Association between weekend catch-up sleep and the systemic immune-inflammation index in adults: Evidence from the NHANES 2017–2020

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2025-02-19 DOI:10.1016/j.jpsychores.2025.112070

Zhaojun Yang , Yehao Luo , Jiali He , Yahui Yuan , Qiaoyun Liu , Jingyi Guo , Yuping Lin , Lu Sun , Guanjie Fan

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引用次数: 0

Abstract

Background

Chronic sleep deprivation is widespread and associated with detrimental health outcomes, including inflammation. A common strategy to address weekday sleep deficits is weekend catch-up sleep (WCS). However, the relevance of the WCS on systemic inflammation, as quantified by the systemic immune-inflammation index (SII), remains inadequately understood.

Methods

This cross-sectional analysis examined data from the National Health and Nutrition Examination Survey (NHANES) 2017–2020 cohort. To explore the relationship between the WCS and the SII, we employed univariate analysis, weighted linear regression, restricted cubic spline (RCS) techniques, and subgroup analyses.

Results

The final sample included 4849 adults. Weighted linear regression confirmed a negative association between the WCS and the SII after adjusting for potential confounders (β = −16.72, 95 % CI: −34.29 to 0.85, P = 0.04). Subgroup analyses revealed that this association varied by obesity, gender, and age. Additionally, the association between the WCS duration and the SII was non-linear (P = 0.006) in adults with a weekday sleep duration of 7–8 h.

Conclusion

WCS can help mitigate the inflammatory burden associated with chronic sleep deprivation. WCS durations of 3 h and longer are particularly beneficial for adults who experience sleep deprivation on weekdays. The association between WCS and SII appears to be moderated by factors such as obesity, gender, and smoking status.

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背景长期睡眠不足是一种普遍现象，与炎症等有害健康的结果有关。解决平日睡眠不足的常见策略是周末补觉（WCS）。然而，人们对以全身免疫炎症指数（SII）量化的 WCS 与全身炎症的相关性仍然了解不足。方法这项横断面分析研究了美国国家健康与营养调查（NHANES）2017-2020 年队列的数据。为了探讨WCS和SII之间的关系，我们采用了单变量分析、加权线性回归、受限立方样条曲线（RCS）技术和亚组分析。在对潜在混杂因素进行调整后，加权线性回归证实 WCS 与 SII 之间存在负相关（β = -16.72，95 % CI：-34.29 至 0.85，P = 0.04）。分组分析表明，这种关联因肥胖、性别和年龄而异。此外，在平日睡眠时间为 7-8 小时的成年人中，WCS 持续时间与 SII 之间的关系是非线性的（P = 0.006）。持续 3 小时或更长时间的 WCS 对平日睡眠不足的成年人尤其有益。WCS与SII之间的关系似乎受肥胖、性别和吸烟状况等因素的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.