was a predictor of onset or recurrence of affective episodes in the overall sample (HR = 2.15, 95 % CI 1.24–3.74) and in the low-risk group (HR = 39.10, 95 % CI 2.75–555.33).</div></div><div><h3>Conclusions</h3><div>The established risk genotypes APOE ε43 and ε44 were linked to the onset and recurrence of affective disorders in both affected and high-risk twins. Body mass index and smoking also emerged as significant risk factors. Furthermore, the predictors investigated may demonstrate different trajectories depending on familial risk for affective disorders. Overall, these findings underscore the importance of incorporating both biomarkers of and lifestyle factors into the prevention and treatment of patients with affective disorders.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"197 ","pages":"Article 112378"},"PeriodicalIF":3.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}