Journal of Psychosomatic Research最新文献

{"title":"Further insights in the relationship between religiosity and telomere length","authors":"Juliane Piasseschi de Bernardin Gonçalves , Thais Chile , Vanessa J.R. de Paula , Marcus Zulian Teixeira , Salma Rose Ribeiz , Martin Schalling , Geraldo Busatto Filho , Giancarlo Lucchetti , Homero Vallada","doi":"10.1016/j.jpsychores.2026.112517","DOIUrl":"10.1016/j.jpsychores.2026.112517","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112517"},"PeriodicalIF":3.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145928538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke mortality in patients with mental health disorders; a cohort study from the Spanish hospital discharge records","authors":"Luis Ayerbe ,&nbsp;Enrique Barbero-Pablos ,&nbsp;Quintí Foguet-Boreu ,&nbsp;María Pérez-Piñar ,&nbsp;Salma Ayis","doi":"10.1016/j.jpsychores.2026.112534","DOIUrl":"10.1016/j.jpsychores.2026.112534","url":null,"abstract":"<div><h3>Introduction</h3><div>Evidence on the clinical outcomes of stroke for patients with psychiatric disorders is poor. It is also unclear if the prognosis of stroke has improved over the last two decades for those with mental health conditions. The aims of this study are first, to compare the hospital mortality between 2019 and 2023 of stroke for patients with and without depression, anxiety, schizophrenia, bipolar, or personality disorders, and second, to investigate whether the stroke mortality in 2019–2023 is lower than in 2005–2009, for those with psychiatric conditions.</div></div><div><h3>Methods</h3><div>Data from all stroke patients registered in the Spanish Hospital Discharge Records were used. The variables registered for each patient include sociodemographics, mortality, and up to 20 diagnoses of past medical history. Multivariable logistic regression models were used in the analyses.</div></div><div><h3>Results</h3><div>Between 2019 and 2023, 311528 patients were registered, of which, 14.40% died. Mortality of ischaemic stroke was higher for patients with schizophrenia OR(CI): 1.63(1. 30-2.04), bipolar OR(CI): 1.39(1. 10-1.77), or personality disorders OR(CI): 1.54(1. 13-2.09). The mortality of haemorrhagic stroke was increased for patients with schizophrenia OR(CI): 1.69(1. 29-2.23). There was a significant reduction in mortality of ischaemic and haemorrhagic stroke, for the whole population, between 2005 and 2009 and 2019–2023. There was no significant reduction in mortality of ischaemic stroke, for those with depression, anxiety, schizophrenia, bipolar, or personality disorders. There was no significant reduction in mortality of haemorrhagic stroke for patients with depression, schizophrenia, or bipolar disorders.</div></div><div><h3>Conclusion</h3><div>Psychiatric disorders are associated with higher stroke mortality, that has not declined between 2005 and 2009 and 2019–2023.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112534"},"PeriodicalIF":3.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personality disorders in patients with fibromyalgia","authors":"Eli Magen ,&nbsp;Akim Geishin ,&nbsp;Abraham Weizman ,&nbsp;Israel Magen ,&nbsp;Eugene Merzon ,&nbsp;Shai Ashkenazi ,&nbsp;Shlomo Vinker ,&nbsp;Ariel Israel","doi":"10.1016/j.jpsychores.2026.112536","DOIUrl":"10.1016/j.jpsychores.2026.112536","url":null,"abstract":"<div><h3>Background</h3><div>Fibromyalgia (FM) frequently co-occurs with mental disorders, but population-scale estimates for personality disorders (PDs) and cluster-specific patterns over extended horizons are limited. We quantified cross-sectional prevalence and 20-year cumulative incidence of recorded PD diagnoses in FM versus matched controls, and assessed the impact of diagnostic opportunity.</div></div><div><h3>Methods</h3><div>We performed a retrospective matched-cohort study within a nationwide Israeli health system. Adults with FM (<em>N</em> = 15,869) were matched 1:5 to controls (<em>N</em> = 79,345) on sex, age, and enrollment year. Outcomes were ICD-10 PD codes (F60–F61; ancillary F63–F69). Cross-sectional prevalence at baseline and end-of-follow-up was compared using conditional logistic regression (odds ratios [ORs], 95% CIs) with false-discovery-rate. Among participants PD-free at baseline, 20-year cumulative incidence (“risk”) was estimated with risk differences (RD, percentage points) and risk ratios (RR) using Wilson and log-Wald intervals. A surveillance-calibrated sensitivity analysis scaled RRs by the FM:control psychiatry-visit ratio to approximate adjusted RRs (aRRs).</div></div><div><h3>Results</h3><div>At baseline, any PD was more prevalent in FM than controls (1.84% vs 0.49%; OR 3.79, 95% CI 3.26–4.42; q &lt; 0.001), with pronounced elevations in Cluster B—especially borderline PD (F60.31)—and smaller signals in Cluster C (avoidant, F60.6). At the end of follow-up, contrasts persisted or strengthened (any PD 2.85% vs 0.57%; OR 5.11, 4.48–5.82; q &lt; 0.001). Among those PD-free at baseline, 20-year risk remained higher in FM (any PD 1.03% vs 0.08%; RD 0.95 pp., 0.78–1.14; RR 12.87, 9.62–17.22), driven by Cluster B (borderline 0.20% vs 0.02%; RD 0.19 pp.; RR 12.34, 6.48–23.51). Surveillance calibration attenuated but did not eliminate Cluster-B excess (e.g., borderline aRR ≈ 3.07).</div></div><div><h3>Conclusions</h3><div>FM is associated with a selective, durable enrichment of Cluster-B PDs—most notably borderline—observable cross-sectionally and as long-term cumulative risk, only partly explained by diagnostic opportunity. Findings support routine PD screening within FM care and motivate mechanistic work on immuno-neuroendocrine and frontolimbic pathways.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112536"},"PeriodicalIF":3.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing exercise interventions for depression in stroke patients: A network and dose-response meta-analysis","authors":"Wei Wang ,&nbsp;Zhide Liang ,&nbsp;Jiao Xiong ,&nbsp;Chuanzhi Wang","doi":"10.1016/j.jpsychores.2026.112519","DOIUrl":"10.1016/j.jpsychores.2026.112519","url":null,"abstract":"<div><h3>Objective</h3><div>Post-stroke depression (PSD) is a common complication following stroke and is associated with increased mortality risk. Evidence suggests that exercise has a beneficial effect on depression. However, the optimal modality and dose of exercise interventions remain unclear. Therefore, this study aims to explore the optimal exercise intervention modality and dose for post-stroke depression.</div></div><div><h3>Methods</h3><div>We screened six databases, including PubMed, Cochrane Library, Embase, Scopus, Web of Science, and CINAHL, for randomized controlled trials (RCTs) published up to September 2025. The Cochrane risk of bias tool was made available to assess the quality of the literature. A random-effects model was employed to perform a network meta-analysis (NMA).</div></div><div><h3>Results</h3><div>A total of 29 randomized controlled trials involving 1061 stroke patients were included. Aerobic exercise was the most effective intervention (Hedges' g = −1.14, 95 % CrI: −1.62 to −0.63, k = 6, SUCRA = 0.89). This was followed by qigong exercise (Hedges' g = −0.55, 95 % CrI: −0.99 to −0.10, <em>n</em> = 7, SUCRA = 0.79), flexibility exercises (Hedges' g = −0.55,95 % CrI: −1.00 to −0.10, <em>n</em> = 6 SUCRA = 0.66), Tai Chi (Hedges' g = −0.44,95 % CrI: −0.86 to −0.01, <em>n</em> = 5 SUCRA = 0.48), and resistance training (Hedges' g = −0.29,95 % CrI: −0.72 to 0.16, n = 5 SUCRA = 0.30), whereas yoga (Hedges' g = −0.03, 95 % CrI: −0.79 to 0.72, <em>n</em> = 2, SUCRA = 0.26) did not reach clinical significance (defined as an effect size &gt;0.2 SD). It was also found that the optimal dose range was 500-1100METs-min/week.</div></div><div><h3>Conclusion</h3><div>Exercise can significantly improve depressive symptoms in patients after stroke. Based on our findings, exercise interventions may be considered a non-pharmacological option for post-stroke depression, as an adjunct to standard care. The optimal dose range appears to be 500–1100 METs-min/week. The effectiveness of different interventions may vary based on patient characteristics, suggesting that clinicians should tailor exercise prescriptions to the individual.</div><div><strong>Registration:</strong> The review protocol has been registered on PROSPERO(CRD42024601846).</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112519"},"PeriodicalIF":3.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric disorders and the burden of chronic gastrointestinal diseases: Evidence from a nationwide cross-sectional study","authors":"Tak Kyu Oh ,&nbsp;In-Ae Song","doi":"10.1016/j.jpsychores.2025.112512","DOIUrl":"10.1016/j.jpsychores.2025.112512","url":null,"abstract":"<div><h3>Objectives</h3><div>Psychiatric disorders are leading contributors to global morbidity. Chronic gastrointestinal (GI) diseases are also highly prevalent. Despite the gut–brain axis theory, large-scale evidence comparing the burden of functional versus organic GI diseases across diverse psychiatric conditions is scarce. We aimed to evaluate the prevalence odds of chronic GI disorders—categorized into functional, organic, and hepatobiliary–pancreatic (HBP) diseases—among adults with psychiatric disorders compared with matched controls.</div></div><div><h3>Methods</h3><div>We performed a nationwide cross-sectional study using South Korea's National Health Insurance Service database. Adults aged ≥18 years with at least one psychiatric diagnosis between 2021 and 2022 were included (<em>n</em> = 526,918). A control cohort without psychiatric diagnoses (<em>n</em> = 473,082) was selected. After 1:1 propensity score matching, 348,304 individuals remained in each group.</div></div><div><h3>Results</h3><div>In the matched cohort (<em>n</em> = 696,608), patients with psychiatric disorders had a significantly higher prevalence of total chronic GI disorders (69.8 % vs 52.1 %; odds ratio [OR] 2.13, 95 % confidence interval [CI] 2.11–2.15; <em>P</em> &lt; 0.001). The magnitude of association was strongest for functional GI disorders (OR 2.12, 95 % CI 2.10–2.14; <em>P</em> &lt; 0.001), followed by organic GI disorders (OR 1.60, 95 % CI 1.57–1.63; <em>P</em> &lt; 0.001) and HBP diseases (OR 1.43, 95 % CI 1.41–1.46; <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Psychiatric disorders are associated with a substantial burden of chronic GI diseases. The association was markedly stronger for functional GI disorders than for organic conditions, supporting the clinical significance of the gut–brain axis in this population.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112512"},"PeriodicalIF":3.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health and knee osteoarthritis","authors":"David Ring","doi":"10.1016/j.jpsychores.2026.112518","DOIUrl":"10.1016/j.jpsychores.2026.112518","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112518"},"PeriodicalIF":3.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145928539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosomatic and cognitive outcomes of non-SARS-Cov-2 recent respiratory infections among Chinese adults: A nationwide investigation","authors":"Lei Li ,&nbsp;Yucheng Yuan ,&nbsp;Wenhao Jiang ,&nbsp;Chenguang Jiang ,&nbsp;Huijun Duan ,&nbsp;Bin Yu ,&nbsp;Tao Zou ,&nbsp;Zhongyan Li ,&nbsp;Peng Xiong ,&nbsp;Yingying Yue ,&nbsp;Taipeng Sun ,&nbsp;Yuqun Zhang ,&nbsp;Wei Xu ,&nbsp;Yubo Zhang ,&nbsp;Xiaoyun Xin ,&nbsp;Zhenhua Hou ,&nbsp;Changchun Hu ,&nbsp;Jue Chen ,&nbsp;Juncai Wang ,&nbsp;Zhi Xu ,&nbsp;Yonggui Yuan","doi":"10.1016/j.jpsychores.2026.112530","DOIUrl":"10.1016/j.jpsychores.2026.112530","url":null,"abstract":"<div><h3>Objectives</h3><div>While post-COVID symptoms are well-documented, symptoms following non-SARS-CoV-2 recent respiratory tract infections (RRIs) remain understudied. This study aimed to investigate the prevalence, associated factors of symptoms following RRIs.</div></div><div><h3>Methods</h3><div>A nationwide cross-sectional survey of 61,012 adults was conducted between December 2023 and January 2024. Self-reported RRIs within one month, SARS-CoV-2 infections, infection times and severity of COVID-19 were documented. Psychosomatic symptoms, subjective cognitive and well-being were measured using brief psychosomatic symptom scale (BPSS), brief brain fog scale (BBFS) and 5-item World Health Organization well-being index (WHO-5). Logistic and linear regressions and pathway analyses were used to examine associated factors.</div></div><div><h3>Results</h3><div>Among 15,715 participants reporting RRIs, 40.8% exhibited psychosomatic symptoms (vs. 25.6% in non-RRI group, FDR-adjusted <em>P</em> &lt; 0.05) and 17.5% reported cognitive symptoms (vs. 9.0%, FDR-adjusted <em>P</em> &lt; 0.05). The most prevalent symptoms included sleep difficulty (18.2%), depression (16.7%), and pain (15.2%). RRIs was more strongly associated with most symptoms than SARS-CoV-2 (OR: 1.41–2.02 vs. 0.88–1.37). Socioeconomic status (OR &lt; 1, FDR-adjusted P &lt; 0.05) and comorbidities (OR &gt; 1, FDR-adjusted P &lt; 0.05) were associated with these symptoms. Participants with both RRIs and previous SARS-CoV-2 infections exhibited increased symptom burdens (psychosomatic: 41.6%; cognitive: 18.0%). Psychosomatic and cognitive symptoms accounted for 71.7% (95% CI: 68.2%–75.4%) and 56.3% (95% CI: 53.1%–59.7%) effects of RRIs on well-being.</div></div><div><h3>Conclusion</h3><div>RRIs were associated with higher symptom reporting than COVID-19 exacerbated by socioeconomic disparities and comorbidities. Our preliminary findings call for integrated frameworks in practice that managing psychosomatic and cognitive symptoms and socioeconomic factors.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112530"},"PeriodicalIF":3.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsychosocial risk factors for the transition from acute to chronic back pain: A prospective cohort study","authors":"Petra Engelmann,&nbsp;Mareike Busmann,&nbsp;Bernd Löwe,&nbsp;Paul Hüsing","doi":"10.1016/j.jpsychores.2025.112500","DOIUrl":"10.1016/j.jpsychores.2025.112500","url":null,"abstract":"<div><h3>Background</h3><div>Biopsychosocial mechanisms are assumed to underlie the chronification of back pain; however, potentially relevant factors have mainly been examined in isolation rather than within comprehensive aetiological models. This study investigated risk factors of chronic back pain based on a current biopsychosocial model for persistent somatic symptoms.</div></div><div><h3>Methods</h3><div>Within the prospective cohort study IDRIS (“From the identification of biopsychosocial risk factors to an increase in pain-related self-efficacy – The online-based conveyance of an explanatory model for chronic back pain”), German adults with (sub)acute back pain (&lt; 12 weeks) completed online questionnaires on biopsychosocial variables at baseline, 1-month and 3-month follow-up. Possible predisposing and maintaining predictors of chronic back pain at 3 months were tested in linear regression models.</div></div><div><h3>Findings</h3><div>Between December 2022 and July 2024, 280 individuals from the general population with (sub)acute back pain (mean age 37.52 (SD 12.41) years; 65 % female) completed all assessments. Predictors of chronic back pain at 3 months were dysfunctional symptom expectations at 1-month follow-up (<em>ß</em> = 0.25, <em>p</em> &lt; 0.001) and high baseline pain severity grades (highest grade: <em>ß</em> = 0.18, <em>p</em> &lt; 0.01). Other postulated variables did not predict pain chronification.</div></div><div><h3>Interpretation</h3><div>This study supports the role of negative pain-related beliefs in the transition from acute to chronic back pain and suggests addressing dysfunctional symptom expectations in secondary prevention interventions to mitigate the risk of pain chronification. Future research should assess postulated predisposing factors for chronic back pain in clinical populations over longer timeframes to evaluate their long-term predictive value.</div></div><div><h3>Funding</h3><div>Stiftung Psychosomatik der Wirbelsäulenerkrankungen.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112500"},"PeriodicalIF":3.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network analysis of fear of progression, anxiety, and depression in parents of children with malignant solid tumors: A cross-sectional study","authors":"Yiming Gao ,&nbsp;Xiaohe Lin,&nbsp;Xiaona Shen,&nbsp;Xiangyu Zhao,&nbsp;Di Zhao,&nbsp;Ping Li","doi":"10.1016/j.jpsychores.2025.112516","DOIUrl":"10.1016/j.jpsychores.2025.112516","url":null,"abstract":"<div><h3>Objective</h3><div>Fear of progression (FoP), anxiety, and depression are common emotional distresses for parents of children with cancer, but yet these concerns often lack attention. This study explored the network connections between FoP, anxiety, and depression in parents of children with malignant solid tumors.</div></div><div><h3>Methods</h3><div>This study that included 447 parents of children with malignant solid tumors. All participants completed the Fear of Progression Questionnaire-parent version (FoP-Q-SF/PR), the 2-item Generalize Anxiety Disorder Scale (GAD-2) and the 2-item Patient Health Questionnaire (PHQ-2). We estimated two network models: regularized partial correlation network and Bayesian Directed Acyclic Graph (DAG).</div></div><div><h3>Results</h3><div>The regularized partial correlation network demonstrated a correlation between FoP, anxiety, and depressive symptoms, with a stronger association observed between anxiety and depression. The results of the Network Centrality Indicator showed that the top three symptoms in terms of expected impact (EI) were “fear of major treatment”, “life anxiety”, and “feeling tense, anxious, or eager”. The DAG showed that the symptoms of FoP activated each other, which in turn activated anxiety and depressive symptoms. In particular, “fear of major treatment” was at the top of the DAG and therefore has the highest predictive priority in the network.</div><div>Conclusion: “Fear of major treatment” was a core symptom in the regularized partial correlation network and an upstream symptom in the DAG. The findings suggest that strengthening health education, building confidence in overcoming the disease, and reinforcing positive coping may help to improve negative emotions in parents of children with malignant solid tumors.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112516"},"PeriodicalIF":3.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross sectional study of post-concussion symptoms following mild traumatic brain injury in an Asian population: Influence of negative mental states and somatic features","authors":"Simon L. Collinson ,&nbsp;Nicole Chen ,&nbsp;Kathryn Ponniah ,&nbsp;Ray Chua ,&nbsp;Annette Chen ,&nbsp;Ang Beng Ti","doi":"10.1016/j.jpsychores.2025.112492","DOIUrl":"10.1016/j.jpsychores.2025.112492","url":null,"abstract":"<div><h3>Objective</h3><div>Persistent post-concussion symptoms resulting from a mild traumatic brain injury that typically last longer than three months may stem from a complex interaction of neurological and psychological factors, particularly negative mental states. Negative mental states including pessimism and depression are associated with post-concussion phenomena may be highly pertinent to Asian societies. The objective of this study was to examine the respective influences of culture specific psychological factors in the presentation of post-concussion symptoms.</div></div><div><h3>Method</h3><div>We examined the relationship between somatisation, depression and pessimism in 83 Asian mild traumatic brain injury (mTBI) outpatients and found depression levels, including cognitive/affective depression and somatic depression sub-factors, were significantly greater in patients with moderate or severe symptoms.</div></div><div><h3>Results</h3><div>Somatic depression was the best predictor of the severity of post-concussion symptoms especially in individuals who were more pessimistic.</div></div><div><h3>Conclusion</h3><div>The findings highlight negative mental states and cultural differences in the manifestation of post-concussion symptoms that should inform both clinical assessment and intervention for persistent PCS.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112492"},"PeriodicalIF":3.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146031455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}