Journal of Psychosomatic Research最新文献

{"title":"Anhedonia as a transdiagnostic link and treatment target for comorbid chronic pain, depression, and fatigue","authors":"Henrik Heitmann , Paul Theo Zebhauser , Peter Henningsen , Thomas R. Tölle , Markus Ploner","doi":"10.1016/j.jpsychores.2025.112243","DOIUrl":"10.1016/j.jpsychores.2025.112243","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"196 ","pages":"Article 112243"},"PeriodicalIF":3.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Participatory development of evidence-based patient narrative videos for patients with eating disorders: Results from two pilot studies","authors":"Melissa-Claire Daugelat , Bettina Gregg , Sophia Helen Adam , Kathrin Schag , Joachim Kimmerle , Katrin Elisabeth Giel","doi":"10.1016/j.jpsychores.2025.112228","DOIUrl":"10.1016/j.jpsychores.2025.112228","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"196 ","pages":"Article 112228"},"PeriodicalIF":3.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric multimorbidity in heart failure","authors":"Kenneth E. Freedland ,&nbsp;Judith A. Skala ,&nbsp;Brian C. Steinmeyer ,&nbsp;Robert M. Carney ,&nbsp;Michael W. Rich","doi":"10.1016/j.jpsychores.2025.112368","DOIUrl":"10.1016/j.jpsychores.2025.112368","url":null,"abstract":"<div><h3>Objective</h3><div>There have been numerous studies of specific psychiatric comorbidities such as major depression in patients with heart disease, but there have been relatively few studies of psychiatric multimorbidity in these patients. The purpose of this cross-sectional study was to investigate the prevalence and correlates of psychiatric multimorbidity in patients with heart failure (HF).</div></div><div><h3>Methods</h3><div>Patients who had been hospitalized with HF were enrolled in this cross-sectional study within 30 days of hospital discharge and interviewed within two weeks after enrollment. Participants completed the NetSCID-5 diagnostic interview, a social determinants of health (SDOH) interview, and perceived stress and health-related quality of life questionnaires.</div></div><div><h3>Results</h3><div>A total of 362 patients completed the interview. The maximum possible lifetime comorbidity count was 11 but the observed maximum was 8; the mean (SD) count was 1.48 (1.63). A total of 135 (37 %) patients had no history of any psychiatric disorder, 97 (27 %) had a lifetime history of a single disorder, and 130 (36 %) had ≥2 lifetime disorders. Higher numbers of psychiatric disorders were associated with younger age, more exposure to SDOH, higher perceived stress, and chronic obstructive pulmonary disease.</div></div><div><h3>Conclusion</h3><div>Psychiatric multimorbidity is prevalent in patients with HF and is associated with worse medical and social health status. New studies of the consequences or treatment of specific psychiatric comorbidities in patients with heart disease should take psychiatric multimorbidity into account, and further research on psychiatric multimorbidity per se is needed.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"197 ","pages":"Article 112368"},"PeriodicalIF":3.3,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal study of post-traumatic growth and rumination in patients undergoing continuous ambulatory peritoneal dialysis: A parallel process latent growth curve modelling approach","authors":"Dengyan Ma ,&nbsp;Xing Li ,&nbsp;Kuo Li ,&nbsp;Xueli Zhou ,&nbsp;Difei Duan ,&nbsp;Bo Gu","doi":"10.1016/j.jpsychores.2025.112354","DOIUrl":"10.1016/j.jpsychores.2025.112354","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the longitudinal trajectories of post-traumatic growth (PTG) and event-related rumination among patients undergoing continuous ambulatory peritoneal dialysis (CAPD), and to explore the dynamic associations between intrusive/deliberate rumination and PTG using a parallel process latent growth curve model.</div></div><div><h3>Methods</h3><div>A total of 195 CAPD patients were followed over a 12-month period with assessments at four time points (baseline, 2nd, 6th, and 12th month). PTG and rumination were measured using the Chinese versions of the Post-Traumatic Growth Inventory and the Event-Related Rumination Inventory. Parallel process latent growth curve modelling was applied to examine individual trajectories and inter-relationships over time, adjusting for demographic and clinical covariates.</div></div><div><h3>Results</h3><div>Both PTG and rumination showed an initial decline from baseline to the 2nd month, followed by a slight increase through the 12-month follow-up. Intrusive rumination at baseline negatively predicted the slope of PTG, suggesting that higher initial IR levels were associated with a slower improvement in PTG. Education level was negatively associated with baseline PTG, and older age was positively associated with baseline IR. Deliberate rumination did not significantly predict PTG trajectory.</div></div><div><h3>Conclusion</h3><div>The findings reveal dynamic trajectories of PTG and rumination among CAPD patients and highlight intrusive rumination as a negative predictor of long-term psychological growth. Longitudinal monitoring and targeted cognitive interventions may support adaptive adjustment in this population.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"197 ","pages":"Article 112354"},"PeriodicalIF":3.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiome abundance of Prevotellaceae in spondyloarthritis patients with positive depression screening: A cross-sectional analysis","authors":"Camilo Vera-Parra ,&nbsp;Oscar Gómez ,&nbsp;Deisy Abril ,&nbsp;Omar-Javier Calixto ,&nbsp;Juan Manuel Bello-Gualtero ,&nbsp;Consuelo Romero-Sánchez","doi":"10.1016/j.jpsychores.2025.112358","DOIUrl":"10.1016/j.jpsychores.2025.112358","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with autoimmune/autoinflammatory diseases are at increased risk for major depressive disorder. In spondyloarthritis (SpA), the prevalence of mild depression is 40 % approximately. This study aimed to assess the differences in gut microbiome abundance profiles between control subjects and patients with SpA, as well as between patients with positive and negative depression screening.</div></div><div><h3>Methods</h3><div>Patients fulfilling the ASAS criteria for SpA and matched controls were included. Sociodemographic and clinical data were collected, including disease activity and functional impairment assessments. Stool samples were obtained for DNA extraction, 16S rRNA PCR amplification with MiSeq sequencing to determine microbiome profiles. All patients completed the PHQ-9, and a linear regression model was developed to assess associations, adjusting for age, sex, and disease factors.</div></div><div><h3>Results</h3><div>62 SpA patients and 30 controls were included. Patients presented more frequently gastrointestinal symptoms and elevated inflammatory markers. Patients with a positive PHQ-9 depression screening had higher disease activity (ASDAS-CRP median 3.05; IQR 2.70 to 3.50 vs. 2.30; IQR 1.35 to 2.90) and greater functional impairment (BASFI median 6.55; IQR 5.50 to 7.60 vs. 2.50; IQR 0.80 to 4.20). Microbiome analysis revealed differences according to depression screening. Regression analysis confirmed that greater functional impairment and higher <em>Prevotellaceae</em> abundance were associated with PHQ-9 scores (<em>R</em>² = 0.557).</div></div><div><h3>Conclusion</h3><div>Greater functional impairment is associated with higher depressive symptoms, while increased abundance of <em>Prevotellaceae</em> correlates with lower PHQ-9 scores in SpA patients. These findings suggest that gut microbiome may play a key role in depression risk with mechanistic and therapeutic implications.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"197 ","pages":"Article 112358"},"PeriodicalIF":3.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of clinical response to an internet-delivered cognitive behavioural based intervention for symptoms of depression, anxiety and disability in people with multiple sclerosis","authors":"Milena Gandy,&nbsp;Wendy Wu,&nbsp;Blake F. Dear","doi":"10.1016/j.jpsychores.2025.112367","DOIUrl":"10.1016/j.jpsychores.2025.112367","url":null,"abstract":"<div><h3>Introduction</h3><div>This study sought to identify demographic, clinical, or psychological factors associated with response to an internet-delivered psychological intervention for depression, anxiety, and disability among adults with Multiple Sclerosis (MS). Identifying these characteristics can help inform psychotherapy referral decisions.</div></div><div><h3>Method</h3><div>Data from participants with a diagnosis of MS (<em>n</em> = 222) were pooled across three clinical trials of an established internet-delivered intervention for people with neurological conditions, including MS. Baseline demographic (age, sex, employment, education, relationship status), clinical (MS type, cognitive difficulties, current psychotropic medication use, previous psychological treatment) and psychological characteristics (baseline symptom severity) were examined. Outcomes included a clinically meaningful response (≥25 % improvement in symptoms) in self-reported symptoms of depression, anxiety, and disability following the intervention. Multivariable logistic regression models were built to identify significant predictors of response. Area under the curve and Negelkerke's R² are reported.</div></div><div><h3>Results</h3><div>No robust or consistent factors were associated with the likelihood of a clinically meaningful response across these primary outcomes. Only a few factors predicted a single outcome: baseline depression symptom severity predicted greater odds of a clinical response in depression, age predicted greater odds of response in anxiety, and MS subtype predicted greater odds of response in disability. Current use of psychotropic medication was the only factor that predicted more than one outcome, specifically depression and disability.</div></div><div><h3>Conclusion</h3><div>Findings highlight the limited predictive value of baseline characteristics, suggesting that referral to internet-delivered psychological interventions for adults with MS should not rely solely on simple demographic or clinical profiles</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"197 ","pages":"Article 112367"},"PeriodicalIF":3.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144909020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and influence of mindfulness-based intervention on migraine patients: A systematic review and meta-analysis","authors":"Yu-Chi Liao ,&nbsp;Wen-Shuan Chen ,&nbsp;Winda Putri Diah Restya ,&nbsp;Yu-Chun Liao ,&nbsp;Yi-Chun Lin ,&nbsp;Ro-Ting Lin","doi":"10.1016/j.jpsychores.2025.112366","DOIUrl":"10.1016/j.jpsychores.2025.112366","url":null,"abstract":"<div><h3>Purpose</h3><div>Migraines are among the top causes of global disability and are often managed with pharmacological treatments, which may produce adverse effects. Mindfulness-based interventions (MBIs) have emerged as promising non-pharmacological approaches, yet existing studies report mixed findings. This meta-analysis aimed to clarify the effectiveness of MBIs in improving pain, psychological, and functional outcomes among adults with migraine.</div></div><div><h3>Methods</h3><div>We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) involving adults (≥18 years) with a clinical diagnosis of migraine. Four databases—Medline, CINAHL, Scopus, and ProQuest Central—were searched from 1982 to July 2025. Risk of bias was assessed using the Cochrane RoB 2.0 tool. Meta-analyses were performed using Comprehensive Meta-Analysis Software Version 4 and R.</div></div><div><h3>Results</h3><div>Fourteen RCTs with 1027 participants were included. MBIs were associated with significant reductions in pain intensity (standardized mean difference: 0.23 [95 % CI: 0.11–0.35]) and pain frequency (0.33 [0.11–0.54]), as well as improvements in quality of life (0.24 [0.08–0.40]). Psychological outcomes improved significantly, including anxiety (0.37 [0.14–0.61]), depression (0.26 [0.06–0.45]), and pain catastrophizing (0.57 [0.35–0.80]). No significant effects were found for activity-related disability (0.18 [−0.01–0.38]) or use of analgesic medications (0.07 [−0.06–0.20]) and triptans (0.04 [−0.13–0.21]).</div></div><div><h3>Conclusions</h3><div>MBIs may serve as effective complements to pharmacological treatments for migraine. They significantly reduce pain intensity, attack frequency, and psychological symptoms, while modestly improving quality of life. These findings support integrating mindfulness practices into routine migraine care to promote psychological well-being and reduce symptom burden.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"197 ","pages":"Article 112366"},"PeriodicalIF":3.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing depression in patients with cancer: High stakes, low evidence","authors":"Cédric Lemogne ,&nbsp;Charles Ouazana Vedrines","doi":"10.1016/j.jpsychores.2025.112357","DOIUrl":"10.1016/j.jpsychores.2025.112357","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"197 ","pages":"Article 112357"},"PeriodicalIF":3.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness and depression in SLE patients: A cross-sectional study in a Brazilian sample","authors":"Valentina Garofani Ramos,&nbsp;Maria Eduarda Pelaez de Campos,&nbsp;Thelma Skare,&nbsp;Thiago Alberto F.G. dos Santos,&nbsp;Gabriela Klitzke,&nbsp;Renato Nisihara","doi":"10.1016/j.jpsychores.2025.112356","DOIUrl":"10.1016/j.jpsychores.2025.112356","url":null,"abstract":"<div><h3>Objective</h3><div>Patients with chronic diseases are at risk for loneliness which may affect their clinical condition. This study aimed to assess the presence of loneliness in patients with Systemic Lupus Erythematosus (SLE) in comparison to controls and to examine its possible association with depression, disease activity, disease cumulative damage, clinical and epidemiological variables.</div></div><div><h3>Methods</h3><div>One hundred and nine SLE patients and 92 controls answered the following scales: CES-D (Center for Epidemiological Studies depression scale), UCLA-BR – [Brazilian version of UCLA (University of California, Los Angeles) Loneliness Scale], SLEDAI (SLE disease activity index) and SLICC/ACR DI (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index), along with clinical and epidemiological variables.</div></div><div><h3>Results</h3><div>SLE patients had more depressive symptoms than controls (<em>p</em> = 0.0001), however their scores on the UCLA BR were comparable (<em>p</em> = 0.14). Depression correlated with loneliness in both patients and controls (<em>r</em> = 0.71 and 0.60 respectively with <em>p</em> &lt; 0.0001). No associations were found between loneliness, disease activity (<em>p</em> = 0.63), SLICC/ACR DI (<em>p</em> = 0.31), and disease duration (<em>p</em> = 0.36). SLE patients with worse perceptions of family relationships exhibited increased loneliness (<em>p</em> = 0.0008).</div></div><div><h3>Conclusion</h3><div>The levels of loneliness in SLE patients are comparable to the controls. In these two groups, loneliness was correlated with depression. No association was found between loneliness and disease activity, cumulative organ damage, or clinical variables in the patients with SLE.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"197 ","pages":"Article 112356"},"PeriodicalIF":3.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144863780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent association of depressed mood and high suicide risk as assessed by the patient safety screener-3 (PSS-3) with prolonged hospitalization: A single-center cross-sectional study","authors":"Hidetaka Tamune ,&nbsp;Kana Kiryu ,&nbsp;Keitaro Takahashi ,&nbsp;Futoshi Suzuki ,&nbsp;Yoshihide Takeshita ,&nbsp;Narimasa Katsuta ,&nbsp;Chihiro Kakiuchi ,&nbsp;Masanobu Ito ,&nbsp;Eri Shoji ,&nbsp;Kazusa Minamitani ,&nbsp;Daiki Taira ,&nbsp;Yoshie Takaoka ,&nbsp;Akiko Koshikiya ,&nbsp;Tetsuya Sakurai ,&nbsp;Yurie Tanemura ,&nbsp;Hiroyuki Harada ,&nbsp;Tatsuro Asai ,&nbsp;Youhei Obata ,&nbsp;Akane Yoshikawa ,&nbsp;Mariko Tada ,&nbsp;Tadafumi Kato","doi":"10.1016/j.jpsychores.2025.112353","DOIUrl":"10.1016/j.jpsychores.2025.112353","url":null,"abstract":"<div><h3>Purpose</h3><div>We developed a Japanese version of the Patient Safety Screener-3 (PSS-3) and applied it to stratify suicide risk in hospitalized patients. Additionally, we tested the hypothesis that PSS-3-assessed depressed mood and suicide risk are independently associated with length of stay (LOS) among hospitalized patients.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted at a university hospital in Tokyo from January to December 2023. The Japanese version of the PSS-3 was used to screen hospitalized patients with advanced cancer. Data were collected from medical charts and Diagnosis Procedure Combination records. Linear mixed-effects models with patient-level random intercepts were used to examine associations among depressed mood, suicide risk, and LOS, adjusting for age, sex, cancer diagnosis, Charlson Comorbidity Index, activities of daily living (ADL), and disturbance of consciousness.</div></div><div><h3>Results</h3><div>Among 2077 screenings, 2019 first assessments on admission were analyzed, of which 90.8 % were performed on admission day. Depressed mood was present in 308 patients (15.3 %), and 26 patients (1.3 %) were assessed as having high suicide risk. Depressed mood prolonged LOS (reference geometric mean: 8.44 days) by 18 % (1.18; 95 % CI, 1.07–1.30), while high suicide risk prolonged it by 40 % (1.40; 95 % CI, 1.03–1.90), in a clinically and statistically balanced model adjusted for age, sex, and cancer diagnosis.</div></div><div><h3>Conclusions</h3><div>The PSS-3 stratified hospitalized patients by depressed mood and suicide risk, both of which were independently associated with prolonged hospitalization. This simple screening tool may facilitate early identification of high-risk patients, optimize resource allocation, and improve patient care.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"197 ","pages":"Article 112353"},"PeriodicalIF":3.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}