Journal of the International Neuropsychological Society最新文献

{"title":"Inhibitory control in children with agenesis of the corpus callosum compared with typically developing children.","authors":"Emilyn Soon, Vanessa Siffredi, Peter J Anderson, Vicki A Anderson, Alissandra McIlroy, Richard J Leventer, Amanda G Wood, Megan M Spencer-Smith","doi":"10.1017/S1355617723000218","DOIUrl":"10.1017/S1355617723000218","url":null,"abstract":"<p><strong>Objectives: </strong>The developmental absence (agenesis) of the corpus callosum (AgCC) is a congenital brain malformation associated with risk for a range of neuropsychological difficulties. Inhibitory control outcomes, including interference control and response inhibition, in children with AgCC are unclear. This study examined interference control and response inhibition: 1) in children with AgCC compared with typically developing (TD) children, 2) in children with different anatomical features of AgCC (complete <i>vs.</i> partial, isolated <i>vs.</i> complex), and 3) associations with white matter volume and microstructure of the anterior (AC) and posterior commissures (PC) and any remnant corpus callosum (CC).</p><p><strong>Methods: </strong>Participants were 27 children with AgCC and 32 TD children 8-16 years who completed inhibitory control assessments and brain MRI to define AgCC anatomical features and measure white matter volume and microstructure.</p><p><strong>Results: </strong>The AgCC cohort had poorer performance and higher rates of below average performance on inhibitory control measures than TD children. Children with complex AgCC had poorer response inhibition performance than children with isolated AgCC. While not statistically significant, there were select medium to large effect sizes for better inhibitory control associated with greater volume and microstructure of the AC and PC, and with reduced volume and microstructure of the remnant CC in partial AgCC.</p><p><strong>Conclusions: </strong>This study provides evidence of inhibitory control difficulties in children with AgCC. While the sample was small, the study found preliminary evidence that the AC (<i>f</i>²=.18) and PC (<i>f</i>²=.30) may play a compensatory role for inhibitory control outcomes in the absence of the CC.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9663385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zooming in on abnormal local and global processing biases after stroke: Frequency, lateralization, and associations with cognitive functions.","authors":"Antonia F Ten Brink, Janet H Bultitude, Stefan Van der Stigchel, Tanja C W Nijboer","doi":"10.1017/S1355617723000231","DOIUrl":"10.1017/S1355617723000231","url":null,"abstract":"<p><strong>Objectives: </strong>The 'attentional spotlight' can be adjusted depending on the task requirements, resulting in processing information at either the local or global level. Stroke can lead to local or global processing biases, or the inability to simultaneously attend both levels. In this study, we assessed the (1) prevalence of abnormal local and global biases following stroke, (2) differences between left- and right-sided brain damaged patients, and (3) relations between local and global interference, the ability to attend local and global levels simultaneously, and lateralized attention, search organization, search speed, visuo-construction, executive functioning, and verbal (working) memory.</p><p><strong>Methods: </strong>Stroke patients admitted for inpatient rehabilitation completed directed (<i>N</i> = 192 total; <i>N</i> = 46 left-sided/<i>N</i> = 48 right-sided lesion) and divided (<i>N</i> = 258 total; <i>N</i> = 67 left-sided/<i>N</i> = 66 right-sided lesion) local-global processing tasks, as well as a conventional neuropsychological assessment. Processing biases and interference effects were separately computed for directed and divided tasks.</p><p><strong>Results: </strong>On the local-global tasks, 7.8-10.9% of patients showed an abnormal local bias and 6.3-8.3% an abnormal global bias for directed attention, and 5.4-10.1% an abnormal local bias and 6.6-15.9% an abnormal global bias for divided attention. There was no significant difference between patients with left- and right-sided brain damage. There was a moderate positive relation between local interference and search speed, and a small positive relation between global interference and neglect.</p><p><strong>Conclusions: </strong>Abnormal local and global biases can occur after stroke and might relate to a range of cognitive functions. A specific bias might require a different approach in assessment, psycho-education, and treatment.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9310613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INS volume 30 issue 1 Cover and Front matter","authors":"","doi":"10.1017/s1355617724000018","DOIUrl":"https://doi.org/10.1017/s1355617724000018","url":null,"abstract":"","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140518991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness is associated with mentalizing and emotion recognition abilities in schizophrenia, but only in a cluster of patients with social cognitive deficits.","authors":"Ł Okruszek, M Jarkiewicz, A Piejka, M Chrustowicz, M Krawczyk, A Schudy, P D Harvey, D L Penn, K Ludwig, M F Green, A E Pinkham","doi":"10.1017/S1355617723000206","DOIUrl":"10.1017/S1355617723000206","url":null,"abstract":"<p><strong>Objective: </strong>Loneliness is a concern for patients with schizophrenia. However, the correlates of loneliness in patients with schizophrenia are unclear; thus, the aim of the study is to investigate neuro- and social cognitive mechanisms associated with loneliness in individuals with schizophrenia.</p><p><strong>Method: </strong>Data from clinical, neurocognitive, and social cognitive assessments were pooled from two cross-national samples (Poland/USA) to examine potential predictors of loneliness in 147 patients with schizophrenia and 103 healthy controls overall. Furthermore, the relationship between social cognition and loneliness was explored in clusters of patients with schizophrenia differing in social cognitive capacity.</p><p><strong>Results: </strong>Patients reported higher levels of loneliness than healthy controls. Loneliness was linked to increased negative and affective symptoms in patients. A negative association between loneliness and mentalizing and emotion recognition abilities was found in the patients with social-cognitive impairments, but not in those who performed at normative levels.</p><p><strong>Conclusions: </strong>We have elucidated a novel mechanism which may explain previous inconsistent findings regarding the correlates of loneliness in individuals with schizophrenia.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9424620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional health and its association with neurocognition in Hispanic and non-Hispanic White people with HIV.","authors":"Lesley A Guareña, Lily Kamalyan, Caitlin Wei-Ming Watson, Kayle Karcher, Anya Umlauf, Erin Morgan, David Moore, Ronald Ellis, Igor Grant, Mariana Cherner, Raeanne C Moore, Zvinka Z Zlatar, Robert K Heaton, María J Marquine","doi":"10.1017/S1355617723000188","DOIUrl":"10.1017/S1355617723000188","url":null,"abstract":"<p><strong>Objective: </strong>Emotional functioning is linked to HIV-associated neurocognitive impairment, yet research on this association among diverse people with HIV (PWH) is scant. We examined emotional health and its association with neurocognition in Hispanic and White PWH.</p><p><strong>Methods: </strong>Participants included 107 Hispanic (41% primarily Spanish-speakers; 80% Mexican heritage/origin) and 216 White PWH (Overall age: <i>M</i> = 53.62, <i>SD</i> = 12.19; 86% male; 63% AIDS; 92% on antiretroviral therapy). Emotional health was assessed via the National Institute of Health Toolbox (NIHTB)-Emotion Battery, which yields T-scores for three factor-based summary scores (negative affect, social satisfaction, and psychological well-being) and 13 individual component scales. Neurocognition was measured via demographically adjusted fluid cognition T-scores from the NIHTB-cognition battery.</p><p><strong>Results: </strong>27%-39% of the sample had problematic socioemotional summary scores. Hispanic PWH showed less loneliness, better social satisfaction, higher meaning and purpose, and better psychological well-being than Whites (<i>ps</i> <.05). Within Hispanics, Spanish-speakers showed better meaning and purpose, higher psychological well-being summary score, less anger hostility, but greater fear affect than English speakers. Only in Whites, worse negative affect (fear affect, perceived stress, and sadness) was associated with worse neurocognition (<i>p</i> <.05); and in both groups, worse social satisfaction (emotional support, friendship, and perceived rejection) was linked with worse neurocognition (<i>p</i> <.05).</p><p><strong>Conclusion: </strong>Adverse emotional health is common among PWH, with subgroups of Hispanics showing relative strengths in some domains. Aspects of emotional health differentially relate to neurocogntition among PWH and cross-culturally. Understanding these varying associations is an important step towards the development of culturally relevant interventions that promote neurocognitive health among Hispanic PWH.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10766342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9753438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"74 Neurobehavioral Symptoms of Dementia as a Risk Factor for Poor Caregiver Sleep Quality","authors":"Rylea M Ranum, Andrew M Kiselica, Kimberly O’Leary","doi":"10.1017/s1355617723007452","DOIUrl":"https://doi.org/10.1017/s1355617723007452","url":null,"abstract":"Objective:Caregivers to persons with dementia (PWD) consistently report lower sleep quality than non-caregiving controls. Low sleep quality, in addition to being unhealthy for the caregiver, may also impact the quality of care provided to the PWD. One factor that may contribute to poor sleep among caregivers is neurobehavioral symptoms (NBS) of the PWD. NBS, such as mood changes, lack of motivation, and disinhibition, are consistently rated as some of the most distressing symptoms by caregivers. Furthermore, they can include some symptoms related to sleep, such as nighttime wandering and REM sleep behaviors. Prior correlational research indicates a very strong association between NBS of the PWD and sleep quality of the caregiver. However, there are third variables, particularly demographics of the caregiver, which may better explain this relationship. When these variables are controlled in research, findings on the association between PWD NBS and caregiver sleep quality are mixed. Thus, we sought to investigate the relation between PWD NBS and caregiver sleep quality while controlling for caregiver demographics.Participants and Methods:Fifty caregivers to PWD completed a survey containing the Mild Behavioral Impairment Checklist as a measure of PWD NBS, the Pittsburgh Sleep Quality Index as a measure of caregiver sleep quality, and caregiver demographics. The relationship between PWD NBS and caregiver sleep quality was assessed using hierarchical linear regression. First, we examined the relationship between caregiver demographics (age, gender, income) and caregiver sleep quality. Second, we added NBS to the model to assess for incremental predictive utility by examining change in R<jats:sup>2</jats:sup>.Results:A significant correlation was found between PWD NBS and caregiver sleep quality, with higher PWD NBS associated with worse caregiver sleep quality (r(48) = .34, <jats:italic>p</jats:italic> = .014). A hierarchal regression found that caregiver demographics explained a non-significant proportion of variance in reported caregiver sleep quality (F(3, 44) = 1.05, <jats:italic>p</jats:italic> = .382, R<jats:sup>2</jats:sup> = .07). When PWD NBS was added in model two, there was a significant change in variance explained in the overall model (F(1,43) = 2.65, <jats:italic>p</jats:italic> = .046, AR<jats:sup>2</jats:sup> = .13, R<jats:sup>2</jats:sup> = .20). Across both models, PWD NBS was the only variable significantly associated with caregiver sleep quality (B = .08, <jats:italic>p</jats:italic> = .011).Conclusions:In line with previous studies, these results indicate a moderate relationship between PWD NBS and caregiver sleep quality. Furthermore, findings suggested that PWD NBS is a risk factor for poor caregiver sleep quality, above and beyond caregiver demographic characteristics. Individuals designing interventions aimed at improving caregiver sleep quality should consider including PWD NBS as an intervention target. Future research shou","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139026683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Symposium 2: The Need for a Highly Individualized Approach to Brain Mapping: Neuroanatomical, Lifespan and Cultural-Language Considerations","authors":"David S. Sabsevitz, Madison Berl, Połczyńska Monika","doi":"10.1017/s1355617723006525","DOIUrl":"https://doi.org/10.1017/s1355617723006525","url":null,"abstract":"&amp; Learning Objectives:Brain mapping is critical in reducing risk for cognitive morbidity in epilepsy and brain tumor surgery. Mapping using functional MRI, and extra- and intraoperative electrical stimulation, requires a high level of expertise in functional neuroanatomy but also an understanding of individual patient characteristics that can impact mapping results and post-operative outcome. Patients can vary considerably with respect to their cognitive status going into surgery. The neuroanatomy of the disease, age and developmental level, and cultural and language differences can all influence patients' performance during brain mapping and impact surgical decision making. The purpose of this session is to discuss the importance of taking a highly individualized approach to brain mapping, focusing on anatomical considerations and individual patient differences in task selection and data interpretation. We will cover language mapping in patients who speak more than one language. Practical information will be provided to help guide informed task selection through illustrative case presentations that highlight the need for individualized brain mapping.Upon conclusion of this course, learners will be able to: <jats:list list-type=\"number\"><jats:list-item><jats:label>1.</jats:label>Discuss informed task selection based on cortical and subcortical functional neuroanatomy</jats:list-item><jats:list-item><jats:label>2.</jats:label>Explain how functional maps change with normal development and factors that should be considered when interpreting results for presurgical planning</jats:list-item><jats:list-item><jats:label>3.</jats:label>Assess differences between the bilingual and monolingual brain, factors that modulate the neuroanatomical representation of language in bilinguals and strategies in mapping multiple languages for surgical planning</jats:list-item></jats:list>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139026731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CE Workshop 07: Cognitive Effects of Cancer and Treatment: “Chemobrain” and Beyond","authors":"Brenna C. McDonald","doi":"10.1017/s135561772300173x","DOIUrl":"https://doi.org/10.1017/s135561772300173x","url":null,"abstract":"&amp; Learning Objectives:Improvements in treatment for non-CNS cancer have greatly improved survivorship, allowing increased attention to cancer- and treatment-related sequelae. Cognitive symptoms (cancer-related cognitive impairment, or CRCI) are reported by a large percentage of cancer survivors, and can have a clinically meaningful impact on educational, vocational, and social functioning, and thus overall quality of life. Better understanding of these concerns is therefore of critical importance, and is needed to guide treatment and potential prevention strategies. Neuropsychological studies over the past 40 years have demonstrated cognitive domains commonly affected in cancer patients treated with chemotherapy, but have also shown cognitive differences in patients not treated with systemic therapy and those receiving other types of treatment (e.g., hormonal therapies) relative to non-cancer control groups. More recently, structural and functional neuroimaging research has added to our understanding of the neural substrate of these cognitive symptoms. This course will describe various neuroimaging modalities used to investigate CRCI, including examination of grey and white matter volume and structural integrity, blood flow, brain activation during cognitive processing and at rest, and structural and functional connectivity. The presentation will also review how neuroimaging findings relate to objective and self-reported cognition and clinical and treatment factors, and discuss potential approaches currently being investigated to treat CRCI. Upon conclusion of this course, learners will be able to:<jats:list list-type=\"number\"><jats:list-item><jats:label>1.</jats:label>Explain commonly affected cognitive domains after non-CNS cancer and treatment</jats:list-item><jats:list-item><jats:label>2.</jats:label>Discuss structural and functional brain changes related to cancer, chemotherapy, and other treatments</jats:list-item><jats:list-item><jats:label>3.</jats:label>Describe treatment interventions being investigated to treat cancer- and treatment-related cognitive symptoms.</jats:list-item></jats:list>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139026854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"78 Utility of the D-KEFS Color Word Interference Test as a Measure of Performance Validity in Adults Referred for a Psychoeducational Evaluation","authors":"Anthony Robinson, Eathan Breaux, Marissa Huber, Matthew Calamia","doi":"10.1017/s1355617723009360","DOIUrl":"https://doi.org/10.1017/s1355617723009360","url":null,"abstract":"Objective:Previous investigations have demonstrated the clinical utility of the Delis-Kaplan Executive Function System (D-KEFS) Color Word Interference Test (CWIT) as an embedded validity indicator in mixed clinical samples and traumatic brain injury. The present study sought to cross-validate previously identified indicators and cutoffs in a sample of adults referred for psychoeducational testing.Participants and Methods:Archival data from 267 students and community members self-referred for a psychoeducational evaluation at a university clinic in the South were analyzed. Referrals included assessment for attention-deficit hyperactivity disorder, specific learning disorder, autism spectrum disorder, or other disorders (e.g., anxiety, depression). Individuals were administered subtests of the D-KEFS including the CWIT and several standalone and embedded performance validity indicators as part of the evaluation. Criterion measures included The b Test, Victoria Symptom Validity Test, Medical Symptom Validity Test, Dot Counting Test, and Reliable Digit Span. Individuals who failed 0 criterion measures were included in the credible group <jats:italic>(n</jats:italic> = 164) and individuals failing 2 or more criterion measures were included in the non-credible group <jats:italic>(n</jats:italic> = 31). Because a subset of the sample were seeking external incentives (e.g., accommodations), individuals who failed only 1 of the criterion measures were excluded <jats:italic>(n</jats:italic> = 72). Indicators of interest included all test conditions examined separately, the inverted Stroop index (i.e., better performance on the interference trial than the word reading or color naming trials), inhibition and inhibition/switching composite, and sum of all conditions.Results:Receiver Operating Characteristics (ROC) curves were significant for all four conditions (p &lt; .001) and the inverted stroop index (p = .032). However, only conditions 2, 3 and 4 met minimal acceptable classification accuracy (AUC = .72 - 81). ROC curves with composite indicators were also significant (p &lt; .001), with all three composite indicators meeting minimal acceptable classification accuracy (AUC = .71- .80). At the previously identified cutoff of age corrected scale score of 6 for all four conditions, specificity was high (.88 -.91), with varying sensitivity (.23 - .45). At the previously identified cutoff of .75 for the inverted stroop index, specificity was high (.87) while sensitivity was low (.19). Composite indicators yielded high specificity (.88 - .99) at previously established cutoffs with sensitivity varying from low to moderate (.19 - .48). Increasing the cutoffs (i.e., requiring higher age corrected scale score to pass) for composite indicators increased sensitivity while still maintaining high specificity. For example, increasing the total score cutoff from 18 to 28 resulted in moderate sensitivity (.26 vs .52) with specificity of .91.Conclusions:While a cutoff of","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139029978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"83 WISC-V Profiles in a Pediatric Sickle Cell Disease Population","authors":"Rebecca Avila-Rieger, Bryan Freilich, Nicole Feirsen, Jodi Uderman","doi":"10.1017/s1355617723001637","DOIUrl":"https://doi.org/10.1017/s1355617723001637","url":null,"abstract":"Objective:Individuals with sickle cell disease (SCD) are at increased risk for developing impairment across cognitive domains, although the most common deficits are thought to be related to processing speed and executive functions. One of the most common ways of evaluating cognitive functioning is through the administration of intellectual tests. While lower overall intellectual functioning in individuals with SCD compared to healthy controls has been found, the specific pattern of strengths and weaknesses across indices is not well known. Anecdotally, it has been observed at our clinic that individuals with SCD are more likely to show relative or significant weaknesses in visuospatial abilities, but this has not been formally investigated. Further, based on the extant research, individuals with SCD would likely demonstrate lower working memory and processing speed indices, but, as far as we are aware, this has not been investigated either. The purpose of the present study is to examine the intellectual profiles, including areas of relative and significant strengths and weaknesses, of children and adolescents with SCD.Participants and Methods:Participants are children and adolescents (age 6-16) with SCD who were referred for a neuropsychological evaluation at Montefiore Medical Center’s Neuropsychological Assessment Service from 2015 to 2022. These participants (N=54) were identified through a thorough review of patients seen through this service and were administered the Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V; Wechsler, 2014). Mean scores were calculated for WISC-V indices. In addition, differences were calculated between WISC-V indices (e.g., VCI-VSI, etc.), and a discrepancy analysis was conducted comparing the base rates of these differences in the present sample to the WISC-V standardization sample.Results:In our sample, the mean total FSIQ of our sample was 85 (SD=14.5). The following mean scores were obtained across indices: VCI, SS=90 (SD=14.5); VSI, SS=86.5 (SD=14.9); FRI, SS=90 (15.5); WMI, SS=89 (SD=15.6); and PSI, SS=82 (SD=17.4). Many of the index score discrepancy base rates were similar to the standardization sample. However, our sample had greater discrepancies between several indices compared to the standardization sample. In particular, the following base rate discrepancies between index scores emerged as being different in our sample compared to the standardization sample: VCI&gt;VSI and VCI&gt;PSI. Notably, a 30+ point difference VCI&gt;VSI was found in 6% of our sample (compared to 1.6% of the standardization sample) and a 30+ point difference between VCI&gt;PSI was found in 12% of our sample (compared to 4.6% of the standardization sample). In addition, a 10+ point difference found between VCI&gt;PSI was found in 50% of our sample (compared to 29% of standardization sample).Conclusions:In our sample, FSIQ and index scores fell approximately 0.5-1.33 SD below the standardization sample means, with the","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139030184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}