Martin Bohner, Jaqueline G Mesquita, Sabrina Streipert
{"title":"Massera's theorem on arbitrary discrete time domains.","authors":"Martin Bohner, Jaqueline G Mesquita, Sabrina Streipert","doi":"10.3934/mbe.2025067","DOIUrl":"https://doi.org/10.3934/mbe.2025067","url":null,"abstract":"<p><p>We present a general version of Massera's theorems for arbitrary discrete domains, based on a newly introduced definition for both linear and nonlinear equations. For scalar nonlinear equations, we identify sufficient conditions that ensure each u-bounded solution approaches a periodic solution asymptotically. In the case of linear systems, we prove that the presence of a u-bounded solution necessarily leads to a periodic solution. We also provide some examples to show the practical implications of our findings.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"22 7","pages":"1861-1874"},"PeriodicalIF":2.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Food choices and body weight changes: A mathematical model analysis.","authors":"Mantana Chudtong, Andrea De Gaetano","doi":"10.3934/mbe.2025065","DOIUrl":"https://doi.org/10.3934/mbe.2025065","url":null,"abstract":"<p><p>A short-term stochastic model of minute-by-minute food intake is formulated, incorporating the interaction of appetite, insulinemia, and glycemia in determining the size and frequency of meals. By assuming a person would maintain his or her eating habit over time, we extend the simulation period to several years and explore scenarios based on food choices (high-fiber vs. high-carbohydrate) or appetite suppression. The model coherently predicts increments or decrements in body weight in the long-term when altering appetite in the short-term. Further, the model shows how food type choice, at the same appetite drive and habitual proposed meal size, induces macroscopic changes in body weight over a very few years. The model is innovative in that it connects the minute-by-minute behavior of the individual with long-term changes in metabolic compensation, in insulin sensitivity, in glycemic variability, and eventually in body size, thus helping to interpret the long-term development of Type 2 diabetes mellitus resulting from an unhealthy lifestyle.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"22 7","pages":"1790-1824"},"PeriodicalIF":2.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P Solán-Fustero, J L Gracia, A Navas-Montilla, Pilar García-Navarro
{"title":"Paramatrized intrusive POD-based reduced-order models applied to advection-diffusion-reaction problems.","authors":"P Solán-Fustero, J L Gracia, A Navas-Montilla, Pilar García-Navarro","doi":"10.3934/mbe.2025066","DOIUrl":"https://doi.org/10.3934/mbe.2025066","url":null,"abstract":"<p><p>Parametrized problems involve high computational costs when looking for the proper values of their input parameters and solved with classical schemes. Reduced-order models (ROMs) based on the proper orthogonal decomposition act as alternative numerical schemes that speed up computational times while maintaining the accuracy of the solutions. They can be used to obtain solutions in a less expensive way for different values of the input parameters. The samples that compose the training set determine some computational limits on the solution that can be computed by the ROM. It is highly interesting to study what can be done to overcome these limits. In this article, the possibilities to obtain solutions to parametrized problems are explored and illustrated with several numerical cases using the two-dimensional (2D) advection-diffusion-reaction equation and the 2D wildfire propagation model.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"22 7","pages":"1825-1860"},"PeriodicalIF":2.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dynamic optimization of fishing tax and tourism fees for sustainable bioeconomic resource management.","authors":"Santanu Bhattacharya, Nandadulal Bairagi","doi":"10.3934/mbe.2025064","DOIUrl":"https://doi.org/10.3934/mbe.2025064","url":null,"abstract":"<p><p>Balancing economic prosperity with environmental conservation is crucial in managing renewable bioeconomic resources. We explored a predator-prey fishery model that incorporates tourism, dynamic harvesting, and pricing strategies. Our analysis showed that increased fishing taxes reduce fishing efforts, enabling fish populations to recover. Furthermore, higher entrance fees for ecotourism support the predator population's growth. Bifurcation analysis revealed key dynamic transitions, including transcritical and Hopf bifurcations. A deeper look into coupled parameter bifurcation uncovered a transcritical bifurcation of the limit cycle, emphasizing the system's complexity. Using Pontryagin's maximum principle, we optimized fishing taxes and ecotourism entrance fees to achieve sustainable trade-offs between ecosystem health and societal revenue. The results highlighted that societal revenue peaked at an intermediate level of entrance fees, suggesting diminishing returns beyond a certain point. Revenue landscape analysis further showed that centralized, two-parameter optimization strategies outperform decentralized, single-parameter approaches. These insights provide policymakers with effective tools to design regulations that promote ecological resilience and economic viability through balanced fishing and tourism practices.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"22 7","pages":"1751-1789"},"PeriodicalIF":2.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shubham Chaudhry, Gauri Agrawal, Maia Martcheva, A K Misra
{"title":"Modeling the impact of temperature on the dynamics of carrier-dependent infectious diseases with control strategies.","authors":"Shubham Chaudhry, Gauri Agrawal, Maia Martcheva, A K Misra","doi":"10.3934/mbe.2025063","DOIUrl":"https://doi.org/10.3934/mbe.2025063","url":null,"abstract":"<p><p>The spread of diseases poses significant threats to human health globally. The dynamic nature of infectious diseases, especially those that also rely on carriers (e.g., house flies) for transmission, requires innovative strategies to control their spread, as environmental conditions such as temperature, humidity, etc., affect the rate of growth of the carrier population. This study introduces a mathematical model to assess the effect of increasing global average temperature rise caused by carbon dioxide emissions and chemical control strategies on the dynamics of such diseases. The stability properties of feasible equilibrium solutions were discussed. Sensitivity analysis was also performed to highlight the key parameters that may help to design effective intervention strategies to control disease transmission. The model was further analyzed for an optimal control problem by incorporating a control measure on the application rate of chemical insecticides to reduce the carrier population. Through the combination of analytical techniques and numerical simulations, we have evaluated the effectiveness of chemical control strategies under varying epidemiological parameters. The model also explored the critical thresholds necessary for achieving disease control and eradication. Our results are valuable to public health officials and policymakers in designing effective interventions against carrier-dependent infectious diseases.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"22 7","pages":"1722-1750"},"PeriodicalIF":2.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gilberto González-Parra, Cristina-Luisovna Pérez, Marcos Llamazares, Rafael-J Villanueva, Jesus Villegas-Villanueva
{"title":"Challenges in the mathematical modeling of the spatial diffusion of SARS-CoV-2 in Chile.","authors":"Gilberto González-Parra, Cristina-Luisovna Pérez, Marcos Llamazares, Rafael-J Villanueva, Jesus Villegas-Villanueva","doi":"10.3934/mbe.2025062","DOIUrl":"https://doi.org/10.3934/mbe.2025062","url":null,"abstract":"<p><p>We propose several spatial-temporal epidemiological mathematical models to study their suitability to approximate the dynamics of the early phase of the COVID-19 pandemic in Chile. The model considers the population density of susceptible, infected, and recovered individuals. The models are based on a system of partial differential equations. The first model considers a space-invariant transmission rate, and the second modeling approach is based on different space-variant transmission rates. The third modeling approach, which is more complex, uses a transmission rate that varies with space and time. One main aim of this study is to present the advantages and drawbacks of the mathematical approaches proposed to describe the COVID-19 pandemic in Chile. We show that the calibration of the models is challenging. The results of the model's calibration suggest that the spread of SARS-CoV-2 in the regions of Chile was different. Moreover, this study provides additional insight since few studies have explored similar mathematical modeling approaches with real-world data.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"22 7","pages":"1680-1721"},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimal therapy schedule of chimeric antigen receptor (CAR) T cell immunotherapy.","authors":"Ruohan Li, Jinzhi Lei","doi":"10.3934/mbe.2025061","DOIUrl":"https://doi.org/10.3934/mbe.2025061","url":null,"abstract":"<p><p>Chimeric antigen receptor (CAR) T-cell therapy is a personalized immunotherapy approach in which a patient's T cells are genetically engineered to express synthetic receptors that specifically recognize and target tumor-associated antigens. This approach has demonstrated remarkable success in treating B-cell malignancies by directing CAR-T cells against the CD19 protein. However, treatment efficacy is influenced by the composition and distribution of CAR-T cell subsets administered to the patient. To investigate the impact of different CAR-T cell subtypes and infusion strategies, we developed a mathematical model that captures the dynamic interactions between tumor cells and CAR-T cells within the tumor immune microenvironment. Through computational simulations, we explored how varying the dosage and subtype proportions of infused CAR-T cells affects tumor dynamics and therapeutic outcomes. Our findings highlight the critical role of CAR-T cell subset composition in optimizing treatment efficacy, underscoring the necessity of precise dosing control and tailored infused strategies to maximize therapeutic success.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"22 7","pages":"1653-1679"},"PeriodicalIF":2.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Observer-based event-triggered impulsive control of delayed reaction-diffusion neural networks.","authors":"Luyao Li, Licheng Fang, Huan Liang, Tengda Wei","doi":"10.3934/mbe.2025060","DOIUrl":"https://doi.org/10.3934/mbe.2025060","url":null,"abstract":"<p><p>In this paper, we present a novel design of an observer-based event-triggered impulsive control strategy for delayed reaction-diffusion neural networks subject to impulsive perturbation. The impulsive instants of impulsive control are determined in an event-triggered way, and the control strength is designed by the sampling output of an impulsive observer. Several criteria with Lyapunov conditions and linear matrix inequalities are established for the global exponential stability of delayed reaction-diffusion neural networks. It inherits the advantages of event-triggered impulsive control such as low triggering frequency and high efficiency, and is applicable for networks with unmeasurable states. Finally, the effectiveness of theoretical results is verified by a numerical example.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"22 7","pages":"1634-1652"},"PeriodicalIF":2.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Physics-informed neural networks for optimal vaccination plan in SIR epidemic models.","authors":"Minseok Kim, Yeongjong Kim, Yeoneung Kim","doi":"10.3934/mbe.2025059","DOIUrl":"https://doi.org/10.3934/mbe.2025059","url":null,"abstract":"<p><p>This work investigates the minimum eradication time in a controlled susceptible-infectious-recovered model with constant infection and recovery rates. The eradication time is defined as the earliest time the infectious population falls below a prescribed threshold and remains below it. Leveraging the fact that this problem reduces to solving a Hamilton-Jacobi-Bellman (HJB) equation, we propose a mesh-free framework based on a physics-informed neural network to approximate the solution. Moreover, leveraging the well-known structure of the optimal control of the problem, we efficiently obtain the optimal vaccination control from the minimum eradication time using the dynamic programming principle. To improve training stability and accuracy, we incorporate a variable scaling method and provide theoretical justification through a neural tangent kernel analysis. Numerical experiments show that this technique significantly enhances convergence, reducing the mean squared residual error by approximately 80% compared with standard physics-informed approaches. Furthermore, the method accurately identifies the optimal switching time. These results demonstrate the effectiveness of the proposed deep learning framework as a computational tool for solving optimal control problems in epidemic modeling as well as the corresponding HJB equations.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"22 7","pages":"1598-1633"},"PeriodicalIF":2.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ghada Mohammed Mansour, Haroon Mohamed Barakat, Islam Abdullah Husseiny, Magdy Nagy, Ahmed Hamdi Mansi, Metwally Alsayed Alawady
{"title":"Measures of cumulative residual Tsallis entropy for concomitants of generalized order statistics based on the Morgenstern family with application to medical data.","authors":"Ghada Mohammed Mansour, Haroon Mohamed Barakat, Islam Abdullah Husseiny, Magdy Nagy, Ahmed Hamdi Mansi, Metwally Alsayed Alawady","doi":"10.3934/mbe.2025058","DOIUrl":"https://doi.org/10.3934/mbe.2025058","url":null,"abstract":"<p><p>Ever since Tsallis introduced Tsallis entropy theory, it has been applied to a wide variety of topics in physics and chemistry, with new applications being discovered annually. The amount of research suggests that the Tsallis entropy concept holds significant potential. This paper introduces weighted cumulative residual Tsallis entropy (WCRTE) and weighted cumulative past Tsallis entropy (WCPTE), as well as their dynamic counterparts for the concomitants of $ m $-generalized order statistics ($ m $-GOSs) derived from the Farlie-Gumbel-Morgenstern bivariate family. The characteristics of the proposed entropy measures were analyzed, demonstrating their ability to characterize the Pareto and exponential distributions. Applications of these findings were presented for order statistics (OSs) systems and record values with uniform, Weibull, and power marginal distributions. Furthermore, the empirical alternatives WCRTE and WCPTE were proposed for calculating new information measures. Two real-world data sets have been evaluated for illustrative purposes, demonstrating satisfactory performance.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"22 6","pages":"1572-1597"},"PeriodicalIF":2.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}