Medical Engineering & Physics最新文献

{"title":"Finite element analysis explores ablation depth and optical zone as key determinants of intraocular pressure reduction after refractive surgery.","authors":"Yunfei Lan, Yongtao Lyu, Xuzhe Qiu, Ye Sun, Hao Wang, Sergei Bosiakov, Bo Wang, Junjie Wang, Lijun Zhang, Lin Jin","doi":"10.1088/1873-4030/ae7600","DOIUrl":"10.1088/1873-4030/ae7600","url":null,"abstract":"<p><strong>Background: </strong>with the increasing prevalence of refractive surgery, its impact on intraocular pressure (IOP) measurement has gained significant attention. This study aimed to elucidate the mechanism by which femtosecond laser-assisted<i>in situ</i>keratomileusis (FS-LASIK)-induced geometric alterations of the cornea affect IOP measurements obtained with the Goldmann applanation tonometer (GAT).</p><p><strong>Methods: </strong>IOP was measured with the GAT in patients undergoing FS-LASIK preoperatively and at 3 and 6 months postoperatively. A corneal finite element (FE) model, including aqueous humor for both pre- and post-operative states, was created to simulate the surgical volume required for correcting myopia of -2, -4, and -6 diopters (<i>D</i>). IOP values were calculated based on the principle of the GAT, and FE simulation results were compared with clinical IOP data measured using the GAT to validate the model.</p><p><strong>Results: </strong>Clinical data from GAT measurements demonstrated a consistent decrease in IOP following surgery. FE results indicated that the postoperative IOP, ranging from 8.26 mmHg to 13.04 mmHg, decreased by 23%-51% compared to the preoperative IOP of 17.04 mmHg. Deeper ablation depths and larger optical zone diameters were associated with lower postoperative IOP.</p><p><strong>Conclusion: </strong>The FE analysis demonstrated a decreasing trend in postoperative IOP with increasing ablation depth and optical zone diameter. These findings provide valuable insights for guiding postoperative IOP monitoring, optimizing surgical parameters, and understanding postoperative corneal biomechanical behavior.</p>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"147 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148266642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-view cross-semantic graph neural network for predicting intraoperative complications in patients with acute myocardial infarction undergoing percutaneous coronary intervention.","authors":"Shuzhi Su, Yanting Li, Yanmin Zhu, Kanghui Wu, Yong Dai","doi":"10.1088/1873-4030/ae74d4","DOIUrl":"https://doi.org/10.1088/1873-4030/ae74d4","url":null,"abstract":"&lt;p&gt;&lt;p&gt;For acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI), accurate prediction of intraoperative complications (IOCs) in AMI patients undergoing PCI is critical for timely risk stratification and clinical intervention. However, existing approaches lack a patient-indicator dual-view synergy modeling framework, leading to semantic isolation between patient and indicator representations. Yet current risk prediction approaches often treat patient characteristics and clinical indicators as separate, disconnected pieces of information. What's missing is a unified framework that jointly models both the 'patient' and the 'indicators' in a synergistic way, capturing how they interact and influence each other. Without this dual-view perspective, valuable clinical insights remain hidden, limiting the accuracy and real-world utility of risk predictions. Guided by a gain-aware feature distillation strategy, an indicator heterogeneous collaborative graph (IHCG) is constructed to disentangle inter-indicator semantics via meta-path-constrained propagation, thereby encoding structured clinical logic beyond raw statistical associations. Concurrently, a patient neighborhood topology graph (PNTG) is instantiated based on high-order phenotypic affinity modeling to capture contextualized risk signatures, with manifold-preserving neighborhood propagation enabling the encoding of population-level pathophysiological coherence beyond isolated clinical profiles. According to IHCG and PNTG, semantic integration across views is achieved through a patient-query asymmetric propagation paradigm. In the paradigm, patient nodes actively drive risk-informed semantic aggregation from clinical indicators via cross-attentional indicator fusion, while indicator nodes provide auxiliary contextual feedback through a lightweight residual semantic feedback pathway, thereby establishing a structured yet asymmetric information flow that aligns individualized risk assessment with population-level clinical semantics. To further ensure coherent bidirectional representation learning, aligning structurally projected embeddings with semantically cross-attended outputs. On the basis of the above modeling, this study develop a novel method for predicting IOCs in patients with AMI undergoing PCI called dual-view cross-semantic graph neural network (DCGNN), and the method resolves cross semantic isolation and grounds intraoperative risk prediction in mechanism-aware clinical reasoning. On the dataset collected from Shanghai Sixth People's Hospital South Campus, DCGNN achieved an AUC of 89.8% and a sensitivity of 90.2%, significantly outperforming baseline methods. Ablation studies, hyperparameter sensitivity analysis, and semantic-aware risk factor attribution (SARFA) further validated the effectiveness, robustness, and interpretability of the proposed method. The study method achieves superior predictive accuracy while enabling traceable risk attributio","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"147 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148266633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of photoplethysmography for early vascular compromise in a customisable<i>in vitro</i>flap model.","authors":"Hiroki Kodama, James M May, Dariush Nikkhah, Panicos A Kyriacou","doi":"10.1088/1873-4030/ae7601","DOIUrl":"10.1088/1873-4030/ae7601","url":null,"abstract":"<p><strong>Background: </strong>Free flap reconstruction is a standard procedure in surgery, yet vascular thrombosis occurs in 3%-5% of cases. Early detection within the first few hours is essential for successful salvage, as the success rate of surgical re-exploration decreases over time. Since current clinical assessment remains subjective and depends on experience, objective and continuous monitoring is required. Photoplethysmography (PPG), which monitors blood volume changes non-invasively, is a candidate for this application. However, the influence of specific waveform changes during early haemodynamic shifts is not fully understood.</p><p><strong>Methods: </strong>This study evaluated the diagnostic capacity of PPG for detecting early vascular changes using a custom silicone phantom. Synthetic vessels mimicking human arterial and venous mechanics were embedded at depths of 3, 9, 15, and 21 mm. A perfusion system simulated normal, early ischaemic, and early congested states. Signal quality was assessed using the signal-to-noise ratio (SNR), and only signals with SNR > 15 dB were used for morphological analysis. Over 50 parameters, including time, area, and slope, were extracted from the waveforms to identify those that characteristically respond to each haemodynamic state.</p><p><strong>Results: </strong>The custom-made free flap phantom was successfully validated. Signal quality assessments limited morphological evaluation to depths up to 15 mm. Analysis showed that Intensity and Area-based parameters were the most effective indicators at all depths. At shallow positions, Time-related features showed clear changes during ischaemia, while Slope and Second Derivative (SDPPG) features emerged as key indicators at depth. Red light was useful for superficial monitoring at 3 mm, whereas Infrared was necessary for assessing deeper states.</p><p><strong>Conclusion: </strong>A custom phantom capable of replicating early haemodynamic compromise was developed. Identifying specific feature variations across depths provides a framework for objective, continuous monitoring. These findings suggest that combining multiple morphological features can improve the reliability of flap assessment.</p>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148151058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A passive T/V-beam absorber architecture for single-axis experimental hand tremor attenuation.","authors":"Manthan Shah, Dylan Goode, Dahlia Mohammadi, Hadi Mohammadi","doi":"10.1088/1873-4030/ae7112","DOIUrl":"10.1088/1873-4030/ae7112","url":null,"abstract":"<p><p>Hand tremor is a debilitating motor symptom associated with neurological disorders such as Parkinson's disease and essential tremor (ET). This study presents the design, parameter tuning, and experimental evaluation of a passive mechanical absorber for tremor attenuation based on T- and V-beam configurations. The proposed device is described as an multi-degree-of-freedom-capable architecture because its geometry can accommodate absorber branches oriented in more than one direction; however, the present experimental validation was conducted using a single-axis, 1-DOF mannequin-based tremor simulator. Therefore, the reported data validate single-axis attenuation only and should not be interpreted as full multidirectional wrist validation. The system operates without external power and is intended as a simple passive alternative to active tremor-suppression devices. Experimental validation demonstrated a reduction of up to 85% in steady-state peak-to-peak displacement relative to the uncontrolled condition. The investigated frequency range was 3.0-6.5 Hz, selected because it overlaps the 4-6 Hz range often reported for Parkinsonian rest tremor and extends into the lower-to-mid range commonly observed in ET during postural or kinetic tasks. Key design parameters, including absorber mass, equivalent stiffness, beam-position geometry, and actuator configuration, were selected using a constrained parametric tuning procedure rather than an unconstrained global optimization. Frequency-domain metrics, including power spectral density and transmissibility, are defined to complement the time-domain amplitude-reduction metric and to verify attenuation at the dominant excitation frequency. The results suggest that the double V-beam configuration provides stronger single-axis attenuation than the single-actuator configuration and supports further development toward wearable tremor-management applications.</p>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-compartment hemodialysis modeling with logistic blood-tissue exchange and slow-pool dynamics.","authors":"Dorota Jakubczyk, Agnieszka Gala-Błądzińska, Paweł Jakubczyk","doi":"10.1088/1873-4030/ae7111","DOIUrl":"10.1088/1873-4030/ae7111","url":null,"abstract":"<p><p>The classical two-compartment (2C) model is widely used to describe solute kinetics during hemodialysis, yet it often misses two key features of real data: the early concentration dip in the first dialysis hour and the long equilibration tail, especially in patients with diabetic kidney disease. Building on our previous 2C Monte Carlo work, we propose an extended three-compartment model with logistic exchange (3C-Logistic) that adds a slow tissue pool representing a slowly equilibrating tissue-associated kinetic compartment and allows the blood-tissue exchangeKcf(t)to vary over time according to a logistic law. The motivation is physiological but should be interpreted cautiously: the logistic time dependence is used as an apparent kinetic representation of delayed tissue- to-blood redistribution, for which progressive microvascular recruitment is one plausible, but not directly measured, mechanism. Using Monte Carlo parameter screening followed by local derivative-free refinement, we show that 3C-Logistic reduces systematic misfit in both the early and late parts of the session and yields a nine-parameter model-derived kinetic description, from which logistic-exchange and slow-pool descriptors(Kc1,Kc2,s,τ,Kfs,Vs)may help characterize diabetic-like and non-diabetic-like redistribution dynamics. We applied the framework to intradialytic kinetics of both urea and phosphate. For urea, the model reconciled the early trough and the long tail with physiologically plausible parameter ranges. For phosphate, fits generally indicated a stronger slow-pool contribution, consistent with slower equilibration from tissue stores. These parameters may serve as exploratory kinetic fingerprints of redistribution capacity, providing a mechanistically motivated, model-based rationale for future studies evaluating dialysis duration, ultrafiltration strategies, and post-dialysis assessments. By capturing the shared features of both solutes within one framework, 3C-Logistic may support the future development of session-by-session personalization strategies after external validation and could guide the design of non-invasive monitoring protocols.</p>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid coronary artery stent computational simulation using the simplex deformable model.","authors":"Changkye Lee, Shijia Zhao, Wei Wu, Rakshita Ramesh Bhat, Priyansh Patel, Yash Vardhan Trivedi, Parth Munjal, Yoshinobu Murasato, Yiannis S Chatzizisis","doi":"10.1088/1873-4030/ae6a9e","DOIUrl":"10.1088/1873-4030/ae6a9e","url":null,"abstract":"<p><p>The objective of this study was to present and demonstrate the feasibility of a simplex deformable model (SDM) for patient-specific coronary stent simulations in two patient-specific cases. Patient-specific 3D artery anatomies were converted into triangular meshes and then transformed into 2-simplex meshes. For each vertex, three neighboring vertices were used to compute outward and inward normal vectors to model stent expansion and arterial wall resistance. Internal forces representing stent mechanics were computed during expansion, and external forces incorporating non-linear hyperelastic arterial behavior were applied after stent-wall contact. Two patient-specific arteries were simulated using the SDM framework, with the finite element method (FEM) as the reference. Relative to FEM, the SDM achieved 360-670 times faster computational time, and reduced vertex counts by 9.5-12.6 times. Bland-Altman analysis showed small mean biases in mean lumen diameter (-0.029 mm for Artery 1;-0.043 mm for Artery 2), and root mean square error was small (0.063 mm for Artery 1; 0.098 mm for Artery 2), and the mean absolute relative error was also low (1.75% for Artery 1; 2.31% for Artery 2). In conclusion, this proof-of-concept study in two patient-specific 3D coronary anatomies suggests that the proposed SDM-based simulations can achieve overall agreement with FEM, while substantially reducing computational time and mesh size.</p>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"147 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13220072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148057991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of critical buckling load enhancements via ultrasonic vibration assisted implantation of microwire-based brain electrodes.","authors":"Dongyang Yi, Njinang Kwankam, Lei Chen","doi":"10.1088/1873-4030/ae691d","DOIUrl":"10.1088/1873-4030/ae691d","url":null,"abstract":"<p><p><i>Objective.</i>Ultrasonic vibration assisted insertion has shown promising results on large and rigid brain electrodes but had limited benefits towards small and flexible electrodes like thin microwires. This study aims to quantitatively investigate the vibration's impact on the electrode's critical buckling load and optimal vibration parameter choice for effective vibration transmission to microwire tips.<i>Approach.</i>A custom ultrasonic insertion platform was developed to deliver controlled longitudinal vibrations to tungsten microwires under a fixed-pinned boundary condition. Experiments varied four factors: wire diameter (50.8-101.6<i>µ</i>m), preload mass (0-112.35 g), vibration frequency (33-42 kHz), and drive voltage amplitude (106 and 212 V_RMS). Vibration characteristics were quantified using Photonic Doppler Velocimetry, and buckling outcomes were assessed by enhancement percentage of the critical buckling load against static theoretical values. Analysis of variance was conducted to investigate vibration parameters' impacts on the critical buckling load enhancement.<i>Main results.</i>Ultrasonic vibration assistance significantly increased the effective critical buckling load, with enhancements exceeding 60% in some cases. ANOVA revealed that all four factors-frequency, voltage, preload mass, and wire diameter-had statistically significant effects (<i>p</i>< 0.05). Higher vibration frequency (38-42 kHz) and smaller wire size (50.8<i>µ</i>m) generally yields higher critical buckling load enhancement while an intermediate level of preload mass (54.51 g) would be beneficial for high efficiency vibration transduction to the tip of small lightweight wire electrodes. Vibration amplitude and corresponding drive voltage should be carefully chosen to mitigate imperfections during the acceleration and deceleration periods.<i>Significance.</i>This study, for the first time, quantitatively demonstrates the enhancement of electrode critical buckling load under ultrasonic vibration assistance. The experimental investigations provided valuable insights and guidelines for vibration assistance parameter selection to ease the brain electrode implantation process.</p>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using a monoplane stereoscopic videoradiography configuration to accurately measure skeletal positions: a proof-of-concept study.","authors":"Tomasz Bugajski, Derek D Lichti, Payam Zandiyeh","doi":"10.1088/1873-4030/ae6cfd","DOIUrl":"10.1088/1873-4030/ae6cfd","url":null,"abstract":"<p><p>Biplanar videoradiography is a validated method for measuring skeletal kinematics. However, using two x-ray source-detector pairs introduces geometric constraints that can compromise image quality. The spatial configuration of the two pairs often requires a larger object-to-image distance (OID), leading to greater magnification and geometric blur. Consequently, increased magnification can limit the effective field of view, restricting multi-joint analyses. Additionally, geometric blur degrades image quality, potentially compromising subsequent bone registrations. To address this limitation, this proof-of-concept study evaluated a monoplane stereoscopic videoradiography (MSV) configuration. MSV uses two x-ray sources captured by a single detector, enabling a smaller OID. A pseudo-dynamic experiment was conducted to assess whether MSV would achieve accurate calibration and subsequent three-dimensional (3D) bone positions. A cube and pelvis phantom were rotated 360° on a turntable in 15° increments. At each increment, positions were recorded using both conventional motion capture (MOCAP) and MSV, with MOCAP acting as the reference standard. During MSV image acquisition, a lead barrier alternately blocked one x-ray source, allowing the other to project onto the detector. Calibration was performed using a bundle adjustment technique, and 3D bone positions were calculated using radiostereometric analysis and model-based tracking and compared against MOCAP. Overall, MSV achieved sub-millimeter and sub-degree accuracy. The calibration yielded a mean residual of 0.22 mm, while rotational and translational biases ranged from 0.36-1.16° and 0.22-1.23 mm, respectively, with precisions of 0.09-0.59° and 0.18-0.58 mm. These results support the feasibility of using MSV to accurately calculate skeletal positions. This approach reduces magnification and, by extension, geometric blur, opening avenues for multi-joint analyses and improved imaging of deeper joints. Future work will focus on implementing a true asynchronous MSV acquisition to extend this approach to dynamic,<i>in vivo</i>kinematic studies.</p>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13459624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of acoustic systems for ultrasound attenuation measurement in polydimethylsiloxane.","authors":"Mathis Martin, Pascal Dargent, Wladimir Urbach, Nicolas Taulier, Alireza Ashofteh","doi":"10.1088/1873-4030/ae691f","DOIUrl":"10.1088/1873-4030/ae691f","url":null,"abstract":"<p><p>Ultrasound absorption by polydimethylsiloxane (PDMS) can have a significant impact on the acoustic radiation force needed for the stimulation of cells in an organ-on-a-chip. Hence, finding the PDMS attenuation coefficient is the key to determining the fraction of absorbed acoustic energy in microfluidic systems. To measure the attenuation coefficient of PDMS, two methods were compared: a vector network analyzer and a pulse transmission method. Ten PDMS samples with thicknesses ranging from 2.5 to 18.5 mm were tested both before and after 24 h water immersion. The attenuation coefficient of PDMS, commonly used in microfluidics, was determined within a frequency range relevant to human health, i.e. 1-3 MHz. For a representative 5 mm thick microfluidic chip, the fraction of absorbed acoustic energy<i>E</i>is estimated to be approximately 21% at 1 MHz and 68% at 3 MHz. This level of absorption is expected to substantially modulate cell stimulation mediated by acoustic radiation forces.</p>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-parameter performance correlation model to advance the customized design of vascular stents.","authors":"Ankun Xie, Changsheng He, Kellen Mitchell, Weiliang Shi, Sai Ma, Yifei Jin, Danyang Zhao","doi":"10.1088/1873-4030/ae691e","DOIUrl":"10.1088/1873-4030/ae691e","url":null,"abstract":"<p><p>The clinical performance of vascular stents hinges on a delicate balance between radial support and bending flexibility. Existing theoretical models are further limited by their focus on single materials or specific geometries, offering little guidance for complex hybrid or functionally graded designs. To overcome these limitations, we present a multi-parameter performance-correlation model (PCM) that unifies material properties, topological features, and cross-sectional parameters into a single analytical framework aimed at accelerating stent design. The PCM derives its governing dimensional relationships from analytical mechanics and is calibrated using a comprehensive finite element analysis database encompassing three representative architectures, four materials, and nine cross-sectional configurations. The model accurately predicts stent mechanical responses, and key analysis reveals that strut width contributes to radial stiffness through a cubic scaling law, significantly stronger than the linear dependence on strut thickness. This finding identifies width enhancement as a more effective strategy for improving radial support without substantially compromising flexibility. Case studies further demonstrate that non-uniform stents yield greater luminal gain at lesion sites, while hybrid designs achieve a functional decoupling of support and compliance. Overall, the proposed PCM offers an efficient tool for early-stage concept screening and design optimization of multi-material, functionally graded vascular stents.</p>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}