调查非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比率与耳鸣之间的关系：来自全国代表性观察性研究的证据

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2025-04-03 DOI:10.1016/j.jpsychores.2025.112114

Ying Cui , Wenjie Miao , Tong Wu , Chenyang Liu , Lin Chen

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引用次数: 0

摘要

耳鸣是一种具有重大心理和生理影响的疾病，严重影响生活质量；然而，其与脂质代谢的关系仍未得到充分探讨。方法本研究以人群为基础，纳入4991名受试者。采用加权多变量logistic回归和限制性三次样条（RCS）分析评估非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值（NHHR）与耳鸣的关系。进行了亚组和敏感性分析，以评估社会人口统计学和健康相关亚组研究结果的一致性和稳健性。结果共有791人报告耳鸣，患病率为15.85%。NHHR与耳鸣风险之间存在显著正相关。在所有协变量调整后的最终模型中，NHHR每增加一个单位，耳鸣的风险增加12%（优势比[OR] = 1.12, 95%可信区间（CI）， 1.02-1.22, P = 0.022）。与NHHR最低的人群相比，NHHR最高的人群耳鸣的风险更高(OR = 1.46；95% ci, 1.02-2.07, p = 0.040)。RCS分析显示，NHHR与耳鸣呈线性相关（非线性P = 0.923）。亚组分析证实，这种关联在不同的社会人口统计学和健康亚组中保持稳定（P为相互作用>；0.05）。结论NHHR与耳鸣风险呈线性正相关关系，提示NHHR在耳鸣发病中的重要作用。研究结果强调了在耳鸣预防和管理中需要综合代谢和心身方法。

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Investigating the association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and tinnitus: Evidence from a nationally representative observational study

Background

Tinnitus, a condition with substantial psychological and physical implications, significantly impacts quality of life; however, its relationship with lipid metabolism remains underexplored.

Methods

This population-based observational study included 4991 participants. Weighted multivariate logistic regression and restricted cubic spline (RCS) analyses were employed to assess the relationship between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and tinnitus. Subgroup and sensitivity analyses were conducted to evaluate the consistency and robustness of findings across sociodemographic and health-related subgroups.

Results

A total of 791 participants reported tinnitus, with a prevalence of 15.85 %. A significant positive association was observed between NHHR and tinnitus risk. In the final model with all covariates adjusted, when NHHR increased by one unit, the risk of tinnitus would increase by 12 % (odds ratio [OR] = 1.12, 95 % confidence interval (CI), 1.02–1.22, P = 0.022). Compared to the lowest NHHR tertile, the highest NHHR tertile had a higher risk of tinnitus (OR = 1.46; 95 % CI, 1.02–2.07, P = 0.040). RCS analysis revealed that NHHR was linearly associated with tinnitus (P for nonlinearity = 0.923). Subgroup analyses confirmed that this association remained stable across various sociodemographic and health subgroups (P for interaction >0.05).

Conclusions

These findings suggest that NHHR is positively and linearly associated with tinnitus risk, highlighting the essential role of NHHR in the development of tinnitus. The findings underscore the need for integrated metabolic and psychosomatic approaches in tinnitus prevention and management.

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.