Journal of Psychosomatic Research最新文献

{"title":"Major depressive disorder, neuroticism, suicidal behaviors, and depression severity are associated with cytokine networks and their intricate interactions with metabolic syndrome","authors":"Michael Maes ,&nbsp;Ketsupar Jirakran ,&nbsp;Asara Vasupanrajit ,&nbsp;Bo Zhou ,&nbsp;Chavit Tunvirachaisakul ,&nbsp;Abbas F. Almulla","doi":"10.1016/j.jpsychores.2024.111951","DOIUrl":"10.1016/j.jpsychores.2024.111951","url":null,"abstract":"<div><h3>Objectives</h3><div>To identify alterations in the immune profiles in outpatients with major depression (MDD), and its associations with key features, such as suicidal ideation, neuroticism, cognitive symptoms, and the depression phenome while accounting for metabolic syndrome (MetS).</div></div><div><h3>Methods</h3><div>In this case-control study, we assayed 48 serum cytokines, chemokines, and growth factors in 67 healthy controls and 66 MDD outpatients. Around 50 % of the outpatient MDD and control participants had a diagnosis of MetS.</div></div><div><h3>Results</h3><div>Ten differentially expressed proteins (DEPs) were upregulated in outpatient MDD (i.e., CXCL12, tumor necrosis factor [TNF]β, platelet-derived growth factor [PDGF], CCL11, interleukins [IL]9, IL4, CCL5, CCL2, CCL4, IL1 receptor antagonist [IL1RN]), indicating an immune and defense response. Six DEPs were downregulated (vascular endothelial growth factor A [VEGFA], IL12, CCL3, colony stimulating factor [CSF]1, IL1B, nerve growth factor [NGF]), indicating lowered neurogenesis and neuron death regulation. Significant interactions between outpatient MDD and MetS caused a) substantial increases in IL4, IL17, TNF, TNFB, CCL2, CCL5, PDGF, IL1RN; and b) downregulation of VEGFA and FGF. A large part of the variance in neuroticism (26 %), suicidal behaviors (23 %), and the MDD phenome (31 %) was predicted by immunological data and interactions between MetS and CCL5, TNFB or VEGFA.</div></div><div><h3>Conclusion</h3><div>Outpatient MDD is characterized by a cytokine profile with neurotoxic potential which partly explains neuroticism, suicidal behaviors, and the phenome's severity. Lowered IL-10 and activated cytokine profiles with neurotoxic potential are characteristics of outpatient MDD and other depression phenotypes, including severe first-episode inpatient MDD. The presence of MetS in outpatient MDD considerably activates immune profiles with neurotoxic potential. Consequently, immune studies in MDD should always be performed in subjects with and without MetS.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111951"},"PeriodicalIF":3.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “A meta-analysis of the prevalence and risk of mental health problems in allergic rhinitis patients”","authors":"Haifei Xiang,&nbsp;Hao Wu","doi":"10.1016/j.jpsychores.2024.111950","DOIUrl":"10.1016/j.jpsychores.2024.111950","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111950"},"PeriodicalIF":3.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strength-based surgical consultation to navigate patient's unhelpful thoughts","authors":"Rudi Haryadi ,&nbsp;Muhammad Harwansyah Putra Sinaga ,&nbsp;Ashari Mahfud ,&nbsp;Jarkawi ,&nbsp;Thrisia Febrianti","doi":"10.1016/j.jpsychores.2024.111947","DOIUrl":"10.1016/j.jpsychores.2024.111947","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111947"},"PeriodicalIF":3.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor stress resilience as an independent risk factor for severe COVID-19 and respiratory infections","authors":"Khairiyah Khadijah ,&nbsp;Rizky Andana Pohan ,&nbsp;Ririn Dwi Astuti ,&nbsp;Putri Bunga Aisyah Pohan ,&nbsp;Muhammad Yasir Arafat Pohan ,&nbsp;Maria Oktasari ,&nbsp;Riza Amalia","doi":"10.1016/j.jpsychores.2024.111953","DOIUrl":"10.1016/j.jpsychores.2024.111953","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111953"},"PeriodicalIF":3.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging cultures: Expanding the MCARE intervention to diverse global Populations","authors":"Tamama Rofiqah ,&nbsp;Ahmad Yanizon ,&nbsp;Riza Amalia ,&nbsp;Muhammad Taufiqurrahman ,&nbsp;Ramtia Darma Putri ,&nbsp;Hanik Mufaridah ,&nbsp;Lutfatulatifah","doi":"10.1016/j.jpsychores.2024.111948","DOIUrl":"10.1016/j.jpsychores.2024.111948","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111948"},"PeriodicalIF":3.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to comments on ‘Mechanisms of psycho-behavioural mindfulness intervention (MCARE) on depressive and anxiety symptoms in patients with acute coronary syndrome: A longitudinal mediation analysis’","authors":"Jiatong Cui ,&nbsp;Guiqin Zhang ,&nbsp;Yunyan Xianyu ,&nbsp;Xiaohong Zhang ,&nbsp;Yu Xin Cheng ,&nbsp;Yu Jia Liu ,&nbsp;Wei Xiong ,&nbsp;Wei Liu ,&nbsp;Qian Liu ,&nbsp;Bing Xiang Yang ,&nbsp;Huijing Zou","doi":"10.1016/j.jpsychores.2024.111952","DOIUrl":"10.1016/j.jpsychores.2024.111952","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111952"},"PeriodicalIF":3.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between anxiety and depression symptoms and pain and function in adolescents and young adults with chronic pain: A meta-analysis","authors":"Nicole Harte ,&nbsp;Rachel V. Aaron ,&nbsp;Kavya Bhattiprolu ,&nbsp;Madelyne A. Bisby ,&nbsp;Milena Gandy ,&nbsp;Taylor Hathway ,&nbsp;Blake F. Dear ,&nbsp;Joanne Dudeney","doi":"10.1016/j.jpsychores.2024.111945","DOIUrl":"10.1016/j.jpsychores.2024.111945","url":null,"abstract":"<div><h3>Objective</h3><div>Chronic pain in adolescents and young adults (AYAs) is associated with adverse functional and psychological outcomes; however, inconsistent findings across studies necessitate a comprehensive synthesis. This meta-analysis aimed to quantify associations between anxiety, depression, and pain/functional outcomes, and explore study and sample moderators, such as age, sex, pain duration, recruitment setting, and measurement tools.</div></div><div><h3>Methods</h3><div>We searched MEDLINE, PsycINFO, CENTRAL, and Embase through May 2024. included 57 studies (<em>N</em> = 12,603) of AYAs aged 12–25 years with chronic pain. Risk of bias and GRADE assessments were conducted. Pearson r correlations were meta-analyzed using a random-effects model.</div></div><div><h3>Results</h3><div>Small associations were found between anxiety, depression, and heightened pain intensity (<em>r</em> = 0.20, 0.24). Moderate-to-large associations were observed between anxiety, depression, and disability (<em>r</em> = 0.32, 0.34), pain interference (<em>r</em> = 0.47, 0.51), pain catastrophizing (both <em>r</em> = 0.50), and poorer quality of life (<em>r</em> = −0.56, −0.61). Anxiety had stronger correlations with pain intensity and catastrophizing in samples with more males. Anxiety measure moderated the anxiety-pain intensity relationship. Depression had stronger correlations with pain intensity for shorter pain duration, and catastrophizing and pain interference for longer pain durations. The depression-catastrophizing association was stronger in older samples.</div></div><div><h3>Conclusion</h3><div>Anxiety and depression significantly impact the chronic pain experience in AYAs, with stronger effects on functional outcomes and quality of life than pain intensity. Tailored interventions that consider age, sex, and pain duration may enhance treatment outcomes in this population.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111945"},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional study of non-suicidal self-injury in adults with depressive disorder: Associations with inflammation and cardiac structure and function","authors":"Jingdi Chen ,&nbsp;Zhenzhen Lin ,&nbsp;Yinglan Gong ,&nbsp;Jinlong Yu ,&nbsp;Fusheng Guo ,&nbsp;Yun Liu ,&nbsp;Puying Liang ,&nbsp;Ziying Feng ,&nbsp;Haoying Hu","doi":"10.1016/j.jpsychores.2024.111944","DOIUrl":"10.1016/j.jpsychores.2024.111944","url":null,"abstract":"<div><h3>Objective</h3><div>Non-suicidal self-injury (NSSI) is associated with cardiovascular disease (CVD), whereas inflammation is associated with both CVD and NSSI. However, few studies have investigated the correlation among NSSI, inflammation, and cardiac structure and function in CVD-free adult patients with depressive disorders.</div></div><div><h3>Methods</h3><div>We recruited 88 CVD-free adult patients with depressive disorders and 37 healthy individuals. Patients were divided into NSSI (<em>n</em> = 21) and non-NSSI (<em>n</em> = 67) groups based on the presence or absence of NSSI. Healthy individuals comprised the controls (<em>n</em> = 37). Echocardiography was applied to assess cardiac structure and function, and C-reactive protein (CRP) levels were measured to indicate inflammation.</div></div><div><h3>Results</h3><div>Compared with controls, the NSSI group exhibited a larger left ventricular end-systolic diameter (LVESD) and smaller left ventricular ejection fraction (LVEF). Left ventricular end-systolic volume (LVESV) was larger in the NSSI group than in the non-NSSI group. The CRP levels were higher in the NSSI group than in the non-NSSI group; however, this difference was not statistically significant. NSSI was positively associated with LVESD (β = 1.928, <em>p</em> = 0.006) and LVESV (β = 5.368, <em>p</em> = 0.003), negatively correlated with LVEF (β = −2.600, <em>p</em> = 0.029), and positively correlated with CRP levels (β = 0.116, <em>p</em> = 0.004). CRP levels did not mediate the association between NSSI and cardiac structure and function.</div></div><div><h3>Conclusions</h3><div>This study indicated that NSSI was associated with left ventricular structure, systolic function, and inflammation, but CRP did not mediate the relationship between NSSI and echocardiogram parameters.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111944"},"PeriodicalIF":3.5,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of preterm birth and neonatal stress exposure with chronic pain in adulthood – Results from the Gutenberg prematurity study","authors":"J. Tesarz ,&nbsp;A.K. Schuster ,&nbsp;M. Hermes ,&nbsp;E. Mildenberger ,&nbsp;M.S. Urschitz ,&nbsp;R.D. Treede ,&nbsp;H. Tost ,&nbsp;M. Ernst ,&nbsp;M. Beutel ,&nbsp;B. Stoffelns ,&nbsp;F. Zepp ,&nbsp;N. Pfeiffer ,&nbsp;A. Fieß","doi":"10.1016/j.jpsychores.2024.111943","DOIUrl":"10.1016/j.jpsychores.2024.111943","url":null,"abstract":"<div><div>Although the effect of early childhood stress on central nervous pain processing is well known, studies on the association of prematurity and chronic pain are scarce. This study used data from a single-centre retrospective cohort study followed by a prospective clinical examination and pain assessment. The study was based on data from the local birth registry. Newborns born between 1969 and 2002 who had reached adulthood were eligible .. Using a selection algorithm, a study cohort stratified by gestational age (GA) was recruited. Chronic pain conditions were assessed using questionnaire and standardized pain drawings. Data on the pre-, peri- and postnatal clinical course was assessed from medical records. Multivariable logistic regression analyses were conducted to investigate associations between prematurity and chronic pain with adjustment for age, gender, socioeconomic status, and perinatal stress factors. 427 participants born preterm and full-term were included (age 28.5 ± 8.7 years). Chronic pain conditions were similarly common between groups with different levels of prematurity (GA ≥ 37 weeks: 34.5 %, GA33-36 weeks: 37.6 %, GA32-29 weeks: 25.2 %, GA &lt; 29 weeks: 30.4 %, <em>p</em> = 0.20). In multivariable analyses, no association between low GA and the presence of chronic pain was found (OR = 0.99 (CI95 %: 0.94–1.04, <em>p</em> = 0.63); this was also true for a subanalysis of widespread pain. While neither fetal nutritional status nor perinatal stressors were associated with pain, exposure to maternal but not paternal smoking during pregnancy was associated with increased risk to develop pain (OR = 2.77 (CI95 %: 1.31–5.88, <em>p</em> = 0.008) in adults born preterm and full-term. This study suggests that prematurity by itself does not increase the risk of chronic pain later in life, but provides preliminary evidence for maternal smoking during pregnancy as risk factor.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111943"},"PeriodicalIF":3.5,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between depression, anxiety, and obesity in adolescent development","authors":"Masnurrima Heriansyah ,&nbsp;Nur Hidayah ,&nbsp;Fattah Hanurawan ,&nbsp;M. Ramli","doi":"10.1016/j.jpsychores.2024.111939","DOIUrl":"10.1016/j.jpsychores.2024.111939","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111939"},"PeriodicalIF":3.5,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}