Journal of Psychosomatic Research最新文献

{"title":"Preoperative psychological distress and acute postoperative pain among abdominal surgery patients","authors":"Carlos Alberto Henao Periañez ,&nbsp;Marcio Alexander Castillo-Díaz","doi":"10.1016/j.jpsychores.2025.112055","DOIUrl":"10.1016/j.jpsychores.2025.112055","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze preoperative psychological distress symptoms and their association with acute postoperative pain in patients undergoing abdominal surgery.</div></div><div><h3>Method</h3><div>Prospective observational study conducted at a University Hospital in Minas Gerais, Brazil. The sample included 118 patients in the hospital's elective abdominal surgery program. Psychological distress symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS). Pain levels were measured using the numeric verbal scale (NVS, 0–10 points) from admission to discharge from the post-anesthesia care unit. Descriptive statistics and an ordinal regression model were utilized to detect related factors, with a threshold for significance established at <em>p</em> &lt; 0.05. Pain levels at discharge from the post-anesthesia care unit was considered the outcome variable.</div></div><div><h3>Findings</h3><div>Preoperatively, 50.8 % exhibited symptoms of anxiety (HADS-A ≥ 8) and 16.1 % exhibited symptoms of depression (HADS-D ≥ 8), with 14.4 % presenting both symptoms. The prevalence of pain (NVS &gt;0) in the post-anesthesia care unit was 40.3 %. At admission, 5.8 % of patients reported moderate to severe pain (NVS ≥ 4), increasing to 29.7 % at 60 min and 22.1 % at discharge. Regression analysis showed that anxiety or depression (OR = 4.49, <em>p</em> &lt; 0.01) significantly increased the likelihood of experiencing higher pain levels, which was even greater when both symptoms coexisted (OR = 10.19, <em>p</em> &lt; 0.01). Additionally, older age (OR = 0.94, p &lt; 0.01) and inadequate pain management (OR = 7.67, p &lt; 0.01) were significant predictors of pain levels at discharge.</div></div><div><h3>Conclusion</h3><div>Preoperative psychological distress, particularly the simultaneous presence of anxiety and depressive symptoms, significantly elevates the likelihood of heightened pain intensity in patients undergoing abdominal surgery.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"190 ","pages":"Article 112055"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacologically treated depression, anxiety, and insomnia in individuals with type 2 diabetes: The role of diabetes duration, age, and age at diabetes onset. A Norwegian population-based registry study from the OMIT cohort","authors":"Ragnhild B. Strandberg ,&nbsp;Roy M. Nilsen ,&nbsp;François Pouwer ,&nbsp;Jannicke Igland ,&nbsp;Jan Ivar Røssberg ,&nbsp;Anne Karen Jenum ,&nbsp;Esben S. Buhl ,&nbsp;Marjolein M. Iversen","doi":"10.1016/j.jpsychores.2025.112057","DOIUrl":"10.1016/j.jpsychores.2025.112057","url":null,"abstract":"<div><h3>Objective</h3><div>To examine whether type 2 diabetes (T2D) duration (‘0–4’; ‘≥5–9’; ≥10–19′; ‘≥20 years') was associated with use of medication for depression, anxiety, or insomnia, and if possible associations were modified by age, age at T2D onset, sex, and education.</div></div><div><h3>Methods</h3><div>We used data from 55,083 adults with T2D in the national registry-based cohort study Outcomes &amp; Multi-morbidity In T2D (2006–2019). Adjusted associations and effect modifications were estimated using binary logistic regressions with generalized estimation equations in the subgroups age (&lt;60, ≥60 years), age at diabetes onset (&lt;40, ≥40 years), sex (men, women), and education (primary, high school, university).</div></div><div><h3>Results</h3><div>At initial registration, 12 % used medication for depression, 10 % for anxiety, and 16 % for insomnia. These prevalence estimates increased with diabetes duration in most subgroups. Individuals with early onset T2D had higher prevalence of depression than those with late onset, which increased with diabetes duration (per category change diabetes duration 0.7 % (95 % CI 0.2, 1.2), P for trend = 0.003). For anxiety and insomnia, a stronger association was found in those with early T2D onset compared to late onset (per category change 1.3 % (95 % CI 0.9, 1.8) and 1.9 (95 % CI 1.3, 2.4), P for interaction = 0.001; 0.01).</div></div><div><h3>Conclusion</h3><div>The prevalence of pharmacologically treated depression, anxiety, and insomnia increased with diabetes duration; this finding may imply that assessment of mental health disorders at the initial phase and along the diabetes trajectory are needed. As the prevalences advanced most prominently in people with early onset T2D, future studies should determine underlying mechanisms to test age-appropriate preventive interventions.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"190 ","pages":"Article 112057"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A psychosocial intervention for prenatal anxiety decreases functional disability among pregnant Pakistani women: A moderated mediation approach using data from a randomized controlled trial","authors":"Soim Park ,&nbsp;Abid Malik ,&nbsp;Ahmed Zaidi ,&nbsp;Jamie Perin ,&nbsp;Najia Atif ,&nbsp;Atif Rahman ,&nbsp;Pamela J. Surkan","doi":"10.1016/j.jpsychores.2025.112058","DOIUrl":"10.1016/j.jpsychores.2025.112058","url":null,"abstract":"<div><h3>Background</h3><div>Given that anxiety is associated with functional disability, we investigated whether an intervention designed to reduce prenatal anxiety could improve functional disability in the postpartum period. We also examined whether perceived social support in the third trimester mediated this relationship, and if the extent of the mediation differed by economic empowerment.</div></div><div><h3>Methods</h3><div>We included 590 pregnant Pakistani women with at least mild anxiety symptoms to a randomized controlled trial (RCT). Women in the intervention arm received six sessions of a Cognitive Behavioral Therapy-based psychosocial intervention for prenatal anxiety. Relaxation techniques (e.g., breathing exercises and meditation) and enhancement of social support were also included in the therapy. The control group received enhanced usual care. Economic empowerment was dichotomized into empowered and non-empowered. We used the Multidimensional Scale of Perceived Social Support (MSPSS) to assess social support, where higher scores indicated greater social support. The WHO Disability Assessment Schedule (WHODAS 2.0) was employed to evaluate functional disability which was neither a primary nor a secondary outcome of the RCT. As an ad hoc analysis of the RCT, regression-based path analysis modeling was employed to examine the main, mediating, and moderating effects. Mediation was estimated with the product of coefficients method.</div></div><div><h3>Results</h3><div>The intervention reduced the postpartum functional disability by 4.7 points (adjusted B = -4.71, bootstrapped 95 % confidence interval (CI): −5.93, −3.49), and social support in the late pregnancy mediated this relationship (B_{indirect effect} = −0.56, bootstrapped 95 % CI: −0.93, −0.26). A statistically significant index of moderated mediation—showing whether the indirect effects of the mediator vary by the levels of the moderator—indicated that economic empowerment significantly moderated the initial segment of the pathway between the intervention and functional disability (B_{difference in indirect effects} = 0.64, bootstrapped 95 % CI: 0.13, 1.27). Social support mediated the main association only for non-empowered women.</div></div><div><h3>Conclusion</h3><div>While social support can mediate the relationship between psychosocial intervention and functional disability in anxious pregnant women, promotion of social support during late pregnancy may be particularly useful in non-empowered women, for reducing functional disability in the postpartum period.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"190 ","pages":"Article 112058"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which factors predict outcome from specialist physiotherapy for functional motor disorder? Prognostic modelling of the Physio4FMD intervention","authors":"Glenn Nielsen ,&nbsp;Teresa C. Lee ,&nbsp;Louise Marston ,&nbsp;Alan Carson ,&nbsp;Mark J. Edwards ,&nbsp;Laura H. Goldstein ,&nbsp;Rachael Maree Hunter ,&nbsp;Kate Holt ,&nbsp;Jon Marsden ,&nbsp;Markus Reuber ,&nbsp;Jon Stone ,&nbsp;Irwin Nazareth","doi":"10.1016/j.jpsychores.2025.112056","DOIUrl":"10.1016/j.jpsychores.2025.112056","url":null,"abstract":"<div><h3>Objectives</h3><div>Physiotherapy is considered part of first line treatment for functional motor disorder (FMD) although not all patients benefit. Predictors of treatment outcome may help to inform triage decisions. We aimed to determine which baseline variables predicted treatment outcome in the pragmatic multicentre Physio4FMD randomised controlled trial of specialist physiotherapy for FMD.</div></div><div><h3>Methods</h3><div>Participants randomised to the specialist physiotherapy arm of the trial were included in the analysis. Treatment outcome was dichotomised into improvement vs no improvement, based on two measures, Short Form 36 Physical Functioning (SF36 PF) and participant-rated Clinical Global Impression Scale of Improvement (CGI-I). Predictors of outcome were selected from baseline variables. Univariate logistic regression was used to calculate the odds ratio of improvement for each variable. Variables associated with improvement at <em>p</em> &lt; 0.1 were considered for inclusion in a multiple logistic regression model.</div></div><div><h3>Results</h3><div>A greater perception of having control over recovery predicted improvement on the CGI-I (OR 1.18, 95 % CI 1.07, 1.31). Predictors of lack of improvement were an increased perception of the permanence of symptoms, predicting lack of improvement on the SF36 PF (OR 0.91, 95 % CI 0.84, 0.99) and older age, predicting lack of improvement on the CGI-I (OR 0.97, 95 % CI 0.95, 0.998).</div></div><div><h3>Conclusions</h3><div>Age and perceptions of symptom control were weak predictors of outcome from specialist physiotherapy. In contrast, a number of factors commonly believed to predict poorer treatment response, including illness duration and levels of pain and fatigue, were not related to the outcomes measured in this study.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"190 ","pages":"Article 112056"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal blood biomarkers and trajectories of depressive symptoms among Chinese middle-aged and older adults","authors":"Jinghong Huang ,&nbsp;Le Chen ,&nbsp;Huiyu Chen ,&nbsp;Qiaodan Liu ,&nbsp;Chuandeng Tu ,&nbsp;Yue Dai ,&nbsp;Yueping Li ,&nbsp;Raoping Tu","doi":"10.1016/j.jpsychores.2025.112052","DOIUrl":"10.1016/j.jpsychores.2025.112052","url":null,"abstract":"<div><h3>Objective</h3><div>Although previous studies have demonstrated allostatic load (AL) predicts depressive symptoms, few studies have considered the association between AL and trajectories of depressive symptoms. This study aims to systematically examine the associations of abnormal blood biomarkers in the three biological systems with trajectories of depressive symptoms.</div></div><div><h3>Methods</h3><div>A total of 6251 participants aged 45+ from the China Health and Retirement Longitudinal Study (CHARLS). Depressive symptoms were assessed using the 10-item Center for Epidemiological Studies Depression Scale (CESD-10) in five visits (waves 2011, 2013, 2015, 2018, and 2020). Biomarkers in three biological systems were evaluated based on standard criteria, including C-reactive protein in the inflammation system; systolic and diastolic blood pressures in the cardiovascular system; and high-density lipoprotein cholesterol (HDL<img>C), total cholesterol/HDL-C ratio, and glycosylated hemoglobin (HbA1c) in the metabolic system. The trajectories of depressive symptoms were measured using group-based trajectory modelling (GBTM). Multinomial logistic regression models were conducted to examine the association between the number of abnormal biological systems and trajectories of depressive symptoms.</div></div><div><h3>Results</h3><div>Four different trajectories of depressive symptoms were identified: mild (44.22 %), moderate (42.09 %), increasing (9.39 %), and severe (4.30 %). Compared to participants with normal values of biomarkers in all three systems, those with abnormal values of biomarkers in three systems had a 2.26-fold risk of developing the severe depressive symptoms trajectory.</div></div><div><h3>Conclusions</h3><div>Our findings highlight the importance of monitoring multiple biological systems to prevent long-term accelerated severe depressive symptoms trajectory.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"191 ","pages":"Article 112052"},"PeriodicalIF":3.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychotherapy in patients with long/post-COVID – A systematic review on the feasibility, acceptability, safety, and efficacy of available and emerging interventions","authors":"Marisa Schurr ,&nbsp;Johanna Graf ,&nbsp;Florian Junne ,&nbsp;Katrin Elisabeth Giel","doi":"10.1016/j.jpsychores.2025.112048","DOIUrl":"10.1016/j.jpsychores.2025.112048","url":null,"abstract":"<div><h3>Backgrounds</h3><div>There is an urgent need for effective treatments for patients with long/post-COVID. Current recommendations for management favor a multimodal approach including psychotherapy and emphasize that interventions should also consider the mental health impact of living with long/post-COVID. This systematic review synthesizes psychotherapeutic interventions that currently target long/post-COVID complaints and summarizes data on the feasibility, acceptability, safety, and efficacy of psychotherapy for patients with long/post-COVID.</div></div><div><h3>Methods</h3><div>This systematic review was conducted according to the PRISMA statement. Studies were retrieved from three databases (PubMed, PsycInfo, Web of Science) and independently assessed by two raters. Studies investigating patients of any age suffering from long/post-COVID were included if the intervention involved psychotherapeutic treatment and changes in long/post-COVID symptoms were reported. The review has been pre-registered on PROSPERO.</div></div><div><h3>Results</h3><div>A total of 12 studies were included in the analysis. Of these, 10 were multimodal approaches with integrated psychotherapeutic interventions, and two were studies on stand-alone psychotherapy. The majority of studies were uncontrolled and demonstrate pre-post improvements in a range of long/post-COVID symptoms. Only one RCT could be identified, which supports the benefit of CBT for COVID-related fatigue. It was not possible to draw general conclusions regarding the efficacy of psychotherapy for long/post-COVID. However, data on feasibility, acceptability, and safety support the potential of psychotherapy as a treatment approach for long/post-COVID.</div></div><div><h3>Conclusion</h3><div>Future studies investigating the potential of psychotherapy approach for long/post-COVID which go beyond the pilot stage are needed to systematically assess feasibility, acceptability, safety, and efficacy in large-scale confirmatory trials.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"190 ","pages":"Article 112048"},"PeriodicalIF":3.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current tobacco smoking prevalence in individuals living with eating disorders: A meta-analysis and meta-regression study","authors":"Beatriz Eugenio Valladão Flores ,&nbsp;Maria Olivia Pozzolo Pedro ,&nbsp;Giuliana Perrotte ,&nbsp;Maria Amalia Accari Pedrosa ,&nbsp;Luiza Florence ,&nbsp;Ligia Florio ,&nbsp;Julio Torales ,&nbsp;Antonio Ventriglio ,&nbsp;João Mauricio Castaldelli-Maia","doi":"10.1016/j.jpsychores.2025.112047","DOIUrl":"10.1016/j.jpsychores.2025.112047","url":null,"abstract":"<div><h3>Objectives</h3><div>A growing body of evidence suggests a potential association between tobacco dependence and eating disorders. Given the appetite-suppressing effects of tobacco, its use may be linked to weight control behaviors among individuals with eating disorders. This study aims to review the prevalence of current smoking among individuals diagnosed with Anorexia Nervosa (AN), Bulimia Nervosa (BN), or Binge Eating Disorder (BED).</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted across international scientific databases to identify eligible studies. Smoking prevalence rates were extracted and aggregated using random-effects models. Meta-regression and sensitivity analyses were performed to explore factors influencing prevalence rates.</div></div><div><h3>Results</h3><div>The final analysis included 30 studies, encompassing 2970 individuals with AN, 5032 with BN, and 7704 with BED. The pooled prevalence of current smoking was 23.4 % for AN, 19.3 % for BN (adjusted for publication bias), and 11.9 % for BED. Meta-regression revealed that studies with higher proportions of female participants and those using non-DSM diagnostic tools reported significantly lower smoking prevalence in BED. Additionally, higher smoking prevalence in BED was observed in North America and in studies with more recent publication years. No significant covariates were identified in the meta-regression models for AN and BN. Sensitivity analyses confirmed the robustness of these findings.</div></div><div><h3>Conclusion</h3><div>This meta-analysis highlights elevated current smoking rates among individuals with AN and BN compared to the general population, particularly among women. Smoking may serve as a weight control strategy in these groups, underscoring the need for integrated smoking cessation interventions within eating disorder treatment. The findings also reveal distinct regional and demographic influences on smoking behavior in BED, suggesting a nuanced approach to prevention and intervention across eating disorder subtypes.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"190 ","pages":"Article 112047"},"PeriodicalIF":3.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-traumatic stress disorder and risk of systemic lupus erythematosus: Meta-analysis and Mendelian randomization study","authors":"Lingfeng Chen ,&nbsp;Mengge Zhang ,&nbsp;Shate Xiang ,&nbsp;Jingjing Zhang ,&nbsp;Runyu Chang ,&nbsp;Chao Hu ,&nbsp;Suhai Qian ,&nbsp;Ting Liu ,&nbsp;Yufeng Shi ,&nbsp;Xinghong Ding","doi":"10.1016/j.jpsychores.2025.112049","DOIUrl":"10.1016/j.jpsychores.2025.112049","url":null,"abstract":"<div><h3>Objective</h3><div>We conducted a meta-analysis and Mendelian randomization study to analyze the association and causal relationship of genetic prediction between post-traumatic stress disorder and the risk of systemic lupus erythematosus.</div></div><div><h3>Methods</h3><div>A meta-analysis was conducted using hazard ratio, relative risk, odds ratio, and 95 % confidence intervals as effect measures. Summary data from genome-wide association studies on post-traumatic stress disorder and systemic lupus erythematosus were utilized to assess the causal relationship of genetic prediction between post-traumatic stress disorder and systemic lupus erythematosus using Mendelian randomization.</div></div><div><h3>Results</h3><div>A meta-analysis showed that post-traumatic stress disorder was positively associated with the risk of systemic lupus erythematosus (RR = 1.85, 95 % CI = 1.61–2.12, <em>p</em> &lt; 0.001). The results of Egger's test showed no publication bias (<em>p</em> = 0.823, <em>p</em> &gt; 0.05). Sensitivity analysis showed that the meta-analysis results were stable (RR = 1.85, 95 % CI = 1.61–2.12). However, Mendelian Randomization analysis revealed no evidence of a causal relationship of genetic prediction between post-traumatic stress disorder and systemic lupus erythematosus (IVW OR: 1.001, 95 % CI: 0.805–1.245, <em>p</em> = 0.993).</div></div><div><h3>Conclusion</h3><div>There is a correlation between post-traumatic stress disorder and systemic lupus erythematosus, but Mendelian Randomization does not support a genetic causal effect of post-traumatic stress disorder on systemic lupus erythematosus. The potential causal relationship between the two factors may necessitate further in-depth research.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"190 ","pages":"Article 112049"},"PeriodicalIF":3.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing cognitive functions in non-neuropsychiatric childhood systemic lupus erythematosus: Cross-sectional study","authors":"Emil Aliyev ,&nbsp;Ecem Selin Akbas Aliyev ,&nbsp;Selcan Demir ,&nbsp;Mubeccel Yeniada Kirseven ,&nbsp;Cihat Celik ,&nbsp;Ozlem Kahraman Erkus ,&nbsp;Halime Tuna Cak Esen ,&nbsp;Ebru Cengel Kultur ,&nbsp;Banu Anlar ,&nbsp;Seza Ozen ,&nbsp;Yelda Bilginer","doi":"10.1016/j.jpsychores.2024.112027","DOIUrl":"10.1016/j.jpsychores.2024.112027","url":null,"abstract":"<div><h3>Objectives</h3><div>Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by multisystem, including neuropsychiatric, involvement. The nervous system is affected in 20–27 % of patients within approximately two years after diagnosis. This study aimed to examine neurocognitive impairment in childhood-onset SLE (cSLE) patients before the development of any neurological, psychiatric, or cognitive manifestations.</div></div><div><h3>Methods</h3><div>The study included 98 children and adolescents. Of these, 34 (35 %) were cSLE groups, and the remaining formed two control groups: 31 (31 %) oligoarticular Juvenile Idiopathic Arthritis (oJIA) patients served as a “patient control” group, and 33 (34 %) healthy participants socio-demographically matched to the cSLE and oJIA patients formed the healthy control (HC) group. None of the subjects in the study exhibited neurological or psychiatric symptoms.</div></div><div><h3>Results</h3><div>The Wechsler Intelligence Scale for Children-IV (WISC-IV) was applied to all groups. Test results showed that the Perceptual Reasoning Index Score (PRIS) was significantly lower in cSLE than in HC (F(2, 95) = 3.365, <em>p</em> = 0.042, Tukey HSD: <em>p</em> = 0.01). ‘Comprehension’ subtest scores were significantly lower in the cSLE group compared to the HC group (H(2) = 8.133, <em>p</em> = 0.017; U = 352.5, <em>p</em> = 0.009). Similarly, ‘symbol search’ subtest scores were significantly lower in the cSLE group compared to the HC group (F(2, 95) = 3.545, <em>p</em> = 0.036, Tukey HSD: <em>p</em> = 0.014).</div></div><div><h3>Conclusion</h3><div>Our results revealed that cSLE may have neurocognitive impairment without presenting any symptoms. Early detection is possible with the neurocognitive test WISC-IV. These results support the inclusion of objective neurocognitive assessment methods into the routine clinical follow-up of childhood-onset SLE.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112027"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of cardiac autonomic activity across consciousness states and levels of sleep depth in individuals with sleep complaints and bipolar disorder or unipolar depressive disorders","authors":"Chloe Leveille ,&nbsp;Mysa Saad ,&nbsp;Daniel Brabant ,&nbsp;David Birnie ,&nbsp;Karina Fonseca ,&nbsp;Elliott Kyung Lee ,&nbsp;Alan Douglass ,&nbsp;Georg Northoff ,&nbsp;Katerina Nikolitch ,&nbsp;Julie Carrier ,&nbsp;Stuart Fogel ,&nbsp;Caitlin Higginson ,&nbsp;Tetyana Kendzerska ,&nbsp;Rebecca Robillard","doi":"10.1016/j.jpsychores.2024.111996","DOIUrl":"10.1016/j.jpsychores.2024.111996","url":null,"abstract":"<div><h3>Objective</h3><div>Autonomic nervous system dysfunction and reduced heart rate variability (HRV) often co-exist with mood disorders, a phenomenon likely influenced by sleep disturbances. This study investigated heart rate (HR) and HRV across wake, rapid eye movement (REM) sleep, and non-REM (NREM) sleep in individuals with sleep complaints and bipolar or unipolar depressive disorder.</div></div><div><h3>Methods</h3><div>Polysomnographic data was retrospectively collated for 120 adult patients with sleep complaints and depressive symptoms [60 diagnosed with bipolar disorder, 60 diagnosed with a unipolar depressive disorder], and 60 healthy controls. HR and time-based HRV variables were computed on 30-s segments and averaged across the night for wake, NREM and REM sleep.</div></div><div><h3>Results</h3><div>Significant group by consciousness state interactions showed that the unipolar and bipolar groups had lower standard deviation of normal-to-normal intervals root mean square of successive R-R interval differences compared to controls during NREM and REM sleep, but not during wake (SDNN: <em>F</em>(4, 330) = 3.0, <em>p</em> = .021, np2 = 0.035; RMSSD: <em>F</em>(4, 332) = 5.8, <em>p &lt;</em> .001, np2 = 0.065). The magnitude of these group differences did not vary significantly between NREM 1, NREM 2 and NREM 3 sleep. These interactions persisted after excluding individuals taking 3rd generation antipsychotic, lithium, anticonvulsant, and cardiovascular medications.</div></div><div><h3>Conclusion</h3><div>Although further work is required to account for the impact of psychotropic and cardiac medications, as well as manic and euthymic states, these findings suggest that the sleep-based autonomic signature of depressive states differs across different types of mood disorders and could potentially inform the development of biomarkers and therapeutic targets.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 111996"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}