Journal of Psychosomatic Research最新文献

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The impact of depression on risk of malignant glioma: A nationwide cohort study 抑郁症对恶性神经胶质瘤风险的影响:一项全国性队列研究。
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychores.2024.111982
Jin Eun , Yoo Hyun Um , Kyungdo Han , Won-Il Joo , Seung Ho Yang
{"title":"The impact of depression on risk of malignant glioma: A nationwide cohort study","authors":"Jin Eun ,&nbsp;Yoo Hyun Um ,&nbsp;Kyungdo Han ,&nbsp;Won-Il Joo ,&nbsp;Seung Ho Yang","doi":"10.1016/j.jpsychores.2024.111982","DOIUrl":"10.1016/j.jpsychores.2024.111982","url":null,"abstract":"<div><h3>Background</h3><div>Malignant glioma (MG) is a malignant brain tumor with a fatal prognosis. Depression is on the rise in society, and its negative association on prognosis of glioma patients is known. This study aimed to investigate the correlation between depression and MG risk by analyzing data from the Korean National Health Insurance System (NHIS).</div></div><div><h3>Methods</h3><div>A retrospective cohort study utilized NHIS data starting with 4,234,415 individuals aged 20 and above who had undergone health check-ups in 2009. Excluding 65,146 for cancer diagnosis, missing data, or a one-year lag period, 3,856,362 individuals were analyzed. Those diagnosed with depression per ICD-10 codes F32 or F33 before the check-ups formed the depression group, while the MG group was identified by ICD-10 code C71.</div></div><div><h3>Results</h3><div>Depression was found to have a significant association with glioma risk (hazard ratio 1.127, 95 % confidence interval 1.101–1.347), even with adjustment for age, sex, income, body-mass index (BMI), smoking, drinking, regular exercise, diabetes mellitus, hypertension and dyslipidemia. Furthermore, the severity of depression had a greater influence on MG incidence. Finally, subgroup analysis according to MG status revealed factors such as income, regular exercise, chronic kidney disease, and BMI to exhibit significant differences related to depression in the no-glioma group, but not in the glioma group.</div></div><div><h3>Conclusions</h3><div>These results suggest that depression may be associated with development of MG.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 111982"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First results from a multimodal psychosomatic post-COVID treatment approach - a prospective longitudinal study 第一个结果来自多模式心身治疗方法-一项前瞻性纵向研究。
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychores.2024.112021
Hanna Hofmann , Angela Fricke , Benjamin Krüger , Paul Köbler , Claudia Lanza , Stephan Zeiß , Jan Cernohorsky , Christine Hertle , Eva Krauss-Köstler , Peter Radermacher , Barbara Stein , Markus Müller , Christiane Waller
{"title":"First results from a multimodal psychosomatic post-COVID treatment approach - a prospective longitudinal study","authors":"Hanna Hofmann ,&nbsp;Angela Fricke ,&nbsp;Benjamin Krüger ,&nbsp;Paul Köbler ,&nbsp;Claudia Lanza ,&nbsp;Stephan Zeiß ,&nbsp;Jan Cernohorsky ,&nbsp;Christine Hertle ,&nbsp;Eva Krauss-Köstler ,&nbsp;Peter Radermacher ,&nbsp;Barbara Stein ,&nbsp;Markus Müller ,&nbsp;Christiane Waller","doi":"10.1016/j.jpsychores.2024.112021","DOIUrl":"10.1016/j.jpsychores.2024.112021","url":null,"abstract":"<div><h3>Background</h3><div>Clinical experiences using a psychosomatic-oriented multimodal treatment approach in patients with post-COVID are promising. We established a half-day multimodal treatment program for post-COVID patients at the Department of Psychosomatic Medicine at General Hospital Nuremberg, Paracelsus Medical University, Germany.</div></div><div><h3>Methods</h3><div>This observational study between January 2022 and March 2023 comprised baseline documentation of Patient Health Questionnaire (PHQ<img>D), ICD-10 Symptom Rating (ISR), Fatigue Scale (FS) and Health Status Questionnaire (SF-12) at admission and discharge of 65 patients suffering from post-COVID. Multimodal psychosomatic treatment was scheduled for 3–4 weeks.</div></div><div><h3>Results</h3><div>At admission, PHQ and FS showed a high level of somatic symptom burden (PHQ-15: <em>M</em> = 16.0, <em>SD</em> = 5.6) and fatigue symptoms (FS: <em>M</em> = 27.1, <em>SD</em> = 4.4). Depressive (PHQ-9: <em>M</em> = 14.0, <em>SD</em> = 5.3) and anxiety symptoms (GAD-7: <em>M</em> = 9.6, <em>SD</em> = 5.6) were moderately and mildly pronounced, respectively. Compared to patients from our standard clinical settings post-COVID patients had a comparably high or even higher mental symptom burden (e.g. PHQ-15: <em>p</em> &lt; .001, <em>d</em> = 0.79; PHQ-9: <em>p</em> = .009, <em>d</em> = 0.39). Compared to admission, symptomatology of post-COVID patients at discharge was improved (e.g. PHQ-15: <em>p</em> = .004, <em>d</em> = 0.26; FS: <em>p</em> = .009, <em>d</em> = 0.32).</div></div><div><h3>Conclusions</h3><div>Despite the short duration of treatment, the patients showed a significant reduction in symptoms between admission and discharge. Further data including a control group and extending the duration of treatment will show whether the changes in symptoms are of the multimodal psychosomatic treatment.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112021"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk of somatic symptom disorder in people with major medical disorders: Cross-sectional results from the population-based Hamburg City Health Study 主要医学疾病患者躯体症状障碍的风险:基于人群的汉堡市健康研究的横断面结果
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychores.2024.111997
Laura Buck , Luisa Peters , Kerstin Maehder , Friederike Hartel , Hanno Hoven , Volker Harth , Martin Härter , Bernd Löwe , Anne Toussaint
{"title":"Risk of somatic symptom disorder in people with major medical disorders: Cross-sectional results from the population-based Hamburg City Health Study","authors":"Laura Buck ,&nbsp;Luisa Peters ,&nbsp;Kerstin Maehder ,&nbsp;Friederike Hartel ,&nbsp;Hanno Hoven ,&nbsp;Volker Harth ,&nbsp;Martin Härter ,&nbsp;Bernd Löwe ,&nbsp;Anne Toussaint","doi":"10.1016/j.jpsychores.2024.111997","DOIUrl":"10.1016/j.jpsychores.2024.111997","url":null,"abstract":"<div><h3>Background</h3><div>Somatic Symptom Disorder (SSD) is characterized by excessive thoughts, emotions, and behaviors related to physical symptoms irrespective of their etiology. Estimates of SSD frequency assessed via self-report questionnaires range between 6.7% (general population) and 53% (specialized setting). This study aims to examine the frequency of risk of SSD and associated factors in people with Major Medical Disorders (MMD) using cross-sectional data from the population-based Hamburg City Health Study.</div></div><div><h3>Methods</h3><div>Risk of SSD was operationalized using the Somatic Symptom Scale-8, the Somatic Symptom Disorder-B Criteria Scale-12, and one item on symptom persistence. People at risk of SSD and not at risk were compared regarding biopsychosocial factors. Factors associated with risk of SSD were identified by hierarchical multiple logistic regression analysis.</div></div><div><h3>Results</h3><div><em>N</em> = 1944 people (mean age 64.8 ± 8 years, 43.8% female) reported at least one MMD. Of those, 6.8% [95%, CI 5.6–7.9%] were at risk of SSD and reported greater healthcare utilization and lower health-related quality of life. Logistic regression identified higher age (<em>p</em>=.032), lower education (<em>p</em>=.002), number of somatic comorbidities (<em>p</em>&lt;.001), and elevated neuroticism (<em>p</em>&lt;.001) and depression (<em>p</em>&lt;.001) scores as factors associated with risk of SSD, with an explained variance of Nagelkerke <em>R</em><sup>2</sup>=0.45.</div></div><div><h3>Conclusion</h3><div>The observed frequency of risk of SSD in people with MMD does not point towards an excessive symptom burden in this sample. However, those at risk experience significant psychosocial burdens and increased healthcare utilization, highlighting a vulnerable subgroup prone to SSD.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 111997"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personality matters: Exploring the associations of personality traits with mood and somatic symptoms in multiple sclerosis 人格问题:探讨多发性硬化症患者人格特质与情绪和躯体症状的关系。
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychores.2024.112022
Duygu Kuzu, Anna L. Kratz
{"title":"Personality matters: Exploring the associations of personality traits with mood and somatic symptoms in multiple sclerosis","authors":"Duygu Kuzu,&nbsp;Anna L. Kratz","doi":"10.1016/j.jpsychores.2024.112022","DOIUrl":"10.1016/j.jpsychores.2024.112022","url":null,"abstract":"<div><h3>Background</h3><div>Research suggest that personality traits influence the mood and somatic symptoms in various different clinical populations. Neuroticism, extraversion, conscientiousness, openness to experience, and agreeableness have been identified as potential predictors of mood and somatic symptoms. However, the literature on personality traits and symptom outcomes in multiple sclerosis (MS) is limited, highlighting the necessity for more in-depth research.</div></div><div><h3>Objective</h3><div>This Cross-sectional study aimed to investigate the association between personality traits and symptomatology in individuals with MS using two separate studies and different personality assessment tools– the NEO Five-Factor Inventory (NEO-FFI) and the Ten Item Personality Inventory (TIPI).</div></div><div><h3>Methods</h3><div>Participants completed surveys assessing mood and somatic symptoms. Linear regression analyses were performed to examine the associations between personality traits and MS symptoms controlling for demographic variables.</div></div><div><h3>Results</h3><div>.The analyses were performed on data from 63 individuals with MS for Study 1 (assessing the NEO-FFI) and 1183 individuals with MS for Study 2 (assessing the TIPI), respectively. Neuroticism was consistently associated with more somatic and mood symptoms in both sample (medium to large effect sizes; β = −0.05 to β = 0.60) Extraversion and conscientiousness were associated with fewer symptoms in Study 2.</div></div><div><h3>Conclusions</h3><div>This study highlights the importance of considering personality factors in understanding and managing symptoms in MS. However, further research is needed to understand the causal relationships between personality and symptom outcomes in MS.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"189 ","pages":"Article 112022"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing immunotherapy outcomes in advanced NSCLC: The role of sleep hygiene education and physical exercise as non-pharmacological interventions 提高晚期非小细胞肺癌的免疫治疗效果:睡眠卫生教育和体育锻炼作为非药物干预的作用
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2024-11-22 DOI: 10.1016/j.jpsychores.2024.111993
Sesilianus Fau , Erasma Fitilai Zalogo
{"title":"Enhancing immunotherapy outcomes in advanced NSCLC: The role of sleep hygiene education and physical exercise as non-pharmacological interventions","authors":"Sesilianus Fau ,&nbsp;Erasma Fitilai Zalogo","doi":"10.1016/j.jpsychores.2024.111993","DOIUrl":"10.1016/j.jpsychores.2024.111993","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"188 ","pages":"Article 111993"},"PeriodicalIF":3.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resilience, psychosomatic health, and support needs of Ukrainian healthcare professionals in wartime: A cross-sectional study 战时乌克兰医护人员的复原力、心身健康和支持需求:横断面研究。
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2024-11-20 DOI: 10.1016/j.jpsychores.2024.111995
Anastasiia Yuriivna Sydorenko , Lennart Kiel , Helle Spindler
{"title":"Resilience, psychosomatic health, and support needs of Ukrainian healthcare professionals in wartime: A cross-sectional study","authors":"Anastasiia Yuriivna Sydorenko ,&nbsp;Lennart Kiel ,&nbsp;Helle Spindler","doi":"10.1016/j.jpsychores.2024.111995","DOIUrl":"10.1016/j.jpsychores.2024.111995","url":null,"abstract":"<div><h3>Background</h3><div>As Ukraine enters its third year of war, healthcare professionals (HPs) continue to face ongoing challenges to their adaptability and resilience. This study aimed to assess the emotional and physical well-being of HPs, evaluate their resilience levels, and identify the most anticipated types of psychological support that would benefit them.</div></div><div><h3>Methods</h3><div>Emotional and somatic states were assessed using the Hospital Anxiety and Depression Scale (HADS) and the Patient Health Questionnaire (PHQ-15). Resilience was measured by the Connor-Davidson Resilience Scale (CD-RISC-10). Open-ended questions were used to identify anticipated measures of psychological support.</div></div><div><h3>Results</h3><div>A total of 1442 HPs participated in the study. The majority exhibited high levels of anxiety and depression. Resilience scores showed negative correlations with anxiety (<em>r</em> = −0.34), depression (<em>r</em> = −0.53), and somatic symptom severity (<em>r</em> = −0.36). The most desired types of psychological support included psychological counselling, spiritual support, and opportunities for rest.</div></div><div><h3>Conclusion</h3><div>It is essential to address the primary needs of HPs in Ukraine to support their professional and personal resilience during wartime. Psychological support should not only focus on treating symptoms and distress but also respond to deeper needs that foster hope and faith in a better future.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"188 ","pages":"Article 111995"},"PeriodicalIF":3.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heart rate variability is not associated with multiple chemical sensitivity in a cross-sectional population-based study - The Danish study of functional disorders 在一项基于人群的横断面研究中,心率变异性与多重化学物质敏感性无关--丹麦功能性紊乱研究。
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2024-11-19 DOI: 10.1016/j.jpsychores.2024.111992
Anne Ahrendt Bjerregaard , Louise Brinth , Marie W. Petersen , Signe U. Schovsbo , Lene Eplov , Susanne Brix , Allan Linneberg , Lise Gormsen , Torben Jørgensen , Thomas M. Dantoft
{"title":"Heart rate variability is not associated with multiple chemical sensitivity in a cross-sectional population-based study - The Danish study of functional disorders","authors":"Anne Ahrendt Bjerregaard ,&nbsp;Louise Brinth ,&nbsp;Marie W. Petersen ,&nbsp;Signe U. Schovsbo ,&nbsp;Lene Eplov ,&nbsp;Susanne Brix ,&nbsp;Allan Linneberg ,&nbsp;Lise Gormsen ,&nbsp;Torben Jørgensen ,&nbsp;Thomas M. Dantoft","doi":"10.1016/j.jpsychores.2024.111992","DOIUrl":"10.1016/j.jpsychores.2024.111992","url":null,"abstract":"<div><h3>Objective</h3><div>Multiple chemical sensitivity (MCS), a functional somatic disorder (FSD), is a multisystem, polysymptomatic disease, characterized by various individual symptoms attributed to low level of volatile chemical exposures. Symptoms relate to the autonomic nerve system (ANS) among others which is mandatory in the MCS delimitations. An accepted measure of ANS is heart rate variability (HRV). The aim was to explore associations between HRV and MCS in the general Danish population.</div></div><div><h3>Methods</h3><div>In the Danish Study of Functional Disorders, 7493 adults filled in questionnaires and participated in a physical health examination (2012–2015). The “E motion” heart rate monitor device assessed time and frequency measures of HRV. For this study, 143 were categorized with MCS of which, 84 were subcategorized as MCS without comorbid FSD. The remaining population (<em>n</em> = 5525) was used as comparison group. Logistic regression models to assess odds ratio (OR) with 95 % confidence intervals (95 % CI) of MCS, and MCS without comorbid FSD for each HRV exposure adjusted for age, sex, and chronic stress.</div></div><div><h3>Results</h3><div>Compared to the general population, median resting heart rate was higher (64.7 vs 63.1 bpm, <em>p</em> = 0.007) and median normal-to-normal intervals was lower (930 vs 952 ms, p = 0.007) in MCS individuals. Resting heart rate was associated with MCS (OR: 1.019, 95 %CI: 1.003; 1.037); but not after adjustment for chronic stress. No other associations with other HRV measures nor in MCS without comorbid FSD were found.</div></div><div><h3>Conclusion</h3><div>HRV was not associated with MCS. The magnitude of the differences between groups was small and of uncertain clinical significance.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"188 ","pages":"Article 111992"},"PeriodicalIF":3.5,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolomics profiling of Type D personality traits D 型人格特征的代谢组学分析。
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2024-11-19 DOI: 10.1016/j.jpsychores.2024.111994
Ruifang Li-Gao , Mariska Bot , Alexander Kurilshikov , Gonneke Willemsen , Marleen M.J. van Greevenbroek , Miranda M.T. Schram , Coen D.A. Stehouwer , Jingyuan Fu , Alexandra Zhernakova , Brenda W.J.H. Penninx , Eco J.C. De Geus , Dorret I. Boomsma , Nina Kupper , for the BBMRI-NL Metabolomics Consortium
{"title":"Metabolomics profiling of Type D personality traits","authors":"Ruifang Li-Gao ,&nbsp;Mariska Bot ,&nbsp;Alexander Kurilshikov ,&nbsp;Gonneke Willemsen ,&nbsp;Marleen M.J. van Greevenbroek ,&nbsp;Miranda M.T. Schram ,&nbsp;Coen D.A. Stehouwer ,&nbsp;Jingyuan Fu ,&nbsp;Alexandra Zhernakova ,&nbsp;Brenda W.J.H. Penninx ,&nbsp;Eco J.C. De Geus ,&nbsp;Dorret I. Boomsma ,&nbsp;Nina Kupper ,&nbsp;for the BBMRI-NL Metabolomics Consortium","doi":"10.1016/j.jpsychores.2024.111994","DOIUrl":"10.1016/j.jpsychores.2024.111994","url":null,"abstract":"<div><h3>Objective</h3><div>Type D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an increased risk of cardiometabolic diseases. Here, we examined the association of Type D traits with 230 (predominantly) lipid metabolites and metabolite ratios.</div></div><div><h3>Methods</h3><div>Four Dutch cohorts were included, comprising 10,834 individuals. Type D personality traits were measured by self-report questionnaires. A proton nuclear magnetic resonance (NMR) metabolomics platform provided 149 absolute measures (98 belonging to lipoprotein subclasses) and 81 derived ratios. For all, linear regression analyses were performed within each cohort, followed by random-effects meta-analyses. A per-measure FDR q-value&lt;0.05 was set as a study-wise significant association.</div></div><div><h3>Results</h3><div>SI was significantly associated with a lower omega-3 fatty acids to total fatty acids (FAw3.FA%) ratio, and a lower free cholesterol to total lipids ratio in very small VLDL (XS.VLDL.FC%). FAw3.FA% was also associated to NA (no study-wise significance though). NA showed a suggestive replication (<em>p</em>-value&lt;.05) of the previous reported associations with depression for 5 out of 18 metabolites from the same metabolomics platform: triglycerides in HDL, serum total triglycerides, VLDL cholesterol, mean diameter for VLDL particles and VLDL triglycerides.</div></div><div><h3>Conclusions</h3><div>In this large meta-analysis, SI was associated with omega-3 fatty acids to total fatty acids ratio, which is suggestive of lower omega-3 fatty acid intake. Only some metabolite biomarkers showed tentative links to Type D and NA. In sum, it seems that there are no major alterations in lipid metabolism associated with Type D traits.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"188 ","pages":"Article 111994"},"PeriodicalIF":3.5,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and metabolic correlates of DSM-5 mixed features in subjects with bipolar depression and mania: A cross-sectional study 双相抑郁和躁狂症患者中 DSM-5 混合特征的临床和代谢相关性:横断面研究
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2024-11-18 DOI: 10.1016/j.jpsychores.2024.111990
Francesco Bartoli, Daniele Cavaleri, Tommaso Callovini, Dario Palpella, Susanna Piacenti, Cristina Crocamo, Giuseppe Carrà, NOMIAC Investigators
{"title":"Clinical and metabolic correlates of DSM-5 mixed features in subjects with bipolar depression and mania: A cross-sectional study","authors":"Francesco Bartoli,&nbsp;Daniele Cavaleri,&nbsp;Tommaso Callovini,&nbsp;Dario Palpella,&nbsp;Susanna Piacenti,&nbsp;Cristina Crocamo,&nbsp;Giuseppe Carrà,&nbsp;NOMIAC Investigators","doi":"10.1016/j.jpsychores.2024.111990","DOIUrl":"10.1016/j.jpsychores.2024.111990","url":null,"abstract":"<div><h3>Objective</h3><div>Evidence on the clinical and metabolic characterization of mixed features (MFs) in bipolar disorder (BD) is limited. We performed a cross-sectional study analyzing clinical and metabolic correlates of MFs in people with bipolar depression or mania/hypomania.</div></div><div><h3>Methods</h3><div>We included people with BD consecutively admitted for inpatient treatment from May 2020 to July 2023 as part of the Northern Milan Area Cohort (NOMIAC) project. The SCID-5 was used to confirm the diagnosis and assess DSM-5 specifiers. Young Mania Rating Scale and Montgomery-Åsberg Depression Rating Scale were used to measure symptom severity. Information on socio-demographic, clinical, and metabolic conditions – including obesity, diabetes, hypertension, dyslipidemia, and hypothyroidism – were collected. Multiple logistic regression models were used to compare clinical and metabolic correlates between subjects with and without DSM-5 MFs.</div></div><div><h3>Results</h3><div>We included 163 inpatients with BD (111 admitted for a manic/hypomanic episode and 52 for a major depressive episode), 39 of whom with MFs. The overall logistic regression model showed that MFs were associated with anxious distress (z = 2.44; <em>p</em> = 0.015) and obesity (z = 2.39; <em>p</em> = 0.017), also being less frequent among moderately/markedly ill people as compared with those borderline/mildly ill (z = −2.71; <em>p</em> = 0.007). Additional analyses corroborated the association between MFs and these characteristics in people with a depressive episode, though not in those with mania/hypomania.</div></div><div><h3>Conclusion</h3><div>Notwithstanding some limitations, our study provides additional insight into the characterization of individuals with MFs, highlighting that anxious distress and symptom severity, along with obesity, may represent core features helpful for the assessment and management of MFs in BD.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"188 ","pages":"Article 111990"},"PeriodicalIF":3.5,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strengthening cancer-spirituality research: A comprehensive analysis of methodological considerations in biomarker studies 加强癌症-精神研究:全面分析生物标志物研究中的方法考虑因素。
IF 3.5 2区 医学
Journal of Psychosomatic Research Pub Date : 2024-11-17 DOI: 10.1016/j.jpsychores.2024.111991
Mahindra Bandari , Cindy Osei , Manisha Bandari
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