Journal of Psychosomatic Research最新文献

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Somatic and mental distress as predictors of number of symptoms associated with environmental factors in an adult general population: Cross-sectional and longitudinal findings 躯体和精神痛苦作为成人人群中与环境因素相关的症状数量的预测因子:横断面和纵向研究结果
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2025-03-15 DOI: 10.1016/j.jpsychores.2025.112098
Ferenc Köteles , Steven Nordin
{"title":"Somatic and mental distress as predictors of number of symptoms associated with environmental factors in an adult general population: Cross-sectional and longitudinal findings","authors":"Ferenc Köteles ,&nbsp;Steven Nordin","doi":"10.1016/j.jpsychores.2025.112098","DOIUrl":"10.1016/j.jpsychores.2025.112098","url":null,"abstract":"<div><h3>Objective</h3><div>Hypotheses were tested of associations between indicators of somatic and mental distress and number of different types of environmental intolerances, referred to as symptoms attributed to environmental factors (SAEFs), and these indicators predicting development of additional SAEFs in a general population. The SAEFs regarded chemicals, buildings, electromagnetic fields and sounds.</div></div><div><h3>Methods</h3><div>Data were used from a Swedish population-based sample of 2336 adults. Cross-sectional and 3-year longitudinal analyses were conducted based on validated questionnaire instruments assessing somatic symptom distress, perceived stress, anxiety and depression.</div></div><div><h3>Results</h3><div>Prevalence percentage of the SAEFs ranged from 2.1 % to 13.4 %; 16.2 % had one SAEF, 4.9 % had two SAEFs, and 1.2 % had three or four SAEFs. Cross-sectionally, Kendall rank correlation analyses and ANOVAs showed that somatic symptom distress (r<sub>tau-b</sub> = 0.214), perceived stress (r<sub>tau-b</sub> = 0.137), anxiety (r<sub>tau-b</sub> = 0.145) and depression (r<sub>tau-b</sub> = 0.100) increased with number of SAEF. In the longitudinal analysis, all four indicators were found to be predictors of an increase in number of SAEFs three years later (odds ratios = 1.021–1.049 for each scale step), with somatic symptom distress as the strongest predictor.</div></div><div><h3>Conclusion</h3><div>The results suggest that all four types of SAEFs are associated with all four indicators of negative affectivity, and that the level of these indicators is associated with number of SAEFs and predict development of additional SAEFs. Among the studied indicators, somatic symptom distress appears to be particularly associated with development of multiple SAEFs, perhaps driven by the motive to find a cause for bothersome symptoms (misattribution).</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112098"},"PeriodicalIF":3.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circulating branched-chain amino acids and risk of psychiatric disorders: A two-sample Mendelian randomization study 循环支链氨基酸与精神疾病风险:一项双样本孟德尔随机化研究
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2025-03-15 DOI: 10.1016/j.jpsychores.2025.112101
Xueren Gao, Weichao Zhang, Fang Wang
{"title":"Circulating branched-chain amino acids and risk of psychiatric disorders: A two-sample Mendelian randomization study","authors":"Xueren Gao,&nbsp;Weichao Zhang,&nbsp;Fang Wang","doi":"10.1016/j.jpsychores.2025.112101","DOIUrl":"10.1016/j.jpsychores.2025.112101","url":null,"abstract":"<div><h3>Objective</h3><div>Several studies have identified biomarkers that help in the prevention, diagnosis, and treatment of psychiatric disorders. The current study aimed to explore the association between circulating branched-chain amino acids (BCAA) and the risk of five psychiatric disorders.</div></div><div><h3>Methods</h3><div>GWAS summary statistics were obtained from the UK Biobank and the FinnGen Biobank. The inverse variance weighted (IVW) method was used as a primary method to assess causal effects. The heterogeneity test, the horizontal pleiotropy test, and leave-one-out analysis were used to assess the robustness and reliability of the results.</div></div><div><h3>Results</h3><div>Total BCAA levels were not significantly associated with the risk of anxiety disorders, alcohol dependence, depression, panic disorder, and bipolar affective disorders. Separate analyses for each BCAA showed that the levels of valine and leucine were not associated with the risk of the mentioned five psychiatric disorders, and the levels of isoleucine were not associated with the risk of depression, panic disorder, and bipolar affective disorders, but with the risk of anxiety disorders (IVW: OR = 0.814, 95 %CI = 0.716–0.925) and alcohol dependence (IVW: 0.690, 95 %CI = 0.560–0.849).</div></div><div><h3>Conclusions</h3><div>Circulating isoleucine was a protective factor for anxiety disorders and alcohol dependence, offering a new research direction and theoretical basis for preventing and managing psychiatric disorders.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112101"},"PeriodicalIF":3.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effectiveness of hands-off approaches alone or in combination with hands-on approaches in the treatment of chronic cervical pain within a biopsychosocial framework: A systematic review 在生物心理社会框架内,不干预方法单独或与实践方法相结合治疗慢性颈椎疼痛的有效性:系统回顾
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2025-03-13 DOI: 10.1016/j.jpsychores.2025.112086
Kübra Canlı , Charbel Najem , Jessica Van Oosterwijck , Mira Meeus , Kayleigh De Meulemeester
{"title":"The effectiveness of hands-off approaches alone or in combination with hands-on approaches in the treatment of chronic cervical pain within a biopsychosocial framework: A systematic review","authors":"Kübra Canlı ,&nbsp;Charbel Najem ,&nbsp;Jessica Van Oosterwijck ,&nbsp;Mira Meeus ,&nbsp;Kayleigh De Meulemeester","doi":"10.1016/j.jpsychores.2025.112086","DOIUrl":"10.1016/j.jpsychores.2025.112086","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to systematically review the current literature comparing hands-off approaches with hands-on approaches from a biopsychosocial perspective of pain processing in people suffering from chronic primary neck pain (CPNP).</div></div><div><h3>Methods</h3><div>An electronic search was conducted on PubMed, Web of Science, Scopus, and Cochrane Library. Initial searches were carried out in November 2022, with electronic database searches repeated on November 25, 2024. Eligibility criteria which were randomized controlled trials comparing hands-off approaches alone or in combination with hands-on approaches and hands-on approaches alone in people with CPNP were checked by two independent authors. The risk of bias was assessed using the revised Cochrane Risk of Bias Tool (RoB). The strength of conclusion was determined using the evidence-based guideline development approach.</div></div><div><h3>Results</h3><div>Fifteen studies with a total of 1029 participants were included in this review. The RoB was rated as low RoB for two studies, some concerns for two studies and high RoB for 11 studies.</div><div>Pain processing was assessed by pain intensity(100 % of the studies), pain sensitivity(53 % of the studies), pain-related participation in social roles(46 % of the studies), pain-related emotions(26 % of the studies), and pain-related beliefs(6 % of the studies). Limited quality of evidence was found for the hands-off approaches alone being more effective on pain intensity than hands-on approaches alone in the long term. Limited- to moderate-quality of evidence was found for hands-off approaches combined with hands-on approaches, being more effective than hands-on approaches alone in improving pain intensity, pain sensitivity, pain-related participation in social roles, pain-related emotions, and pain-related beliefs in the short-, mid- or long-term.</div></div><div><h3>Conclusions</h3><div>The current findings suggest that hands-off approaches alone are superior to hands-on approaches in the long term, at least for pain intensity. Hands-off approaches in combination with hands-on approaches were also more effective than hands-on approaches for pain processing. However, substantial heterogeneity warrants a cautious interpretation of these results. More high-quality, randomized, controlled trials with homogenous data collection and larger sample sizes are needed.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112086"},"PeriodicalIF":3.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychological resilience to trauma and longitudinal sleep outcomes among current and former nurses 现任和前任护士对创伤的心理弹性和纵向睡眠结果
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2025-03-07 DOI: 10.1016/j.jpsychores.2025.112090
Laura Sampson , Arielle A.J. Scoglio , Kristen Nishimi , Karmel W. Choi , Ariel H. Kim , Yiwen Zhu , Qi Sun , Jae Hee Kang , Eric B. Rimm , Karestan C. Koenen , Laura D. Kubzansky
{"title":"Psychological resilience to trauma and longitudinal sleep outcomes among current and former nurses","authors":"Laura Sampson ,&nbsp;Arielle A.J. Scoglio ,&nbsp;Kristen Nishimi ,&nbsp;Karmel W. Choi ,&nbsp;Ariel H. Kim ,&nbsp;Yiwen Zhu ,&nbsp;Qi Sun ,&nbsp;Jae Hee Kang ,&nbsp;Eric B. Rimm ,&nbsp;Karestan C. Koenen ,&nbsp;Laura D. Kubzansky","doi":"10.1016/j.jpsychores.2025.112090","DOIUrl":"10.1016/j.jpsychores.2025.112090","url":null,"abstract":"<div><h3>Objective</h3><div>A life-disrupting stressor (e.g. pandemic) may cause or exacerbate poor sleep health; resilience may offset impacts. We assessed relationships between pre-pandemic psychological resilience to trauma and sleep-related outcomes during the first year of the pandemic among current and former nurses.</div></div><div><h3>Methods</h3><div>Using data from 18,670 women in the Nurses' Health Study II, we characterized pre-pandemic resilience by cross-classifying experiences of higher versus lower lifetime trauma burden with unfavorable, adequate, and favorable psychological health (through January 2020). Sleep was measured before (2017) and during the pandemic, including: changes, quality, and duration. We modeled trajectories of sleep duration assessed at five time points (pre-pandemic in 2017, and then in four COVID-19-related surveys, 2020–2021) using latent class growth analysis.</div></div><div><h3>Results</h3><div>We observed four trajectories of sleep duration, all showing stable patterns, with averages ranging from 5.5 to 6 to 8.5–9 h of sleep per 24 h. Women with higher trauma/unfavorable psychological health had the highest risk for all poor sleep outcomes (e.g., RR for being in the shortest sleep trajectory versus healthy sleep duration: 2.53; 95 % CI: 2.21, 2.91). Relative to women categorized as most resilient, only women with lower trauma/favorable psychological health showed lower risk of getting less sleep after the pandemic started compared to no change (RR: 0.76; 95 % CI: 0.70, 0.83). This same pattern was observed for poor sleep quality.</div></div><div><h3>Conclusion</h3><div>Higher pre-pandemic resilience may have protected women against poor sleep outcomes during the pandemic. Findings could have long-term health implications, particularly if they generalize to other stressors.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112090"},"PeriodicalIF":3.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of emotional freedom techniques on anxiety, depression, and anticipatory grief in people with cancer: A meta-analysis and systematic review 情绪释放技术对癌症患者焦虑、抑郁和预期悲伤的影响:荟萃分析和系统回顾
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2025-03-07 DOI: 10.1016/j.jpsychores.2025.112088
Dandan Zheng , Xianghao Lin , Xiaofen Gao , Lifei Wang , Mingyuan Zhu
{"title":"The impact of emotional freedom techniques on anxiety, depression, and anticipatory grief in people with cancer: A meta-analysis and systematic review","authors":"Dandan Zheng ,&nbsp;Xianghao Lin ,&nbsp;Xiaofen Gao ,&nbsp;Lifei Wang ,&nbsp;Mingyuan Zhu","doi":"10.1016/j.jpsychores.2025.112088","DOIUrl":"10.1016/j.jpsychores.2025.112088","url":null,"abstract":"<div><h3>Objective</h3><div>Emotional Freedom Techniques (EFT) is a self-healing method that combines Eastern meridian acupuncture and Western psychology. This meta-analysis evaluates the efficacy of EFT in reducing anxiety, depression, and anticipatory grief symptoms in people with cancer.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted across nine databases, including Cochrane Library, Embase, PubMed, Web of Science, Google Scholar, CBM, WeiPu, CNKI, and WanFang, up to May 2024. We included randomized controlled trials (RCTs) focused on EFT's effects on psychological symptoms and well-being in people with cancer. Eligible RCTs were screened, quality-assessed, and analyzed using RevMan 5.3 software.</div></div><div><h3>Results</h3><div>From 1026 articles, ten RCTs met the inclusion criteria, involving 774 patients (388 in the EFT group and 386 in the control group). EFT reduced symptoms of depression (MD = −7.41, 95 % CI [−9.32, −5.51], <em>P</em> &lt; .001) and anxiety (MD = −7.92, 95 % CI [−11.01, −4.83], <em>P</em> &lt; .001). For anticipatory grief, EFT improved symptoms related to sadness, anger, death attitude, somatic symptoms, religious comfort, and perceived social support, but did not affect disease adjustment, self-awareness, or psychological distress. EFT also improved sleep quality (MD = −1.96, 95 % CI [−2.80, −1.13], P &lt; .001).</div></div><div><h3>Conclusion</h3><div>EFT significantly alleviates anxiety, depression, and certain aspects of anticipatory grief, as well as sleep issues in people with cancer, though it shows limited efficacy in psychological distress, disease adjustment, and self-awareness. Further research should standardize outcomes to verify EFT's comprehensive benefits.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112088"},"PeriodicalIF":3.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Latent profiles of psychosocial adaptation in hospitalized persons with stroke and their association with coping styles and illness uncertainty: A cross-sectional study 住院中风患者的潜在社会心理适应特征及其与应对方式和疾病不确定性的关系:一项横断面研究
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2025-03-06 DOI: 10.1016/j.jpsychores.2025.112089
Qianying Deng , Yingjie Fu , Yuenv Wang , Zheng Wang , Siyi Su , Luyi Xu , Jing Fang , Jufang Li
{"title":"Latent profiles of psychosocial adaptation in hospitalized persons with stroke and their association with coping styles and illness uncertainty: A cross-sectional study","authors":"Qianying Deng ,&nbsp;Yingjie Fu ,&nbsp;Yuenv Wang ,&nbsp;Zheng Wang ,&nbsp;Siyi Su ,&nbsp;Luyi Xu ,&nbsp;Jing Fang ,&nbsp;Jufang Li","doi":"10.1016/j.jpsychores.2025.112089","DOIUrl":"10.1016/j.jpsychores.2025.112089","url":null,"abstract":"<div><h3>Objective</h3><div>Current studies on psychosocial adaptation of persons with stroke mainly focused on the overall level and ignored its heterogeneity. The aim of the current study was to identify the latent profiles of psychosocial adaptation of persons with stroke and further explore their association with coping styles and illness uncertainty.</div></div><div><h3>Methods</h3><div>A total of 361 hospitalized persons with stroke were recruited at two affiliated hospitals of a medical university in southeastern China from October 2023 to March 2024. Latent profile analysis was used to identify latent profiles of psychosocial adaptation of persons with stroke.</div></div><div><h3>Results</h3><div>Three different profiles of psychosocial adaptation of persons with stroke were identified: good adaptation group (with the lowest item mean scores of the dimensions, accounted for 32.4 %), moderate adaptation-poor social environment group (with moderate item mean scores of the dimensions and with a high score in the social environment dimension, accounted for 51.5 %) and poor adaptation group (with the highest item mean scores of the dimensions, accounted for 16.1 %). Living status (OR = 0.20, <em>p</em> = 0.018; OR = 7.72, <em>p</em> &lt; 0.001), per capita monthly household income (OR = 13.32, <em>p</em> = 0.015; OR = 13.08, <em>p</em> = 0.003; OR = 5.11, <em>p</em> = 0.038), medical payment methods (OR = 5.74, p = 0.015), mRS (OR = 0.37, p = 0.015), confrontation (OR = 0.77, <em>p</em> = 0.010), ambiguity (OR = 1.26, p &lt; 0.001; OR = 1.22, <em>p</em> = 0.014) and complexity (OR = 1.15, <em>p</em> = 0.045) were associated with different profiles of psychosocial adaptation.</div></div><div><h3>Conclusions</h3><div>Nearly two-thirds of the persons with stroke exhibited moderate psychosocial adaptation or poor psychosocial adaptation, which needs further improvement. Healthcare providers need to adopt individualized approaches to improve their level of psychosocial adaptation in practice.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112089"},"PeriodicalIF":3.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Within person predictors of physical activity and fatigue in long Covid: Findings from an ecological momentary assessment study 长期Covid期间身体活动和疲劳的个人预测因素:一项生态瞬时评估研究的结果
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2025-03-06 DOI: 10.1016/j.jpsychores.2025.112091
Christopher Burton , Helen Dawes , Caroline Dalton
{"title":"Within person predictors of physical activity and fatigue in long Covid: Findings from an ecological momentary assessment study","authors":"Christopher Burton ,&nbsp;Helen Dawes ,&nbsp;Caroline Dalton","doi":"10.1016/j.jpsychores.2025.112091","DOIUrl":"10.1016/j.jpsychores.2025.112091","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to examine the extent to which current perceived demand for energy and affect predict subsequent physical activity and fatigue in people with Long Covid using an intensive longitudinal method (ecological momentary assessment).</div></div><div><h3>Methods</h3><div>Analysis of data from a study of 69 adults with self-reported Long Covid combining 3-hourly self-report data perceived energy, and fatigue, on a smartphone app with continuous physical activity recording. We tested three hypotheses derived from cognitive behavioural and neuroscientific models of fatigue. These related to expectation, current affect and recalled emotional demand. Analysis used linear mixed effects models with fatigue and physical activity as outcomes.</div></div><div><h3>Results</h3><div>Expectation of energy need for the next 3 h was predictive of physical activity, fatigue and recalled demandingness of the period. (<em>p</em>-values 0.005 to &lt;0.0001). Currently feeling positive was predictive of slightly more subsequent physical activity and less fatigue 3 h later (<em>p</em> = 0.01). Feeling negative was not predictive of physical activity or subsequent fatigue but was predictive of subsequent recall of the period being emotionally demanding. Feeling more anxious was predictive of greater fatigue 3 h later (<em>p</em> = 0.001) but not of reduced physical activity. Absolute effects were small: a one-point increase in anticipated demand (on a scale of 1–7) was associated with an extra 2.2 min of moderate or vigorous physical activity and a one standard deviation increase in anxiety was associated with a one-point increase in fatigue (0–100 scale).</div></div><div><h3>Conclusion</h3><div>In the day-to-day experience of Long Covid expectation and affect have little detectable effect on subsequent physical activity or fatigue.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112091"},"PeriodicalIF":3.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interrelationships between glucose metabolism and gonadal hormones in female first-episode patients with schizophrenia 女性首发精神分裂症患者糖代谢与性激素的相互关系
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2025-03-04 DOI: 10.1016/j.jpsychores.2025.112087
Jing Yao , Fengchun Wu , Meihong Xiu
{"title":"Interrelationships between glucose metabolism and gonadal hormones in female first-episode patients with schizophrenia","authors":"Jing Yao ,&nbsp;Fengchun Wu ,&nbsp;Meihong Xiu","doi":"10.1016/j.jpsychores.2025.112087","DOIUrl":"10.1016/j.jpsychores.2025.112087","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia (SCZ) is a complex mental disorder that typically emerges in late adolescence or early adulthood. The underlying molecular mechanisms of SCZ remain unclear. There is growing evidence supporting the involvement of abnormalities in metabolic and endocrine systems in the pathophysiology of SCZ. Our study was designed to explore the interrelationship between gonadal hormones and glucose metabolism in patients with SCZ.</div></div><div><h3>Methods</h3><div>One hundred and twenty-four female first-episode patients diagnosed with SCZ according to DSM-IV were recruited. The glucose metabolism parameters, including fasting glucose, insulin, and insulin resistance index were measured. In addition, gonadal hormones, including follicle-stimulating hormone, testosterone, estradiol, progesterone, and luteinizing hormone were also determined in the same group of patients.</div><div>Results: Abnormal glucose metabolism and sex hormones were observed in female DNFES patients, with a particularly high rate of insulin resistance (49.6 %). Correlation analysis revealed significant associations between glucose metabolic disturbance and sex hormones (all <em>p</em> &lt; 0.05). Moreover, regression analysis adjusted for age, waist circumference, and BMI revealed that estradiol was negatively correlated with fasting insulin in female patients (β = −0.37, <em>t</em> = −4.0, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>These results provide evidence supporting the presence of disturbance in glucose metabolism and gonadal hormones at the onset of SCZ in female patients, suggesting that these dysregulations interact with each other to be involved in the disease's pathophysiological process.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"192 ","pages":"Article 112087"},"PeriodicalIF":3.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-pharmacological treatment options for fatigue: A systematic review of RCTs in adults 疲劳的非药物治疗选择:成人随机对照试验的系统回顾
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2025-02-28 DOI: 10.1016/j.jpsychores.2025.112084
Carlotta Steen , Anna Zalpur , Marissa Bentele , Stephan Zipfel , Andreas Stengel
{"title":"Non-pharmacological treatment options for fatigue: A systematic review of RCTs in adults","authors":"Carlotta Steen ,&nbsp;Anna Zalpur ,&nbsp;Marissa Bentele ,&nbsp;Stephan Zipfel ,&nbsp;Andreas Stengel","doi":"10.1016/j.jpsychores.2025.112084","DOIUrl":"10.1016/j.jpsychores.2025.112084","url":null,"abstract":"<div><h3>Objective</h3><div>Fatigue is a significant contributor to the burden experienced by patients with chronic disorders. The development of standardized treatments is challenging due to the lack of consensus concerning the etiology of fatigue. The aim of this systematic review is to provide an overview of non-pharmacological interventions for fatigue. The efficacy and differences in fatigue treatment across conditions will be explored.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted using the databases PubMed, Web of Science, PsycInfo and CINAHL.</div><div>Trials were eligible when (1) adult patients (≥ 18 years old) with disorders causing fatigue were included, (2) non-pharmacological interventions performed, (3) treatment was compared to standard care, placebo or active control group, (4) fatigue was the only primary outcome assessed with a multidimensional tool, and (5) a randomized controlled trial (RCT) design was applied.</div></div><div><h3>Results</h3><div>7592 papers were screened. 91 RCTs were eligible, with data reported in 95 papers. Specific fatigue interventions were present for a broad range of conditions. Findings demonstrated promising evidence for physical activity, CBT, online programs and multidimensional modules. Additional types of interventions were effective, but evidence was limited due to risk of bias and small sample sizes. Due to high heterogeneity concerning methodology, a meta-analysis was not possible.</div></div><div><h3>Conclusion</h3><div>Several non-pharmacological treatment options for fatigue are promising. No clear evidence was found that fatigue should be treated differently depending on the underlying condition. However, further research is necessary with a focus on a transdiagnostic approach to fatigue, high study quality and long-term follow-ups.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"191 ","pages":"Article 112084"},"PeriodicalIF":3.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the relationship between religiosity and telomere length in older individuals 探索老年人宗教信仰与端粒长度之间的关系
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2025-02-28 DOI: 10.1016/j.jpsychores.2025.112085
Juliane Piasseschi de Bernardin Gonçalves , Thais Chile , Vanessa J.R. de Paula , Marcus Zulian Teixeira , Salma Rose Ribeiz , Martin Schalling , Geraldo Busatto Filho , Giancarlo Lucchetti , Homero Vallada
{"title":"Exploring the relationship between religiosity and telomere length in older individuals","authors":"Juliane Piasseschi de Bernardin Gonçalves ,&nbsp;Thais Chile ,&nbsp;Vanessa J.R. de Paula ,&nbsp;Marcus Zulian Teixeira ,&nbsp;Salma Rose Ribeiz ,&nbsp;Martin Schalling ,&nbsp;Geraldo Busatto Filho ,&nbsp;Giancarlo Lucchetti ,&nbsp;Homero Vallada","doi":"10.1016/j.jpsychores.2025.112085","DOIUrl":"10.1016/j.jpsychores.2025.112085","url":null,"abstract":"<div><h3>Objectives</h3><div>Although telomere length is an established marker of biological aging, the impact of religious beliefs on telomere length remains uncertain.</div></div><div><h3>Methods</h3><div>This cross-sectional study investigated the relationship between religiosity and telomere length among senior Brazilians, aged 60 and older. The study examined the association between organizational, non-organizational, and intrinsic religiosity with telomere length, adjusting for sociodemographic, mental, physical health, and medication. Hierarchical linear regression models were used.</div></div><div><h3>Results</h3><div>821 participants (62.2 % female, mean age 68.9 years, SD = 6.48) were studied. Female gender and younger age were linked to longer telomeres, but no significant associations were found between religious beliefs and telomere length in adjusted or unadjusted models.</div></div><div><h3>Conclusions</h3><div>This study found no evidence of an association between religiosity and telomere length among older Brazilian adults. While prior research highlights religiosity's positive health effects, its direct influence on telomere length remains unclear, warranting further exploration.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"191 ","pages":"Article 112085"},"PeriodicalIF":3.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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