Journal of Psychosomatic Research最新文献

{"title":"A description of the development of an innovative multi-component long COVID treatment program based on central sensitization with preliminary patient satisfaction data","authors":"B. Munipalli ,&nbsp;A. Smith ,&nbsp;A.R. Baird ,&nbsp;C.S. Dobrowolski ,&nbsp;M.E. Allman ,&nbsp;L.G. Thomas ,&nbsp;B.K. Bruce","doi":"10.1016/j.jpsychores.2024.111884","DOIUrl":"10.1016/j.jpsychores.2024.111884","url":null,"abstract":"<div><h3>Objective</h3><p>Estimates of the prevalence of Long COVID in the United States or worldwide are imprecise, but millions of people are thought to be affected. No effective treatment exists for the often devastating symptoms of Long COVID. Central Sensitization has been postulated as a causal/explanatory mechanism for developing Long COVID. No treatment to date has targeted Central Sensitization. The present cross-sectional study describes the first 140 patients treated in a multi-component treatment program that targets Central Sensitization to reduce symptom burden, improve functioning, and lower the psychological distress observed in these patients.</p></div><div><h3>Methods</h3><p>140 patients diagnosed with Long COVID after an extensive medical evaluation were assessed for function, depression, and pain catastrophizing using questionnaires and patient satisfaction measures after completion of a 16-h Cognitive Behavioral Therapy treatment program focused on Central Sensitization.</p></div><div><h3>Results</h3><p>Upon admission, patients diagnosed with Long COVID were significantly impaired in their ability to function due to their symptoms. Further, 70% of the patients were depressed. Pain catastrophizing was observed in up to 20% of patients.</p></div><div><h3>Conclusion</h3><p>Patient satisfaction measures were high for the sample at the end of the treatment program suggesting that a multicomponent treatment program targeting Central Sensitization is acceptable to patients. Further research is needed to explore the effectiveness and durability of this treatment approach.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"185 ","pages":"Article 111884"},"PeriodicalIF":3.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of psychotropic medication dispensing to people living with cystic fibrosis in Australia: 2013–2022","authors":"Louise Lord ,&nbsp;Peter Wark ,&nbsp;Mark Hew ,&nbsp;Brooke Blakeley ,&nbsp;Michelle Steeper ,&nbsp;Sue Kirsa ,&nbsp;Jenni Ilomäki","doi":"10.1016/j.jpsychores.2024.111877","DOIUrl":"10.1016/j.jpsychores.2024.111877","url":null,"abstract":"<div><h3>Objective</h3><p>People living with cystic fibrosis (PwCF) are at increased risk of mental health conditions. There is little evidence addressing psychotropic medication use in PwCF. This study aimed to estimate the dispensing prevalence of antidepressant, anxiolytic, antipsychotic, psychostimulant, and hypnotic/sedative medication in PwCF in Australia between 2013 and 2022.</p></div><div><h3>Method</h3><p>A 10% random sample of Australian Pharmaceutical Benefits Scheme data was used to identify PwCF and their medications between 2013 and 2022. Annual prevalence of psychotropic medication dispensing was estimated using a 3-year rolling average, stratified by sex, age, and medication class.</p></div><div><h3>Results</h3><p>Psychotropic medications were dispensed to 206/478 (41.3%) PwCF. Antidepressant and anxiolytic dispensing prevalence was highest in adult females, increasing from 201 5 by 50% to their peak in 2021 (antidepressants 36.8%; anxiolytics 12.3%). Psychostimulant prevalence was highest in adolescent males and increased over three-fold during the study period from 3.6% to 13.2%. The prevalence of antipsychotic medication was lower than other classes with adult females having the highest prevalence (3.1% and 5.8% in 201 5 and 2022 respectively). Hypnotic/sedative medications remained consistently low or decreased in all groups except male children, where it increased from 0.6% to 2.8% from 201 5 to 2022.</p></div><div><h3>Conclusion</h3><p>Psychotropic medication use is higher among Australian PwCF compared to the general population, with varying prevalence across age and sex groups. This is of interest due to complexities with CF comorbidities and potential medication influences and interactions. Future studies should investigate the reasons for psychotropic use disparities within PwCF with the aim to establish targeted guidelines and optimize outcomes.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"186 ","pages":"Article 111877"},"PeriodicalIF":3.5,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022399924002897/pdfft?md5=abd7aad7578a863deca3b0eac63bfd61&pid=1-s2.0-S0022399924002897-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142039793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Report on the 11th annual EAPM conference in Lausanne, Switzerland","authors":"","doi":"10.1016/j.jpsychores.2024.111882","DOIUrl":"10.1016/j.jpsychores.2024.111882","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"186 ","pages":"Article 111882"},"PeriodicalIF":3.5,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between hospital-diagnosed tinnitus and suicide: A Nationwide Danish longitudinal study","authors":"Martin Mølhave ,&nbsp;Sebastian Udholm ,&nbsp;Keith Hawton ,&nbsp;Therese Ovesen ,&nbsp;Annette Erlangsen","doi":"10.1016/j.jpsychores.2024.111879","DOIUrl":"10.1016/j.jpsychores.2024.111879","url":null,"abstract":"<div><h3>Objectives</h3><p>Tinnitus is a source of significant distress among some people. Associations have been suggested between tinnitus and mental disorders, and with suicidal thoughts and attempts. However, whether this extends to suicide in the general population remains uncertain.</p></div><div><h3>Methods</h3><p>This is a retrospective cohort study including all individuals aged 15 years or older, using Danish nationwide, longitudinal, population-based register data from 1 January 1990 through 31 December 2021. The main outcome was death by suicide. Poisson regression models were used to estimate adjusted incidence rate ratios (IRR) with the 95% confidence intervals (CI).</p></div><div><h3>Results</h3><p>Among 7,438,007 individuals (49.8% males) observed over 144,050,344 person-years, 85,677 (57.7% males) were diagnosed with tinnitus. In all, 23,824 suicide deaths were identified, of which 225 had tinnitus. Suicide rates were 24.2 and 16.5 per 100,000 person-years for those with and without tinnitus, respectively, giving an adjusted IRR of 1.4 (95% CI 1.2–1.6). Suicide rates were adjusted for demographic characteristics, concomitant hearing loss, and co-existing mental disorders before tinnitus. Increased suicide rates were linked to a higher number of hospital contacts and to recent hospital contacts, suggesting dose-response and temporal associations.</p></div><div><h3>Conclusions</h3><p>The findings reveal an association between tinnitus and suicide, particularly among individuals with co-existing mental disorders. Dose-response and temporal associations were found between tinnitus and suicide. Concurrent hearing loss had no influence on the tinnitus-suicide association. Attention towards patients experiencing tinnitus related distress is warranted, especially those with pre-existing mental disorders.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"185 ","pages":"Article 111879"},"PeriodicalIF":3.5,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective investigation of the prognosis of noncardiac chest pain in emergency department patients","authors":"Guillaume Foldes-Busque ,&nbsp;Clermont E. Dionne ,&nbsp;Marie-Andrée Tremblay ,&nbsp;Stéphane Turcotte ,&nbsp;Richard P. Fleet ,&nbsp;Patrick M. Archambault ,&nbsp;Isabelle Denis","doi":"10.1016/j.jpsychores.2024.111883","DOIUrl":"10.1016/j.jpsychores.2024.111883","url":null,"abstract":"<div><h3>Objectives</h3><p>This study sought to describe the 2-year evolution of the intensity and frequency of noncardiac chest pain (NCCP), NCCP-related disability and health-related quality of life in a cohort of emergency department (ED) patients. It also aimed to identify and characterize subgroups of patients who share similar NCCP trajectories.</p></div><div><h3>Methods</h3><p>672 consecutive patients with NCCP were prospectively recruited in two EDs. NCCP, physical and mental health-related quality of life and pain-related impairment were assessed at baseline and 6 months, 1 year and 2 years after the index ED visit.</p></div><div><h3>Results</h3><p>Significant reductions in the intensity and frequency of NCCP and in NCCP-related disability were observed over time, with 58.1% of patients being considered NCCP-free at the 2-year follow-up. Four trajectories of NCCP intensity were identified through latent class growth mixture modelling: Worsening Trajectory (6.8%), Persistence Trajectory (20.5%), Limited Improvement Trajectory (13.1%) and Remission Trajectory (59.5%). Physical quality of life was significantly higher in the latter two trajectories at all assessment points. Patients in the Remission Trajectory reported a better mental quality of life and a greater decrease in NCCP-related disability over time than those in the other trajectories.</p></div><div><h3>Conclusions</h3><p>Over 40% of ED patients with NCCP experienced persistent biopsychosocial morbidity that warrants further clinical attention.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"186 ","pages":"Article 111883"},"PeriodicalIF":3.5,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022399924002952/pdfft?md5=25c09ebc6cdb315ca6bae1c2a51992b2&pid=1-s2.0-S0022399924002952-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142097711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the delirium diagnostic tool-provisional (DDT-Pro) in geriatric medical inpatients with diagnostic permutations of the 3Ds with and without delirium","authors":"María Botero Urrea ,&nbsp;Maria Carolina González ,&nbsp;María Margarita Villa García ,&nbsp;Marcela Alviz Núñez ,&nbsp;Juan D. Velásquez-Tirado ,&nbsp;María V. Ocampo ,&nbsp;Paula T. Trzepacz ,&nbsp;José G. Franco","doi":"10.1016/j.jpsychores.2024.111880","DOIUrl":"10.1016/j.jpsychores.2024.111880","url":null,"abstract":"<div><h3>Objective</h3><p>Validations of brief delirium tools have not included analysis of psychiatric disorders comorbidities or control groups. We validated the Delirium Diagnostic Tool-Provisional (DDT-Pro) in 422 geriatric inpatients with high incidence of depression and/or dementia.</p></div><div><h3>Methods</h3><p>Cross-sectional study using two delirium reference standards, DSM-5-TR and Delirium Rating Scale-Revised-98 (DRS-R98). We assessed concurrent and construct DDT-Pro validity too.</p></div><div><h3>Results</h3><p>There were 117 (27.7%) delirium cases using DDT-Pro, 104 (24.6%) per DSM-5-TR and 93 (22.0%) per DRS-R98; 133 patients (31.5%) had depression and 105 (24.9%) dementia, some comorbid with delirium. DDT-Pro accuracy (AUC under ROC curve) ranges were 88.3–95.9% vs DSM-5-TR and 92.7–95.0% vs DRS-R98 for whole sample and four diagnostic groups, without statistical differences. DDT-Pro ≤6 had the most balanced sensitivity-specificity for delirium diagnosis against both DSM-5-TR and DRS-R98 with similar specificity but higher sensitivity for DRS-R98 than DSM-5-TR delirium, with the highest values in patients with depression and dementia (≥92% sensitivity, ≥81% specificity). Positive and negative likelihood ratios support diagnostic strength. Concurrent validity was high reflected by significant correlations (<em>p</em> &lt; 0.001) of DDT-Pro total and item scores with DRS-R98 and Delirium Frontal Index scores, highest in groups with comorbid depression and/or dementia. The DDT-Pro represented a single construct for delirium demonstrated by one factor with high item loadings and high internal consistency reliability of its items.</p></div><div><h3>Conclusions</h3><p>The DDT-Pro demonstrated strong performance metrics in general hospital elderly inpatients with preexisting depression and/or dementia, which is unique among brief delirium tools. Its optimized cutoff score was the same as in other populations.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"185 ","pages":"Article 111880"},"PeriodicalIF":3.5,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Female Reproductive Factors with depression and suicidal ideation in postmenopausal women: Evidence from NHANES 2007–2018","authors":"Shujie Zhang ,&nbsp;Yanan Zhang ,&nbsp;Junhuan Mao","doi":"10.1016/j.jpsychores.2024.111881","DOIUrl":"10.1016/j.jpsychores.2024.111881","url":null,"abstract":"<div><h3>Objective</h3><p>This cross-sectional research aimed to examine how reproductive factors influence depression and suicidal ideation among postmenopausal women.</p></div><div><h3>Methods</h3><p>Data from the 2007 to 2018 US National Health and Nutrition Examination Survey were analyzed for this study. The Patient Health Questionnaire (PHQ-9) was adopted to measure depression and suicidal ideation in the participants.</p></div><div><h3>Results</h3><p>Out of 3076 participants, 9.5% (348/3076) experienced depression, and 3.4% (128/3076) reported suicidal ideation. Following the adjustment for confounding factors, premature menopause (OR = 1.81, 95% CI: 1.03–3.15) was significantly associated with an increased risk of depression. Moreover, postmenopausal women with a higher number of pregnancies exhibited a greater risk of depression (OR = 1.29, 95% CI: 1.09–1.53; <em>P</em> &lt; 0.001). Conversely, a longer reproductive lifespan (OR = 0.96, 95% CI: 0.93–0.99) and a higher number of livebirths (OR = 0.68, 95% CI: 0.54–0.86; <em>P</em> &lt; 0.001) were linked to a decreased risk of depression. Furthermore, the use of oral contraceptives (OR = 0.52, 95% CI: 0.28–0.97; <em>P</em> = 0.021) was significantly associated with a decreased likelihood of experiencing suicidal ideation, while the number of livebirths (OR = 0.68, 95% CI: 0.48–0.97; <em>P</em> = 0.018) exhibited a negative correlation with suicidal ideation.</p></div><div><h3>Conclusion</h3><p>Our results indicate that reproductive factors are significantly associated with the risk of depression and suicidal ideation in postmenopausal women. Further longitudinal studies with repeated measures of depression are necessary to establish causal relationships.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111881"},"PeriodicalIF":3.5,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of negative affect prior to and following disordered eating behaviors among women with eating disorder pathology: An examination of the role of state-interoception","authors":"Kelly A. Romano ,&nbsp;Carol B. Peterson ,&nbsp;Lisa M. Anderson ,&nbsp;Justin Anker ,&nbsp;Kristin E. Heron","doi":"10.1016/j.jpsychores.2024.111878","DOIUrl":"10.1016/j.jpsychores.2024.111878","url":null,"abstract":"<div><h3>Objective</h3><p>Affect regulation theories of eating disorders (ED) posit that negative affect increases in the hours before and decreases following disordered eating behaviors (DEBs) in daily life, yet findings from studies assessing affective changes post-DEBs are mixed. This inconsistency may be due to the previously unassessed role of other transdiagnostic processes in these associations, such as interoception (the ability to sense and integrate information from bodily sensations). To address this research gap, the present study examined whether different interoception dimensions moderated negative affect trajectories surrounding DEBs in the natural environment.</p></div><div><h3>Method</h3><p>150 women with ED pathology (<em>M</em>age = 21.0, <em>SD</em> = 4.1) completed 4 surveys targeting affect and DEBs each day for a 10-day ecological momentary assessment period. Polynomial multilevel models examined negative affect trajectories pre- and post-DEBs (dietary restriction, overeating, loss of control eating), and whether these trajectories varied based on daily interoception dimensions (not distracting, self-regulation, body listening and trust).</p></div><div><h3>Results</h3><p>Negative affect increased prior to loss of control eating—but not dietary restriction or overeating—and decreased following all DEBs. Further, the magnitude of the decrease in negative affect that emerged post-dietary restriction decreased in strength as daily “not distracting” interoception increased. The other interoception dimensions did not moderate negative affect trajectories surrounding DEBs.</p></div><div><h3>Conclusions</h3><p>Allowing oneself to experience (vs. distract from) uncomfortable bodily sensations may weaken affect dysregulation processes that follow dietary restriction in daily life and are theorized to maintain DEBs. These results provide insight that may strengthen EDs theories, research, and inform interoception-focused interventions.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"185 ","pages":"Article 111878"},"PeriodicalIF":3.5,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analgesia of noninvasive electrical stimulation of the dorsolateral prefrontal cortex: A systematic review and meta-analysis","authors":"Qiqi Wu ,&nbsp;Xiaoyun Li ,&nbsp;Yinhua Zhang ,&nbsp;Shengxiong Chen ,&nbsp;Richu Jin ,&nbsp;Weiwei Peng","doi":"10.1016/j.jpsychores.2024.111868","DOIUrl":"10.1016/j.jpsychores.2024.111868","url":null,"abstract":"<div><h3>Objective</h3><p>The dorsolateral prefrontal cortex (DLPFC) is implicated in pain modulation, suggesting its potential as a therapeutic target for pain relief. However, studies on transcranial electrical stimulation (tES) over the DLPFC yielded diverse results, likely due to differences in stimulation protocols or pain assessment methods. This study aims to evaluate the analgesic effects of DLPFC-tES using a meta-analytical approach.</p></div><div><h3>Methods</h3><p>A meta-analysis of 29 studies involving 785 participants was conducted. The effects of genuine and sham DLPFC-tES on pain perception were examined in healthy individuals and patients with clinical pain. Subgroup analyses explored the impact of stimulation parameters and pain modalities.</p></div><div><h3>Results</h3><p>DLPFC-tES did not significantly affect pain outcomes in healthy populations but showed promise in reducing pain-intensity ratings in patients with clinical pain (Hedges' g = −0.78, 95% CI = [−1.33, −0.24], <em>p</em> = 0.005). Electrode placement significantly influenced the analgesic effect, with better results observed when the anode was at F3 and the cathode at F4.</p></div><div><h3>Conclusions</h3><p>DLPFC-tES holds potential as a cost-effective pain management option, particularly for clinical populations. Optimizing electrode placement, especially with an symmetrical configuration, may enhance therapeutic efficacy. These findings underscore the promise of DLPFC-tES for alleviating perceived pain intensity in clinical settings, emphasizing the importance of electrode placement optimization.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"185 ","pages":"Article 111868"},"PeriodicalIF":3.5,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141978643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations of spirituality and Hispanic ethnicity with neuroendocrine biomarkers among patients with colorectal cancer","authors":"Elizabeth Cruz ,&nbsp;Armando Mendez ,&nbsp;Amanda Ting ,&nbsp;David Spiegel ,&nbsp;Thomas C. Tsai ,&nbsp;Charles S. Carver ,&nbsp;Youngmee Kim","doi":"10.1016/j.jpsychores.2024.111865","DOIUrl":"10.1016/j.jpsychores.2024.111865","url":null,"abstract":"<div><h3>Objective</h3><p>Dealing with cancer evokes not only physical and emotional distress, but may also promote resilience through spirituality. Patients with cancer are vulnerable to neuroendocrine dysregulation. This longitudinal observational study examined the degree to which spirituality was associated with neuroendocrine biomarkers and the moderating role of Hispanic ethnicity.</p></div><div><h3>Methods</h3><p>Participants were adults who were recently diagnosed with colorectal cancer (<em>n</em> = 81, 55 years old, 66% male, 63% Hispanic, 72% advanced cancer, 7 months post-diagnosis). The domains of spirituality (faith, meaning, and peace) and ethnicity (Hispanic vs. non-Hispanic) were self-reported. Cortisol and alpha amylase (sAA) were assayed from saliva samples collected at waking and bedtime on seven consecutive days. Mean levels at waking and bedtime, and diurnal slopes over seven days were calculated. Age and cancer stage were covariates. <strong>Results:</strong> Overall, patients reported moderate to high levels of spirituality. General linear modeling revealed that greater faith was associated with higher levels of sAA at waking and bedtime as well as more blunted diurnal pattern of sAA only among Hispanic patients (<em>p</em> ≤ .045). Greater peace was associated with steeper diurnal pattern of sAA, regardless of ethnicity (<em>B</em> = 0.021, <em>p</em> = .005). Meaning and cortisol were not significantly associated with study variables.</p></div><div><h3>Conclusions</h3><p>Findings indicate that presence of peace facing a cancer diagnosis associated with neuroendocrine regulation, whereas drawing on one's faith, particularly among Hispanic patients, associated with neuroendocrine dysregulation during the first months after the diagnosis. Further investigations of psychobiobehavioral moderators and mediators for healthy neuroendocrine functioning among patients with cancer are warranted.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"185 ","pages":"Article 111865"},"PeriodicalIF":3.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}