Journal of Psychosomatic Research最新文献

{"title":"Development of predictive model for post-stroke depression at discharge based on decision tree algorithm: A multi-center hospital-based cohort study","authors":"Guo Li ,&nbsp;Jinfeng Miao ,&nbsp;Ping Jing ,&nbsp;Guohua Chen ,&nbsp;Junhua Mei ,&nbsp;Wenzhe Sun ,&nbsp;Yan Lan ,&nbsp;Xin Zhao ,&nbsp;Xiuli Qiu ,&nbsp;Ziqin Cao ,&nbsp;Shanshan Huang ,&nbsp;Zhou Zhu ,&nbsp;Suiqiang Zhu","doi":"10.1016/j.jpsychores.2024.111942","DOIUrl":"10.1016/j.jpsychores.2024.111942","url":null,"abstract":"<div><h3>Objective</h3><div>Post-stroke depression (PSD) is one of the most common and severe neuropsychological sequelae after stroke. Using a prediction model composed of multiple predictors may be more beneficial than verifying the predictive performance of any single predictor. The primary objective of this study was to construct practical prediction tools for PSD at discharge utilizing a decision tree (DT) algorithm.</div></div><div><h3>Methods</h3><div>A multi-center prospective cohort study was conducted from May 2018 to October 2019 and stroke patients within seven days of onset were consecutively recruited. The independent predictors of PSD at discharge were identified through multivariate logistic regression with backward elimination. Classification and regression tree (CART) algorithm was employed as the DT model's splitting method.</div></div><div><h3>Results</h3><div>A total of 876 stroke patients who were discharged from the neurology departments of three large general Class A tertiary hospitals in Wuhan were eligible for analysis. Firstly, we divided these 876 patients into PSD and non-PSD groups, history of coronary heart disease (OR = 1.835; 95 % CI, 1.106–3.046; <em>P</em> = 0.019), length of hospital stay (OR = 1.040; 95 % CI, 1.013–1.069; <em>P</em> = 0.001), NIHSS score (OR = 1.124; 95 % CI, 1.052–1.201; <em>P</em> = 0.001), and Mini mental state examination (MMSE) score (OR = 0.935; 95 % CI, 0.893–0.978; <em>P</em> = 0.004) were significant predictors. The subgroup analysis results have shown that hemorrhagic stroke, history of hypertension and higher modified Rankin Scale score (mRS) score were associated with PSD at discharge in the young adult stroke patients.</div></div><div><h3>Conclusions</h3><div>Several predictors of PSD at discharge were identified and convenient DT models were constructed to facilitate clinical decision-making.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111942"},"PeriodicalIF":3.5,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on ‘Mechanisms of psycho-behavioural mindfulness intervention (MCARE) on depressive and anxiety symptoms in patients with acute coronary syndrome: A longitudinal mediation analysis’","authors":"Rikas Saputra ,&nbsp;Isnaria Rizki Hayati ,&nbsp;Yenni Lidyawati ,&nbsp;Rizky Andana Pohan ,&nbsp;Erfan Ramadhani ,&nbsp;Ramtia Darma Putri ,&nbsp;Kadek Suhardita","doi":"10.1016/j.jpsychores.2024.111941","DOIUrl":"10.1016/j.jpsychores.2024.111941","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111941"},"PeriodicalIF":3.5,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142320249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between overweight and varying degrees of obesity with subjective well-being and depressive symptoms: A two sample Mendelian randomization study","authors":"Xinxin Luo ,&nbsp;Zhichao Ruan ,&nbsp;Ling Liu","doi":"10.1016/j.jpsychores.2024.111940","DOIUrl":"10.1016/j.jpsychores.2024.111940","url":null,"abstract":"<div><h3>Objective</h3><div>This study utilized the Mendelian randomization (MR) method to elucidate the causal relationship between genetically predicted overweight and various degrees of obesity with depressive symptoms and subjective well-being (SWB).</div></div><div><h3>Methods</h3><div>Pooled genome-wide association studies (GWAS) data for overweight (BMI ≥ 25 kg/m²), class 1 obesity (BMI ≥ 30 kg/m²), and class 2 obesity (BMI ≥ 35 kg/m²) were used as exposures. Summary GWAS data for depressive symptoms and SWB were used as outcomes. Multiple MR methods, primarily inverse-variance weighted (IVW), were applied, and sensitivity analyses were conducted to assess heterogeneity and pleiotropy.</div></div><div><h3>Results</h3><div>The MR analysis provided evidence that genetically predicted overweight(IVW β = 0.033; 95 %CI 0.008–0.057; <em>P</em> = 0.010) and class 1 obesity(IVW β = −0.033; 95 %CI -0.047 – -0.020; <em>P</em> &lt; 0.001) were causally associated with increased depressive symptoms. Genetically predicted class 2 obesity(IVW β = 1.428; 95 %CI 1.193–1.710; <em>P</em> &lt; 0.001) were associated with reduced SWB. There was no strong evidence of a causal association between genetically predicted overweight and class 1 obesity with SWB. Similarly, genetically predicted class 2 and class 3 obesity did not show strong evidence of a causal association with depressive symptoms. Sensitivity analysis revealed relationships of a similar magnitude.</div></div><div><h3>Conclusion</h3><div>This genetically informed MR study suggests that Overweight and class 1 obesity may causally increased depressive symptoms but not decrease SWB. In contrast, class 2 obesity may causally decrease SWB but not increase depressive symptoms.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111940"},"PeriodicalIF":3.5,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of psychological interventions on clinical outcomes in patients with cardiovascular diseases: A systematic review and meta-analysis","authors":"Yangfan Nie ,&nbsp;Naijuan Wang ,&nbsp;Meixuan Chi ,&nbsp;Anan Li ,&nbsp;Siying Ji ,&nbsp;Zhaoying Zhu ,&nbsp;Shan Li ,&nbsp;Yunying Hou","doi":"10.1016/j.jpsychores.2024.111938","DOIUrl":"10.1016/j.jpsychores.2024.111938","url":null,"abstract":"<div><h3>Objective</h3><div>To perform a systematic review and meta-analysis to evaluate the effects of psychological interventions on the clinical outcomes of patients with cardiovascular diseases (CVDs).</div></div><div><h3>Methods</h3><div>We searched PubMed, Web of Science, Embase, the Cochrane Library, and CINAHL from the establishment of each database to August 1, 2023. Randomized controlled trials (RCTs) on psychological interventions in patients with CVDs were included. Statistical analyses were performed using Review Manager 5.3 and Stata 17.0, and pooled measures were presented as the relative risk (RR) and 95 % confidence interval (CI).</div></div><div><h3>Results</h3><div>A total of 32 studies were included, involving 15,814 patients. Our results showed that psychological interventions could reduce cardiac mortality (RR = 0.81, 95 % CI = 0.68 to 0.96) and the occurrence of myocardial infarction (MI) (RR = 0.79, 95 % CI = 0.69 to 0.89), arrhythmia (RR = 0.61, 95 % CI = 0.42 to 0.89) and angina (RR = 0.92, 95 % CI = 0.87 to 0.97). However, no statistically significant differences were detected in the risk of all-cause mortality, all-cause rehospitalization rates, cardiac rehospitalization rates, revascularization, heart failure (HF), or stroke between the psychological intervention and control groups.</div></div><div><h3>Conclusions</h3><div>Psychological interventions can reduce cardiac mortality and the occurrence of MI, arrhythmia, and angina in patients with CVDs. It is crucial to incorporate psychological interventions into the existing treatment and management of patients with CVDs. High-quality RCTs should be conducted to explore the optimal psychological intervention methods and the maximum beneficiaries.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111938"},"PeriodicalIF":3.5,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate change anxiety and its association with somatic symptom distress and idiopathic environmental intolerances: A cross-sectional study","authors":"V. Pitron ,&nbsp;C. Lemogne ,&nbsp;S. Clayton ,&nbsp;D. Léger ,&nbsp;O. Van den Bergh ,&nbsp;M. Witthöft","doi":"10.1016/j.jpsychores.2024.111937","DOIUrl":"10.1016/j.jpsychores.2024.111937","url":null,"abstract":"<div><h3>Context</h3><p>Individuals need greater climate change awareness in order to mitigate and adapt to climate changes but this awareness can lead to negative health outcomes including climate change anxiety.</p></div><div><h3>Objective</h3><p>To explore the associations between climate change anxiety, idiopathic environmental intolerances and somatic symptom distress, after accounting for modern health worries, anxiety and depression.</p></div><div><h3>Methods</h3><p>A non-representative sample of healthy volunteers completed a cross-sectional online survey that included the Climate Change Anxiety scale (CCA-13), single questions about idiopathic intolerance to five environmental agents, the Somatic Symptoms scale (SSS-8), the Modern Health Worries scale (MHW-12), and the Patient Health Questionnaire for symptoms of anxiety and depression (PHQ-4). Participants also reported their sex, age and subjective socioeconomic status. Bivariate analyses investigated associations between variables and path analyses explored potential mediating factors.</p></div><div><h3>Results</h3><p>432 participants completed the questionnaire, 421 of whom were included in analyses (67 % women, mean age: 32.7 standard deviation: 12.4). Climate change anxiety, idiopathic environmental intolerances, somatic symptom distress, modern health worries, and symptoms of anxiety and depression were positively correlated in bivariate analyses (Pearson's ranging from 0.22 to 0.57, all <em>p</em> &lt; 0.001). In path analyses, modern health worries (R² = 9.9 %) partially mediated the relation between climate change anxiety (R² = 20.3 %) and two correlated outcome variables, idiopathic environmental intolerances (R² = 36.8 %) and somatic symptom distress (R² = 32.4 %).</p></div><div><h3>Conclusions</h3><p>Climate change anxiety may negatively affect perceived physical health. Stakeholders should aim at promoting climate change awareness while addressing modern health worries to avoid negative health outcomes.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111937"},"PeriodicalIF":3.5,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ability of peripheral neurophysiological biomarkers to predict future psychological conditions among geriatric populations","authors":"Wei-Chia Huang ,&nbsp;Chi-Shin Wu ,&nbsp;Kai-Chieh Chang ,&nbsp;Hsin-Shui Chen ,&nbsp;Chin-Kai Chang ,&nbsp;Juey-Jen Hwang ,&nbsp;Su-Hua Huang ,&nbsp;Yung-Ming Chen ,&nbsp;Bor-Wen Cheng ,&nbsp;Min-Hsiu Weng ,&nbsp;Chih-Cheng Hsu ,&nbsp;Wei-Lieh Huang","doi":"10.1016/j.jpsychores.2024.111936","DOIUrl":"10.1016/j.jpsychores.2024.111936","url":null,"abstract":"<div><h3>Objective</h3><p>Though the association between peripheral neurophysiological biomarkers and psychological conditions is widely discussed, there is still limited evidence about the ability of peripheral biomarkers to predict psychological outcomes, especially among geriatric populations.</p></div><div><h3>Methods</h3><p>The study is designed as a prospective cohort study. We collected information from participants aged over 55 years. The participants were evaluated at the start of the study (T0) and 6–9 months later (T1). Information about demographic profiles, peripheral neurophysiological biomarker recordings (including heart rate variability, finger temperature, skin conductance, and electromyogram), and psychological measurements (including Brief Symptom Rating Scale-5, Chinese Happiness Inventory, and Short Portable Mental Status Questionnaire) were collected at T0. At T1, participants reported self-rated questionnaires for psychological outcomes (Patient Health Questionnaire-15, health anxiety questionnaire, Beck Depression Inventory-II, and Beck Anxiety Inventory) and were evaluated with Mini-Mental State Examination by the staff. The association between the peripheral biomarkers and psychological outcomes was evaluated via multiple regression models.</p></div><div><h3>Results</h3><p>A total of 385 participants were included in the study and the average age was 74.49 ± 7.34 years. Both stepwise multiple linear and logistic models showed a significant association between decreased skin conductance and increased/presence of depression at T1. The receiver operating characteristic (ROC) curve analysis of skin conductance for depression was fair (area under curve = 0.812).</p></div><div><h3>Conclusions</h3><p>The ability of skin conductance to predict depression among geriatric populations may facilitate the detection of geriatric depression and future research on the pathophysiology.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111936"},"PeriodicalIF":3.5,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor stress resilience in adolescence predicts higher risk of severe COVID-19 and other respiratory infections: A prospective cohort study of 1.4 million Swedish men","authors":"Agnes af Geijerstam ,&nbsp;Monica Hunsberger ,&nbsp;Kirsten Mehlig ,&nbsp;Jenny Nyberg ,&nbsp;Margda Waern ,&nbsp;Maria Åberg ,&nbsp;Lauren Lissner","doi":"10.1016/j.jpsychores.2024.111935","DOIUrl":"10.1016/j.jpsychores.2024.111935","url":null,"abstract":"<div><h3>Objectives</h3><p>To investigate the associations between stress resilience in late adolescence and later risk of severe COVID-19 and other lower respiratory infections. A secondary aim was to examine potential confounding between low cardiorespiratory fitness (CRF) and stress resilience in relation to respiratory infection.</p></div><div><h3>Methods</h3><p>We conducted a registry-based cohort study of 1.4 million Swedish men, undergoing military conscription between 1968 and 2005. All were assessed by a psychologist for stress resilience, receiving a score between 1 and 9. The outcomes were hospitalization or death due to COVID-19 from March 2020 to September 2021 and hospitalization due to bacterial or viral pneumonia from conscription until January 2020. A secondary aim was to examine potential confounding between low cardiorespiratory fitness (CRF) and stress resilience in relation to respiratory infection.</p></div><div><h3>Results</h3><p>Poor stress resilience in late adolescence is associated with later risk of severe lower respiratory infections. Using a high resilience score as the reference, the hazard ratio (95 % CI) for death due to COVID-19 for the lowest scores was 1.49 (1.01–2.18) adjusted for CRF and other confounders. The corresponding adjusted hazard ratios for hospitalization due to bacterial pneumonia were 2.28 (2.03–2.57) and for viral pneumonia 1.92 (1.33–2.79). No significant interaction was seen between stress resilience and CRF in the analysis.</p></div><div><h3>Conclusions</h3><p>Poor stress resilience is a prospective factor for severe COVID-19 as well as for bacterial and viral respiratory pneumonia endpoints, independent of CRF. These findings imply an effect of late adolescent stress resilience on the immune system later in life.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111935"},"PeriodicalIF":3.5,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022399924003477/pdfft?md5=96e8e11d53f73e5989f7cc7982194c7f&pid=1-s2.0-S0022399924003477-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The bowel function instrument for rectal cancer survivors with anastomosis and ostomy","authors":"Salene M.W. Jones,&nbsp;Katherine A. Guthrie,&nbsp;Kathryn Arnold,&nbsp;Robert Krouse","doi":"10.1016/j.jpsychores.2024.111931","DOIUrl":"10.1016/j.jpsychores.2024.111931","url":null,"abstract":"<div><h3>Objective</h3><div>Rectal cancer is often treated with surgery such as ostomy or anastomosis. The Bowel Function Instrument (BFI) is a valid and reliable 18-item measure of physical bowel symptoms. Some items on the BFI do not apply to those with ostomies. We reanalyzed data from a previous validation study to inform the best method for scoring the BFI for both people with ostomies and anastomosis.</div></div><div><h3>Methods</h3><div>People (<em>n</em> = 575) with rectal cancer treated with ostomy (<em>n</em> = 181, 31 %) or anastomosis (<em>n</em> = 394, 69 %) completed the BFI and Short Form 12 (SF12) measure on a mailed survey. The full BFI has three subscales and a total score based on 14 items: soilage/urgency (4 items); frequency of bowel movements (6 items); and dietary changes (4 items). We used confirmatory factor analysis (CFA) to examine two versions (8-item, 11-item) of the BFI adapted for use with both ostomy and anastomosis. We also examined reliability and validity of the version supported by the <span>CFA</span>.</div></div><div><h3>Results</h3><div>CFA results supported the 8-item BFI that included only the soilage/urgency items and dietary changes items but not the frequency items. The 8-item BFI was reliable (Cronbach's alpha of 0.788). The 8-item BFI score significantly correlated with all SF12 subscales with Pearson correlations ranging from 0.115 (Vitality) to 0.318 (social function).</div></div><div><h3>Conclusions</h3><div>The 8-item version of the BFI was valid and reliable as a total score for people with ostomy or anastomosis. The 8-item BFI may be useful for monitoring bowel function during and after treatment for rectal cancer.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111931"},"PeriodicalIF":3.5,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse childhood experiences and psychiatric comorbidity in multiple sclerosis, inflammatory bowel disease, and rheumatoid arthritis in the Canadian longitudinal study on aging","authors":"Julia O'Mahony ,&nbsp;Charles N. Bernstein ,&nbsp;Ruth Ann Marrie","doi":"10.1016/j.jpsychores.2024.111893","DOIUrl":"10.1016/j.jpsychores.2024.111893","url":null,"abstract":"<div><h3>Objectives</h3><p>Adverse childhood experiences (ACE) are associated with immune-mediated inflammatory diseases (IMID). We evaluated whether: (i) ACE associate with psychiatric comorbidity among individuals with IMID, including rheumatoid arthritis (RA), multiple sclerosis (MS), and inflammatory bowel disease (IBD); (ii) whether psychiatric disorders mediate the relationship between ACE and IMID; and (iii) whether these findings differ from those in individuals with other chronic physical disorders.</p></div><div><h3>Methods</h3><p>Using data from the Canadian Longitudinal Study on Aging (CLSA) we performed a retrospective case-control study of participants aged 45–85 years recruited between 2010 and 2015. ACE were queried using questions derived from the Childhood Experiences of Violence Questionnaire-Short Form and the National Longitudinal Study of Adolescent to Adult Health Wave III questionnaire. We used multivariable logistic regression and causal mediation analysis to address our objectives.</p></div><div><h3>Results</h3><p>We included 13,977 CLSA participants. Among the 31 % of IMID participants who reported a comorbid psychiatric disorder, 79 % reported a history of ACE. ACE associated with increased odds (OR [95 % CI]) of a psychiatric disorder (2.55 [1.02–6.35]) among participants with IMID; this did not differ across IMID. The total effect (OR [95 % CI]) of ACE on IMID was 1.11 (1.07–1.16), of which 10.60 % (8.04–17.47) was mediated by psychiatric disorders. We found similar associations among participants with other chronic physical disorders.</p></div><div><h3>Conclusion</h3><p>Our findings suggest that psychiatric disorders partially mediate the association between ACE and IMID. Most participants with IMID and comorbid psychiatric disorders report a history of ACE and may benefit from trauma-informed mental health care.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111893"},"PeriodicalIF":3.5,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022399924003052/pdfft?md5=8870d2d1c82cfd83a3e2a53504baf83a&pid=1-s2.0-S0022399924003052-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connecting the dots: Network structures of internalizing and functional symptoms in a population-based cohort","authors":"Urvi Saini ,&nbsp;Judith G.M. Rosmalen ,&nbsp;Albertine J. Oldehinkel ,&nbsp;Hanna M. van Loo","doi":"10.1016/j.jpsychores.2024.111932","DOIUrl":"10.1016/j.jpsychores.2024.111932","url":null,"abstract":"<div><h3>Objective</h3><p>Comorbidities between internalizing disorders (IDs) and functional disorders (FDs) are well-documented, indicating shared pathways. However, their symptom-level relationships have been largely unexplored. This exploratory study employs a network approach to investigate symptoms of major depressive disorder (MDD), generalized anxiety disorder (GAD), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), and irritable bowel syndrome (IBS) to identify bridge symptoms explaining comorbidity between the two domains.</p></div><div><h3>Methods</h3><p>We used cross-sectional data on 72,919 adult subjects from the Lifelines Cohort Study, a Dutch general population sample. A total of 38 symptoms representing diagnostic criteria of IDs and FDs were assessed with validated questionnaires. Network models were estimated using eLasso, based on the Ising model, to identify bridge symptoms. The Network Comparison Test (NCT) was used to test whether there were differences in network structure and strength across sex and age.</p></div><div><h3>Results</h3><p>Symptoms were moderately connected, with a network density of 52.7%. ID and FD symptoms clustered in their respective domains, but were connected through the bridge symptoms, fatigue, difficulty concentrating, trouble sleeping, and unrefreshing sleep. Fatigue and difficulty concentrating had the most connections, associated with 86.6% and 78.9% of the other symptoms, respectively. NCTs indicated no differences in network connectivity between females versus males or younger versus older adults (&gt;50 years).</p></div><div><h3>Conclusions</h3><p>ID and FD symptoms are moderately interconnected. Bridge symptoms displaying strong connections to multiple disorders may play a central role in the mechanisms underpinning the comorbidity between IDs and FDs.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111932"},"PeriodicalIF":3.5,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022399924003441/pdfft?md5=eec1874c88390a039d4d3ffb8d888913&pid=1-s2.0-S0022399924003441-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}