Journal of the International Neuropsychological Society最新文献

{"title":"Self-reported everyday functioning among adults with human immunodeficiency virus: Longitudinal associations with global neurocognitive functioning and depressive symptoms.","authors":"Maximo R Prescott, Emily W Paolillo, Carlos D Rivera Saldana, Donald Franklin, Elizabeth C Pasipanodya, Mariam A Hussain, Raeanne C Moore, Robert K Heaton, Jessica L Montoya, David J Moore","doi":"10.1017/S1355617725101094","DOIUrl":"10.1017/S1355617725101094","url":null,"abstract":"<p><strong>Objective: </strong>Diagnosing HIV-Associated Neurocognitive Disorders (HAND) requires attributing neurocognitive impairment and functional decline at least partly to HIV-related brain effects. Depressive symptom severity, whether attributable to HIV or not, may influence self-reported functioning. We examined longitudinal relationships among objective global cognition, depressive symptom severity, and self-reported everyday functioning in people with HIV (PWH).</p><p><strong>Methods: </strong>Longitudinal data from 894 PWH were collected at a university-based research center (2002-2016). Participants completed self-report measures of everyday functioning to assess both dependence in instrumental activities of daily living (IADL) and subjective cognitive difficulties at each visit, along with depressive symptom severity (BDI-II). Multilevel modeling examined within- and between-person predictors of self-reported everyday functioning outcomes.</p><p><strong>Results: </strong>Participants averaged 6 visits over 5 years. Multilevel regression showed a significant interaction between visit-specific global cognitive performance and mean depression symptom severity on likelihood of dependence in IADL (<i>p</i> = 0.04), such that within-person association between worse cognition and greater likelihood of IADL dependence was strongest among individuals with lower mean depressive symptom severity. In contrast, participants with higher mean depressive symptom severity had higher likelihoods of IADL dependence regardless of cognition. Multilevel modelling of subjective cognitive difficulties showed no significant interaction between global cognition and mean depressive symptom severity (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>The findings indicate a link between cognitive abilities and IADL dependence in PWH with low to moderate depressive symptoms. However, those with higher depressive symptoms severity report IADL dependence regardless of cognitive status. This is clinically significant because everyday functioning is measured through self-report rather than performance-based assessments.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-8"},"PeriodicalIF":2.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normative data for Vietnamese population: Effects of age, education, and sex on test performance.","authors":"Truc Tran Thanh Nguyen, Thanh-Liem Do, Huong Thi Thu Tran, Ingo Kilimann, Cong-Thang Tran","doi":"10.1017/S1355617725101100","DOIUrl":"https://doi.org/10.1017/S1355617725101100","url":null,"abstract":"<p><strong>Objective: </strong>Normative data of neuropsychological tests in the Vietnamese population is considerably lacking. We aim to evaluate the effects of age, education, and sex on the performance of common neuropsychological tests, and to generate normative data for these tests in cognitively normal Vietnamese adults.</p><p><strong>Method: </strong>Participants were recruited from two hospitals in Ho Chi Minh City, with inclusion criteria as follows: age ≥ 40 years, normal cognition and function, and Mini-Mental State Examination (MMSE) scores ≥ 26. Neuropsychological tests were administered in a paper-and-pencil format, including the CERAD Word List, Trail Making Tests, Digit Span, Animal Naming, and Clock Drawing Test. Effects of age, education, and sex on test performance were evaluated using multiple linear regression analyses. Normed scores were reported as regression-based and discrete norms tables.</p><p><strong>Results: </strong>Participants included 385 cognitively normal Vietnamese, with age 61.4 ± 10.9 years (range 40 - 89), female 56%, who were relatively highly educated (42% attended college and beyond, 36% attended high school or equivalent institutions, 22% had less than high school education), and had MMSE scores 27.8 ± 1.0. Trail Making Test Part B was completed within 300 s by only 204/385 (53%) participants. Regression analyses demonstrated significant associations between age and education with performance on all or most tests, and between sex and all CERAD Word List measures and Clock Drawing Test.</p><p><strong>Conclusions: </strong>The present work provides the first known normative data for a relatively comprehensive neuropsychological battery in Vietnamese adults. Performance on all tests was significantly influenced by age and education.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile of impairments in social and non-social cognition in vascular dementia compared to Alzheimer's disease and behavioral variant frontotemporal dementia.","authors":"Fijanne Strijkert, Rients Bauke Huitema, Barbara Charlotte van Munster, Jacoba Margje Spikman","doi":"10.1017/S1355617725101045","DOIUrl":"https://doi.org/10.1017/S1355617725101045","url":null,"abstract":"<p><strong>Objective: </strong>Impairments in emotion recognition, a crucial component of social cognition, have been previously demonstrated in patients with behavioral variant frontotemporal dementia (bv-FTD) and Alzheimer's disease (AD). However, to date, it is unclear whether patients with early-stage vascular dementia (VaD) display deficient emotion recognition. We investigated profiles of impairments in emotion recognition and non-social cognitive functions, comparing VaD patients to bv-FTD and AD patients, and healthy control participants (HC).</p><p><strong>Method: </strong>Eighty-one memory clinic patients with early-stage VaD (<i>n</i> = 30), bv-FTD (<i>n</i> = 21) and AD (<i>n</i> = 30), and 40 HCs were included and performed Ekman 60 Faces Test (EFT; emotion recognition), Auditory Verbal Learning Test (AVLT; memory - encoding and retrieval) and Trailmaking Test (TMT A, TMT B, TMT B/A; information processing speed, executive functions). Differences between groups were analyzed with analysis of variance (ANOVA), using age, education and sex adjusted norm Z scores.</p><p><strong>Results: </strong>All patient groups performed significantly worse than HCs on EFT (<i>p</i> < .001). Mean performance of VaD patients was in between bv-FTD and AD (only bv-FTD < AD, <i>p</i> < .01). All patient groups were also impaired on AVLT encoding, TMT-B and TMT B/A. Social and non-social neurocognitive functions differed between groups, with specific impairments in processing speed in VaD, emotion recognition in bv-FTD and memory retrieval in AD, and memory encoding and cognitive control impaired in all three groups.</p><p><strong>Conclusions: </strong>We found significantly different profiles in VaD, bv-FTD and AD. Assessing emotion recognition has additive value in the distinction between patient groups, allowing for more timely and accurate diagnosis in clinical practice.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-7"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entorhinal tau impairs short-term memory binding in preclinical Alzheimer's disease.","authors":"Lara Huyghe, Lisa Quenon, Yasmine Salman, Lise Colmant, Thomas Gérard, Vincent Malotaux, Emilien Boyer, Laurence Dricot, Renaud Lhommel, John L Woodard, Adrian Ivanoiu, Bernard Hanseeuw","doi":"10.1017/S1355617725000165","DOIUrl":"https://doi.org/10.1017/S1355617725000165","url":null,"abstract":"<p><strong>Objective: </strong>The entorhinal cortex (EC) is the first cortical region affected by tau pathology in Alzheimer's disease (AD), but its functions remain unclear. The EC is thought to support memory binding, which can be tested using the Visual Short-Term Memory Binding Test (VSTMBT). We aimed to test whether VSTMBT performance can identify individuals with preclinical AD before noticeable episodic memory impairment and whether these performances are related to amyloid (Aβ) pathology and/or EC tau burden.</p><p><strong>Methods: </strong>Ninety-four participants underwent the VSTMBT (including a shape-only condition (SOC) and a shape-color binding condition (SCBC)), standard neuropsychological assessment including the Preclinical Alzheimer Cognitive Composite (PACC5), an Aβ status examination, a 3D-T1 MRI and a [¹⁸F]-MK-6240 tau-PET scan. Participants were classified as follows: 54 Aβ-negative cognitively normal (Aβ - CN), 22 Aβ-positive CN (Aβ + CN, preclinical AD), and 18 Aβ + individuals with Mild Cognitive Impairment (Aβ + MCI, prodromal AD).</p><p><strong>Results: </strong>Aβ + CN individuals performed worse than Aβ-CN participants in the SCBC while the SOC only distinguished Aβ - CN from MCI participants. The SCBC performance was predicted by tau burden in the EC after adjusting for Aβ, white matter hypointensities, inferior temporal cortex (ITC) tau burden, age, sex, and education. The SCBC was more sensitive than the PACC5 in identifying CN individuals with a positive tau-PET scan.</p><p><strong>Conclusion: </strong>Impaired visual short-term memory binding performance was evident from the preclinical stage of sporadic AD and related to tau pathology in the EC, suggesting that SCBC performance could detect early tau pathology in the EC among CN individuals.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-12"},"PeriodicalIF":2.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are there associations between Executive Functions and Theory of Mind in attention deficit hyperactivity disorder? Results from a systematic review with meta-analysis.","authors":"D A Ferreira, F L Osório","doi":"10.1017/S1355617725000190","DOIUrl":"https://doi.org/10.1017/S1355617725000190","url":null,"abstract":"<p><strong>Background: </strong>Deficits in Executive Function (EF) and Theory of Mind (ToM) are common and significant in attention deficit hyperactivity disorder (ADHD), impacting self-regulation and social interaction. The nature of ToM deficits is believed to be partially associated with preexisting deficits in other core cognitive domains of ADHD, such as EF, which are essential for making mental inferences, especially complex ones. Evaluating these associations at a meta-analytic level is relevant.</p><p><strong>Objective: </strong>To conduct a systematic literature review followed by a meta-analysis to identify potential associations between EF and ToM among individuals with ADHD and their healthy counterparts, considering different developmental stages.</p><p><strong>Method: </strong>A systematic review was conducted in seven different databases. The methodological quality of the studies was assessed using the Newcastle-Ottawa Scale. The meta-analytic measurement was estimated with the correlation coefficient as the outcome. Due to the presence of heterogeneity, a random-effects model was adopted. Independent meta-analyses were conducted for different EF subdomains and ADHD and healthy control groups. Subgroup analyses were performed to examine the influence of age on the outcome of interest.</p><p><strong>Results: </strong>Fifteen studies were analyzed. Moderate associations were found when comparing EF and ToM between individuals with ADHD (0.20-0.38) and healthy subjects (0.02-0.40). No significant differences were found between child and adult samples (<i>p</i> > 0.20).</p><p><strong>Conclusion: </strong>The association between EF and ToM was significant, with a moderate effect size, although no significant differences were found according to age, the presence of ADHD, or EF subdomains. Future research is suggested to expand the age groups and overcome the methodological limitations indicated in this review.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-17"},"PeriodicalIF":2.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective cognitive functioning in adults hospitalized after traumatic brain injury: A four-year follow-up.","authors":"Simon Beaulieu-Bonneau, Éléonore Sarazin, Marie-Christine Ouellet","doi":"10.1017/S1355617725000207","DOIUrl":"https://doi.org/10.1017/S1355617725000207","url":null,"abstract":"<p><strong>Objective: </strong>To document the evolution of subjective cognitive functioning over four years in adults hospitalized after traumatic brain injury (TBI), comparing mild and moderate-severe TBI, and accounting for sociodemographic and clinical factors.</p><p><strong>Method: </strong>This secondary analysis of a longitudinal observational cohort study includes 222 adult participants hospitalized following a TBI (mean age = 41 ± 15 years; 29% women; 65% mild, 35% moderate-severe TBI). Data were collected via in-person/telephone interview and self-report questionnaires administered 4, 8, 12, 24, 36, and 48 months post-TBI. The primary outcome measure for subjective cognitive functioning was the Medical Outcomes Study Cognitive Functioning Scale (MOS-COG).</p><p><strong>Results: </strong>Mixed model analyses revealed a significant Time effect, with post hoc tests showing a better perceived cognitive functioning on the MOS-COG at 4 months than at 24 and 36 months after TBI. The TBI severity effect and TBI severity*Time interaction were not significant. Secondary effects revealed that poorer subjective cognitive functioning was associated with higher levels of symptoms of depression, anxiety, insomnia, and fatigue, and lower quality of life. Overall, the MOS-Cog score was about one standard deviation below the normative mean, suggesting greater cognitive complaints than in the general population, regardless of injury severity.</p><p><strong>Conclusions: </strong>The results suggest that subjective cognitive functioning is poorer than normative values and fairly stable over four years after TBI, with a slight decrease between 4 and 24-36 months, and is similar between mild and moderate-severe TBI.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of low scores in the Uniform Data Set version 3.0: Comparison of older adults with and without a self-reported history of traumatic brain injury.","authors":"Charles E Gaudet, Colleen E Jackson, Breton Asken, Monica Ly, Caroline Altaras, Steve Lenio, Jesse Mez, Michael L Alosco","doi":"10.1017/S1355617725000116","DOIUrl":"https://doi.org/10.1017/S1355617725000116","url":null,"abstract":"<p><strong>Objective: </strong>To assess for differences in low score frequency on cognitive testing amongst older adults with and without a self-reported history of traumatic brain injury (TBI) in the National Alzheimer's Coordinating Center (NACC) dataset.</p><p><strong>Method: </strong>The sample included adults aged 65 or older who completed the Uniform Data Set 3.0 neuropsychological test battery (N = 7,363) and was divided by individuals with and without a history of TBI, as well as cognitive status as measured by the CDR. We compared TBI- and TBI + groups by the prevalence of low scores obtained across testing. Three scores falling at or below the 2^nd percentile or four scores at or below the 5^th percentile were criteria for an atypical number of low scores. Nonparametric tests assessed associations among low score prevalence and demographics, symptoms of depression, and TBI history.</p><p><strong>Results: </strong>Among cognitively normal participants (CDR = 0), older age, male sex and greater levels of depression were associated with low score frequency; among participants with mild cognitive impairment (CDR = 0.5-1), greater levels of depression, shorter duration of time since most recent TBI, and no prior history of TBI were associated with low score frequency.</p><p><strong>Conclusions: </strong>Participants with and without a history of TBI largely produced low scores on cognitive testing at similar frequencies. Cognitive status, sex, education, depression, and TBI recency showed variable associations with the number of low scores within subsamples. Future research that includes more comprehensive TBI history is indicated to characterize factors that may modify the association between low scores and TBI history.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-10"},"PeriodicalIF":2.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensorimotor functions, visuospatial perception and visuospatial abilities in adult attention deficit hyperactivity disorder and autism spectrum disorder.","authors":"Maurizio Cundari, Susanna Vestberg, Amelia Hansson, Joakim Kennberg, Peik Gustafsson, Anders Rasmussen","doi":"10.1017/S1355617725000189","DOIUrl":"https://doi.org/10.1017/S1355617725000189","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate sensorimotor functions that require cerebellar processing, and visuospatial perception and visuospatial abilities in adult patients with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD).</p><p><strong>Method: </strong>We included patients with unmedicated ADHD (<i>n</i> = 52), medicated ADHD (<i>n</i> = 39), ASD (<i>n</i> = 33), the combination of unmedicated ADHD and ASD (<i>n</i> = 31) and controls (<i>n</i> = 78). A multimodal set of neurocognitive tests and motor tasks were administrated to evaluate cognitive and motor skills.</p><p><strong>Results: </strong>All patient groups exhibited significantly worse performances than controls in sensorimotor functions, visuospatial perception, and visuospatial abilities. We observed significant associations between sensorimotor functions and visuospatial perception and visuospatial abilities. We conducted a regression analysis to evaluate the impact of potential confounders on neurocognitive outcomes. The results indicated that age, level of education, and insomnia, but not anxiety or depression, affected the performance on some tests.</p><p><strong>Conclusions: </strong>Our results reveal deficits in sensorimotor functions, visuospatial perception, and visuospatial abilities in patients with neuropsychiatric disorders. Clear deficits emerged, despite the majority of patients showing a mild degree of severity index of ADHD/ASD across all groups (61-84%). The results are consistent with the idea that these disorders are linked to cerebellar deficits. Our results suggest that these objective tests have the potential to enhance clinical evaluations.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-13"},"PeriodicalIF":2.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Familiarity deficits in aMCI under conditions that minimize the influence of recollection.","authors":"Evi Myftaraj, Aathmika Nandan, Nicole D Anderson","doi":"10.1017/S1355617725000219","DOIUrl":"https://doi.org/10.1017/S1355617725000219","url":null,"abstract":"<p><strong>Objective: </strong>Familiarity, the sense of knowing without recalling specific details, plays a critical role in memory processing and is mediated by the perirhinal cortex (PRC), a brain region that is critical for differentiating objects with high feature overlap, and is affected first by amnestic mild cognitive impairment (aMCI). Investigating familiarity in aMCI is crucial for insights into early diagnostic markers of cognitive impairment.</p><p><strong>Method: </strong>We conducted two studies probing familiarity in aMCI. The first study employed a response deadline procedure (RDP) where participants were presented with pictures of objects and then completed an item recognition test under two deadlines: a long deadline of 5000 ms, indexing recollection, and a short deadline of 1200ms, indexing familiarity. The second study utilized a frequency judgment (FJ) task in which participants saw pictures of highly similar objects a variable number of times, and then were asked how many times each object was presented. Their frequency judgments were correlated with the actual presentation frequencies as a measure of familiarity.</p><p><strong>Results: </strong>In the RDP, individuals with aMCI had significantly lower recognition accuracy than healthy counterparts, in the long and short deadline, indicating impaired recollection and familiarity. In the FJ task, individuals with aMCI had significantly lower frequency judgment correlations, indicating impaired familiarity.</p><p><strong>Discussion: </strong>These results highlight the importance of minimizing the role of recollection when aiming to understand familiarity deficits and underscore the potential of familiarity as an early diagnostic marker of cognitive decline.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-10"},"PeriodicalIF":2.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posttraumatic headache and clinical recovery after pediatric concussion.","authors":"Mica Gabrielle Marbil, Jean-Michel Galarneau, Keith Owen Yeates, Nori Mercuri Minich, Andrew D Hershey, Serena L Orr, Dana M Defta, H Gerry Taylor, Erin D Bigler, Daniel M Cohen, Ann Bacevice, Barbara A Bangert, Ashley L Ware","doi":"10.1017/S1355617725000128","DOIUrl":"https://doi.org/10.1017/S1355617725000128","url":null,"abstract":"<p><strong>Objective: </strong>To examine the association of posttraumatic headache (PTH) type with postconcussive symptoms (PCS), pain intensity, and fluid cognitive function across recovery after pediatric concussion.</p><p><strong>Methods: </strong>This prospective, longitudinal study recruited children (aged 8-16.99 years) within 24 hours of sustaining a concussion or mild orthopedic injury (OI) from two pediatric hospital emergency departments. Based on parent-proxy ratings of pre- and postinjury headache, children were classified as concussion with no PTH (<i>n</i> = 18), new PTH (<i>n</i> = 43), worse PTH (<i>n</i> = 58), or non-worsening chronic PTH (<i>n</i> = 19), and children with OI with no PTH (<i>n</i> = 58). Children and parents rated PCS and children rated pain intensity weekly up to 6 months. Children completed computerized testing of fluid cognition 10 days, 3 months, and 6- months postinjury. Mixed effects models compared groups across time on PCS, pain intensity, and cognition, controlling for preinjury scores and covariates.</p><p><strong>Results: </strong>Group differences in PCS decreased over time. Cognitive and somatic PCS were higher in new, chronic, and worse PTH relative to no PTH (up to 8 weeks postinjury; <i>d</i> = 0.34 to 0.87 when significant) and OI (up to 5 weeks postinjury; <i>d</i> = 0.30 to 1.28 when significant). Pain intensity did not differ by group but declined with time postinjury. Fluid cognition was lower across time in chronic PTH versus no PTH (<i>d</i> = -0.76) and OI (<i>d</i> = -0.61) and in new PTH versus no PTH (<i>d</i> = -0.51).</p><p><strong>Conclusions: </strong>Onset of PTH was associated with worse PCS up to 8 weeks after pediatric concussion. Chronic PTH and new PTH were associated with moderately poorer fluid cognitive functioning up to 6 months postinjury. Pain declined over time regardless of PTH type.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-13"},"PeriodicalIF":2.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}