Journal of the International Neuropsychological Society最新文献

{"title":"Investigating acculturation in context as a framework for understanding cognition in Hispanics/Latinos of the Hispanic Community Health Study/Study of Latinos.","authors":"Melissa Lamar, Wassim Tarraf, Catherine Pichardo, Sayaka Kuwayama, Carmen R Isasi, Earle C Chambers, Mayra L Estrella, Maria M Llabre, James R Pike, Amber Pirzada, Bharat Thyagarajan, Hector M González, Linda C Gallo, Martha L Daviglus","doi":"10.1017/S1355617726102161","DOIUrl":"10.1017/S1355617726102161","url":null,"abstract":"<p><strong>Objectives: </strong>Traditional risk factors for cognitive impairment in non-Latino White adults do not manifest the same level of risk in Latinos. Despite research investigating culturally relevant factors, including acculturation, as it relates to Latino cognition, few studies have incorporated contextual factors for a more wholistic approach. We investigated acculturation-related factors within the context of socioenvironmental factors to study cognition in 8,476 self-identified Hispanic/Latino adults 45 years and older participating in the Hispanic Community Health Study/Study of Latinos baseline visit (2008-2011).</p><p><strong>Methods: </strong>Acculturation-related (e.g., nativity, social/language-based) and socioenvironmental contextualizing factors at the individual-level (e.g., social network size, social isolation) as well as the neighborhood-level (e.g., income inequality, deprivation) were determined via questionnaire or geospatial coding. Cognitive tests included verbal learning and memory, letter fluency and digit symbol substitution. We included all acculturation in context variables in the same regression models as predictors of the separate cognitive outcomes (i.e., global and the four test-specific cognitive scores) adjusting for age at baseline, sex, and education.</p><p><strong>Results: </strong>Higher language- and social-based acculturation scores, later ages of migration, US-based parental nativity, greater familial structural support, fewer experiences of unfair treatment, as well as lower levels of neighborhood gentrification, income inequality, and deprivation were associated with higher global cognition. Many of these same variables were associated with test-specific cognitive performance.</p><p><strong>Conclusion: </strong>This study, one of the first of its kind in Hispanic Community Health Study/Study of Latinos, suggests that contextualizing acculturation as it relates to cognition may point toward specific factors that may influence successful aging in middle-aged and older Hispanics/Latinos.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-11"},"PeriodicalIF":3.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance on face-valid IADL tasks in the lab is less related to independent performance of similar tasks at home than is performance on the D-KEFS: a face validity paradox.","authors":"Allie R Geiger, Yana Suchy, Michael Estrada, Libby A DesRuisseaux, Michelle Gereau Mora, Stacey Lipio Brothers","doi":"10.1017/S1355617726102173","DOIUrl":"https://doi.org/10.1017/S1355617726102173","url":null,"abstract":"<p><strong>Objective: </strong>Estimating functional independence is a critical component of neuropsychological evaluations in older adults. Commonly, three methods are used to estimate a patient's ability to engage in instrumental activities of daily living (IADLs): (1) rating scales of functional independence and (2) performance-based measures comprising IADL tasks (reflecting two face-valid approaches), and (3) performance-based measures of executive functions (EF; reflecting a more theory-based approach). The purpose of the present study was to compare these three methods' abilities to predict independent IADL capacity at home.</p><p><strong>Method: </strong>Community-dwelling older adults (<i>n</i> = 114) completed self-report and performance-based measures of IADLs, as well as traditional tests of EF at baseline. Following, participants completed the DAILIES protocol comprising 3 weeks of IADL tasks (e.g., paying bills, rescheduling appointments, etc.) performed independently at home.</p><p><strong>Results: </strong>Analyses showed that (a) EF performance speed and self-reported IADLs emerged as unique predictors (i.e., beyond each other) of the <i>accuracy</i> of the DAILIES task completion, and (b) EF performance speed also accounted for variance in the <i>timeliness</i> of DAILIES task completion. These relationships held beyond general cognitive status. However, receiver operating characteristic (ROC) analyses revealed that only EF performance speed had utility in identifying participants with below average accuracy and timeliness on the DAILIES protocol.</p><p><strong>Conclusion: </strong>These findings suggest that traditionally measured EF may have more incremental utility than at least some more face-valid predictors (i.e., certain performance-based or self-reported IADLs) in predicting independent IADL capacity at home, at least among older adults without a diagnosis of a cognitive disorder.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-10"},"PeriodicalIF":3.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home stimulation is associated with cognitive ability, working memory, and school readiness in preschool-age children with sickle cell disease.","authors":"Emily J Carlson, Andrew M Heitzer, Haitao Pan, Xiaomeng Yuan, Zhongheng Cai, Kathryn Russell, Winfred C Wang, Jane S Hankins, Jerlym Porter, Lisa M Jacola, Jane E Schreiber","doi":"10.1017/S1355617726102136","DOIUrl":"https://doi.org/10.1017/S1355617726102136","url":null,"abstract":"<p><strong>Objectives: </strong>Research has indicated that many medical and psychosocial factors contribute to cognitive deficits in sickle cell disease (SCD). Some studies of SCD in early childhood found cognitive functioning to be associated with socioeconomic status but not disease severity. The current study examined how the home environment is associated with cognitive functioning and school readiness in children with SCD.</p><p><strong>Methods: </strong>Young children (<i>n</i> = 29; M _<i>age</i> = 4.4 years <i>SD</i> = 0.3) with SCD underwent an evaluation of cognitive and academic skills. Subsequently, researchers and caregivers completed the Home Observation for Measurement of the Environment (HOME), an in-home measure of cognitive stimulation. Linear regression was used to examine the relationship between each of the HOME subscales and cognitive and academic measures while controlling for genotype.</p><p><strong>Results: </strong>The total score from the HOME inventory was associated with overall IQ, working memory, and school readiness. Among the subscales of the HOME inventory, Learning Materials, Modeling, and Variety were associated with cognitive and academic outcomes.</p><p><strong>Conclusions: </strong>Stimulation in a child's home may affect cognitive and academic development in young children with SCD. Future research should examine the benefits of increasing learning materials and the variety of activities in the homes of young SCD patients.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-9"},"PeriodicalIF":3.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148820090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive workload and its relationship with neurocognitive performance before and after breast cancer chemotherapy.","authors":"Zev M Nakamura, Brent J Small, Tim A Ahles, Patrick J Smith","doi":"10.1017/S1355617726102112","DOIUrl":"10.1017/S1355617726102112","url":null,"abstract":"<p><strong>Objectives: </strong>To compare associations between neurocognitive testing and two different self-report paradigms: (1) recall-based (PROMIS Cognitive Function) and (2) real-time, task-specific (NASA-Task Load Index [NASA-TLX]) among 56 patients with breast cancer.</p><p><strong>Methods: </strong>This is a secondary analysis from a phase II, single-arm trial of memantine to prevent cognitive decline among patients receiving chemotherapy for breast cancer (NCT04033419). Before chemotherapy and 4 weeks after their final cycle, participants completed neuropsychological assessment and self-report measures. Memantine was administered between assessments. At pre-chemotherapy, multivariable linear regression evaluated associations between a unit-weighted, composite neurocognitive test score with PROMIS Cognitive Function and NASA-TLX, controlling for age, cancer stage, and cognitive reserve. Explanatory analyses examined associations within individual neurocognitive subtests. Multivariable regression explored the extent to which pre-treatment self-reported cognition predicted post-treatment performance.</p><p><strong>Results: </strong>Pre-chemotherapy, higher NASA-TLX scores (greater perceived workload) were robustly associated with worse performance (<i>β</i> = -0.31 [-0.50, -0.12], <i>p</i> = .002). Relationships were strongest for executive function: Animal Fluency (IQR = 35): -3.3 (-5.8, -0.8), <i>p</i> = .011; COWA (IQR = 36) = -6.7 (-12.8, -0.7), <i>p</i> = .031; One Touch Stockings (IQR = 31): -0.70 (-1.0, -0.3), <i>p</i> < .001. Pre-treatment NASA-TLX was also associated with post-treatment performance in univariable but not multivariable models. PROMIS Cognitive Function and neurocognitive performance were not associated.</p><p><strong>Conclusions: </strong>The NASA-TLX and neurocognitive performance were strongly associated, particularly in the executive function domain. Future work involving the NASA-TLX in cancer populations, including its use in everyday contexts, will help clarify whether it may enhance CRCI characterization.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-9"},"PeriodicalIF":3.0,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary evaluation of a novel Brief Mathematics Achievement Test as a proxy for measuring quality of education in culturally and linguistically diverse populations.","authors":"Thomas Rune Nielsen, Vaitsa Giannouli, Maria Özden, Alfonso Delgado-Álvarez, Alvaro Lozano-Ruiz, Sanne Franzen, Tamlyn Watermeyer","doi":"10.1017/S1355617726102100","DOIUrl":"https://doi.org/10.1017/S1355617726102100","url":null,"abstract":"<p><strong>Objectives: </strong>Reading ability is commonly used as a proxy for educational quality but may be unsuitable for cross-cultural comparisons. This study aimed to evaluate a novel Brief Mathematics Achievement Test (BMAT) as a proxy measure of quality of education (QoE) in culturally and linguistically diverse populations.</p><p><strong>Methods: </strong>Data on demographic variables, socioeconomic status (SES), country-level QoE, and performance on the BMAT and brief cognitive tests, were collected from 157 cognitively healthy participants (18-89 years) including native-born and immigrant populations in five European countries.</p><p><strong>Results: </strong>No significant differences were found between females and males or between participants with native-born and immigrant backgrounds in BMAT scores. In correlation analyses, BMAT scores were strongly correlated with SES, level of education, and performance on a brief cognitive composite, moderately with student-teacher ratio, country income classification, and a quality of education index, and weakly with age. In regression models controlling for key demographic variables and socioeconomic status, BMAT scores were significantly associated with level of education and the QoE index, while showing no significant relationship with immigrant status. Also, after controlling for demographic variables, SES, and the quality of education index, BMAT scores were the only significant predictor of performance on the brief cognitive composite.</p><p><strong>Conclusions: </strong>These findings provide preliminary evidence supporting the potential utility of the BMAT as an objective proxy measure of QoE in culturally and linguistically diverse populations.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-6"},"PeriodicalIF":3.0,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized controlled trial of Understanding Social Situations versus problem-solving training in improving social function in people with psychosis.","authors":"Joanna M Fiszdon, Kaicheng Wang, Daniel Fulford, Lori Parente, Alexis Nasse, Jimmy Choi, David L Roberts","doi":"10.1017/S1355617726102070","DOIUrl":"10.1017/S1355617726102070","url":null,"abstract":"<p><strong>Objectives: </strong>Poor social function in people with psychosis has been linked to impairments in social cognition and neurocognition, which in turn have been identified as promising treatment targets. We developed a novel social cognitive intervention, Understanding Social Situations (USS), that minimizes cognitive load by leveraging delivery methods common to cognitive rehabilitation. USS focuses on making good judgments about what others may be feeling and thinking, and how they might respond in various social scenarios. In the current trial, we evaluated the efficacy of USS versus an active control.</p><p><strong>Methods: </strong>103 Veterans with psychotic spectrum disorders were randomized to two months of USS training or a problem-solving training matched for nonspecific treatment factors. Comprehensive assessments included clinician-aided self-report social functioning, social skills performance, and pre/post/follow-up ecological momentary assessments about the extent and quality of social interactions.</p><p><strong>Results: </strong>Participants in USS had significant within but not between group improvements on a clinician-aided self-report measure of social function. Social skills performance did not change for either condition. Momentary assessments revealed no change in frequency of social contacts, but those in the USS condition showed within-group improvements on comfort level during current social interactions and anticipated positive appraisals of future interactions. Those randomized to problem-solving training had significantly greater improvements in depression at post-training.</p><p><strong>Conclusions: </strong>More rigorous trials are needed evaluating the impact of social cognitive interventions on real-world social functioning. It may be particularly important to link interventions to lived social experience and to assess the quality of social interactions.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-10"},"PeriodicalIF":3.0,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13311466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148279641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychological criteria for Mild Cognitive Impairment (MCI) best identify neuroimaging-based risk profiles: A Department of Defense/Alzheimer's Disease Neuroimaging Initiative study.","authors":"Anastasia Matchanova, Monica T Ly, Conner Frank, Abigail Zaratan, Katherine J Bangen, Mark W Bondi, Lisa Delano-Wood","doi":"10.1017/S1355617726102057","DOIUrl":"10.1017/S1355617726102057","url":null,"abstract":"<p><strong>Objectives: </strong>Few studies have examined how differing diagnostic criteria for mild cognitive impairment (MCI) relate to neuroimaging markers of cerebrovascular disease and neurodegeneration in Veterans. We compared three MCI diagnostic schemes on their associations with white matter hyperintensity (WMH) burden, hippocampal volume, and cortical thickness in nondemented Vietnam-era Veterans.</p><p><strong>Methods: </strong>228 Veterans (mean age = 69.65) were classified using: (1) Alzheimer's Disease Neuroimaging Initiative (ADNI) criteria (subjective memory concerns, impaired Logical Memory, global Clinical Dementia Rating = 0.5); (2) neuropsychological criteria (>1 standard deviation [SD] below norms on two tests within a domain or one test across three domains); and (3) typical criteria (subjective memory concerns and >1.5 SD below norms on one test). Regression models predicting WMH burden adjusted for age and intracranial volume and included MCI status and hippocampal volume; ADNI-based models also included posttraumatic stress disorder symptom severity.</p><p><strong>Results: </strong>Neuropsychological criteria were associated with greater WMH burden (<i>β</i> = 0.45, <i>p</i> = .024), whereas typical and ADNI criteria were not. Sensitivity analyses found that meeting neuropsychological criteria for amnestic MCI interacted with lower hippocampal volume to predict greater WMH burden (<i>β</i> = -0.001, <i>p</i> = .028). No criteria were associated with cortical thickness.</p><p><strong>Conclusions: </strong>Neuropsychological criteria more sensitively identified Veterans with greater WMH burden and demonstrated a small, hippocampal volume-dependent effect in amnestic MCI. These findings support the clinical utility of multi-test neuropsychological approaches for detecting complex brain changes in high-comorbidity populations, with implications for risk stratification and targeted intervention in aging Veterans.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-10"},"PeriodicalIF":3.0,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13311454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148279653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WAIS-IV performance in fluent Danish-speaking Arabic-Danish bilingual university students: Effects of acculturation and bilingualism.","authors":"Ro J Robotham, Fie Larsen, Ida Thornberg Carlsen, Merwa Ibrahim, T Rune Nielsen","doi":"10.1017/S1355617726102045","DOIUrl":"10.1017/S1355617726102045","url":null,"abstract":"<p><strong>Objectives: </strong>Psychologists are increasingly asked to assess intellectual functions in adults from diverse cultural and linguistic backgrounds. This study investigated the impact of acculturation and bilingualism on Wechsler Adult Intelligence Scale (WAIS)-IV performance among Arabic-Danish bilingual university students.</p><p><strong>Methods: </strong>Forty-eight academically high-achieving participants (69% female), fluent in Danish and educated entirely in Denmark, were recruited in Greater Copenhagen and completed a demographic questionnaire, the Danish version of the WAIS-IV, and self-report measures of acculturation and bilingualism.</p><p><strong>Results: </strong>Several WAIS-IV indexes and subtests were significantly associated with degree of bilingualism and acculturation, even after controlling for educational variables. Despite being academically high-achieving university students, participants scored below the national mean on most indexes and subtests. In fact, only performances on the Processing Speed Index, and the Coding and Symbol Search subtests were at the expected level. Notably, the lowest scores were observed on Block Design, which showed a strong correlation with Arabic acculturation scores. Finally, participants had index profiles that were more uneven than predicted based on the norms.</p><p><strong>Conclusions: </strong>These findings underscore the influence of cultural and linguistic factors on WAIS-IV performance and suggest that WAIS-IV may not fully capture the intellectual abilities of bilingual individuals, even when they are fluent in the test language and have the same educational experience as the norm population.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"384-393"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148206812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"King-Devick test normative values and reliable change analysis for elite Finnish adolescent ice hockey athletes.","authors":"Jouko Leinonen, Kati Peltonen, Laura Hokkanen, Tiina Finsjö","doi":"10.1017/S1355617726102094","DOIUrl":"10.1017/S1355617726102094","url":null,"abstract":"<p><strong>Objectives: </strong>Concussion, a common injury in contact sports, often leads to oculomotor symptoms. The King-Devick (K-D) is a rapid number naming test that evaluates saccadic eye movements, visual tracking, and processing speed. We studied the effects of age and dyslexia status on K-D outcome. The aim was to determine the threshold for a clinically meaningful change in K-D test outcome in adolescent athletes.</p><p><strong>Methods: </strong>A total of 1506 Finnish athletes (mean age = 16.3, SD = 1.6) were assessed with K-D before the season. Twenty-eight percent (n = 416) participated in two consecutive baseline assessments one year apart, enabling reliable change analysis. Furthermore, results from 28 concussed athletes, assessed using the K-D test 3 days post injury, were compared to their own baseline data.</p><p><strong>Results: </strong>We found that older athletes were faster in the K-D test, and dyslexic athletes (n = 95) were significantly slower than healthy controls. When evaluated 3 days post-concussion, 54% of the studied athletes were slower in the K-D test as compared to individual baseline. The clinically significant increase in the K-D test time, performed in Finnish, was 4.4 sec. The odds ratio for significantly decreased performance post-concussion was 3.3-fold, as compared to healthy controls.</p><p><strong>Conclusions: </strong>Age, dyslexia, and spoken language affect K-D test performance, so they should be addressed when clinically using the K-D test. Taking this into account and by using specific thresholds, the K-D test could be a cost-effective method in assessing the athletes' functional vision both at baseline and after concussion.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"418-426"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive dispersion in the Alzheimer's disease spectrum.","authors":"Justine Marsault, Guillaume T Vallet, Sven Joubert","doi":"10.1017/S1355617726102082","DOIUrl":"10.1017/S1355617726102082","url":null,"abstract":"<p><strong>Objectives: </strong>Subjective cognitive decline (SCD) may represent the earliest observable stage of Alzheimer's disease (AD), yet identifying individuals at risk of progressing remains challenging. Cognitive dispersion, or intra-individual variability (IIV-D), may serve as a sensitive early marker. This study examined IIV-D across diagnostic groups, focusing on SCD and amnestic mild cognitive impairment (aMCI) progressors (SCD-p, aMCI-p; progressing to a more advanced disease stage) versus non-progressors (SCD-np, aMCI-np; not progressing to a more advanced stage). We expected greater IIV-D across groups (AD > aMCI > SCD > controls) and in progressors.</p><p><strong>Methods: </strong>A total of 308 participants aged 65-94 (67 healthy controls [HC], 126 SCD, 79 aMCI, 36 AD) from the Consortium for the Early Identification of Alzheimer's Disease - Quebec (CIMA-Q) were included. SCD and aMCI participants were followed for up to eight years (34 SCD-p, 92 SCD-np; 29 aMCI-p, 50 aMCI-np). Analyses of covariance assessed baseline across- and verbal memory within-domain IIV-D, maximum discrepancy (MD), and domain-specific deviation.</p><p><strong>Results: </strong>IIV-D increased with disease severity (HC = SCD < aMCI < AD). Among SCD participants, progressors showed greater episodic memory deviation than non-progressors, primarily driven by poorer Logical Memory delayed recall. In aMCI, progressors showed higher IIV-D across all indices (across- and within-domain, IIV-D and MD), with domain-specific differences limited to episodic memory.</p><p><strong>Conclusions: </strong>These findings indicate that IIV-D measures distinguish aMCI progressors from non-progressors, although they do not appear to enhance predictive accuracy for progression to AD and may not yet be a reliable marker at the SCD stage.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"363-374"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}