Journal of the International Neuropsychological Society最新文献

{"title":"Odor increases synchronization of brain activity when watching emotional movies.","authors":"Eloïse Gerardin, Jérôme Delforge, Océane Dousteyssier, Céline Manetta, Giuliano Gaeta, Arnaud Pêtre, Laurence Dricot, Armin Heinecke, Ron Kupers","doi":"10.1017/S1355617725101082","DOIUrl":"https://doi.org/10.1017/S1355617725101082","url":null,"abstract":"<p><strong>Objective: </strong>Recent functional magnetic resonance imaging (fMRI) studies have shown that interpersonal synchronization of brain activity can be measured between people sharing similar emotional, narrative, or attentional states. There is evidence that odors can modulate the activity of brain regions involved in memory, emotion and social cognition, suggesting a link between shared olfactory experiences and synchronized brain activity in social contexts.</p><p><strong>Method: </strong>We used fMRI to investigate the effects of a positively-valenced odor on inter-subject correlation (ISC) of brain activity in healthy volunteers watching movies. While being inside an MRI scanner, participants (<i>N</i> = 20) watched short movie clips to induce either positive (happiness, tenderness) or negative (sadness, fear) emotions. Two movie clips were presented for each emotional category. Participants were scanned in two separate randomized sessions, once while watching the movie clips in the presence of an odor, and once without.</p><p><strong>Results: </strong>When all emotional categories were combined, the odor condition showed significantly higher ISC compared to the control condition in bilateral superior temporal gyri (STG), right middle temporal gyrus, left calcarine, and lingual gyrus. When splitting the movies according to valence, odor-induced increases in ISC were stronger for the negative movies. For the negative movies, ISC in the supramarginal gyrus and STG was larger in the second compared to first movie clips, indicating a time-by odor interaction.</p><p><strong>Conclusion: </strong>These findings show that odor increases ISC and that its effects depend on emotional valence. Our results further emphasize the critical role of the STG in odor-based social communication.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-11"},"PeriodicalIF":2.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognizing improved Complex Figure memory assessment: The Emory 4-choice Complex Figure recognition task.","authors":"David W Loring, Felicia C Goldstein, James J Lah, Daniel M Bolt","doi":"10.1017/S135561772510115X","DOIUrl":"https://doi.org/10.1017/S135561772510115X","url":null,"abstract":"<p><strong>Objective: </strong>We compare the Emory 10-item, 4-choice Rey Complex Figure (CF) Recognition task with the Meyers and Lange (M&L) 24-item yes/no CF Recognition task in a large cohort of healthy research participants and in patients with heterogeneous movement disorder diagnoses. While both tasks assess CF recognition, they differ in key aspects including the saliency of target and distractor responses, self-selection versus forced-choice formats, and the length of the item sets.</p><p><strong>Participants and methods: </strong>There were 1056 participants from the Emory Healthy Brain Study (EHBS; average MoCA = 26.8, SD = 2.4) and 223 movement disorder patients undergoing neuropsychological evaluation (average MoCA = 24.3, SD = 4.0).</p><p><strong>Results: </strong>Both recognition tasks differentiated between healthy and clinical groups; however, the Emory task demonstrated a larger effect size (Cohen's <i>d</i> = 1.02) compared to the M&L task (Cohen's <i>d</i> = 0.79). d-prime scoring of M&L recognition showed comparable group discrimination (Cohen's <i>d</i> = 0.81). Unidimensional two-parameter logistic item response theory analysis revealed that many M&L items had low discrimination values and extreme difficulty parameters, which contributed to the task's reduced sensitivity, particularly at lower cognitive proficiency levels relevant to clinical diagnosis. Dimensionality analyses indicated the influence of response sets as a potential contributor to poor item performance.</p><p><strong>Conclusions: </strong>Emory CF Recognition task demonstrates superior psychometric properties and greater sensitivity to cognitive impairment compared to the M&L task. Its ability to more precisely measure lower levels of cognitive functioning, along with its brevity, suggests it may be more effective for diagnostic use, especially in clinical populations with cognitive decline.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-8"},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive decline over 7 years in aging patients with childhood-onset epilepsy: A population-based prospective follow-up study.","authors":"Mira Karrasch, Bruce Hermann, Tove Roos, Juho Joutsa, Juha O Rinne, Riitta Parkkola, Petri Tiitta, Matti Sillanpää","doi":"10.1017/S1355617725101021","DOIUrl":"https://doi.org/10.1017/S1355617725101021","url":null,"abstract":"<p><strong>Objective: </strong>The cognitive trajectory of aging individuals with childhood-onset epilepsy is poorly understood. Our aim was to examine cognitive change over a 7-year period in aging individuals with epilepsy, originally recruited for prospective follow up in the early 1960's.</p><p><strong>Method: </strong>36 participants with childhood-onset epilepsy from a prospective population-based cohort and 39 controls participated in the 50-year and 57-year follow-up data collections. Eight participants had active epilepsy, 28 were in remission. Eleven neuropsychological tests were used to measure language/semantic function, episodic memory and learning, executive function, visuomotor function, and working memory. Regression-based standardized change scores were used to control for sources of error in test-retest assessments.</p><p><strong>Results: </strong>Participants with epilepsy lacked a test-retest effect in language functions. A significant decline was found in participants with active epilepsy in episodic memory functions overall, and in those with remitted epilepsy in learning, immediate recall and set-shifting. The risk of clinically significant general cognitive decline was higher in participants with active epilepsy (OR 61.25, 95% CI 5.92-633.81, <i>p</i> = .0006). Among those with remitted epilepsy the risk was lower and non-significant (OR 2.19, 95% CI 0.58-8.23, <i>p</i> = .24).</p><p><strong>Conclusions: </strong>Our results demonstrate poorer cognitive trajectories in participants with childhood-onset epilepsy compared to controls, particularly in those with active epilepsy. The risk of general cognitive decline was lower in participants with remitted epilepsy, but a decline in episodic memory functions was observed. Our findings likely reflect faster brain aging in childhood-onset epilepsy, even in individuals with early remission.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-10"},"PeriodicalIF":2.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of chronic pain and opioid use is associated with cognitive decline and mild cognitive impairment.","authors":"Tyler R Bell, Jeremy A Elman, Daniel E Gustavson, Michael J Lyons, Christine Fennema-Notestine, McKenna E Williams, Matthew S Panizzon, Rahul C Pearce, Chandra A Reynolds, Mark Sanderson-Cimino, Rosemary Toomey, Amy Jak, Carol E Franz, William S Kremen","doi":"10.1017/S1355617725101057","DOIUrl":"10.1017/S1355617725101057","url":null,"abstract":"<p><strong>Background: </strong>The impact of chronic pain and opioid use on cognitive decline and mild cognitive impairment (MCI) is unclear. We investigated these associations in early older adulthood, considering different definitions of chronic pain.</p><p><strong>Methods: </strong>Men in the Vietnam Era Twin Study of Aging (VETSA; <i>n</i> = 1,042) underwent cognitive testing and medical history interviews at average ages 56, 62, and 68. Chronic pain was defined using pain intensity and interference ratings from the SF-36 over 2 or 3 waves (categorized as mild versus moderate-to-severe). Opioid use was determined by self-reported medication use. Amnestic and non-amnestic MCI were assessed using the Jak-Bondi approach. Mixed models and Cox proportional hazards models were used to assess associations of pain and opioid use with cognitive decline and risk for MCI.</p><p><strong>Results: </strong>Moderate-to-severe, but not mild, chronic pain intensity (<i>β</i> = -.10) and interference (<i>β</i> = -.23) were associated with greater declines in executive function. Moderate-to-severe chronic pain intensity (<i>HR</i> = 1.75) and interference (<i>HR</i> = 3.31) were associated with a higher risk of non-amnestic MCI. Opioid use was associated with a faster decline in verbal fluency (<i>β</i> = -.18) and a higher risk of amnestic MCI (<i>HR</i> = 1.99). There were no significant interactions between chronic pain and opioid use on cognitive decline or MCI risk (all <i>p</i>-values > .05).</p><p><strong>Discussion: </strong>Moderate-to-severe chronic pain intensity and interference related to executive function decline and greater risk of non-amnestic MCI; while opioid use related to verbal fluency decline and greater risk of amnestic MCI. Lowering chronic pain severity while reducing opioid exposure may help clinicians mitigate later cognitive decline and dementia risk.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-11"},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the cerebellar cognitive affective syndrome (CCAS) scale in CCAS patients and cerebellar controls.","authors":"Stacha F I Reumers, Roderick P P W M Maas, Veerle J M van den Brandt, Lotte A H Kocken, Iris M Wiegand, Frank-Erik de Leeuw, Dennis J L G Schutter, Bart P C van de Warrenburg, Roy P C Kessels","doi":"10.1017/S1355617725101033","DOIUrl":"https://doi.org/10.1017/S1355617725101033","url":null,"abstract":"<p><strong>Objective: </strong>The cerebellar cognitive affective syndrome (CCAS) scale has been developed to screen for possible cognitive and affective impairments in cerebellar patients, but previous studies stressed concerns regarding insufficient specificity of the scale. Also, direct comparisons of CCAS scale performance between cerebellar patients with and without CCAS are currently lacking. The aim of this study was to evaluate the validity of the CCAS scale in cerebellar patients.</p><p><strong>Method: </strong>In this study, cerebellar patients with CCAS (<i>n</i> = 49), without CCAS (<i>n</i> = 30), and healthy controls (<i>n</i> = 32) were included. The Dutch/Flemish version of the CCAS scale was evaluated in terms of validity and reliability using an extensive neuropsychological assessment as the gold standard for CCAS. Correlations were examined between the CCAS scale and possible confounding factors. Additionally, a correction for dysarthria was applied to timed neuropsychological tests to explore the influence of dysarthria on test outcomes.</p><p><strong>Results: </strong>Cerebellar patients with CCAS performed significantly worse on the CCAS scale compared to cerebellar controls. Sensitivity was acceptable, but specificity was insufficient due to high false-positive rates. Correlations were found between outcomes of the scale and both education and age. Although dysarthria did not affect the validity of the CCAS scale, it may influence timed neuropsychological test outcomes.</p><p><strong>Conclusions: </strong>Evaluation of the CCAS scale revealed insufficient specificity. Our findings call for age- and education-dependent reference values, which may improve the validity and usability of the scale. Dysarthria might be a confounding factor in timed test items and should be considered to prevent misclassification.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-11"},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unequal neighborhoods, unequal skills: Adaptive functioning and access to community resources.","authors":"Allison E Gornik, Christina E Love, Alison E Pritchard, Rebecca W Lieb, Lisa A Jacobson, Rowena Ng, Rachel K Peterson, Luther G Kalb","doi":"10.1017/S1355617725101070","DOIUrl":"https://doi.org/10.1017/S1355617725101070","url":null,"abstract":"<p><strong>Objective: </strong>To examine the relationship between children's adaptive functioning and neighborhood resources - such as school quality, access to healthy food, green spaces, and housing quality - using a large, diverse clinical outpatient sample.</p><p><strong>Method: </strong>Pediatric outpatients (N = 6,942; age M = 10.44 years; 67.0% male; 50.3% White; 33.9% Medicaid), aged 1-18, who underwent neuropsychological or psychological evaluation were included if their caregiver completed the Adaptive Behavior Assessment System, 3rd Edition (ABAS-3) and had a nationally normed Child Opportunity Index (COI) score, a composite measure of 29 geo-coded neighborhood characteristics.</p><p><strong>Results: </strong>Children from higher-opportunity neighborhoods demonstrated significantly stronger adaptive functioning across conceptual, social, and practical domains. Those in the top 40% of neighborhood advantage exhibited stronger adaptive skills than those in the bottom 60%. Neighborhood resources and family financial resources were associated with greater adaptive skills beyond child age, sex, and racial/ethnic background.</p><p><strong>Conclusion: </strong>Neighborhood resources are linked to children's adaptive functioning, possibly due to increased opportunities to practice these skills in safer, more supportive environments. These findings emphasize the importance of considering environmental factors in assessing adaptive skills and highlight the need for public health investments and legislation related to community resources.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-6"},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verbal initiation, selection, strategy, and inhibition in stroke: A brief executive function screening tool.","authors":"Mia R Phillips, Jessica Byrne, Casey Gilbert, Lucy Ford, Gail A Robinson","doi":"10.1017/S1355617725101112","DOIUrl":"https://doi.org/10.1017/S1355617725101112","url":null,"abstract":"<p><strong>Objective: </strong>Executive dysfunction is prevalent in early stroke and can predict long-term outcomes. Impairments can be subtle and undetected in cognitive stroke screens. To better assess executive functions, this study introduced a novel sentence completion test, which assesses multiple executive processes in <5 minutes (Brief Executive Language Screen - Sentence Completion; BELS-SC). The aim was to determine construct, convergent and divergent validity, sensitivity and specificity of the BELS-SC, and to explore differences between left and right hemisphere stroke patients (LHS and RHS, respectively) on the BELS-SC and standard executive function tests.</p><p><strong>Method: </strong>Eighty-eight acute/early sub-acute stroke patients and 116 age-matched healthy controls were included.</p><p><strong>Results: </strong>Principal Component Analysis (PCA) suggested four to five factors of the BELS-SC: Initiation, Selection, Inhibition (with strategy loading on Inhibition), Inhibition Response Time, and Semantic Retrieval Response Time. The BELS-SC had good sensitivity (.84) but poorer specificity (.66) differentiating controls and stroke, and good sensitivity (.83) and specificity (.80) differentiating executive function impaired versus executive function intact groups. BELS-SC Initiation and Inhibition subtests demonstrated convergent and divergent validity with corresponding Hayling subtests. LHS and RHS showed impairment across initiation, selection, inhibition and strategy; however, greatest deficits were shown by RHS on Inhibition items requiring suppression of one dominant response. More patients were impaired on BELS-SC than other executive function tests.</p><p><strong>Conclusions: </strong>The BELS-SC demonstrated convergent, divergent, and construct validity, good sensitivity and specificity, taps multiple executive processes, and provides insight into strategy. Use in early stroke may aid in targeted and timely cognitive rehabilitation.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-17"},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-reported everyday functioning among adults with human immunodeficiency virus: Longitudinal associations with global neurocognitive functioning and depressive symptoms.","authors":"Maximo R Prescott, Emily W Paolillo, Carlos D Rivera Saldana, Donald Franklin, Elizabeth C Pasipanodya, Mariam A Hussain, Raeanne C Moore, Robert K Heaton, Jessica L Montoya, David J Moore","doi":"10.1017/S1355617725101094","DOIUrl":"https://doi.org/10.1017/S1355617725101094","url":null,"abstract":"<p><strong>Objective: </strong>Diagnosing HIV-Associated Neurocognitive Disorders (HAND) requires attributing neurocognitive impairment and functional decline at least partly to HIV-related brain effects. Depressive symptom severity, whether attributable to HIV or not, may influence self-reported functioning. We examined longitudinal relationships among objective global cognition, depressive symptom severity, and self-reported everyday functioning in people with HIV (PWH).</p><p><strong>Methods: </strong>Longitudinal data from 894 PWH were collected at a university-based research center (2002-2016). Participants completed self-report measures of everyday functioning to assess both dependence in instrumental activities of daily living (IADL) and subjective cognitive difficulties at each visit, along with depressive symptom severity (BDI-II). Multilevel modeling examined within- and between-person predictors of self-reported everyday functioning outcomes.</p><p><strong>Results: </strong>Participants averaged 6 visits over 5 years. Multilevel regression showed a significant interaction between visit-specific global cognitive performance and mean depression symptom severity on likelihood of dependence in IADL (<i>p</i> = 0.04), such that within-person association between worse cognition and greater likelihood of IADL dependence was strongest among individuals with lower mean depressive symptom severity. In contrast, participants with higher mean depressive symptom severity had higher likelihoods of IADL dependence regardless of cognition. Multilevel modelling of subjective cognitive difficulties showed no significant interaction between global cognition and mean depressive symptom severity (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>The findings indicate a link between cognitive abilities and IADL dependence in PWH with low to moderate depressive symptoms. However, those with higher depressive symptoms severity report IADL dependence regardless of cognitive status. This is clinically significant because everyday functioning is measured through self-report rather than performance-based assessments.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-8"},"PeriodicalIF":2.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normative data for Vietnamese population: Effects of age, education, and sex on test performance.","authors":"Truc Tran Thanh Nguyen, Thanh-Liem Do, Huong Thi Thu Tran, Ingo Kilimann, Cong-Thang Tran","doi":"10.1017/S1355617725101100","DOIUrl":"https://doi.org/10.1017/S1355617725101100","url":null,"abstract":"<p><strong>Objective: </strong>Normative data of neuropsychological tests in the Vietnamese population is considerably lacking. We aim to evaluate the effects of age, education, and sex on the performance of common neuropsychological tests, and to generate normative data for these tests in cognitively normal Vietnamese adults.</p><p><strong>Method: </strong>Participants were recruited from two hospitals in Ho Chi Minh City, with inclusion criteria as follows: age ≥ 40 years, normal cognition and function, and Mini-Mental State Examination (MMSE) scores ≥ 26. Neuropsychological tests were administered in a paper-and-pencil format, including the CERAD Word List, Trail Making Tests, Digit Span, Animal Naming, and Clock Drawing Test. Effects of age, education, and sex on test performance were evaluated using multiple linear regression analyses. Normed scores were reported as regression-based and discrete norms tables.</p><p><strong>Results: </strong>Participants included 385 cognitively normal Vietnamese, with age 61.4 ± 10.9 years (range 40 - 89), female 56%, who were relatively highly educated (42% attended college and beyond, 36% attended high school or equivalent institutions, 22% had less than high school education), and had MMSE scores 27.8 ± 1.0. Trail Making Test Part B was completed within 300 s by only 204/385 (53%) participants. Regression analyses demonstrated significant associations between age and education with performance on all or most tests, and between sex and all CERAD Word List measures and Clock Drawing Test.</p><p><strong>Conclusions: </strong>The present work provides the first known normative data for a relatively comprehensive neuropsychological battery in Vietnamese adults. Performance on all tests was significantly influenced by age and education.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile of impairments in social and non-social cognition in vascular dementia compared to Alzheimer's disease and behavioral variant frontotemporal dementia.","authors":"Fijanne Strijkert, Rients Bauke Huitema, Barbara Charlotte van Munster, Jacoba Margje Spikman","doi":"10.1017/S1355617725101045","DOIUrl":"https://doi.org/10.1017/S1355617725101045","url":null,"abstract":"<p><strong>Objective: </strong>Impairments in emotion recognition, a crucial component of social cognition, have been previously demonstrated in patients with behavioral variant frontotemporal dementia (bv-FTD) and Alzheimer's disease (AD). However, to date, it is unclear whether patients with early-stage vascular dementia (VaD) display deficient emotion recognition. We investigated profiles of impairments in emotion recognition and non-social cognitive functions, comparing VaD patients to bv-FTD and AD patients, and healthy control participants (HC).</p><p><strong>Method: </strong>Eighty-one memory clinic patients with early-stage VaD (<i>n</i> = 30), bv-FTD (<i>n</i> = 21) and AD (<i>n</i> = 30), and 40 HCs were included and performed Ekman 60 Faces Test (EFT; emotion recognition), Auditory Verbal Learning Test (AVLT; memory - encoding and retrieval) and Trailmaking Test (TMT A, TMT B, TMT B/A; information processing speed, executive functions). Differences between groups were analyzed with analysis of variance (ANOVA), using age, education and sex adjusted norm Z scores.</p><p><strong>Results: </strong>All patient groups performed significantly worse than HCs on EFT (<i>p</i> < .001). Mean performance of VaD patients was in between bv-FTD and AD (only bv-FTD < AD, <i>p</i> < .01). All patient groups were also impaired on AVLT encoding, TMT-B and TMT B/A. Social and non-social neurocognitive functions differed between groups, with specific impairments in processing speed in VaD, emotion recognition in bv-FTD and memory retrieval in AD, and memory encoding and cognitive control impaired in all three groups.</p><p><strong>Conclusions: </strong>We found significantly different profiles in VaD, bv-FTD and AD. Assessing emotion recognition has additive value in the distinction between patient groups, allowing for more timely and accurate diagnosis in clinical practice.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-7"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}