Journal of Psychosomatic Research最新文献

{"title":"Comparing autonomic nervous system function in patients with functional somatic syndromes, stress-related syndromes and healthy controls","authors":"Maaike Van Den Houte ,&nbsp;Indra Ramakers ,&nbsp;Lukas Van Oudenhove ,&nbsp;Omer Van den Bergh ,&nbsp;Katleen Bogaerts","doi":"10.1016/j.jpsychores.2024.112025","DOIUrl":"10.1016/j.jpsychores.2024.112025","url":null,"abstract":"<div><h3>Background</h3><div>The goal of this study was to examine autonomic nervous system function by measuring heart rate (HR), heart rate variability (HRV), skin conductance levels (SCL), and peripheral skin temperature (ST) in response to and during recovery from psychosocial stressors in patients with functional somatic syndromes (FSS; fibromyalgia and/or chronic fatigue syndrome), stress-related syndromes (SRS; overstrain or burn-out), and healthy controls (HC).</div></div><div><h3>Methods</h3><div>Patients with FSS (<em>n</em> = 26), patients with SRS (<em>n</em> = 59), and HC (<em>n</em> = 30) went through a standardized psychosocial stress test consisting of a resting phase (120 s), the STROOP color word task (120 s), a mental arithmetic task (120 s) and a stress talk (120 s), each followed by a 120 s recovery period. HR, HRV, SCL, and ST were monitored continuously.</div></div><div><h3>Results</h3><div>Average HR and SCL were higher, and HRV was lower, in both patient groups compared to HC during rest (0.50 &lt; Cohen's d &lt; 0.97). A larger SC response to psychosocial stress was found in FSS compared to HC (d = 0.71). However, HR increased less during psychosocial stress and showed a smaller reduction during recovery in both patient groups compared to HC (0.68 &lt; d &lt; 0.98). HRV was lower in both patient groups compared to HC during recovery (0.91 &lt; d &lt; 0.98). There were no differences in ST levels or responses between groups.</div></div><div><h3>Conclusions</h3><div>Our results indicate a dominance of the sympathetic nervous system in both patient groups compared to controls, suggesting that autonomic nervous system dysfunction is a transdiagnostic feature for stress-related and functional somatic syndromes.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112025"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diminished salivary cortisol response to mental stress predict all-cause mortality in general population","authors":"Han Yin ,&nbsp;Zihan Gao ,&nbsp;Mengyang Jia ,&nbsp;Cheng Jiang ,&nbsp;Yuanhao Wang ,&nbsp;Dahui Xue ,&nbsp;Jingnan Huang ,&nbsp;Huhao Feng ,&nbsp;Nana Jin ,&nbsp;Jingjin Liu ,&nbsp;Lixin Cheng ,&nbsp;Qingshan Geng","doi":"10.1016/j.jpsychores.2024.112031","DOIUrl":"10.1016/j.jpsychores.2024.112031","url":null,"abstract":"<div><h3>Objectives</h3><div>To characterize individuals with a diminished salivary cortisol response to mental stress, assess its association with all-cause mortality, and quantify the mediating effects of the most relevant and modifiable factors to identify potential target for prevention.</div></div><div><h3>Methods</h3><div>Data from MIDUS II study with a 16-year follow-up, were used to categorize 1129 participants as responders or non-responders based on the existence of increase in salivary cortisol under mental stress. LASSO-logistics analysis identified the most relevant factors. Cox regression models and restricted cubic splines evaluated the prognostic impact. Further analyses examined the mediating effects of identified factors on prognosis.</div></div><div><h3>Results</h3><div>After employing Inverse Probability of Treatment Weighting to adjust for demographic differences between groups, individuals with diminished cortisol responses were found to have higher levels of depressive symptoms (<em>p</em> = 0.050), increased inflammation (IL-6, 2.30 [1.41, 3.79] vs. 1.96[1.33, 3.31], <em>p</em> = 0.011), and were less likely to regularly exercise (74.3 % vs. 79.9 %, <em>p</em> = 0.030). IL-6 (OR: 1.25 [1.04, 1.52]，<em>p</em> = 0.021) and regularly exercising (OR 0.71 [0.51, 0.97], <em>p</em> = 0.032) emerged as significant modifiable factors in multivariate analysis. A notable prognostic association of diminished cortisol response with all-cause mortality (HR = 1.33 [1.01–1.76], <em>p</em> = 0.046) was observed, consistent across various subgroups and supported by non-linear model analysis. Approximately 13 % of the mortality risk associated with diminished cortisol response was mediated by increased IL-6 levels (<em>p</em> = 0.043).</div></div><div><h3>Conclusion</h3><div>Diminished salivary cortisol response is linked to an increased risk of all-cause mortality, significantly mediated by elevated IL-6. This study offers a new perspective on prognostic prediction while highlighting potential avenues for intervention.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112031"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional study on the impact of adverse childhood experiences on psychological distress in patients with an implantable cardioverter-defibrillator","authors":"Marc Dörner ,&nbsp;Roland von Känel ,&nbsp;Aju P. Pazhenkottil ,&nbsp;Rahel Altwegg ,&nbsp;Noelle König ,&nbsp;Ladina Nager ,&nbsp;Veronica Attanasio ,&nbsp;Lisa Guth ,&nbsp;Sina Zirngast ,&nbsp;Anna Menzi ,&nbsp;Mary Princip ,&nbsp;Claudia Zuccarella-Hackl","doi":"10.1016/j.jpsychores.2024.112033","DOIUrl":"10.1016/j.jpsychores.2024.112033","url":null,"abstract":"<div><div>Objective: Previous studies implied detrimental effects of adverse childhood experiences (ACE) on cardiovascular disease and mental health. Still, data on the influence of ACE on psychological distress in patients with an implantable cardioverter-defibrillator (ICD) are lacking. Methods: We prospectively recruited 423 patients with an ICD. To determine associations between ACE (ACE questionnaire, cut-off ≥4), depression (Patient Health Questionnaire-8), anxiety (Generalized Anxiety Disorder-7 scale), and post-traumatic stress disorder (PTSD) symptoms (Post-Traumatic Stress Diagnostic Scale), we conducted a binary logistic regression analysis. Regression models were adjusted for conventional risk factors of psychological distress in ICD patients. To identify indirect mediating effects of resilience (Resilience Scale) on ACE and psychological distress, we applied the PROCESS regression path analysis modeling tool. Results: 49.1 % of all patients reported at least one ACE, and 9.7 % experienced even four or more ACE. A high-risk ACE profile (≥ 4) was associated with higher levels of anxiety (OR 3.68, 95 % CI 1.37–9.84, <em>p</em> = 0.009), depression (OR 4.08, 95 % CI 1.67–9.97, <em>p</em> = 0.002), and PTSD symptoms (OR 2.20, 95 % CI 1.03–5.21, <em>p</em> = 0.041). Greater resilience partially mediated the relationship between ACE and depression (indirect effect 0.11, 95 % CI 0.01–0.26) as well as anxiety (indirect effect 0.08, 95 % CI 0.008–0.19). Conclusions: The current study suggests an association between ACE and psychological distress in patients with an ICD. However, resilience could mitigate the adverse effects of ACE. Future studies should strive to unravel the complex mechanisms of ACE and its effects on cardiovascular and mental health in ICD patients.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112033"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of depressive symptom trajectories with chronic kidney disease in middle-aged and older adults","authors":"Longyang Han ,&nbsp;Yiqun Li ,&nbsp;Minglan Jiang ,&nbsp;Xiao Ren ,&nbsp;Wenyan Wu ,&nbsp;Xiaowei Zheng","doi":"10.1016/j.jpsychores.2024.112036","DOIUrl":"10.1016/j.jpsychores.2024.112036","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to investigate the association between trajectories of depressive symptoms and the subsequent risk of chronic kidney disease (CKD) by measuring depressive symptoms repeatedly in older adults with normal renal function.</div></div><div><h3>Methods</h3><div>A total of 9650 participants, comprising community-dwelling middle-aged and older adults from the China Health and Retirement Longitudinal Study, were included. Depressive symptoms were assessed at three time points: Wave 1 (2011−2012), Wave 2 (2013–2014), and Wave 3 (2015–2016). Trajectories of depressive symptoms were determined using latent mixed models, and the association between these trajectories and CKD was verified using COX proportional hazards models.</div></div><div><h3>Results</h3><div>Five trajectory patterns of depressive symptoms were identified: low CESD-10 score (Low-Stable, 3702 participants, 38.36 %), moderate CESD-10 score (Moderate-Stable, 3602 participants, 37.33 %), continuously increasing CESD-10 score from moderate initiation (Moderate-Increasing, 825 participants, 8.55 %), continuously decreasing CESD-10 score from high initiation (High-Decreasing, 1032 participants, 10.69 %), and stable high CESD-10 score (High-stable, 489 participants, 5.07 %). During the two-year follow-up period from Wave 3 to Wave 4 (2017–2018), 420 CKD events occurred. Participants in the Moderate-Stable, Moderate-Increasing, High-Decreasing, and High-Stable groups had an increased risk of developing CKD compared to those in the Low-Stable group, with multivariable-adjusted hazard ratios (95 % confidence interval) were 1.32 (1.02–1.71), 1.68 (1.15–2.45), 2.26 (1.63–3.13), and 3.73 (2.57–5.43), respectively, comparted to those with low-stable trajectory.</div></div><div><h3>Conclusion</h3><div>Middle-aged and older adults with increasing (Moderate-Increasing) and persistent depressive symptoms (including Moderate-Stable, High-Decreasing, and High-Stable) face a higher risk of developing CKD over time.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112036"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meaning in life as a pathway to longevity and better health outcomes","authors":"Rizky Andana Pohan ,&nbsp;Ririn Dwi Astuti ,&nbsp;Nining Maizura ,&nbsp;Putri Bunga Aisyah Pohan ,&nbsp;Erfan Ramadhani ,&nbsp;Rikas Saputra","doi":"10.1016/j.jpsychores.2024.112035","DOIUrl":"10.1016/j.jpsychores.2024.112035","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112035"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of depression on risk of malignant glioma: A nationwide cohort study","authors":"Jin Eun ,&nbsp;Yoo Hyun Um ,&nbsp;Kyungdo Han ,&nbsp;Won-Il Joo ,&nbsp;Seung Ho Yang","doi":"10.1016/j.jpsychores.2024.111982","DOIUrl":"10.1016/j.jpsychores.2024.111982","url":null,"abstract":"<div><h3>Background</h3><div>Malignant glioma (MG) is a malignant brain tumor with a fatal prognosis. Depression is on the rise in society, and its negative association on prognosis of glioma patients is known. This study aimed to investigate the correlation between depression and MG risk by analyzing data from the Korean National Health Insurance System (NHIS).</div></div><div><h3>Methods</h3><div>A retrospective cohort study utilized NHIS data starting with 4,234,415 individuals aged 20 and above who had undergone health check-ups in 2009. Excluding 65,146 for cancer diagnosis, missing data, or a one-year lag period, 3,856,362 individuals were analyzed. Those diagnosed with depression per ICD-10 codes F32 or F33 before the check-ups formed the depression group, while the MG group was identified by ICD-10 code C71.</div></div><div><h3>Results</h3><div>Depression was found to have a significant association with glioma risk (hazard ratio 1.127, 95 % confidence interval 1.101–1.347), even with adjustment for age, sex, income, body-mass index (BMI), smoking, drinking, regular exercise, diabetes mellitus, hypertension and dyslipidemia. Furthermore, the severity of depression had a greater influence on MG incidence. Finally, subgroup analysis according to MG status revealed factors such as income, regular exercise, chronic kidney disease, and BMI to exhibit significant differences related to depression in the no-glioma group, but not in the glioma group.</div></div><div><h3>Conclusions</h3><div>These results suggest that depression may be associated with development of MG.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 111982"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First results from a multimodal psychosomatic post-COVID treatment approach - a prospective longitudinal study","authors":"Hanna Hofmann ,&nbsp;Angela Fricke ,&nbsp;Benjamin Krüger ,&nbsp;Paul Köbler ,&nbsp;Claudia Lanza ,&nbsp;Stephan Zeiß ,&nbsp;Jan Cernohorsky ,&nbsp;Christine Hertle ,&nbsp;Eva Krauss-Köstler ,&nbsp;Peter Radermacher ,&nbsp;Barbara Stein ,&nbsp;Markus Müller ,&nbsp;Christiane Waller","doi":"10.1016/j.jpsychores.2024.112021","DOIUrl":"10.1016/j.jpsychores.2024.112021","url":null,"abstract":"<div><h3>Background</h3><div>Clinical experiences using a psychosomatic-oriented multimodal treatment approach in patients with post-COVID are promising. We established a half-day multimodal treatment program for post-COVID patients at the Department of Psychosomatic Medicine at General Hospital Nuremberg, Paracelsus Medical University, Germany.</div></div><div><h3>Methods</h3><div>This observational study between January 2022 and March 2023 comprised baseline documentation of Patient Health Questionnaire (PHQ<img>D), ICD-10 Symptom Rating (ISR), Fatigue Scale (FS) and Health Status Questionnaire (SF-12) at admission and discharge of 65 patients suffering from post-COVID. Multimodal psychosomatic treatment was scheduled for 3–4 weeks.</div></div><div><h3>Results</h3><div>At admission, PHQ and FS showed a high level of somatic symptom burden (PHQ-15: <em>M</em> = 16.0, <em>SD</em> = 5.6) and fatigue symptoms (FS: <em>M</em> = 27.1, <em>SD</em> = 4.4). Depressive (PHQ-9: <em>M</em> = 14.0, <em>SD</em> = 5.3) and anxiety symptoms (GAD-7: <em>M</em> = 9.6, <em>SD</em> = 5.6) were moderately and mildly pronounced, respectively. Compared to patients from our standard clinical settings post-COVID patients had a comparably high or even higher mental symptom burden (e.g. PHQ-15: <em>p</em> &lt; .001, <em>d</em> = 0.79; PHQ-9: <em>p</em> = .009, <em>d</em> = 0.39). Compared to admission, symptomatology of post-COVID patients at discharge was improved (e.g. PHQ-15: <em>p</em> = .004, <em>d</em> = 0.26; FS: <em>p</em> = .009, <em>d</em> = 0.32).</div></div><div><h3>Conclusions</h3><div>Despite the short duration of treatment, the patients showed a significant reduction in symptoms between admission and discharge. Further data including a control group and extending the duration of treatment will show whether the changes in symptoms are of the multimodal psychosomatic treatment.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112021"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of somatic symptom disorder in people with major medical disorders: Cross-sectional results from the population-based Hamburg City Health Study","authors":"Laura Buck ,&nbsp;Luisa Peters ,&nbsp;Kerstin Maehder ,&nbsp;Friederike Hartel ,&nbsp;Hanno Hoven ,&nbsp;Volker Harth ,&nbsp;Martin Härter ,&nbsp;Bernd Löwe ,&nbsp;Anne Toussaint","doi":"10.1016/j.jpsychores.2024.111997","DOIUrl":"10.1016/j.jpsychores.2024.111997","url":null,"abstract":"<div><h3>Background</h3><div>Somatic Symptom Disorder (SSD) is characterized by excessive thoughts, emotions, and behaviors related to physical symptoms irrespective of their etiology. Estimates of SSD frequency assessed via self-report questionnaires range between 6.7% (general population) and 53% (specialized setting). This study aims to examine the frequency of risk of SSD and associated factors in people with Major Medical Disorders (MMD) using cross-sectional data from the population-based Hamburg City Health Study.</div></div><div><h3>Methods</h3><div>Risk of SSD was operationalized using the Somatic Symptom Scale-8, the Somatic Symptom Disorder-B Criteria Scale-12, and one item on symptom persistence. People at risk of SSD and not at risk were compared regarding biopsychosocial factors. Factors associated with risk of SSD were identified by hierarchical multiple logistic regression analysis.</div></div><div><h3>Results</h3><div><em>N</em> = 1944 people (mean age 64.8 ± 8 years, 43.8% female) reported at least one MMD. Of those, 6.8% [95%, CI 5.6–7.9%] were at risk of SSD and reported greater healthcare utilization and lower health-related quality of life. Logistic regression identified higher age (<em>p</em>=.032), lower education (<em>p</em>=.002), number of somatic comorbidities (<em>p</em>&lt;.001), and elevated neuroticism (<em>p</em>&lt;.001) and depression (<em>p</em>&lt;.001) scores as factors associated with risk of SSD, with an explained variance of Nagelkerke <em>R</em>²=0.45.</div></div><div><h3>Conclusion</h3><div>The observed frequency of risk of SSD in people with MMD does not point towards an excessive symptom burden in this sample. However, those at risk experience significant psychosocial burdens and increased healthcare utilization, highlighting a vulnerable subgroup prone to SSD.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 111997"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personality matters: Exploring the associations of personality traits with mood and somatic symptoms in multiple sclerosis","authors":"Duygu Kuzu,&nbsp;Anna L. Kratz","doi":"10.1016/j.jpsychores.2024.112022","DOIUrl":"10.1016/j.jpsychores.2024.112022","url":null,"abstract":"<div><h3>Background</h3><div>Research suggest that personality traits influence the mood and somatic symptoms in various different clinical populations. Neuroticism, extraversion, conscientiousness, openness to experience, and agreeableness have been identified as potential predictors of mood and somatic symptoms. However, the literature on personality traits and symptom outcomes in multiple sclerosis (MS) is limited, highlighting the necessity for more in-depth research.</div></div><div><h3>Objective</h3><div>This Cross-sectional study aimed to investigate the association between personality traits and symptomatology in individuals with MS using two separate studies and different personality assessment tools– the NEO Five-Factor Inventory (NEO-FFI) and the Ten Item Personality Inventory (TIPI).</div></div><div><h3>Methods</h3><div>Participants completed surveys assessing mood and somatic symptoms. Linear regression analyses were performed to examine the associations between personality traits and MS symptoms controlling for demographic variables.</div></div><div><h3>Results</h3><div>.The analyses were performed on data from 63 individuals with MS for Study 1 (assessing the NEO-FFI) and 1183 individuals with MS for Study 2 (assessing the TIPI), respectively. Neuroticism was consistently associated with more somatic and mood symptoms in both sample (medium to large effect sizes; β = −0.05 to β = 0.60) Extraversion and conscientiousness were associated with fewer symptoms in Study 2.</div></div><div><h3>Conclusions</h3><div>This study highlights the importance of considering personality factors in understanding and managing symptoms in MS. However, further research is needed to understand the causal relationships between personality and symptom outcomes in MS.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112022"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing immunotherapy outcomes in advanced NSCLC: The role of sleep hygiene education and physical exercise as non-pharmacological interventions","authors":"Sesilianus Fau ,&nbsp;Erasma Fitilai Zalogo","doi":"10.1016/j.jpsychores.2024.111993","DOIUrl":"10.1016/j.jpsychores.2024.111993","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"188 ","pages":"Article 111993"},"PeriodicalIF":3.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}