Mathematical Biosciences and Engineering最新文献_第9页

Approximating reproduction numbers: a general numerical method for age-structured models. 近似繁殖数：年龄结构模型的一般数值方法。

IF 2.6 4区工程技术

Mathematical Biosciences and Engineering Pub Date : 2024-03-07 DOI: 10.3934/mbe.2024236

Simone De Reggi, Francesca Scarabel, Rossana Vermiglio

引用次数: 0

Safety and efficacy of carbamazepine in the treatment of trigeminal neuralgia: A metanalysis in biomedicine. 卡马西平治疗三叉神经痛的安全性和有效性：生物医学中的荟萃分析。

IF 2.6 4区工程技术

Mathematical Biosciences and Engineering Pub Date : 2024-03-07 DOI: 10.3934/mbe.2024235

M Guo, W Shen, M Zhou, Y Song, J Liu, W Xiong, Y Gao

{"title":"Safety and efficacy of carbamazepine in the treatment of trigeminal neuralgia: A metanalysis in biomedicine.","authors":"M Guo, W Shen, M Zhou, Y Song, J Liu, W Xiong, Y Gao","doi":"10.3934/mbe.2024235","DOIUrl":"10.3934/mbe.2024235","url":null,"abstract":"Trigeminal neuralgia is a debilitating condition characterized by severe facial pain. Carbamazepine has been widely used as a first-line treatment option for trigeminal neuralgia, but there is a need to evaluate its safety and efficacy based on existing evidence. This meta-analysis aims to systematically assess the available literature and provide a comprehensive evaluation of the safety and efficacy of carbamazepine in the treatment of trigeminal neuralgia. A thorough search of electronic databases yielded a total of 15 relevant studies that met the inclusion criteria. The pooled analysis of these studies revealed that carbamazepine demonstrated significant efficacy in reducing pain intensity and frequency in patients with trigeminal neuralgia. Moreover, the drug was generally well-tolerated, with the most common adverse events being mild and transient. Subgroup analyses based on different dosages and treatment durations further supported the overall findings. However, caution should be exercised in patients with certain comorbidities or specific populations, as some rare but severe adverse events were reported. In conclusion, this meta-analysis provides strong evidence supporting the safety and efficacy of carbamazepine as a valuable therapeutic option for the management of trigeminal neuralgia. These results can guide clinicians in making informed decisions regarding the use of carbamazepine and contribute to optimizing treatment strategies for patients with trigeminal neuralgia. Further research is warranted to explore long-term safety and efficacy outcomes, as well as to compare carbamazepine with alternative treatment modalities.","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"21 4","pages":"5335-5359"},"PeriodicalIF":2.6,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamics and optimal control of tuberculosis model with the combined effects of vaccination, treatment and contaminated environments. 具有疫苗接种、治疗和污染环境综合效应的结核病模型的动力学和优化控制。

IF 2.6 4区工程技术

Mathematical Biosciences and Engineering Pub Date : 2024-03-07 DOI: 10.3934/mbe.2024234

Tao-Li Kang, Hai-Feng Huo, Hong Xiang

{"title":"Dynamics and optimal control of tuberculosis model with the combined effects of vaccination, treatment and contaminated environments.","authors":"Tao-Li Kang, Hai-Feng Huo, Hong Xiang","doi":"10.3934/mbe.2024234","DOIUrl":"https://doi.org/10.3934/mbe.2024234","url":null,"abstract":"Tuberculosis has affected human beings for thousands of years, and until today, tuberculosis still ranks third among 29 infectious diseases in China. However, most of the existing mathematical models consider a single factor, which is not conducive to the study of tuberculosis transmission dynamics. Therefore, this study considers the combined effects of vaccination, treatment, and contaminated environments on tuberculosis, and builds a new model with seven compartments of $ SVEITRW $ based on China's tuberculosis data. The study shows that when the basic reproduction number $ R_{0} $ is less than 1, the disease will eventually disappear, but when $ R_{0} $ is greater than 1, the disease may persist. In the numerical analysis part, we use Markov-chain Monte-Carlo method to obtain the optimal parameters of the model. Through the next generation matrix theory, we calculate that the $ R_{0} $ value of tuberculosis in China is $ 2.1102 $, that is, if not controlled, tuberculosis in China will not disappear over time. At the same time, through partial rank correlation coefficients, we find the most sensitive parameter to the basic reproduction number $ R_{0} $. On this basis, we combine the actual prevalence of tuberculosis in China, apply Pontryagin's maximum principle, and perform cost-effectiveness analysis to obtain the conditions required for optimal control. The analysis shows that four control strategies could effectively reduce the prevalence of TB, and simultaneously controlling $ u_{2}, u_{3}, u_{4} $ is the most cost-effective control strategy.","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"21 4","pages":"5308-5334"},"PeriodicalIF":2.6,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep CNNs for glioma grading on conventional MRIs: Performance analysis, challenges, and future directions. 用于传统磁共振成像胶质瘤分级的深度 CNN：性能分析、挑战和未来方向。

IF 2.6 4区工程技术

Mathematical Biosciences and Engineering Pub Date : 2024-03-06 DOI: 10.3934/mbe.2024232

Sonam Saluja, Munesh Chandra Trivedi, Ashim Saha

{"title":"Deep CNNs for glioma grading on conventional MRIs: Performance analysis, challenges, and future directions.","authors":"Sonam Saluja, Munesh Chandra Trivedi, Ashim Saha","doi":"10.3934/mbe.2024232","DOIUrl":"https://doi.org/10.3934/mbe.2024232","url":null,"abstract":"The increasing global incidence of glioma tumors has raised significant healthcare concerns due to their high mortality rates. Traditionally, tumor diagnosis relies on visual analysis of medical imaging and invasive biopsies for precise grading. As an alternative, computer-assisted methods, particularly deep convolutional neural networks (DCNNs), have gained traction. This research paper explores the recent advancements in DCNNs for glioma grading using brain magnetic resonance images (MRIs) from 2015 to 2023. The study evaluated various DCNN architectures and their performance, revealing remarkable results with models such as hybrid and ensemble based DCNNs achieving accuracy levels of up to 98.91%. However, challenges persisted in the form of limited datasets, lack of external validation, and variations in grading formulations across diverse literature sources. Addressing these challenges through expanding datasets, conducting external validation, and standardizing grading formulations can enhance the performance and reliability of DCNNs in glioma grading, thereby advancing brain tumor classification and extending its applications to other neurological disorders.","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"21 4","pages":"5250-5282"},"PeriodicalIF":2.6,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on synergistic effect of multiple physical fields on hot mix asphalt during compaction process. 压实过程中多种物理场对热拌沥青的协同效应研究

IF 2.6 4区工程技术

Mathematical Biosciences and Engineering Pub Date : 2024-03-06 DOI: 10.3934/mbe.2024229

Huanan Yu, Yutang Gao, Guoping Qian, Chao Zhang, Changyun Shi, Jinguo Ge, Wan Dai

{"title":"Study on synergistic effect of multiple physical fields on hot mix asphalt during compaction process.","authors":"Huanan Yu, Yutang Gao, Guoping Qian, Chao Zhang, Changyun Shi, Jinguo Ge, Wan Dai","doi":"10.3934/mbe.2024229","DOIUrl":"https://doi.org/10.3934/mbe.2024229","url":null,"abstract":"The multiple physical fields of hot mix asphalt (HMA) during the compaction process have a significant impact on the durability of asphalt pavement, and this research aimed to evaluate the synergistic effect of the HMA field compaction of multi-physical field evolution during the compaction process. First, the temperature field, structural layer thickness variation, and structural layer density variation were monitored during field compaction. Second, the evolution properties of compaction thickness were obtained under the synergistic influence of multi-physical fields by temperature field and compaction thickness. Finally, the evolution properties of compaction density were obtained under the synergistic influence of multi-physical fields based on the temperature field and structural layer density. The results showed that the field compaction process could be characterized by three stages under the synergistic impact of multi-physical fields. The cooling of the temperature field presents two-stage characteristics. There were cubic polynomial evolution properties for the temperature field versus time and the density versus temperature field. There was an exponential relationship between the thickness of the compacted layer and the number of mills. The aggregate particles showed different motion characteristics in the horizontal and vertical directions and vertical directions. The vertical displacement was larger than the horizontal displacement under the synergistic influence of multi-physical fields during the three stages of compaction. The migration and reorganization of aggregate particles affected the evolution of the multi-physics fields of the compaction process under the action of different compaction modes.","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"21 4","pages":"5181-5206"},"PeriodicalIF":2.6,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of a COVID-19 model with media coverage and limited resources. 在媒体报道和资源有限的情况下分析 COVID-19 模型。

IF 2.6 4区工程技术

Mathematical Biosciences and Engineering Pub Date : 2024-03-06 DOI: 10.3934/mbe.2024233

Tao Chen, Zhiming Li, Ge Zhang

引用次数: 0

Modeling different infectious phases of hepatitis B with generalized saturated incidence: An analysis and control. 用广义饱和发病率模拟乙型肝炎的不同传染阶段：分析与控制。

IF 2.6 4区工程技术

Mathematical Biosciences and Engineering Pub Date : 2024-03-06 DOI: 10.3934/mbe.2024230

Tahir Khan, Fathalla A Rihan, Muhammad Ibrahim, Shuo Li, Atif M Alamri, Salman A AlQahtani

{"title":"Modeling different infectious phases of hepatitis B with generalized saturated incidence: An analysis and control.","authors":"Tahir Khan, Fathalla A Rihan, Muhammad Ibrahim, Shuo Li, Atif M Alamri, Salman A AlQahtani","doi":"10.3934/mbe.2024230","DOIUrl":"https://doi.org/10.3934/mbe.2024230","url":null,"abstract":"Hepatitis B is one of the global health issues caused by the hepatitis B virus (HBV), producing 1.1 million deaths yearly. The acute and chronic phases of HBV are significant because worldwide, approximately 250 million people are infected by chronic hepatitis B. The chronic stage is a long-term, persistent infection that can cause liver damage and increase the risk of liver cancer. In the case of multiple phases of infection, a generalized saturated incidence rate model is more reasonable than a simply saturated incidence because it captures the complex dynamics of the different infection phases. In contrast, a simple saturated incidence rate model assumes a fixed shape for the incidence rate curve, which may not accurately reflect the dynamics of multiple infection phases. Considering HBV and its various phases, we constructed a model to present the dynamics and control strategies using the generalized saturated incidence. First, we proved that the model is well-posed. We then found the reproduction quantity and model equilibria to discuss the time dynamics of the model and investigate the conditions for stabilities. We also examined a control mechanism by introducing various controls to the model with the aim to increase the population of those recovered and minimize the infected people. We performed numerical experiments to check the biological significance and control implementation.","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"21 4","pages":"5207-5226"},"PeriodicalIF":2.6,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modelling mosquito population suppression based on competition system with strong and weak Allee effect. 基于强阿利效应和弱阿利效应竞争系统的蚊子种群抑制模型。

IF 2.6 4区工程技术

Mathematical Biosciences and Engineering Pub Date : 2024-03-06 DOI: 10.3934/mbe.2024231

Chen Liang, Hai-Feng Huo, Hong Xiang

引用次数: 0

The impact of MCCK1, an inhibitor of IKBKE kinase, on acute B lymphocyte leukemia cells. IKBKE 激酶抑制剂 MCCK1 对急性 B 淋巴细胞白血病细胞的影响。

IF 2.6 4区工程技术

Mathematical Biosciences and Engineering Pub Date : 2024-03-05 DOI: 10.3934/mbe.2024228

Shuangshuang Wen, Peng Zhao, Siyu Chen, Bo Deng, Qin Fang, Jishi Wang

{"title":"The impact of MCCK1, an inhibitor of IKBKE kinase, on acute B lymphocyte leukemia cells.","authors":"Shuangshuang Wen, Peng Zhao, Siyu Chen, Bo Deng, Qin Fang, Jishi Wang","doi":"10.3934/mbe.2024228","DOIUrl":"10.3934/mbe.2024228","url":null,"abstract":"B-cell acute lymphoblastic leukemia (B-ALL) is a malignant blood disorder, particularly detrimental to children and adolescents, with recurrent or unresponsive cases contributing significantly to cancer-associated fatalities. IKBKE, associated with innate immunity, tumor promotion, and drug resistance, remains poorly understood in the context of B-ALL. Thus, this research aimed to explore the impact of the IKBKE inhibitor MCCK1 on B-ALL cells. The study encompassed diverse experiments, including clinical samples, in vitro and in vivo investigations. Quantitative real-time fluorescence PCR and protein blotting revealed heightened IKBKE mRNA and protein expression in B-ALL patients. Subsequent in vitro experiments with B-ALL cell lines demonstrated that MCCK1 treatment resulted in reduced cell viability and survival rates, with flow cytometry indicating cell cycle arrest. In vivo experiments using B-ALL mouse tumor models substantiated MCCK1's efficacy in impeding tumor proliferation. These findings collectively suggest that IKBKE, found to be elevated in B-ALL patients, may serve as a promising drug target, with MCCK1 demonstrating potential for inducing apoptosis in B-ALL cells both in vitro and in vivo.","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"21 4","pages":"5164-5180"},"PeriodicalIF":2.6,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Numerical and graphical simulation of the non-linear fractional dynamical system of bone mineralization. 骨矿化非线性分数动力系统的数值和图形模拟。

IF 2.6 4区工程技术

Mathematical Biosciences and Engineering Pub Date : 2024-03-04 DOI: 10.3934/mbe.2024227

Ritu Agarwal, Pooja Airan, Mohammad Sajid

引用次数: 0