Medical Engineering & Physics最新文献

{"title":"EMI caused artifact removal in LED-based photoacoustic tomography system for image quality enhancement","authors":"Xinyu Lu ,&nbsp;Enxiang Shen ,&nbsp;Jie Yuan ,&nbsp;Xiao Yin ,&nbsp;Zhendong Yao","doi":"10.1016/j.medengphy.2025.104450","DOIUrl":"10.1016/j.medengphy.2025.104450","url":null,"abstract":"<div><div>The Light Emitting Diode (LED) based photoacoustic computed tomography (PACT) system offers advantages such as safety, low cost, portability, and wavelength adjustability. In order to obtain high-quality photoacoustic signals, LEDs are driven by periodic nanosecond pulses. This results in a significant variation in the current flowing through the LEDs during the turn-on and turn-off moments, generating strong electromagnetic interference (EMI) around the LED circuit. In LED-based PACT systems, the light source is typically placed near the ultrasound transducer. Under the influence of the EMI emitted from the LEDs, the coil in the ultrasound transducer picks up induced currents, causing the transducer to emit ultrasonic signals. The ultrasonic echoes are received by the transducer, mixing with the photoacoustic signals and resulting in image artifacts. In this study, we propose an optimized design for the LED-based PACT system that suppresses EMI, thereby reducing image artifacts. We designed several circuit modules to reduce EMI and incorporated external electromagnetic wave absorption techniques, then conducted EMI measurements and imaging comparison experiments to demonstrate the effectiveness of this design. The proposed approach is expected to advance the application of LED-based PACT systems in fields such as surface vascular imaging and photoacoustic endoscopy.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"145 ","pages":"Article 104450"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of thickness variation on the rigidity of ankle foot orthoses provided to the NHS: A case for the need for quality control.","authors":"Panagiotis E Chatzistergos, Nicola Eddison, Ilias Theodorakos, Nachiappan Chockalingam","doi":"10.1016/j.medengphy.2025.104404","DOIUrl":"https://doi.org/10.1016/j.medengphy.2025.104404","url":null,"abstract":"<p><strong>Background: </strong>Drape-forming is a cost-effective method used worldwide to manufacture bespoke ankle foot orthoses (AFOs). It involves draping a heated polymer material sheet over a positive cast of the user's limb. Previous research has shown that the manual nature of drape-forming can influence the thickness of the final AFO and even lead to structures that are inadequately rigid to be clinically effective. This study assesses the difference between the prescribed and the final thickness of AFOs meant for use by UK's National Health Service (NHS) and estimates its potential impact on AFO rigidity.</p><p><strong>Methods: </strong>A clinically relevant method to measure AFO thickness as part of the manufacturing process was developed and validated. This method was used by three major UK manufacturers for all bespoke rigid AFOs they provided to the NHS within a predefined period. A validated finite element model was used to estimate the impact of the observed difference between prescribed and final thickness on AFO stiffness.</p><p><strong>Results: </strong>86 AFOs were assessed in total. Final thickness was between 4.0% and 35.5% lower than the prescribed one (median thickness reduction= 17.4%). This discrepancy in thickness led to a relative reduction in AFO stiffness ranging between 7.0% and 80.0% (median stiffness reduction= 30.7%).</p><p><strong>Discussion: </strong>The adequacy of AFO thickness cannot be judged based on prescription thickness. Measurements of final thickness as part of standard practice should be considered to enhance the provision of bespoke AFOs. Further research is needed to establish thresholds of acceptable manufacturing-induced deviation from the prescribed AFO thickness.</p>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"144 ","pages":"104404"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical evaluation of intelligent fluid-solid coupling vaginal dilatation system: Experimental and numerical analysis.","authors":"Renling Zou, Hongwei Tan, Xuan Zhang, Qingbin Fang, Xuelian Gu, Rui Guan","doi":"10.1016/j.medengphy.2025.104408","DOIUrl":"https://doi.org/10.1016/j.medengphy.2025.104408","url":null,"abstract":"<p><strong>Objectives: </strong>Cervical cancer is a serious threat to women's life and health and has a high mortality rate. Colposcopy is an important method for early clinical cervical cancer screening, but the traditional vaginal dilator has problems such as discomfort in use and cumbersome operation. For this reason, this study aims to design an intelligent vaginal dilatation system to automate colposcopy and enhance patient comfort.</p><p><strong>Methods: </strong>An intelligent vaginal dilatation system combining flexible and rigid dilatation techniques is proposed. A fluid-solid coupled finite element method was used to simulate the dilation process of the system during colposcopy. The smart dilator was inserted into a simulated vaginal model in the simulation, and the fluid domain pressure inlet was set to be 1.5 kPa, and the solid material was a hyperelastic model of medical silicone rubber. Subsequently, the prototype machining was completed and in vitro dilatation displacement and pressure experiments were conducted.</p><p><strong>Results: </strong>The simulation results showed that the maximum expansion of the system was 32.2 mm, and the average pressure on the simulated vaginal wall was 605.91 kPa. The average maximum expansion of the system in the in-vitro expansion displacement experiment was 30.49 ± 0.05 mm, which was basically the same as the simulation results. The results of the in vitro pressure experiment showed that the intelligent dilatation system had a larger force area on the vaginal wall at the same level of dilatation, and the pressure value was smaller and more uniformly distributed. Compared with the traditional duckbill dilator, it can effectively reduce the local pressure feeling and improve the uniformity of dilation.</p><p><strong>Conclusion: </strong>The intelligent vaginal dilatation system proposed in this study is superior to traditional dilators in terms of dilatation performance, safety and comfort. The feasibility of its design and potential for clinical application were verified.</p>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"144 ","pages":"104408"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A knowledge graph-based post-stroke gait assessment system: A pilot study","authors":"Yiran Jiao ,&nbsp;Zengkun Liu ,&nbsp;Stacey Reading ,&nbsp;Marie-Claire Smith ,&nbsp;Jianhua Lin ,&nbsp;Yanxin Zhang","doi":"10.1016/j.medengphy.2025.104449","DOIUrl":"10.1016/j.medengphy.2025.104449","url":null,"abstract":"<div><div>Instrumented gait analysis (IGA) has been widely used in research, but not typically in clinical practice, as it requires expertise in data analysis and interpretation. Post-stroke clinical gait assessment could be improved by integrating artificial intelligence into IGA, but previous gait assessment systems have relatively low clinical utility. This study aims to develop a clinically oriented automatic post-stroke gait assessment system based on knowledge graph (KG) to better support clinicians. A domain KG is first constructed in the field of gait analysis. This system can process IGA data to identify gait abnormalities and their potential causes based on kinematic analysis and KG. A preliminary evaluation with twenty post-stroke patients and four domain experts tested the system's performance in clinical settings, showing an average recall, precision, and F-score of 1, 0.78, and 0.89. Four clinical professionals showed high behavioural intention to use the system in clinical settings (4.33 ± 0.41 on a 5-point Likert scale based on the Technology Acceptance Model). The results depicted that this system has potential to be applied in clinical settings to provide useful supplementary insights for clinicians, which may promote the interpretation and clinical utility of IGA. The schema of this KG could be generalised or extended to gait analysis related to other diseases.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"145 ","pages":"Article 104449"},"PeriodicalIF":2.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on the printing efficiency, precision, and cell viability in 3D bioprinting","authors":"Bowen Li ,&nbsp;Zhen Wang ,&nbsp;Chuanzhen Huang ,&nbsp;Longhua Xu ,&nbsp;Shuiquan Huang ,&nbsp;Meina Qu ,&nbsp;Zhengkai Xu ,&nbsp;Dijia Zhang ,&nbsp;Baosu Guo ,&nbsp;Tianye Jin ,&nbsp;Chunhui Ji","doi":"10.1016/j.medengphy.2025.104448","DOIUrl":"10.1016/j.medengphy.2025.104448","url":null,"abstract":"<div><div>Three-dimensional (3D) bioprinting demonstrates significant potential for advancing regenerative medicine through precise fabrication of functional tissue constructs via controlled deposition of cells, biomaterials, and bioactive factors. However, balancing key parameters-printing efficiency, resolution, and cell viability-remains challenging for replicating native tissue complexity. This review comprehensively examines recent advancements in three prominent bioprinting modalities: inkjet, extrusion-based, and digital light processing (DLP). Analysis reveals inherent performance trade-offs among these technologies. Inkjet bioprinting achieves high resolution (10-80 μm) at moderate speeds but exhibits limited cell viability (74-85%). Extrusion-based methods enable higher fabrication rates (0.00785-62.83 mm³/s) with variable viability (40-90%) at reduced resolution (100-2000 μm). DLP offers superior efficiency (0.648-840 mm³/s) and ultra-high resolution (2-50 μm) with favorable viability (75-95%), although limitations persist regarding photoinitiator toxicity and light penetration depth. Critical examination identifies energy-induced cell damage as a significant factor, with shear stress and UV exposure representing key detrimental influences. Bioink properties also emerge as crucial determinants of printing outcomes. The review further integrates modeling approaches for extrusion-based bioprinting and discusses preliminary computational modeling attempts. Future directions should focus on developing low-viscosity cell-compatible bioinks, advancing hybrid printing strategies, and establishing predictive models to harmonize printing parameters with biological outcomes. Interdisciplinary collaboration remains essential to fully realize the clinical potential of bioprinted tissues and organoids.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"145 ","pages":"Article 104448"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methods for quantitative analyses of nerve fiber deformation in the myenteric plexus under loading of mouse distal colon and rectum","authors":"Amirhossein Shokrani ,&nbsp;Atta Seck ,&nbsp;Bin Feng ,&nbsp;David M. Pierce","doi":"10.1016/j.medengphy.2025.104444","DOIUrl":"10.1016/j.medengphy.2025.104444","url":null,"abstract":"<div><div>Visceral pain in the large bowel is a hallmark of irritable bowel syndrome (IBS) and the primary reason patients seek gastroenterological care. Notably, mechanical distension of the distal colon and rectum (colorectum) reliably evokes abdominal pain and thus understanding mechanotransduction of sensory nerve endings (nerve fibers) in the colorectum is crucial for understanding and treating IBS-related bowel pain. To facilitate such understanding we aimed to establish novel methods to mechanically test, image, and analyze large-strain deformations of networks of nerve fibers in the myenteric plexus of the colorectum, and thus enable quantitative analyses. We successfully delivered circumferential, displacement-driven deformations to intact segments of colorectum while maintaining the myenteric plexus in focus during fluorescent imaging to capture the deforming nerve fibers. We also established a semi-automated method to recapitulate the network morphology and a code to calculate the stretch ratios of individual nerve fibers deforming within the myenteric plexus of mouse colorectum. Our code allows plotting of stretch ratios for each fiber, stretch ratios vs. fiber angles, and stretch ratios vs. fiber lengths. Our methods not only facilitate analyses of deformations of networks of colorectal nerve fibers in the context of visceral nociception but are also applicable to analyzing the in-plane deformation of other two-dimensional fiber networks. We provide free, public access to our analysis code for MATLAB, including input files for a simple test case, at <span><span>github.uconn.edu/imLab/Fiber-Network_Analyses</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"146 ","pages":"Article 104444"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse events associated with single-use bronchoscopes: analysis from the MAUDE database","authors":"Xibin Su,&nbsp;Huitong Cheng,&nbsp;Wentao Rao,&nbsp;Chenghong Xue,&nbsp;Donghui Gan,&nbsp;Binjian Liu","doi":"10.1016/j.medengphy.2025.104443","DOIUrl":"10.1016/j.medengphy.2025.104443","url":null,"abstract":"<div><h3>Background</h3><div>Bronchoscopy is an aerosol-generating procedure and associated with a high risk of viral transmission, particularly during the coronavirus disease (COVID-19) pandemic. This circumstance has expedited the adoption of single-use flexible bronchoscopes (SUFBs) due to their potential to mitigate healthcare personnel exposure to SARS-CoV-2 and reduce patient infection risks.</div></div><div><h3>Objective</h3><div>This study aims at analyzing reported adverse events and complications associated with SUFBs, while delineating recommendations for risk mitigation strategies and ensuring patient safety through an examination of data from the Manufacturer and User Facility Device Experience (MAUDE) database.</div></div><div><h3>Methods</h3><div>We conducted an evaluation of adverse events related to SUFBs as documented in the FDA MAUDE database from January 1, 2014, to June 30, 2025. All reports were manually reviewed and categorized based on the primary device problem and any associated patient outcomes.</div></div><div><h3>Results</h3><div>A total of 280 reports were issued regarding SUFBs. Manual review categorized these into 280 primary device-related problems and 286 patient-related outcomes. The primary category of device-related problems predominately pertained to breakage/fracture (85 cases; 30.4 %), and a loss of image/display (57 cases; 20.4 %). Among patient adverse events, the most frequently encountered were foreign bodies and airway obstruction.</div></div><div><h3>Conclusion</h3><div>Our study augments the existing clinical literature and body of knowledge by providing a comprehensive understanding of potential problems related to SUFBs. It underscores the imperative for continuous surveillance and vigilance to ensure the safety and effectiveness of SUFBs.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"146 ","pages":"Article 104443"},"PeriodicalIF":2.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PSCT-Net: A parallel symmetric CNN-transformer hybrid network for medical image segmentation","authors":"Bing Wang ,&nbsp;Hao Shi ,&nbsp;Zutong Zhao ,&nbsp;Shiyin Zhang","doi":"10.1016/j.medengphy.2025.104442","DOIUrl":"10.1016/j.medengphy.2025.104442","url":null,"abstract":"<div><div>The precision of medical image segmentation is important in clinical analysis and diagnosis. CNN-Transformer based hybrid approaches show great potential in medical image segmentation due to their complementarity in modeling local and global contextual dependencies. However, local representations and global representations possess their own distinct structures and semantic characteristics, simplistic or inappropriate fusion strategies are insufficient to leverage their complementary strengths, Impeding the model to achieve optimal segmentation performance. For resolving this dilemma, we proposed A Parallel Symmetric CNN-Transformer Hybrid Network for Medical Image Segmentation (PSCT-Net)that implements a three-phase fusion mechanism to sufficiently and efficiently fuse heterogeneous and complementary features: 1) During the encoding stage, we design a layer-wise feature fusion (LWFF) module efficiently merges both CNN and Transformer learned local and global feature, enabling the network to learn more distinctive multi-scale feature. 2) For skip connections, we introduce a multi-scale feature fusion (MSFF) module to capture spatial and channel dependencies among features from different encoding layers while filtering redundant information through multi-scale feature spatial fusion (MFSF) and multi-scale feature channel fusion (MFCF). 3) In the decode stage, We also adopt a dual-branch architecture and through the LWFF module integrates upsampled features from the same decode layer enables the network to more accurately restore the image resolution information. Additionally, we through the CrossTransformer block further enhance the network's capability in processing boundary details. Comprehensive experiments on four medical datasets demonstrate the superiority, effectiveness, and robustness of our PSCT-Net.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"146 ","pages":"Article 104442"},"PeriodicalIF":2.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations for tracking the residual forearm in people with trans-radial limb difference using marker-based motion capture","authors":"N Pickard,&nbsp;D Howard,&nbsp;VH Nagaraja,&nbsp;L Kenney","doi":"10.1016/j.medengphy.2025.104441","DOIUrl":"10.1016/j.medengphy.2025.104441","url":null,"abstract":"<div><div>Upper-limb prostheses users report unsatisfactory ‘socket fit’, leading to poor outcomes. Previous attempts to measure socket-residuum coupling as a proxy for upper-limb socket fit were limited by their modelling approach (&lt;6-degrees of freedom (DoF) models) and focused on trans-humeral prosthesis users. Prince described a 6-DoF model to track trans-radial (TR) socket-limb coupling, but this required bespoke measurement equipment and was only demonstrated in one intact-limbed participant. Current International Society of Biomechanics (ISB) recommendations for marker-based forearm tracking include ulna styloid markers, therefore being unsuitable for people with TR limb difference. To identify alternative marker frames, ten intact limb participants performed six different movements, nine times each. Displacement of an ulna marker ‘cloud’ of markers was evaluated, for 18 alternative tracking frames, none of which utilised wrist markers. The optimal frames were a) for a long residuum/full forearm - markers on humeral epicondyles and mid-distal ulna bone (62.5–75 % of a typical ulna), and b) for a shorter residuum – markers on humeral epicondyles and distal ulna bone (25–50 % of a typical ulna). These frames compared favourably to the ISB frame in the point cloud displacement metric. This study provides novel solutions to tracking the ulna bone of people with TR limb difference.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"146 ","pages":"Article 104441"},"PeriodicalIF":2.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical finite element simulation of the pelvic organs under dynamic loading and validation against experimental data from magnetic resonance imaging","authors":"Camille Lafond ,&nbsp;Louise Hohnadel ,&nbsp;Thomas Brunel ,&nbsp;Nicolas Pirrò ,&nbsp;Marc-Emmanuel Bellemare ,&nbsp;Dominique Chamoret ,&nbsp;Sébastien Roth","doi":"10.1016/j.medengphy.2025.104433","DOIUrl":"10.1016/j.medengphy.2025.104433","url":null,"abstract":"<div><div>Pelvic organ prolapse (POP) is a prevalent condition affecting women, particularly those over the age of 50. The etiology and pathophysiology of this condition remain poorly understood within the medical community. In recent years, researchers, particularly medical engineers and biomechanical scientists, have initiated studies on this female pathology. Numerous finite element analyses have been conducted to determine the material properties of tissues involved in POP. Building on the material properties established in prior research, this study presents a patient-specific model derived from patient-specific MRI data. Intra-abdominal pressure (IAP) and boundary conditions were determined from MRI analysis, and the models were validated against MRI simulations encompassing 11 seconds with a 1-second step interval. This study compares the outcomes of our models with MRI results, providing insights into POP biomechanics. A good correlation was observed between MRI data and the finite element method (FEM) models in healthy patients, particularly for the bladder when fluid properties, such as urine, were included. A relative error between 18% and 26% was observed for bladder displacement. Moreover, the models provided acceptable results for the uterus, vagina, and rectum. Visual results supporting these findings are presented in this study.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"146 ","pages":"Article 104433"},"PeriodicalIF":2.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145099335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}