Journal of Psychosomatic Research最新文献

{"title":"Prevalence and risk factors of post-traumatic stress disorder and psychological distress symptoms in populations affected by Ebola in DR Congo before and during the COVID-19 pandemic","authors":"Rose Darly Dalexis ,&nbsp;Seyed Mohammad Mahdi Moshirian Farahi ,&nbsp;Jacqueline Bukaka ,&nbsp;Farid Mansoub Bekarkhanechi ,&nbsp;Olea Balayulu-Makila ,&nbsp;Noble Luyeye ,&nbsp;Jude Mary Cénat","doi":"10.1016/j.jpsychores.2025.112063","DOIUrl":"10.1016/j.jpsychores.2025.112063","url":null,"abstract":"<div><h3>Background</h3><div>Ebola virus disease (May 19–September 16, 2020) and COVID-19 simultaneously affected the province of Equateur in DR Congo (DRC). To date, no longitudinal studies have explored symptoms of post-traumatic stress disorder (PTSD) and psychological distress (PD) related to COVID-19 or Ebola in DRC.</div></div><div><h3>Methods</h3><div>A representative sample of 1669 participants aged ≥18 was recruited in March–April 2019 (Time 1) and August–September 2020 (Time 2). Questionnaires assessed PTSD (PCL-5) and PD (<em>K</em>−10) symptoms, social support, Ebola and COVID-19 exposure and related stigmatization.</div></div><div><h3>Results</h3><div>Prevalence of PTSD (58.24 % in T1 to 43.74% at T2, <em>x</em>^<em>2</em>(1) = 5.83, <em>p</em> &lt; .001) and PD symptoms (49.44 % in T1 to 28.94 % at T2, <em>x</em>^<em>2</em> (1) = 5.83, <em>p</em> &lt; .001) decreased from the Ebola outbreak to the COVID-19 pandemic. Populations living in rural areas consistently reported higher prevalence of PTSD and PD symptoms. Generalized estimating equation (GEE) models showed that stigmatization related to Ebola is the most important predictor of both PTSD (<em>B</em> = 0.90, <em>p</em> &lt; .0001) and PD (<em>B</em> = 1.22, <em>p</em> &lt; .001) symptoms, followed by exposure to Ebola (<em>B</em> = 0.41, <em>p</em> &lt; .001 and <em>B</em> = 0.56, <em>p</em> &lt; .001). COVID-19 related stigmatization only predicted PTSD symptoms (<em>B</em> = 0.21, <em>p</em> = .009). GEE models also confirmed that PTSD (<em>B</em> = −0.78, <em>p</em> &lt; .001) and PD (<em>B</em> = −1.25, <em>p</em> &lt; .001) decreased from Ebola outbreak to the COVID-19 pandemic. A significant interaction was found between Ebola stigmatization and time (<em>B</em> = -0.40, <em>p</em> = .021) for PTSD, and between exposure to Ebola and time (<em>B</em> = -0.36, <em>p</em> = .026) for PD.</div></div><div><h3>Conclusions</h3><div>This study confirms that Ebola related stigmatization is the most important predictor of mental health problems. Community-based strategies can address, reduce, and eliminate this issue.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"190 ","pages":"Article 112063"},"PeriodicalIF":3.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning for the early prediction of long-term cognitive outcome in autoimmune encephalitis","authors":"Yingchi Zhang ,&nbsp;Xiaodan Shi ,&nbsp;Zhirong Fan ,&nbsp;Ewen Tu ,&nbsp;Dianwei Wu ,&nbsp;Xiuxiu Leng ,&nbsp;Ting Wan ,&nbsp;Xiaomu Wang ,&nbsp;Xuan Wang ,&nbsp;Wei Lu ,&nbsp;Fang Du ,&nbsp;Wen Jiang","doi":"10.1016/j.jpsychores.2025.112051","DOIUrl":"10.1016/j.jpsychores.2025.112051","url":null,"abstract":"<div><h3>Background and objective</h3><div>Autoimmune encephalitis (AE) is an immune-mediated disease. Some patients experience persistent cognitive deficits despite receiving immunotherapy. We aimed to develop a prediction model for long-term cognitive outcomes in patients with AE.</div></div><div><h3>Method</h3><div>In this multicenter cohort study, a total of 341 patients with AE were enrolled from February 2014 to July 2023. Cognitive impairment was identified using the telephone Mini-Mental State Examination (t-MMSE). Six machine learning (ML) algorithms were used to assess the risk of developing cognitive impairment.</div></div><div><h3>Results</h3><div>The median age of the patients with AE was 30.0 years (23.0–48.25), and 48.90 % (129/264) were female in the training cohort.77 (29.2 %) patients were identified with cognitive impairment after a median follow-up of 49 months. Among 16 features, the following six features were finally selected to develop the model: Cognitive Reserve Questionnaire (CRQ), Clinical Assessment Scale for Autoimmune Encephalitis (CASE), status epilepticus (SE), age, MRI abnormalities, and delayed immunotherapy. Compared to other ML models, the random forest (RF) model demonstrated superior performance with an AUC of 0.90. The accuracy, sensitivity, and specificity in the testing cohort were 0.87, 0.79, and 0.90, respectively.</div></div><div><h3>Conclusion</h3><div>The RF model based on CRQ, CASE scores, SE, age, MRI abnormalities and delayed immunotherapy demonstrates superior predictive performance and shows promise in predicting the risk of long-term cognitive outcomes in patients with AE in clinical settings.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"190 ","pages":"Article 112051"},"PeriodicalIF":3.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum inflammatory cytokines levels and post-stroke depression among stroke patients: A meta-analysis and systematic review","authors":"Yao Zhou ,&nbsp;Lijuan Zhao ,&nbsp;Yunzhu Tang ,&nbsp;Shuxia Qian","doi":"10.1016/j.jpsychores.2025.112050","DOIUrl":"10.1016/j.jpsychores.2025.112050","url":null,"abstract":"<div><h3>Background</h3><div>Post-stroke depression (PSD) is a common neuropsychiatric complication after stroke. Neuroinflammation triggered by the stroke event may be its predisposing factor.</div></div><div><h3>Methods</h3><div>We systematically searched all electronic databases up to December 22, 2024. Observational studies comparing cytokine levels between PSD and non-PSD patients were included. Sensitivity analysis, subgroup analysis, and meta-regression were conducted to assess robustness, explore heterogeneity, and identify effect modifiers.</div></div><div><h3>Results</h3><div>A total of 26 studies with 6573 acute stroke patients were included, of whom 2453 developed PSD. PSD patients were older (63.7 vs. 62.8 years) and included more females (36.4 % vs. 35.1 %) than non-PSD patients. PSD patients had significantly higher serum levels of IL-1β (SMD = 0.35, 95 % CI = [0.07, 0.63], <em>p</em> = 0.02), IL-6 (SMD = 0.74, 95 % CI = [0.50, 0.97], <em>p</em> &lt; 0.001), IL-18 (SMD = 0.49, 95% CI = [0.13, 0.86], <em>p</em> = 0.007), TNF-α (SMD = 0.44, 95 % CI = [0.15, 0.72], <em>p</em> = 0.003) and IFN-γ (SMD = 0.11, 95 % CI = [0.02, 0.19], <em>p</em> = 0.01), while IL-10 levels showed no significant difference (<em>p</em> = 0.06). IL-6 levels remained associated with PSD diagnosis at 1, 3 and 6 months. Meta-regression identified female proportion (IL-6: <em>p</em> = 0.043; IL-10: <em>p</em> = 0.024), mean age (IL-18: <em>p</em> = 0.015; TNF-α: <em>p</em> = 0.040), BMI (IL-18: <em>p</em> = 0.019), and diabetes proportion (IL-6: <em>p</em> = 0.009; TNF-α: <em>p</em> = 0.033) as significant moderators.</div></div><div><h3>Conclusions</h3><div>Inflammatory cytokines may serve as biomarkers for PSD, offering insights into its pathophysiology and potential diagnostic tools.</div><div>Prospero registration number: CRD42024548753.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"190 ","pages":"Article 112050"},"PeriodicalIF":3.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which type and dosage of mindfulness-based interventions are most effective for chronic pain? A systematic review and network meta-analysis","authors":"Mengting Zhu ,&nbsp;Samuel Yeung-shan Wong ,&nbsp;Claire Chenwen Zhong ,&nbsp;Yu Zeng ,&nbsp;Luyao Xie ,&nbsp;Eric Kam-pui Lee ,&nbsp;Vincent Chi-ho Chung ,&nbsp;Regina Wing-shan Sit","doi":"10.1016/j.jpsychores.2025.112061","DOIUrl":"10.1016/j.jpsychores.2025.112061","url":null,"abstract":"<div><div>Chronic pain exerts an enormous personal and economic burden worldwide. While clinical trials have confirmed the benefits of mindfulness-based interventions (MBIs) in chronic pain management, knowledge on the best type and dosage remains unknown. This study aims to compare the clinical effectiveness of different MBIs on chronic pain and to identify the optimal dosage of MBIs. The primary outcome was pain intensity and secondary outcomes were physical function and depression. We applied a random-effect pairwise meta-analysis to synthesize data, and network meta-analysis to compare effectiveness among different types and dosages of MBIs. The findings were further categorized according to the partially contextualized framework. A total of 68 studies with 5,339 participants were included. Mindfulness-based stress reduction demonstrated the most promising results for improving pain intensity (SMD −0.76, 95 % CI −1.06 to −0.46, Surface Under the Cumulative Ranking Area (SUCRA) 0.75) and depression (SMD −0.77, 95 % CI −0.98 to −0.56, SUCRA 0.86), supported by moderate and high certainty of evidence, respectively. On the other hand, mindfulness-oriented recovery enhancement emerged as the most effective for enhancing physical function (SMD −1.42, 95 % CI −2.28 to −0.57, SUCRA 0.96), albeit with low certainty of evidence. An 8-week course, conducted once per week, with sessions lasting between 90 and 120 min, appeared to be the optimal dosage for addressing pain intensity, physical function, and depression. Our findings contribute to the evidence supporting the use of MBIs in chronic pain management and informing the development of evidence-based guidelines and standardizing the course structures of MBIs.</div><div>Systematic review registration: PROSPERO CRD42021293938.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"191 ","pages":"Article 112061"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transitions in patterns of family resilience and their associations with parent-child interaction: A longitudinal study using latent transition analysis among families of children with chronic illness","authors":"Xuewei Chen ,&nbsp;Fangyu Yang ,&nbsp;Yinzhu Pan ,&nbsp;Qiongying Xu ,&nbsp;Yao Zhang ,&nbsp;Jingrui Tao ,&nbsp;Chaoqun Dong","doi":"10.1016/j.jpsychores.2025.112054","DOIUrl":"10.1016/j.jpsychores.2025.112054","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate transitions in patterns of family resilience among Chinese families of children with chronic illness over a one-year period, as well as their relationship to parent-child interaction.</div></div><div><h3>Methods</h3><div>A representative sample of parents of children with chronic illness was drawn from two hospitals in Zhejiang Province, China, using convenience sampling. A total of 214 parents were assessed for family resilience, parent-adolescent communication, and child-parent relationships at three time points with a one-year interval: baseline (T1), 6 months (T2), and 12 months (T3) after the baseline survey.</div></div><div><h3>Results</h3><div>Latent profile analysis identified three distinct patterns, including (1) low family resilience, (2) moderate family resilience, and (3) high family resilience. The latent transition analysis revealed four transition patterns: stable low (72.4 %), stable moderate-high (22.5 %), improved from low to either high or moderate (4.2 %), and worsened from high to moderate (0.9 %). A one-way ANOVA revealed significant effects of the transition patterns of family resilience on open family communication, intimacy, and conflict within parent-child relationships.</div></div><div><h3>Conclusions</h3><div>The high proportion within the “stable low” transition pattern and the enduring stability of family resilience over time underscore the significance of early intervention efforts aimed at enhancing family resilience or mitigating its decline among families of children with chronic illness.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"190 ","pages":"Article 112054"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative psychological distress and acute postoperative pain among abdominal surgery patients","authors":"Carlos Alberto Henao Periañez ,&nbsp;Marcio Alexander Castillo-Díaz","doi":"10.1016/j.jpsychores.2025.112055","DOIUrl":"10.1016/j.jpsychores.2025.112055","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze preoperative psychological distress symptoms and their association with acute postoperative pain in patients undergoing abdominal surgery.</div></div><div><h3>Method</h3><div>Prospective observational study conducted at a University Hospital in Minas Gerais, Brazil. The sample included 118 patients in the hospital's elective abdominal surgery program. Psychological distress symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS). Pain levels were measured using the numeric verbal scale (NVS, 0–10 points) from admission to discharge from the post-anesthesia care unit. Descriptive statistics and an ordinal regression model were utilized to detect related factors, with a threshold for significance established at <em>p</em> &lt; 0.05. Pain levels at discharge from the post-anesthesia care unit was considered the outcome variable.</div></div><div><h3>Findings</h3><div>Preoperatively, 50.8 % exhibited symptoms of anxiety (HADS-A ≥ 8) and 16.1 % exhibited symptoms of depression (HADS-D ≥ 8), with 14.4 % presenting both symptoms. The prevalence of pain (NVS &gt;0) in the post-anesthesia care unit was 40.3 %. At admission, 5.8 % of patients reported moderate to severe pain (NVS ≥ 4), increasing to 29.7 % at 60 min and 22.1 % at discharge. Regression analysis showed that anxiety or depression (OR = 4.49, <em>p</em> &lt; 0.01) significantly increased the likelihood of experiencing higher pain levels, which was even greater when both symptoms coexisted (OR = 10.19, <em>p</em> &lt; 0.01). Additionally, older age (OR = 0.94, p &lt; 0.01) and inadequate pain management (OR = 7.67, p &lt; 0.01) were significant predictors of pain levels at discharge.</div></div><div><h3>Conclusion</h3><div>Preoperative psychological distress, particularly the simultaneous presence of anxiety and depressive symptoms, significantly elevates the likelihood of heightened pain intensity in patients undergoing abdominal surgery.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"190 ","pages":"Article 112055"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacologically treated depression, anxiety, and insomnia in individuals with type 2 diabetes: The role of diabetes duration, age, and age at diabetes onset. A Norwegian population-based registry study from the OMIT cohort","authors":"Ragnhild B. Strandberg ,&nbsp;Roy M. Nilsen ,&nbsp;François Pouwer ,&nbsp;Jannicke Igland ,&nbsp;Jan Ivar Røssberg ,&nbsp;Anne Karen Jenum ,&nbsp;Esben S. Buhl ,&nbsp;Marjolein M. Iversen","doi":"10.1016/j.jpsychores.2025.112057","DOIUrl":"10.1016/j.jpsychores.2025.112057","url":null,"abstract":"<div><h3>Objective</h3><div>To examine whether type 2 diabetes (T2D) duration (‘0–4’; ‘≥5–9’; ≥10–19′; ‘≥20 years') was associated with use of medication for depression, anxiety, or insomnia, and if possible associations were modified by age, age at T2D onset, sex, and education.</div></div><div><h3>Methods</h3><div>We used data from 55,083 adults with T2D in the national registry-based cohort study Outcomes &amp; Multi-morbidity In T2D (2006–2019). Adjusted associations and effect modifications were estimated using binary logistic regressions with generalized estimation equations in the subgroups age (&lt;60, ≥60 years), age at diabetes onset (&lt;40, ≥40 years), sex (men, women), and education (primary, high school, university).</div></div><div><h3>Results</h3><div>At initial registration, 12 % used medication for depression, 10 % for anxiety, and 16 % for insomnia. These prevalence estimates increased with diabetes duration in most subgroups. Individuals with early onset T2D had higher prevalence of depression than those with late onset, which increased with diabetes duration (per category change diabetes duration 0.7 % (95 % CI 0.2, 1.2), P for trend = 0.003). For anxiety and insomnia, a stronger association was found in those with early T2D onset compared to late onset (per category change 1.3 % (95 % CI 0.9, 1.8) and 1.9 (95 % CI 1.3, 2.4), P for interaction = 0.001; 0.01).</div></div><div><h3>Conclusion</h3><div>The prevalence of pharmacologically treated depression, anxiety, and insomnia increased with diabetes duration; this finding may imply that assessment of mental health disorders at the initial phase and along the diabetes trajectory are needed. As the prevalences advanced most prominently in people with early onset T2D, future studies should determine underlying mechanisms to test age-appropriate preventive interventions.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"190 ","pages":"Article 112057"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A psychosocial intervention for prenatal anxiety decreases functional disability among pregnant Pakistani women: A moderated mediation approach using data from a randomized controlled trial","authors":"Soim Park ,&nbsp;Abid Malik ,&nbsp;Ahmed Zaidi ,&nbsp;Jamie Perin ,&nbsp;Najia Atif ,&nbsp;Atif Rahman ,&nbsp;Pamela J. Surkan","doi":"10.1016/j.jpsychores.2025.112058","DOIUrl":"10.1016/j.jpsychores.2025.112058","url":null,"abstract":"<div><h3>Background</h3><div>Given that anxiety is associated with functional disability, we investigated whether an intervention designed to reduce prenatal anxiety could improve functional disability in the postpartum period. We also examined whether perceived social support in the third trimester mediated this relationship, and if the extent of the mediation differed by economic empowerment.</div></div><div><h3>Methods</h3><div>We included 590 pregnant Pakistani women with at least mild anxiety symptoms to a randomized controlled trial (RCT). Women in the intervention arm received six sessions of a Cognitive Behavioral Therapy-based psychosocial intervention for prenatal anxiety. Relaxation techniques (e.g., breathing exercises and meditation) and enhancement of social support were also included in the therapy. The control group received enhanced usual care. Economic empowerment was dichotomized into empowered and non-empowered. We used the Multidimensional Scale of Perceived Social Support (MSPSS) to assess social support, where higher scores indicated greater social support. The WHO Disability Assessment Schedule (WHODAS 2.0) was employed to evaluate functional disability which was neither a primary nor a secondary outcome of the RCT. As an ad hoc analysis of the RCT, regression-based path analysis modeling was employed to examine the main, mediating, and moderating effects. Mediation was estimated with the product of coefficients method.</div></div><div><h3>Results</h3><div>The intervention reduced the postpartum functional disability by 4.7 points (adjusted B = -4.71, bootstrapped 95 % confidence interval (CI): −5.93, −3.49), and social support in the late pregnancy mediated this relationship (B_{indirect effect} = −0.56, bootstrapped 95 % CI: −0.93, −0.26). A statistically significant index of moderated mediation—showing whether the indirect effects of the mediator vary by the levels of the moderator—indicated that economic empowerment significantly moderated the initial segment of the pathway between the intervention and functional disability (B_{difference in indirect effects} = 0.64, bootstrapped 95 % CI: 0.13, 1.27). Social support mediated the main association only for non-empowered women.</div></div><div><h3>Conclusion</h3><div>While social support can mediate the relationship between psychosocial intervention and functional disability in anxious pregnant women, promotion of social support during late pregnancy may be particularly useful in non-empowered women, for reducing functional disability in the postpartum period.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"190 ","pages":"Article 112058"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which factors predict outcome from specialist physiotherapy for functional motor disorder? Prognostic modelling of the Physio4FMD intervention","authors":"Glenn Nielsen ,&nbsp;Teresa C. Lee ,&nbsp;Louise Marston ,&nbsp;Alan Carson ,&nbsp;Mark J. Edwards ,&nbsp;Laura H. Goldstein ,&nbsp;Rachael Maree Hunter ,&nbsp;Kate Holt ,&nbsp;Jon Marsden ,&nbsp;Markus Reuber ,&nbsp;Jon Stone ,&nbsp;Irwin Nazareth","doi":"10.1016/j.jpsychores.2025.112056","DOIUrl":"10.1016/j.jpsychores.2025.112056","url":null,"abstract":"<div><h3>Objectives</h3><div>Physiotherapy is considered part of first line treatment for functional motor disorder (FMD) although not all patients benefit. Predictors of treatment outcome may help to inform triage decisions. We aimed to determine which baseline variables predicted treatment outcome in the pragmatic multicentre Physio4FMD randomised controlled trial of specialist physiotherapy for FMD.</div></div><div><h3>Methods</h3><div>Participants randomised to the specialist physiotherapy arm of the trial were included in the analysis. Treatment outcome was dichotomised into improvement vs no improvement, based on two measures, Short Form 36 Physical Functioning (SF36 PF) and participant-rated Clinical Global Impression Scale of Improvement (CGI-I). Predictors of outcome were selected from baseline variables. Univariate logistic regression was used to calculate the odds ratio of improvement for each variable. Variables associated with improvement at <em>p</em> &lt; 0.1 were considered for inclusion in a multiple logistic regression model.</div></div><div><h3>Results</h3><div>A greater perception of having control over recovery predicted improvement on the CGI-I (OR 1.18, 95 % CI 1.07, 1.31). Predictors of lack of improvement were an increased perception of the permanence of symptoms, predicting lack of improvement on the SF36 PF (OR 0.91, 95 % CI 0.84, 0.99) and older age, predicting lack of improvement on the CGI-I (OR 0.97, 95 % CI 0.95, 0.998).</div></div><div><h3>Conclusions</h3><div>Age and perceptions of symptom control were weak predictors of outcome from specialist physiotherapy. In contrast, a number of factors commonly believed to predict poorer treatment response, including illness duration and levels of pain and fatigue, were not related to the outcomes measured in this study.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"190 ","pages":"Article 112056"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal blood biomarkers and trajectories of depressive symptoms among Chinese middle-aged and older adults","authors":"Jinghong Huang ,&nbsp;Le Chen ,&nbsp;Huiyu Chen ,&nbsp;Qiaodan Liu ,&nbsp;Chuandeng Tu ,&nbsp;Yue Dai ,&nbsp;Yueping Li ,&nbsp;Raoping Tu","doi":"10.1016/j.jpsychores.2025.112052","DOIUrl":"10.1016/j.jpsychores.2025.112052","url":null,"abstract":"<div><h3>Objective</h3><div>Although previous studies have demonstrated allostatic load (AL) predicts depressive symptoms, few studies have considered the association between AL and trajectories of depressive symptoms. This study aims to systematically examine the associations of abnormal blood biomarkers in the three biological systems with trajectories of depressive symptoms.</div></div><div><h3>Methods</h3><div>A total of 6251 participants aged 45+ from the China Health and Retirement Longitudinal Study (CHARLS). Depressive symptoms were assessed using the 10-item Center for Epidemiological Studies Depression Scale (CESD-10) in five visits (waves 2011, 2013, 2015, 2018, and 2020). Biomarkers in three biological systems were evaluated based on standard criteria, including C-reactive protein in the inflammation system; systolic and diastolic blood pressures in the cardiovascular system; and high-density lipoprotein cholesterol (HDL<img>C), total cholesterol/HDL-C ratio, and glycosylated hemoglobin (HbA1c) in the metabolic system. The trajectories of depressive symptoms were measured using group-based trajectory modelling (GBTM). Multinomial logistic regression models were conducted to examine the association between the number of abnormal biological systems and trajectories of depressive symptoms.</div></div><div><h3>Results</h3><div>Four different trajectories of depressive symptoms were identified: mild (44.22 %), moderate (42.09 %), increasing (9.39 %), and severe (4.30 %). Compared to participants with normal values of biomarkers in all three systems, those with abnormal values of biomarkers in three systems had a 2.26-fold risk of developing the severe depressive symptoms trajectory.</div></div><div><h3>Conclusions</h3><div>Our findings highlight the importance of monitoring multiple biological systems to prevent long-term accelerated severe depressive symptoms trajectory.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"191 ","pages":"Article 112052"},"PeriodicalIF":3.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}