Journal of Psychosomatic Research最新文献

{"title":"Recurrent pain in older age: A cross-sectional network analysis of biopsychosocial-existential interactions","authors":"Nadezhda Golovchanova ,&nbsp;Xiang Zhao ,&nbsp;Ida Flink ,&nbsp;Christiana Owiredua ,&nbsp;Katja Boersma","doi":"10.1016/j.jpsychores.2024.112016","DOIUrl":"10.1016/j.jpsychores.2024.112016","url":null,"abstract":"<div><h3>Objective</h3><div>Chronic pain is a prevalent condition in older adults, associated with substantial distress. For many older people, chronic pain interferes with their daily life which is reflected in various life domains. This study aimed to investigate whether interactions among self-reported indicators of biological, psychological, social, and existential life domains differ for older adults with no pain, with non-interfering pain, and with interfering pain.</div></div><div><h3>Method</h3><div>The study was based on the cross-sectional 65+ and Safe Study data (<em>N</em> = 622; age range 64–106 years; 60.6 % women). Network analysis was used to assess the inter-variable associations for older adults reporting no pain, non-interfering pain, and interfering pain separately. Network visualization and centrality tests were performed. Permutation-based analyses were conducted to investigate the connections among variables in three subgroups.</div></div><div><h3>Results</h3><div>We identified a structural difference between the networks of older adults with no pain and interfering pain, suggesting differences in connectivity among the life domains. The strength centrality metrics showed the central role of presence of meaning in the networks of older adults with no pain and with non-interfering pain, while for older adults with interfering pain, anxiety appeared to be dominant.</div></div><div><h3>Conclusion</h3><div>The findings illuminated that anxiety regulation and meaning-enhancement are potentially important intervention targets for older adults with recurrent pain. Overall, the study highlighted the value of a holistic biopsychosocial-existential approach for understanding and managing pain in older adults.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112016"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic evidence of the causal relationships between psychiatric disorders and cardiovascular diseases","authors":"Yanchao Wen ,&nbsp;Xingyu Wang ,&nbsp;Liufei Deng ,&nbsp;Guiming Zhu ,&nbsp;Xinyu Si ,&nbsp;Xue Gao ,&nbsp;Xiangfeng Lu ,&nbsp;Tong Wang","doi":"10.1016/j.jpsychores.2024.112029","DOIUrl":"10.1016/j.jpsychores.2024.112029","url":null,"abstract":"<div><h3>Objective</h3><div>Our primary objective is to investigate the causal relationships between 12 psychiatric disorders (PDs) and atrial fibrillation (AF), coronary artery disease (CAD), myocardial infarction (MI), and heart failure (HF).</div></div><div><h3>Methods</h3><div>Firstly, we used linkage disequilibrium score regression to calculate the genetic correlations between 12 PDs and 4 cardiovascular diseases (CVDs). Subsequently, we performed two-sample and bidirectional Mendelian randomization (MR) analyses of phenotypes with significant genetic correlations to explore the causal relationships between PDs and CVDs. Inverse variance weighted with modified weights (MW-IVW), Robust Adjusted Profile Score, Inverse Variance Weighted, weighted median and weighted mode were used to evaluate causal effects, with MW-IVW being the main analysis method. And to validate the MR results, we conducted the replicate analyses using data from the FinnGen database.</div></div><div><h3>Results</h3><div>Conducting MR analyses in phenotypes with significant genetic correlations, we identified bidirectional causal relationships between depression (DEP) and MI (DEP as exposure: OR = 1.1324, 95 % confidence interval (CI): 1.0984–1.1663, <em>P</em> &lt; 0.0001; MI as exposure: OR = 1.0268, 95 % CI: 1.0160–1.0375, <em>P</em> &lt; 0.0001). Similar relationships were observed in Attention Deficit/Hyperactivity Disorder (ADHD) and HF (ADHD as exposure: OR = 1.0270, 95 % CI: 1.0144–1.0395, <em>P</em> &lt; 0.0001; HF as exposure: OR = 1.0980, 95 % CI: 1.0502–1.1458, <em>P</em> &lt; 0.0001).</div></div><div><h3>Conclusions</h3><div>In our study, we conducted the comprehensive analyses between 12 PDs and CVDs. By bidirectional MR analysis, we observed significant causal relationships between MI and DEP, HF and ADHD. These findings suggest possible complex causal relationships between PDs and CVDs.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112029"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction of chronic diseases and levels of mastery on the course of depression","authors":"Delphine A. Ambe ,&nbsp;Richard C. Oude Voshaar ,&nbsp;Radboud M. Marijnissen ,&nbsp;Heidi de Kam ,&nbsp;Nathaly Rius-Ottenheim ,&nbsp;Almar A.L. Kok ,&nbsp;Didi Rhebergen","doi":"10.1016/j.jpsychores.2024.112000","DOIUrl":"10.1016/j.jpsychores.2024.112000","url":null,"abstract":"<div><h3>Background</h3><div>Chronic diseases may negatively interfere with the course of depression. Our aim was to examine whether the association between chronic disease and course of depression is moderated by mastery.</div></div><div><h3>Method</h3><div><em>N</em> = 1146 persons, aged 18–88, with depressive disorder according to DSM-IV criteria were followed for two years. Outcomes were change in depression severity (change in IDS-SR) (<em>n</em> = 945), chronic course (life chart interview) (<em>n</em> = 971), depression at follow-up (DSM-diagnosis) (n = 971), and time to remission (life chart interview) (<em>n</em> = 799). Predictors were number of chronic somatic diseases and mastery. Regression models (linear, logistic and Cox) were used, adjusted for depression severity, sociodemographics, loneliness, smoking and alcohol use. Next, an interaction term (chronic diseases*mastery) was added to the models.</div></div><div><h3>Results</h3><div>We only found significant interaction between mastery and chronic diseases (<em>p</em> = 0.02), when outcome was defined as change in depression severity. In analyses, stratified for level of mastery, chronic diseases were significantly associated with chronic course in persons with moderate (B = 1.03; <em>p</em> = 0.03) and high (B = 1.10; <em>p</em> = 0.02) mastery levels. In unstratified analyses, mastery was associated with both chronic course (B = -0.18, p = 0.03) and time to remission (B = 1.03; <em>p</em> &lt; 0.001). Chronic diseases did not reach significance in three outcomes.</div></div><div><h3>Conclusion</h3><div>While impact of chronic diseases on depression trajectories was less consistent than expected, when present, this association was moderated by mastery, suggesting that persons with higher levels of mastery may have difficulties coping with somatic illnesses. In clinical practice, attention to the impact of somatic diseases and coping strategies, in persons with higher levels of mastery, is warranted.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112000"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antenatal socioeconomic status of childhood family and the risk of pain spreading (ROPS) in early and mid-adulthood - a descriptive study from the northern Finland birth cohort 1966","authors":"Eveliina Heikkala ,&nbsp;Ina Rissanen ,&nbsp;Christophe Tanguay-Sabourin ,&nbsp;Etienne Vachon-Presseau ,&nbsp;Jeremy Rui Chang ,&nbsp;Arnold Yu Lok Wong ,&nbsp;Jaro Karppinen ,&nbsp;Petteri Oura","doi":"10.1016/j.jpsychores.2024.112014","DOIUrl":"10.1016/j.jpsychores.2024.112014","url":null,"abstract":"<div><h3>Objective</h3><div>The Risk of Pain Spreading (ROPS) is a six-item tool capturing key data-driven prognostic factors for chronic pain and its spreading. Higher values on the ROPS indicate a higher risk. Early factors potentially associated with the ROPS are unknown. We aimed to examine the associations between antenatal socioeconomic status of childhood family (antenatal SES) and ROPS at ages 31 and 46 years.</div></div><div><h3>Methods</h3><div>The study was based on the Northern Finland Birth Cohort 1966 and previously formulated latent clusters of antenatal family SES: Highest status (the reference), Small, Larger, Average wealth, and Rural families. The ROPS ranged from zero (the reference) to two or more points out of six. A multinomial regression model was used to identify antenatal SES clusters associated with ROPS.</div></div><div><h3>Results</h3><div>At 31 years (<em>n</em> = 8252), only the Larger families cluster was associated with having accumulated points (two or more) (Odds ratio [OR]: 1.46, 95 % Confidence Interval [CI]: 1.14–1.87) on the ROPS compared to the Highest status families cluster. Corresponding finding was observed at 46 years (<em>n</em> = 6245), but the Small families and Average wealth families clusters were also associated with this outcome. The association of Larger families cluster was, however, the strongest (OR 1.48, 95 % CI 1.16–1.89).</div></div><div><h3>Conclusions</h3><div>Offspring born into families with ≥5 members are likely to accumulate higher sums of key data-driven prognostic factors for worse pain across the life course until middle age. In future, associations between antenatal SES and pain would be important to be examined in a light of the ROPS.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112014"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The myth of a cancer-specific temperament: An analysis of affective temperament in cancer patients","authors":"Elisabeth L. Zeilinger ,&nbsp;Matthias Knefel ,&nbsp;Andreas Erfurth ,&nbsp;Denise Andrzejewski ,&nbsp;Otto Lesch ,&nbsp;Caterina Sturtzel ,&nbsp;Matthias Unseld ,&nbsp;Simone Lubowitzki ,&nbsp;Rupert Bartsch ,&nbsp;Thorsten Fuereder ,&nbsp;Ulrich Jäger ,&nbsp;Barbara Kiesewetter ,&nbsp;Maria T. Krauth ,&nbsp;Gerald Prager ,&nbsp;Markus Raderer ,&nbsp;Philipp B. Staber ,&nbsp;Peter Valent ,&nbsp;Alexander Gaiger","doi":"10.1016/j.jpsychores.2024.112015","DOIUrl":"10.1016/j.jpsychores.2024.112015","url":null,"abstract":"<div><h3>Objective</h3><div>We investigate the prevalence of five affective temperaments (depressive, cyclothymic, hyperthymic, irritable, and anxious) in a large sample of cancer patients and associations of temperament with cancer site as well as the impact of temperament on overall survival of cancer patients.</div></div><div><h3>Methods</h3><div>Data for this prospective cohort study was collected in the outpatient clinic of a large cancer center. We used the <em>Temperament Evaluation in Memphis, Pisa and San Diego – Münster Version</em> (TEMPS-M) and recorded patient data. The sample consisted of 2531 patients with seven different cancer/disease-sites. Kruskal-Wallis tests and pairwise Wilcoxon rank sum test were applied to compare temperament scales across disease groups. For analyzing survival time, we used a Cox regression model and log-rank tests.</div></div><div><h3>Results</h3><div>The five affective temperaments were similarly distributed across all disease groups. We found higher levels of depressive, cyclothymic, and anxious temperament in women and higher levels of hyperthymic and irritable temperament in men. Temperament was mostly not predictive of survival, with only two significant results in the regression models. Here, cyclothymic temperament was predictive of mortality in the full sample and hyperthymic temperament was predictive of the pancreatic cancer subsample.</div></div><div><h3>Conclusions</h3><div>Our study provides evidence to debunk the myth of a cancer-specific temperament. Neither did we find a temperament profile that was different from studies with general population samples, nor were there any disease-specific profiles differentiating various types of cancer.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112015"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating cardiovascular mortality in patients with hypertension using machine learning: The role of depression classification based on lifestyle and physical activity","authors":"Xingyu Liu ,&nbsp;Zeyu Luo ,&nbsp;Fengshi Jing ,&nbsp;Hao Ren ,&nbsp;Changjin Li ,&nbsp;Lei Wang ,&nbsp;Tao Chen","doi":"10.1016/j.jpsychores.2024.112030","DOIUrl":"10.1016/j.jpsychores.2024.112030","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aims to harness machine learning techniques, particularly the Random Survival Forest (RSF) model, to assess the impact of depression on cardiovascular disease (CVD) mortality among hypertensive patients. A key objective is to elucidate the interplay between mental health, lifestyle, and physical activity while comparing the effectiveness of the RSF model against the traditional Cox proportional hazards model in predicting CVD mortality.</div></div><div><h3>Methods</h3><div>Data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007 to 2014 were used for comprehensive depression screening. The Patient Health Questionnaire-9 (PHQ-9) was employed to categorize depression severity levels among participants. The final cohort included 9271 participants, selected after excluding those with incomplete data. Participants were followed up for a median of 7.1 years, and cardiovascular mortality was assessed up to December 31, 2019. We employed the RSF model to predict cardiovascular mortality with high effectiveness and precision. And to ensure comparability, we developed the traditional Cox proportional hazards model using the same set of predictors.</div></div><div><h3>Results</h3><div>RSF model outperformed the Cox proportional hazards model in predicting cardiovascular mortality among hypertensive patients with varying depression levels. The RSF model's integrated area under the curve (iAUC) scores were 0.842, 0.893, and 0.760 for none, mild, and severe depression, respectively, surpassing the Cox model's scores of 0.826, 0.805, and 0.746.</div></div><div><h3>Conclusion</h3><div>The RSF model provides a more accurate prediction of CVD mortality among hypertensive patients with varying degrees of depression, offering a valuable tool for personalized patient care. Its ability to stratify patients into risk categories can assist healthcare professionals in making informed decisions, underscoring the potential of machine learning in public health and clinical settings. This model demonstrates particular utility in settings where detailed, patient-specific risk assessments are critical for managing long-term health outcomes. Future research should focus on external validation and integration of more diverse variables to enhance predictive power.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112030"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint effects of depressive symptoms and triglyceride-glucose index on cardiovascular events in acute coronary syndrome patients: The mediating role of TyGi","authors":"Chengqian Xu ,&nbsp;Di Wang ,&nbsp;Mengru Sun ,&nbsp;Bingji Huang ,&nbsp;Yini Wang ,&nbsp;Ping Lin","doi":"10.1016/j.jpsychores.2024.112034","DOIUrl":"10.1016/j.jpsychores.2024.112034","url":null,"abstract":"<div><h3>Objective</h3><div>Our aim was to explore the joint impacts of depressive symptoms along with triglyceride-glucose index (TyGi) on major adverse cardiovascular events (MACE) in patients who have acute coronary syndrome (ACS) and investigate whether the impact of depressive symptoms on MACE is mediated through the TyGi.</div></div><div><h3>Methods</h3><div>This extensive cohort study included 3681 ACS patients. Depressive symptoms and TyGi were assessed at baseline, and the patients were subsequently followed for two years to monitor the occurrence of MACE.</div></div><div><h3>Results</h3><div>Throughout the two-year monitoring period, 387 (10.5 %) patients with ACS experienced MACE. The TyGi was positively correlated with MACE risk (hazard ratio [HR]: 1.301, 95 % confidence interval [CI]: 1.112–1.522, <em>p</em> = .001). A nonlinear relation was observed between the TyGi and MACE (<em>p</em> for nonlinearity = 0.04). Joint analyses revealed that, unlike the non-depression &amp; TyG low group, the depression &amp; TyG low group had a two-fold elevation in MACE risk (HR: 2.108, 95 % CI: 1.499–2.966), while the depression &amp; TyG high group represented an even higher risk (HR: 2.442, 95 % CI: 1.786–3.339). The mediation analysis results showcased that the TyGi was a significant mediator of the interplay between depressive symptoms and MACE.</div></div><div><h3>Conclusion</h3><div>Depressive symptoms and the TyGi jointly influence MACE risk in ACS patients, with the TyGi mediating this relation. Close monitoring and management of depressive symptoms and the TyGi are crucial during ACS rehabilitation.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112034"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal study of resilience and social function in patients with colorectal cancer and stomas","authors":"Min Wang ,&nbsp;Yanhua Xu ,&nbsp;Bing Xiang Yang ,&nbsp;Dan Luo ,&nbsp;Hao Hou ,&nbsp;Qian Liu","doi":"10.1016/j.jpsychores.2024.112013","DOIUrl":"10.1016/j.jpsychores.2024.112013","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the dynamic changes, influencing factors, and relationships between resilience and social function in patients with colorectal cancer (CRC) and stomas at different postoperative stages, and to inform precise psychosocial rehabilitation interventions.</div></div><div><h3>Methods</h3><div>A longitudinal study was conducted at a tertiary hospital in eastern China from January 2021 to June 2023. Patients completed a self-designed socio-demographic questionnaire one month post-surgery, and the Connor and Davidson Resilience Scale (CD-RISC) and Social Dysfunction Screening Scale (SDSS) at 1, 3, and 5 months post-surgery. Data were analyzed using repeated measures ANOVA, Spearman correlation, group-based trajectory modeling, and binary logistic regression.</div></div><div><h3>Results</h3><div>A total of 131 patients were included in the analysis. Resilience showed an initial increase followed by a decline, while social function consistently improved. A moderate negative correlation between social dysfunction and resilience was observed at all time points. Influencing factors for resilience and social function varied across different postoperative stages. Significant differences in resilience trajectories were observed based on education and family income. Resilience trajectories significantly impacted social function trajectories (OR 19.39, 95 % CI 2.46–152.91, <em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>This study identifies distinct trajectories of resilience and social function in patients with colorectal cancer and stomas. Low resilience is linked to severe social function deficits. Stage-specific interventions are crucial to enhance social adaptation and improve overall quality of life. Tailored support is needed throughout recovery to address the unique challenges faced by these patients.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112013"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained improvements in sick leave, fatigue and functional status following a concentrated micro-choice based treatment for patients with long COVID: A 1 year prospective uncontrolled study","authors":"Bente Frisk ,&nbsp;Marte Jürgensen ,&nbsp;Birgitte Espehaug ,&nbsp;Eirik Søfteland ,&nbsp;Gerd Kvale","doi":"10.1016/j.jpsychores.2024.112023","DOIUrl":"10.1016/j.jpsychores.2024.112023","url":null,"abstract":"<div><h3>Background</h3><div>Long COVID has affected approximately 200 million people globally, with substantial consequences for the individuals, healthcare systems and society. Treatment guidelines lack clear recommendations regarding increased activity. This study aimed to evaluate primary outcomes as patients' satisfaction, illness perception and patient activation. In addition, potential changes in functional levels, sick leave, fatigue, dyspnea, and exercise capacity from baseline to 12-month follow-up after a concentrated micro-choice-based intervention in patients with long COVID.</div></div><div><h3>Methods</h3><div>This prospective interventional study, study start 26 May 2021, with 12-month follow-up included 78 patients with long COVID aged 19–67 years, mean age 40.3 ± 12.0 years. The intervention was structured into three equally important phases: pre-treatment preparation, a 3-day concentrated micro-choice-based intervention and integrating the changes into everyday living.</div></div><div><h3>Results</h3><div>At 3 and 12-month follow-ups, 71 (91 %) and 65 (83 %) patients, respectively completed questionnaires and physical tests. The patients reported significant enhancements in illness perception and health activation. Sick leave decreased significantly from 63 % at baseline to 43 % and 23 % at 3 and 12-month, respectively (<em>p</em> &lt; 0.001). Fatigue decreased significantly at 3-month (mean difference (MD) = −5.5, 95 % CI: −6.6 to −4.3) and at 12-month (MD = −7.0, CI: −8.3 to −5.7). Functional level and exercise capacity increased (p &lt; 0.001), and dyspnea decreased (p &lt; 0.001), at both follow-ups regardless of baseline fatigue severity.</div></div><div><h3>Conclusion</h3><div>The micro-choice-based intervention for patients with long COVID was safe, highly satisfactory and significantly enhanced health activation alongside rapid improvements in functional levels and fatigue which continued improving throughout the follow-up year, together with significant reduction in sick leave.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112023"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health anxiety in cancer patients, assessed with the Whiteley Index","authors":"Andreas Hinz ,&nbsp;Mareike Ernst ,&nbsp;Thomas Schulte ,&nbsp;Markus Zenger ,&nbsp;Michael Friedrich ,&nbsp;Nadja Dornhöfer","doi":"10.1016/j.jpsychores.2024.112017","DOIUrl":"10.1016/j.jpsychores.2024.112017","url":null,"abstract":"<div><h3>Objective</h3><div>Health anxiety (HA) is frequently observed in patients suffering from a severe disease such as cancer. This study aimed to test the psychometric properties of the Whiteley Index-7 (WI-7) measuring HA and to identify prognostic factors for heightened HA in cancer patients.</div></div><div><h3>Methods</h3><div>A sample of 1723 cancer patients, treated in a German rehabilitation clinic, completed the Whiteley Index-7, the Generalized Anxiety Disorder screener GAD-7, the Patient Health Questionnaire PHQ-9, the Fear of Progression questionnaire FoP-Q-12, the Concerns About Cancer Recurrence questionnaire CARQ-4, and two subscales of the EORTC QLQ-SURV100.</div></div><div><h3>Results</h3><div>The internal consistency of the WI-7 was good (Cronbach's α = 0.85), and the correlations between the WI-7 and other scales were as follows: 0.64 (GAD-7), 0.63 (PHQ-9), 0.75 (FoP-Q-12), 0.71 (CARQ-4), 0.66 (SURV-HD), and 0.75 (SURV-NHO). Women showed markedly higher levels of HA than men (effect size: <em>d</em> = 0.40), and patients aged 60 years and above reported lower levels of HA than younger patients (<em>d</em> = −0.32). Melanoma patients showed the highest HA mean score (M = 10.9), and patients receiving antibody therapy showed heightened levels of HA (M = 10.7). When considering age and sex, the effects of tumor type and treatment become smaller than in the univariate analyses.</div></div><div><h3>Conclusion</h3><div>The WI-7 is a suitable instrument for assessing HA in cancer patients. When evaluating the effects of cancer type or treatment on HA, one has to take into account the age and sex distribution. Younger patients and women deserve special attention regarding HA.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112017"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}