身体活动在抑郁症状和慢性疾病发病率之间的双向关联中的作用：爱尔兰老龄化纵向研究的前瞻性分析。

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2025-10-04 DOI:10.1016/j.jpsychores.2025.112398

André O. Werneck , Felipe B. Schuch , Davy Vancampfort , Liye Zou , José Francisco López-Gil , Joseph Firth , Nicola Veronese , Nilufar Mossaheb , Brendon Stubbs

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引用次数: 0

摘要

目的：探讨抑郁症状与慢性疾病发病率之间的双向关联，并探讨体育锻炼在上述关联中的调节作用。方法：分析来自爱尔兰老龄化纵向研究的数据，包括四波（2012-2018）的7279名参与者（55.7%为女性，平均年龄= 62.5±9.2岁），包括6年的随访。抑郁症状使用8项流行病学研究中心抑郁量表进行评估，而慢性疾病发生率包括13种自我报告的情况。随机截距交叉滞后面板模型检验了双向关联，调整了混杂因素，并按基线体力活动水平分层。结果：抑郁症状与慢性疾病发生率之间存在显著的双向关联。抑郁症状预测未来慢性病发病率（非标准化β系数[B] = 0.005; 95% CI: 0.001-0.008），慢性病发病率预测未来抑郁症状（B = 0.216; 95% CI: 0.100-0.331）。值得注意的是，这些关联仅在低和中等基线体力活动水平的参与者中具有显著性，其中慢性病预测抑郁症状（低基线PA水平：B = 0.006; 95% CI = 0.001至0.012）。中度基线PA水平：B = 0.008；95% CI = 0.002 ~ 0.014)和抑郁症状预测慢性疾病的发病率（低基线PA水平：B = 0.234; 95% CI = 0.002 ~ 0.466）。中度基线PA水平：B = 0.318；95% CI = 0.126 ~ 0.511)。结论：本研究证实抑郁症状与慢性疾病发病率之间存在双向关联。体力活动可能是一个调节因素，因为这种双向关联仅在体力活动水平低或中等的参与者中显着。

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The role of physical activity in the bidirectional association between depressive symptoms and chronic disease incidence: A prospective analysis of the Irish longitudinal study on ageing

Aim

To examine the bidirectional associations between depressive symptoms and chronic disease incidence and to investigate the moderating role of physical activity in the above-presented associations.

Methods

Data from the Irish Longitudinal Study on Ageing were analyzed, including 7279 participants (55.7 % women, mean age = 62.5 ± 9.2 years) across four waves (2012–2018), comprising six years of follow-up. Depressive symptoms were assessed using the 8-item Center for Epidemiologic Studies Depression scale, while chronic disease incidence covered 13 self-reported conditions. Random-intercept cross-lagged panel models examined bidirectional associations, adjusting for confounders and stratifying by baseline physical activity levels.

Results

A significant bidirectional association was observed between depressive symptoms and incident chronic diseases. Depressive symptoms predicted future chronic disease incidence (unstandardized beta coefficient [B] = 0.005; 95 %CI: 0.001–0.008), while chronic disease incidence predicted future depressive symptoms (B = 0.216; 95 %CI: 0.100–0.331). Notably, these associations were only significant among participants with low and moderate baseline physical activity levels, where chronic diseases predicted depressive symptoms (Low baseline PA level: B = 0.006; 95 %CI = 0.001 to 0.012. Moderate baseline PA level: B = 0.008; 95 %CI = 0.002 to 0.014) and depressive symptoms predicted chronic disease incidence (Low baseline PA level: B = 0.234; 95 %CI = 0.002 to 0.466. Moderate baseline PA level: B = 0.318; 95 %CI = 0.126 to 0.511).

Conclusion

This study confirms bidirectional associations between depressive symptoms and chronic disease incidence. Physical activity may be a moderating factor as this bidirectional association was only significant among participants with low or moderate levels of physical activity.

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.