Medical Engineering & Physics最新文献

{"title":"3D bioheat transfer mapping reveals nanomagnetic particles effectiveness in radiofrequency hyperthermia breast cancer treatment comparing to experimental study","authors":"Mahsa Kavousi ,&nbsp;Erfan Saadatmand ,&nbsp;Mahboubeh Masoumbeigi ,&nbsp;Rabi Mahdavi ,&nbsp;Nader Riyahi Alam","doi":"10.1016/j.medengphy.2024.104249","DOIUrl":"10.1016/j.medengphy.2024.104249","url":null,"abstract":"<div><div>Radiofrequency (RF) hyperthermia has been widely used for tumor ablation since magnetic-fluid-hyperthermia (MFH) can be utilized for increasing temperature in tumor-region as a complementary-method for hyperthermia. In this study, the effectiveness of using the magnetite-nanoparticles (Fe₃O₄) in RF hyperthermia for breast cancer (BC) treatment by determining 3D-temperature-distribution using bioheat-transfer-mapping was evaluated. A breast-phantom with a tumor region was placed in an RF-device with 13.56 MHz frequency in different states (with and without-nanomagnetite). Parallelly, the calculations of the RF-wave and bioheat-equation were accomplished by numerical-simulation and finite-element-method (FEM) in COMSOL-software. The temperature differences were experimentally measured at different points of the phantom with a precision of 0.1 °C, with temperature of 3.6 °C and 6.1 °C in without and with nanomagnetic conditions in tumor area, respectively, and also for normal area with temperature of 1.8 °C and 1.9 °C in non-presence and presence states of 0.05 gr magnetite for both conditions, respectively. Moreover, the difference between the simulation and the experimental results was 0.54–1.1 %. The conformity between temperature measurement in experimental and simulation studies in tumor and normal areas showed the effectiveness of the application of MNPs for RF hyperthermia in tissue equivalent breast phantom. Finally, the positive effect of 0.05 gr of MNPs on BC treatment was confirmed.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142571570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring focused ultrasound ablation surgery (FUAS) using echo amplitudes of the therapeutic focused transducer","authors":"Yufeng Zhou ,&nbsp;Xiaobo Gong ,&nbsp;Yaqin You","doi":"10.1016/j.medengphy.2024.104247","DOIUrl":"10.1016/j.medengphy.2024.104247","url":null,"abstract":"<div><h3>Objective</h3><div>B-mode sonography is commonly used to monitor focused ultrasound ablation surgery (FUAS), but has limitations in sensitivity. More accurate and reliable prediction of coagulation is required.</div></div><div><h3>Methods</h3><div>The focused ultrasound (FUS) transducer was adapted for echo reception. Numerical simulations compared the normalized echo amplitudes from the FUS transducer and imaging probe at varying tissue depths and frequencies with a 3 mm necrosis at focus. An <em>ex vivo</em> experiment then evaluated echo changes from the FUS transducer and ultrasound imaging probe under different settings. Finally, coagulation prediction using FUS echo data was compared to sonography in a clinical <em>ex vivo</em> context.</div></div><div><h3>Results</h3><div>The echo amplitudes from the FUS transducer exhibit a less pronounced decline with increasing tissue penetration depth compared to the ultrasound imaging probe. In <em>ex vivo</em> bovine liver experiments at depths of 2 cm and 4 cm, the FUS transducer detected normalized echo amplitudes that were significantly larger (i.e., 2∼3 folds) than those received by the ultrasound imaging probe. Moreover, multi-layered <em>ex vivo</em> tissue experiments that replicate clinical conditions revealed that coagulation prediction utilizing the FUS transducer's echo amplitudes achieved superior accuracy (91.2% vs. 60.3 %), sensitivity (92.1% vs. 54.5 %), and negative prediction (78.9% vs. 30.6 %), but similar specificity (88.2% vs. 84.6 %) and positive prediction (95.9% vs. 93.8 %) in comparison to sonography.</div></div><div><h3>Conclusion</h3><div>The echo amplitude of the FUS transducer serves as a sensitive and dependable metric for monitoring the FUAS outcomes. Its utilization may augment the procedure's safety and efficacy.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated analysis of clinical indicators and mechanical properties in cancellous bone","authors":"Jiapeng He ,&nbsp;Zhen Pan ,&nbsp;Guowei Zhou ,&nbsp;Jiangming Yu ,&nbsp;Dayong Li","doi":"10.1016/j.medengphy.2024.104245","DOIUrl":"10.1016/j.medengphy.2024.104245","url":null,"abstract":"<div><div>Cancellous bone plays a critical role as a shock absorber in the human skeletal system. Accurate assessment of its microstructure and mechanical properties is crucial for osteoporosis diagnosis and treatment. However, various methods with different indicators are adopted currently in the clinical and laboratory assessments which lead to confusion and inconvenience for cancellous bone analysis. In the current work, correlations among clinical indicators including CT-derived Hounsfield Unit (HU) &amp; bone mineral density (BMD), laboratory indicators (mass density &amp; volume fraction), and mechanical properties (modulus &amp; strength) are explored. The results show that different indicators can be linearly linked through the HU value which can be adopted as a good microstructure indicator of cancellous bone. Additionally, the impacts of cancellous bone specimen preparation on clinical CT imaging and mechanical properties are also investigated. The results indicate common marrow-removal treatment can lead to decrease in mean HU value, deviation in HU value distribution, while it will increase the modulus and strength. The current work provides a valuable insight into the cancellous properties based on comprehensive analysis on the clinical and laboratory assessments which is critical for accurate diagnosis and personalized treatment.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A method of nucleus image segmentation and counting based on TC-UNet++ and distance watershed","authors":"Kaifeng Zheng ,&nbsp;Jie Pan ,&nbsp;Ziyan Jia ,&nbsp;Shuyan Xiao ,&nbsp;Weige Tao ,&nbsp;Dachuan Zhang ,&nbsp;Qing Li ,&nbsp;Lingjiao Pan","doi":"10.1016/j.medengphy.2024.104244","DOIUrl":"10.1016/j.medengphy.2024.104244","url":null,"abstract":"<div><div>Nucleus segmentation and counting play a crucial role in many cell analysis applications. However, the dense distribution and blurry boundaries of nucleus make nucleus segmentation tasks challenging. This paper proposes a novel segmentation and counting method. Firstly, TC-UNet++ is proposed to achieve a global segmentation. Then, the distance watershed method is used to finish local segmentation, which separate the adhesion and overlap part of the image. Finally, counting method is performed to obtain information on the counting number, area and center of mass of nucleus. TC-UNet++ achieved a Dice coefficient of 89.95% for cell instance segmentation on the Data Science Bowl dataset, surpassing the original U-Net++ by 0.23%. It also showed a 5.09% improvement in counting results compared to other methods. On the ALL-IDB dataset, TC-UNet++ reached a Dice coefficient of 83.97%, a 7.93% increase over the original U-Net++. Additionally, its counting results improved by 16.82% compared to other approaches. These results indicate that our method has a more complete and reasonable nucleus segmentation and counting scheme compared to other methods.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone ingrowth in randomly distributed porous interbody cage during lumbar spinal fusion","authors":"Rahul Gautam Talukdar ,&nbsp;Santanu Dhara ,&nbsp;Sanjay Gupta","doi":"10.1016/j.medengphy.2024.104248","DOIUrl":"10.1016/j.medengphy.2024.104248","url":null,"abstract":"<div><div>Porous interbody cages are often used in spinal fusion surgery since they allow bone ingrowth which facilitates long-term stability. However, the extent of bone ingrowth in and around porous interbody cages has scarcely been investigated. Moreover, tissue differentiation might not be similar around the superior and inferior cage-bone interfaces. Using mechanobiology-based numerical framework and physiologic loading conditions, the study investigates the spatial distribution of evolutionary bone ingrowth within randomly distributed porous interbody cages, having varied porosities. Finite Element (FE) microscale models, corresponding to cage porosities of 60 %, 72 %, and 83 %, were developed for the superior and inferior interfacial regions of the cage, along with the macroscale model of the implanted lumbar spine. The implant-bone relative displacements of different porosity models were mapped from macroscale to microscale model. Bone formation of 10–40 % was predicted across the porous cage models, resulting in an average Young's modulus ranging between 765 MPa and 915 MPa. Maximum bone ingrowth of ∼34 % was observed for the 83 % porous cage, which was subject to low implant-bone relative displacements (maximum 50μm). New bone formation was found to be greater at the superior interface (∼34 %) as compared to the inferior interface (∼30 %) for P83 model. Relatively greater volume of fibrous tissue was formed at the implant-bone interface for the cage with 60 % and 72 % porosities, which might lead to cage migration and eventual failure of the implant. Hence, the interbody cage with 83 % porosity appears to be most favorable for bone ingrowth, provided sufficient mechanical strength is offered.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental studies on penetration process of high-speed water-jet into ballistic gelatin","authors":"Li Liu ,&nbsp;XiaoYi Yang ,&nbsp;PengFei Wang ,&nbsp;Yu Huang ,&nbsp;Xing Huang","doi":"10.1016/j.medengphy.2024.104250","DOIUrl":"10.1016/j.medengphy.2024.104250","url":null,"abstract":"<div><div>To reveal the penetration mechanism and present the penetration characteristics of high-speed micro-jet with injection volume larger than 0.3 mL into soft tissue, the present study conducted experimental research on high-speed water-jet penetration into ballistic gelatin. The free jet dynamics of an air-powered needle-free injector that can emit up to 1.27 mL of liquid at once and the penetration dynamics were visualized to reveal the details of the penetration process. In the early unstable stage, the jet is emitted in the form of pulses, and the first jet pulse can rapidly generate an initial slender channel in gelatin in a very short time. In the subsequent stable stage, energy input produces dispersion and further increases the penetration depth slowly. Changing the driving pressure by the power source mainly changes the penetration depth increment by dispersion; while changing the nozzle diameter mainly affects the penetration depth in the initial stage. The central position of the dispersion area in the injection direction was firstly defined in the present work and it was found that an approximate linear relationship between this position and the maximum penetration depth exits for different nozzle diameters and driving pressures when injecting the same liquid dose. These research results can provide a basis for a thorough understanding of the penetration characteristics of high-speed micro-jet with injection volume larger than 0.3 mL into soft tissue, as well as the design and operation of the air-powered needle-free injector.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodology to identify subject-specific dynamic laxity tests to stretch individual parts of knee ligaments","authors":"Michael Skipper Andersen,&nbsp;Ilias Theodorakos","doi":"10.1016/j.medengphy.2024.104246","DOIUrl":"10.1016/j.medengphy.2024.104246","url":null,"abstract":"<div><div>The mechanical properties of ligaments are important for multiple applications and are often estimated from laxity tests. However, the typical laxity tests are not optimized for this application and, a potential exists to develop better laxity tests in this respect. Therefore, the purpose of this study was to develop a methodology to identify optimal, dynamic laxity tests that isolate the stretch of the individual ligaments from each other. To this end, we applied an existing rigid body-based knee model and a dataset of ∼100.000 random samples of applied forces (0–150 N), moments (0–10 Nm) and knee flexion angles (0–90°) through Monte Carlo Simulations. For each modelled ligament bundle, we identified ten load cases; one producing the highest force and nine equally spaced between the maximal and zero force, where the maximal force in all other ligament bundles were minimized. We compared these novel laxity tests to standard internal/external and varus/valgus laxity tests using an isolation metric.</div><div>We found that no laxity test could stretch the anterior part of the posterior cruciate and medial cruciate ligaments (PCL and MCL), whereas for all other ligaments, except the posterior PCL, the new laxity tests isolated the ligament stretch 28 % to 450 % better than standard tests.</div><div>From our study, we conclude that it is possible to define better laxity tests than currently exist and these may be highly relevant for determination of mechanical properties of ligaments <em>in vivo</em>. Future studies should generalize our results and translate them to modern laxity measurements technologies.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical usability and efficacy of a robotic bone fracture reduction system: A pilot animal study","authors":"Hyunhee Bang ,&nbsp;Hyun-Joo Lee ,&nbsp;Suk-Joong Lee ,&nbsp;Sanghyun Joung ,&nbsp;Joon-Woo Kim ,&nbsp;Chang-wug Oh ,&nbsp;Il-Hyung Park","doi":"10.1016/j.medengphy.2024.104242","DOIUrl":"10.1016/j.medengphy.2024.104242","url":null,"abstract":"<div><div>Challenges in minimally invasive surgeries, such as intramedullary nailing for long bone fractures, include radiation overexposure for patients and surgeons, potential malreduction, and physical burden on surgeons in maintaining the reduction status. A robotic bone fracture reduction system was developed in this study to address these problems. The system consists of a hexapod with six degrees of freedom, with a fracture reduction device and a master device. This study aimed to evaluate the novel system in a preclinical setting. The length of the six axes in the system can be adjusted to precisely control the length, angle, and rotation so that no additional traction is required. Fluoroscopic images can be remotely examined to reduce the risk of radiation exposure for surgeons. In this study, alignment accuracy and radiation exposure were measured using 32 bovine bone fracture models, and these surgical outcomes were compared to those of conventional manual surgery to verify the clinical usability and effectiveness of the system. The alignment accuracy was assessed by analyzing length, angulation, and rotation. The four surgeons participating in this study were divided into two groups (expert and novice) according to their clinical experience. All parameters in robotic surgery significantly decreased by approximately 4 mm and 8° on average (<em>p</em> ≤ 0.05) compared to conventional surgery. The mean radiation exposure in robot-assisted surgery was 0.11 mSv, showing a significant decrease compared to conventional surgery (<em>p</em> &lt; 0.05). Reduction accuracy was higher in robotic surgery performed by the novice group than in conventional surgery performed by the expert group; however, standard deviation values were inversed. In conclusion, the bone fracture reduction robot system increased the alignment accuracy through precise control while reducing radiation exposure in surgeons, as the surgery was performed remotely. The use of this system is predicted to improve the accuracy and reproducibility of the surgery and the safety of medical staff.<span><span>¹</span></span></div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contactless femoral implant stability monitoring in cementless total hip arthroplasty, A step towards clinical implementation","authors":"George Athanassoulis Makris ,&nbsp;Leonard Pastrav ,&nbsp;Michiel Mulier ,&nbsp;Georges Frederic Vles ,&nbsp;Wim Desmet ,&nbsp;Kathleen Denis","doi":"10.1016/j.medengphy.2024.104243","DOIUrl":"10.1016/j.medengphy.2024.104243","url":null,"abstract":"<div><div>The clinical implementation of currently used devices for intraoperative fixation monitoring of femoral implants via vibration-based methods in cementless total hip arthroplasty is challenging, due to practical and regulatory issues. Motivated by the effectiveness of electromagnetic excitation in similar dental applications, this study investigates the use of electromagnetic excitation for femoral implant stability monitoring during cementless total hip arthroplasty. The results obtained from electromagnetic excitation were largely consistent with reference results obtained through impact excitation, with a Pearson Correlation Coefficient of 0.79 in the 0.1–8 kHz frequency band. Moreover, the peak frequencies obtained via the two methods yielded a relative difference of 0.20 ± 0.22 %. Next, the excitation device was successfully utilized in conjunction with a laser vibrometer to monitor the stability of the femoral implant during an in vitro insertion, proving the feasibility of contactless implant stability monitoring. These results indicate the promising potential of this contactless method for clinical implementation.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platform for precise, personalised glucose forecasting through continuous glucose and physical activity monitoring and deep learning","authors":"Deepjyoti Kalita ,&nbsp;Hrishita Sharma ,&nbsp;Jayanta Kumar Panda ,&nbsp;Khalid B. Mirza","doi":"10.1016/j.medengphy.2024.104241","DOIUrl":"10.1016/j.medengphy.2024.104241","url":null,"abstract":"<div><div>Emerging research has demonstrated the advantage of continuous glucose monitoring for use in artificial pancreas and diabetes management in general. Recent studies demonstrate that glucose level forecasting using deep learning can help avoid postprandial hyperglycemia (≥ 180 mg/dL) or hypoglycemia (≤70 mg/dL) from delayed or increased insulin dosing in artificial pancreas. In this paper, a novel hybrid deep learning framework with integration of content-based attention learning is presented, to effectively predict the glucose measurements with prediction horizons (PH) = 15, 30 and, 60 minutes for T1D and T2D patients based on past data. We also present a complete cloud-based system and mobile app used for collecting CGM sensor, physical activity data, CHO values and insulin measurements to perform glucose forecasts using the proposed model running on Cloud. This model was validated using clinical data of individual with Type 1 diabetes (OhioT1DM) and individual with Type 2 diabetes. The mean absolute relative difference (MARD) was 12.33±3.15, 7.14±1.76% for PH=60 and, 30 min respectively on OhioT1DM clinical Dataset. The root mean squared error (RMSE) was 29.41±5.92 mg/dL and 17.19±3.22 mg/dL and the mean absolute error (MAE) was 21.96±4.67 mg/dL and 12.58±2.34 mg/dL for PH=60 and, 30 min respectively on the same clinical dataset. It was observed that inclusion of physical activity leads to improved glucose forecasting accuracy. Furthermore, all these results were obtained by training the model on only 8 days of clinical data of a single patient, followed by testing on clinical data on the following days. The results indicate that training on a single patient data may lead to better <em>personalisation</em> and better glucose forecasting results compared to existing works.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142424689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}